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Q641Z2

- PTN9_RAT

UniProt

Q641Z2 - PTN9_RAT

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Protein

Tyrosine-protein phosphatase non-receptor type 9

Gene

Ptpn9

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei470 – 4701SubstrateBy similarity
Active sitei515 – 5151Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei559 – 5591SubstrateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. peptidyl-tyrosine dephosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 9 (EC:3.1.3.48)
Gene namesi
Name:Ptpn9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi628726. Ptpn9.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Tyrosine-protein phosphatase non-receptor type 9PRO_0000094766Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

PTM databases

PhosphoSiteiQ641Z2.

Expressioni

Gene expression databases

GenevestigatoriQ641Z2.

Interactioni

Protein-protein interaction databases

IntActiQ641Z2. 2 interactions.
STRINGi10116.ENSRNOP00000023831.

Structurei

3D structure databases

ProteinModelPortaliQ641Z2.
SMRiQ641Z2. Positions 277-583.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 243160CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST
Domaini303 – 574272Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni515 – 5217Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00770000120472.
HOGENOMiHOG000006971.
HOVERGENiHBG006880.
InParanoidiQ641Z2.
KOiK18038.
OMAiMTTRFEE.
OrthoDBiEOG79GT5R.
PhylomeDBiQ641Z2.
TreeFamiTF351975.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00194. PTPc. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q641Z2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF
60 70 80 90 100
LMARKFDVLR AVELFHCYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN
110 120 130 140 150
VRDPTGASIA LFTARLHHPH KSVQHVVLQA LFYLLDRAVD SFETQRNGLV
160 170 180 190 200
FIYDMCGSNY ANFELDLGKK VLNLLKGAFP ARLKKVLIVG APIWFRVPYS
210 220 230 240 250
IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYIK IDLATWNFQF
260 270 280 290 300
LPQVNGHPDP FDEIILFSLP PALDWDSVHV PGPHAMTIQE LVDYVNTRQK
310 320 330 340 350
QGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS
360 370 380 390 400
GHTQTDYINA SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM
410 420 430 440 450
TTRFEEGGRR KCGQYWPLEK DSRIQFGFLT VTNLGVENMN HYKKTTLEIH
460 470 480 490 500
NTEERQKRQV THFQFLSWPD YGVPSSAASL IDFLRVVRSQ QSMAVGSLGA
510 520 530 540 550
RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT LNVFQTVSRM
560 570 580 590
RTQRAFSIQT PEQYYFCYKA ILEFAEREGM VPSGHSLLAM DGQ
Length:593
Mass (Da):67,962
Last modified:October 25, 2004 - v1
Checksum:i377836BB6B10D33D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082041 mRNA. Translation: AAH82041.1.
AF520784 mRNA. Translation: AAM98071.1.
RefSeqiNP_001013058.1. NM_001013040.1.
UniGeneiRn.163020.

Genome annotation databases

EnsembliENSRNOT00000023831; ENSRNOP00000023831; ENSRNOG00000017600.
GeneIDi266611.
KEGGirno:266611.
UCSCiRGD:628726. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082041 mRNA. Translation: AAH82041.1 .
AF520784 mRNA. Translation: AAM98071.1 .
RefSeqi NP_001013058.1. NM_001013040.1.
UniGenei Rn.163020.

3D structure databases

ProteinModelPortali Q641Z2.
SMRi Q641Z2. Positions 277-583.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q641Z2. 2 interactions.
STRINGi 10116.ENSRNOP00000023831.

PTM databases

PhosphoSitei Q641Z2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000023831 ; ENSRNOP00000023831 ; ENSRNOG00000017600 .
GeneIDi 266611.
KEGGi rno:266611.
UCSCi RGD:628726. rat.

Organism-specific databases

CTDi 5780.
RGDi 628726. Ptpn9.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00770000120472.
HOGENOMi HOG000006971.
HOVERGENi HBG006880.
InParanoidi Q641Z2.
KOi K18038.
OMAi MTTRFEE.
OrthoDBi EOG79GT5R.
PhylomeDBi Q641Z2.
TreeFami TF351975.

Miscellaneous databases

NextBioi 624448.
PROi Q641Z2.

Gene expression databases

Genevestigatori Q641Z2.

Family and domain databases

Gene3Di 3.40.525.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00650. CRAL_TRIO. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM01100. CRAL_TRIO_N. 1 hit.
SM00194. PTPc. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view ]
SUPFAMi SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEi PS50191. CRAL_TRIO. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Heneberg P., Draber P.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 532-593.
    Strain: Wistar.

Entry informationi

Entry nameiPTN9_RAT
AccessioniPrimary (citable) accession number: Q641Z2
Secondary accession number(s): Q8K3Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 25, 2004
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3