Q641Z2 (PTN9_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase non-receptor type 9
EC=3.1.3.48

Gene names

Name:

Ptpn9

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	593 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamily. Contains 1 CRAL-TRIO domain. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasmic part Inferred from electronic annotation. Source: Compara
Molecular_function	protein tyrosine phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 593	593	Tyrosine-protein phosphatase non-receptor type 9		PRO_0000094766
Regions
	Domain	84 – 243	160	CRAL-TRIO
	Domain	303 – 574	272	Tyrosine-protein phosphatase
	Region	515 – 521	7	Substrate binding By similarity
Sites
	Active site	515	1	Phosphocysteine intermediate By similarity
	Binding site	470	1	Substrate By similarity
	Binding site	559	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q641Z2 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 377836BB6B10D33D	FASTA	593	67,962
	10 20 30 40 50 60 MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF LMARKFDVLR 70 80 90 100 110 120 AVELFHCYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN VRDPTGASIA LFTARLHHPH 130 140 150 160 170 180 KSVQHVVLQA LFYLLDRAVD SFETQRNGLV FIYDMCGSNY ANFELDLGKK VLNLLKGAFP 190 200 210 220 230 240 ARLKKVLIVG APIWFRVPYS IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYIK 250 260 270 280 290 300 IDLATWNFQF LPQVNGHPDP FDEIILFSLP PALDWDSVHV PGPHAMTIQE LVDYVNTRQK 310 320 330 340 350 360 QGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS GHTQTDYINA 370 380 390 400 410 420 SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM TTRFEEGGRR KCGQYWPLEK 430 440 450 460 470 480 DSRIQFGFLT VTNLGVENMN HYKKTTLEIH NTEERQKRQV THFQFLSWPD YGVPSSAASL 490 500 510 520 530 540 IDFLRVVRSQ QSMAVGSLGA RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT 550 560 570 580 590 LNVFQTVSRM RTQRAFSIQT PEQYYFCYKA ILEFAEREGM VPSGHSLLAM DGQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	Heneberg P., Draber P. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 532-593. Strain: Wistar.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC082041 mRNA. Translation: AAH82041.1. AF520784 mRNA. Translation: AAM98071.1.
IPI	IPI00471655.
RefSeq	NP_001013058.1. NM_001013040.1.
UniGene	Rn.163020.
3D structure databases
ProteinModelPortal	Q641Z2.
SMR	Q641Z2. Positions 277-583.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000023831.
PTM databases
PhosphoSite	Q641Z2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000023831; ENSRNOP00000023831; ENSRNOG00000017600.
GeneID	266611.
KEGG	rno:266611.
UCSC	RGD:628726. rat.
Organism-specific databases
CTD	5780.
RGD	628726. Ptpn9.
Phylogenomic databases
eggNOG	COG5599.
GeneTree	ENSGT00700000104092.
HOGENOM	HOG000006971.
HOVERGEN	HBG006880.
InParanoid	Q641Z2.
KO	K01104.
OMA	MTTRFEE.
OrthoDB	EOG4DJJW7.
Gene expression databases
Genevestigator	Q641Z2.
Family and domain databases
Gene3D	3.40.525.10. 1 hit.
InterPro	IPR001251. CRAL-TRIO_dom. IPR011074. CRAL/TRIO_N_dom. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF00650. CRAL_TRIO. 1 hit. PF00102. Y_phosphatase. 1 hit. [Graphical view]
PRINTS	PR00700. PRTYPHPHTASE.
SMART	SM01100. CRAL_TRIO_N. 1 hit. SM00194. PTPc. 1 hit. SM00516. SEC14. 1 hit. [Graphical view]
SUPFAM	SSF52087. CRAL_TRIO_C. 1 hit. SSF46938. Sec14p_like_N. 1 hit.
PROSITE	PS50191. CRAL_TRIO. 1 hit. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	624448.

Entry information

Entry name

PTN9_RAT

Accession

Primary (citable) accession number: Q641Z2
Secondary accession number(s): Q8K3Y9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	October 25, 2004
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program