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Q641Z2 (PTN9_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 9

EC=3.1.3.48
Gene names
Name:Ptpn9
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length593 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamily.

Contains 1 CRAL-TRIO domain.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Protein phosphatase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 593593Tyrosine-protein phosphatase non-receptor type 9
PRO_0000094766

Regions

Domain84 – 243160CRAL-TRIO
Domain303 – 574272Tyrosine-protein phosphatase
Region515 – 5217Substrate binding By similarity

Sites

Active site5151Phosphocysteine intermediate By similarity
Binding site4701Substrate By similarity
Binding site5591Substrate By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q641Z2 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 377836BB6B10D33D

FASTA59367,962
        10         20         30         40         50         60 
MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF LMARKFDVLR 

        70         80         90        100        110        120 
AVELFHCYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN VRDPTGASIA LFTARLHHPH 

       130        140        150        160        170        180 
KSVQHVVLQA LFYLLDRAVD SFETQRNGLV FIYDMCGSNY ANFELDLGKK VLNLLKGAFP 

       190        200        210        220        230        240 
ARLKKVLIVG APIWFRVPYS IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYIK 

       250        260        270        280        290        300 
IDLATWNFQF LPQVNGHPDP FDEIILFSLP PALDWDSVHV PGPHAMTIQE LVDYVNTRQK 

       310        320        330        340        350        360 
QGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS GHTQTDYINA 

       370        380        390        400        410        420 
SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM TTRFEEGGRR KCGQYWPLEK 

       430        440        450        460        470        480 
DSRIQFGFLT VTNLGVENMN HYKKTTLEIH NTEERQKRQV THFQFLSWPD YGVPSSAASL 

       490        500        510        520        530        540 
IDFLRVVRSQ QSMAVGSLGA RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT 

       550        560        570        580        590 
LNVFQTVSRM RTQRAFSIQT PEQYYFCYKA ILEFAEREGM VPSGHSLLAM DGQ 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]Heneberg P., Draber P.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 532-593.
Strain: Wistar.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC082041 mRNA. Translation: AAH82041.1.
AF520784 mRNA. Translation: AAM98071.1.
RefSeqNP_001013058.1. NM_001013040.1.
UniGeneRn.163020.

3D structure databases

ProteinModelPortalQ641Z2.
SMRQ641Z2. Positions 277-583.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ641Z2. 2 interactions.
STRING10116.ENSRNOP00000023831.

PTM databases

PhosphoSiteQ641Z2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000023831; ENSRNOP00000023831; ENSRNOG00000017600.
GeneID266611.
KEGGrno:266611.
UCSCRGD:628726. rat.

Organism-specific databases

CTD5780.
RGD628726. Ptpn9.

Phylogenomic databases

eggNOGCOG5599.
GeneTreeENSGT00750000117312.
HOGENOMHOG000006971.
HOVERGENHBG006880.
InParanoidQ641Z2.
KOK18038.
OMAMTTRFEE.
OrthoDBEOG79GT5R.
PhylomeDBQ641Z2.
TreeFamTF351975.

Gene expression databases

GenevestigatorQ641Z2.

Family and domain databases

Gene3D3.40.525.10. 1 hit.
3.90.190.10. 1 hit.
InterProIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00650. CRAL_TRIO. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM01100. CRAL_TRIO_N. 1 hit.
SM00194. PTPc. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEPS50191. CRAL_TRIO. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio624448.
PROQ641Z2.

Entry information

Entry namePTN9_RAT
AccessionPrimary (citable) accession number: Q641Z2
Secondary accession number(s): Q8K3Y9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 25, 2004
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families