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Q641Y2

- NDUS2_RAT

UniProt

Q641Y2 - NDUS2_RAT

Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

Gene

Ndufs2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.By similarity

    Cofactori

    Binds 1 4Fe-4S cluster.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi326 – 3261Iron-sulfur (4Fe-4S)Curated
    Metal bindingi332 – 3321Iron-sulfur (4Fe-4S)Curated
    Metal bindingi347 – 3471Iron-sulfur (4Fe-4S)Curated

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. NAD binding Source: InterPro
    4. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    5. quinone binding Source: InterPro

    GO - Biological processi

    1. response to oxidative stress Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    Complex I-49kD
    Short name:
    CI-49kD
    NADH-ubiquinone oxidoreductase 49 kDa subunit
    Gene namesi
    Name:Ndufs2Imported
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi1307109. Ndufs2.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Matrix side 1 Publication

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex I Source: Ensembl

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3333MitochondrionBy similarityAdd
    BLAST
    Chaini34 – 463430NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialPRO_0000342702Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei62 – 621N6-acetyllysineBy similarity
    Modified residuei118 – 1181Symmetric dimethylarginineBy similarity

    Keywords - PTMi

    Acetylation, Methylation

    Proteomic databases

    PRIDEiQ641Y2.

    2D gel databases

    World-2DPAGE0004:Q641Y2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ641Y2.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits. Component of the iron-sulfur (IP) fragment of the enzyme By similarity. Interacts with NDUFAF3 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ641Y2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 49 kDa subunit family.Sequence Analysis

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    GeneTreeiENSGT00390000009529.
    HOVERGENiHBG000760.
    KOiK03935.
    OMAiARFTINY.
    OrthoDBiEOG7WT411.
    PhylomeDBiQ641Y2.

    Family and domain databases

    Gene3Di1.10.645.10. 1 hit.
    HAMAPiMF_01358. NDH1_NuoD.
    InterProiIPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view]
    PfamiPF00346. Complex1_49kDa. 1 hit.
    [Graphical view]
    SUPFAMiSSF56762. SSF56762. 1 hit.
    TIGRFAMsiTIGR01962. NuoD. 1 hit.
    PROSITEiPS00535. COMPLEX1_49K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q641Y2-1 [UniParc]FASTAAdd to Basket

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    MAALRAVCSL RGVGAQVLRA GSGIRLPSQP SRGARRWQPD IEWAEQFSGA    50
    VMYPSKETAH WKPPPWNDVD VLKEKVVTNV TLNFGPQHPA AHGVLRLVLE 100
    LSGEMVRKCD PHIGLLHRGT EKLIEYKTYL QALPYFDRLD YVSMMCNEQA 150
    YSLAVEKLLN IQPPPRAQWI RVLFGEITRI LNHIMAVTTH ALDIGAMTPF 200
    FWMFEEREKM FEFYERVSGA RMHAAYIRPG GVHQDLPLGL MDDIYEFSKN 250
    FSLRIDEVEE MLTNNRIWRN RTVDIGVVSA EDALNYGFSG VMLRGSGIQW 300
    DLRKTQPYDV YDQVEFDVPI GSRGDCYDRY LCRVEEMRQS LRIIEQCLNK 350
    MPPGEIKVDD AKVSPPKRAE MKTSMESLIH HFKLYTEGYQ VPPGATYTAI 400
    EAPKGEFGVY LVSDGSSRPY RCKIKAPGFA HLAGLDKMSK GHMLADVVAI 450
    IGTQDIVFGE IDR 463
    Length:463
    Mass (Da):52,562
    Last modified:October 25, 2004 - v1
    Checksum:iB9919E581C229C19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC082067 mRNA. Translation: AAH82067.1.
    RefSeqiNP_001011907.1. NM_001011907.1.
    XP_003751325.1. XM_003751277.2.
    UniGeneiRn.99666.

    Genome annotation databases

    EnsembliENSRNOT00000058423; ENSRNOP00000055224; ENSRNOG00000038372.
    GeneIDi289218.
    KEGGirno:289218.
    UCSCiRGD:1307109. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC082067 mRNA. Translation: AAH82067.1 .
    RefSeqi NP_001011907.1. NM_001011907.1.
    XP_003751325.1. XM_003751277.2.
    UniGenei Rn.99666.

    3D structure databases

    ProteinModelPortali Q641Y2.
    ModBasei Search...
    MobiDBi Search...

    2D gel databases

    World-2DPAGE 0004:Q641Y2.

    Proteomic databases

    PRIDEi Q641Y2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000058423 ; ENSRNOP00000055224 ; ENSRNOG00000038372 .
    GeneIDi 289218.
    KEGGi rno:289218.
    UCSCi RGD:1307109. rat.

    Organism-specific databases

    CTDi 4720.
    RGDi 1307109. Ndufs2.

    Phylogenomic databases

    GeneTreei ENSGT00390000009529.
    HOVERGENi HBG000760.
    KOi K03935.
    OMAi ARFTINY.
    OrthoDBi EOG7WT411.
    PhylomeDBi Q641Y2.

    Miscellaneous databases

    NextBioi 629400.
    PROi Q641Y2.

    Gene expression databases

    Genevestigatori Q641Y2.

    Family and domain databases

    Gene3Di 1.10.645.10. 1 hit.
    HAMAPi MF_01358. NDH1_NuoD.
    InterProi IPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view ]
    Pfami PF00346. Complex1_49kDa. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56762. SSF56762. 1 hit.
    TIGRFAMsi TIGR01962. NuoD. 1 hit.
    PROSITEi PS00535. COMPLEX1_49K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Brown Norway1 Publication.
      Tissue: TestisImported.
    2. "Proteome profile of the mature rat olfactory bulb."
      Maurya D.K., Sundaram C.S., Bhargava P.
      Proteomics 9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiNDUS2_RAT
    AccessioniPrimary (citable) accession number: Q641Y2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3