Reviewed,
UniProtKB/Swiss-Prot Q641Y2 (NDUS2_RAT)
Last modified
November 25, 2008.
Version 34.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial EC=1.6.5.3 EC=1.6.99.3 Alternative name(s): NADH-ubiquinone oxidoreductase 49 kDa subunit Complex I-49kD Short name=CI-49kD | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 463 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. |
| Catalytic activity | NADH + ubiquinone = NAD(+) + ubiquinol. NADH + acceptor = NAD(+) + reduced acceptor. |
| Cofactor | Binds 1 4Fe-4S cluster. |
| Subunit structure | Complex I is composed of 45 different subunits. Component of the iron-sulfur (IP) fragment of the enzyme By similarity. |
| Subcellular location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix sideBy similarity. |
| Sequence similarities | Belongs to the complex I 49 kDa subunit family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 33 | 33 | Mitochondrion By similarity | ||||||
| Chain | 34 – 463 | 430 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | PRO_0000342702 | |||||
Sites | |||||||||
| Metal binding | 326 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
| Metal binding | 332 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
| Metal binding | 347 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Brown Norway. Tissue: Testis. |
| [2] | Maurya D.K., Bhargava P. Submitted (MAY-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 57-73; 76-96; 97-107; 128-138; 159-166; 172-179; 210-216; 255-266; 272-323; 343-350; 384-404 AND 426-437. Strain: Wistar. Tissue: Olfactory bulb. |
Cross-references
Sequence databases | |
|---|---|
| BC082067 mRNA. Translation: AAH82067.1. | |
| RefSeq | NP_001011907.1. |
| UniGene | Rn.99666 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 289218. |
| KEGG | rno:289218. |
Organism-specific databases | |
| RGD | 1307109. Ndufs2. |
Phylogenomic databases | |
| HOVERGEN | Q641Y2. |
Family and domain databases | |
| InterPro | IPR014029. NADH-UbQ_OxRdtase_49kDa_CS. IPR010219. NADH_DH_1_dsu. IPR001135. NADH_UbQ_OxRdtase_49kDa. [Graphical view] |
| Pfam | PF00346. Complex1_49kDa. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01962. NuoD. 1 hit. |
| PROSITE | PS00535. COMPLEX1_49K. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 629400. |
Entry information
| Entry name | NDUS2_RAT | ||||||||
| Accession | Primary (citable) accession number: Q641Y2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


