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Q641Z2

- PTN9_RAT

UniProt

Q641Z2 - PTN9_RAT

Protein

Tyrosine-protein phosphatase non-receptor type 9

Gene

Ptpn9

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei470 – 4701SubstrateBy similarity
    Active sitei515 – 5151Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei559 – 5591SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 9 (EC:3.1.3.48)
    Gene namesi
    Name:Ptpn9
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi628726. Ptpn9.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 593593Tyrosine-protein phosphatase non-receptor type 9PRO_0000094766Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    PTM databases

    PhosphoSiteiQ641Z2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ641Z2.

    Interactioni

    Protein-protein interaction databases

    IntActiQ641Z2. 2 interactions.
    STRINGi10116.ENSRNOP00000023831.

    Structurei

    3D structure databases

    ProteinModelPortaliQ641Z2.
    SMRiQ641Z2. Positions 277-583.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini84 – 243160CRAL-TRIOPROSITE-ProRule annotationAdd
    BLAST
    Domaini303 – 574272Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni515 – 5217Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00750000117312.
    HOGENOMiHOG000006971.
    HOVERGENiHBG006880.
    InParanoidiQ641Z2.
    KOiK18038.
    OMAiMTTRFEE.
    OrthoDBiEOG79GT5R.
    PhylomeDBiQ641Z2.
    TreeFamiTF351975.

    Family and domain databases

    Gene3Di3.40.525.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR001251. CRAL-TRIO_dom.
    IPR011074. CRAL/TRIO_N_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00650. CRAL_TRIO. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM01100. CRAL_TRIO_N. 1 hit.
    SM00194. PTPc. 1 hit.
    SM00516. SEC14. 1 hit.
    [Graphical view]
    SUPFAMiSSF46938. SSF46938. 1 hit.
    SSF52087. SSF52087. 1 hit.
    SSF52799. SSF52799. 1 hit.
    PROSITEiPS50191. CRAL_TRIO. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q641Z2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF    50
    LMARKFDVLR AVELFHCYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN 100
    VRDPTGASIA LFTARLHHPH KSVQHVVLQA LFYLLDRAVD SFETQRNGLV 150
    FIYDMCGSNY ANFELDLGKK VLNLLKGAFP ARLKKVLIVG APIWFRVPYS 200
    IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYIK IDLATWNFQF 250
    LPQVNGHPDP FDEIILFSLP PALDWDSVHV PGPHAMTIQE LVDYVNTRQK 300
    QGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS 350
    GHTQTDYINA SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM 400
    TTRFEEGGRR KCGQYWPLEK DSRIQFGFLT VTNLGVENMN HYKKTTLEIH 450
    NTEERQKRQV THFQFLSWPD YGVPSSAASL IDFLRVVRSQ QSMAVGSLGA 500
    RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT LNVFQTVSRM 550
    RTQRAFSIQT PEQYYFCYKA ILEFAEREGM VPSGHSLLAM DGQ 593
    Length:593
    Mass (Da):67,962
    Last modified:October 25, 2004 - v1
    Checksum:i377836BB6B10D33D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC082041 mRNA. Translation: AAH82041.1.
    AF520784 mRNA. Translation: AAM98071.1.
    RefSeqiNP_001013058.1. NM_001013040.1.
    UniGeneiRn.163020.

    Genome annotation databases

    EnsembliENSRNOT00000023831; ENSRNOP00000023831; ENSRNOG00000017600.
    GeneIDi266611.
    KEGGirno:266611.
    UCSCiRGD:628726. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC082041 mRNA. Translation: AAH82041.1 .
    AF520784 mRNA. Translation: AAM98071.1 .
    RefSeqi NP_001013058.1. NM_001013040.1.
    UniGenei Rn.163020.

    3D structure databases

    ProteinModelPortali Q641Z2.
    SMRi Q641Z2. Positions 277-583.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q641Z2. 2 interactions.
    STRINGi 10116.ENSRNOP00000023831.

    PTM databases

    PhosphoSitei Q641Z2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000023831 ; ENSRNOP00000023831 ; ENSRNOG00000017600 .
    GeneIDi 266611.
    KEGGi rno:266611.
    UCSCi RGD:628726. rat.

    Organism-specific databases

    CTDi 5780.
    RGDi 628726. Ptpn9.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00750000117312.
    HOGENOMi HOG000006971.
    HOVERGENi HBG006880.
    InParanoidi Q641Z2.
    KOi K18038.
    OMAi MTTRFEE.
    OrthoDBi EOG79GT5R.
    PhylomeDBi Q641Z2.
    TreeFami TF351975.

    Miscellaneous databases

    NextBioi 624448.
    PROi Q641Z2.

    Gene expression databases

    Genevestigatori Q641Z2.

    Family and domain databases

    Gene3Di 3.40.525.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR001251. CRAL-TRIO_dom.
    IPR011074. CRAL/TRIO_N_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00650. CRAL_TRIO. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM01100. CRAL_TRIO_N. 1 hit.
    SM00194. PTPc. 1 hit.
    SM00516. SEC14. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46938. SSF46938. 1 hit.
    SSF52087. SSF52087. 1 hit.
    SSF52799. SSF52799. 1 hit.
    PROSITEi PS50191. CRAL_TRIO. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. Heneberg P., Draber P.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 532-593.
      Strain: Wistar.

    Entry informationi

    Entry nameiPTN9_RAT
    AccessioniPrimary (citable) accession number: Q641Z2
    Secondary accession number(s): Q8K3Y9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3