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Q641Y2

- NDUS2_RAT

UniProt

Q641Y2 - NDUS2_RAT

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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

Gene

Ndufs2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.By similarity

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi326 – 3261Iron-sulfur (4Fe-4S)Curated
Metal bindingi332 – 3321Iron-sulfur (4Fe-4S)Curated
Metal bindingi347 – 3471Iron-sulfur (4Fe-4S)Curated

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. NAD binding Source: InterPro
  4. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  5. quinone binding Source: InterPro

GO - Biological processi

  1. response to oxidative stress Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiREACT_262146. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-49kD
Short name:
CI-49kD
NADH-ubiquinone oxidoreductase 49 kDa subunit
Gene namesi
Name:Ndufs2Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi1307109. Ndufs2.

Subcellular locationi

Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Matrix side 1 Publication

GO - Cellular componenti

  1. mitochondrial respiratory chain complex I Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3333MitochondrionBy similarityAdd
BLAST
Chaini34 – 463430NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialPRO_0000342702Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621N6-acetyllysineBy similarity
Modified residuei118 – 1181Symmetric dimethylarginineBy similarity

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PRIDEiQ641Y2.

2D gel databases

World-2DPAGE0004:Q641Y2.

Expressioni

Gene expression databases

GenevestigatoriQ641Y2.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. Component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Interacts with NDUFAF3 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ641Y2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.Sequence Analysis

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000009529.
HOVERGENiHBG000760.
InParanoidiQ641Y2.
KOiK03935.
OMAiARFTINY.
OrthoDBiEOG7WT411.
PhylomeDBiQ641Y2.

Family and domain databases

Gene3Di1.10.645.10. 1 hit.
HAMAPiMF_01358. NDH1_NuoD.
InterProiIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.
TIGRFAMsiTIGR01962. NuoD. 1 hit.
PROSITEiPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q641Y2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAALRAVCSL RGVGAQVLRA GSGIRLPSQP SRGARRWQPD IEWAEQFSGA
60 70 80 90 100
VMYPSKETAH WKPPPWNDVD VLKEKVVTNV TLNFGPQHPA AHGVLRLVLE
110 120 130 140 150
LSGEMVRKCD PHIGLLHRGT EKLIEYKTYL QALPYFDRLD YVSMMCNEQA
160 170 180 190 200
YSLAVEKLLN IQPPPRAQWI RVLFGEITRI LNHIMAVTTH ALDIGAMTPF
210 220 230 240 250
FWMFEEREKM FEFYERVSGA RMHAAYIRPG GVHQDLPLGL MDDIYEFSKN
260 270 280 290 300
FSLRIDEVEE MLTNNRIWRN RTVDIGVVSA EDALNYGFSG VMLRGSGIQW
310 320 330 340 350
DLRKTQPYDV YDQVEFDVPI GSRGDCYDRY LCRVEEMRQS LRIIEQCLNK
360 370 380 390 400
MPPGEIKVDD AKVSPPKRAE MKTSMESLIH HFKLYTEGYQ VPPGATYTAI
410 420 430 440 450
EAPKGEFGVY LVSDGSSRPY RCKIKAPGFA HLAGLDKMSK GHMLADVVAI
460
IGTQDIVFGE IDR
Length:463
Mass (Da):52,562
Last modified:October 25, 2004 - v1
Checksum:iB9919E581C229C19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082067 mRNA. Translation: AAH82067.1.
RefSeqiNP_001011907.1. NM_001011907.1.
XP_003751325.1. XM_003751277.2.
UniGeneiRn.99666.

Genome annotation databases

EnsembliENSRNOT00000058423; ENSRNOP00000055224; ENSRNOG00000038372.
GeneIDi289218.
KEGGirno:289218.
UCSCiRGD:1307109. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082067 mRNA. Translation: AAH82067.1 .
RefSeqi NP_001011907.1. NM_001011907.1.
XP_003751325.1. XM_003751277.2.
UniGenei Rn.99666.

3D structure databases

ProteinModelPortali Q641Y2.
ModBasei Search...
MobiDBi Search...

2D gel databases

World-2DPAGE 0004:Q641Y2.

Proteomic databases

PRIDEi Q641Y2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000058423 ; ENSRNOP00000055224 ; ENSRNOG00000038372 .
GeneIDi 289218.
KEGGi rno:289218.
UCSCi RGD:1307109. rat.

Organism-specific databases

CTDi 4720.
RGDi 1307109. Ndufs2.

Phylogenomic databases

GeneTreei ENSGT00390000009529.
HOVERGENi HBG000760.
InParanoidi Q641Y2.
KOi K03935.
OMAi ARFTINY.
OrthoDBi EOG7WT411.
PhylomeDBi Q641Y2.

Enzyme and pathway databases

Reactomei REACT_262146. Respiratory electron transport.

Miscellaneous databases

NextBioi 629400.
PROi Q641Y2.

Gene expression databases

Genevestigatori Q641Y2.

Family and domain databases

Gene3Di 1.10.645.10. 1 hit.
HAMAPi MF_01358. NDH1_NuoD.
InterProi IPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view ]
Pfami PF00346. Complex1_49kDa. 1 hit.
[Graphical view ]
SUPFAMi SSF56762. SSF56762. 1 hit.
TIGRFAMsi TIGR01962. NuoD. 1 hit.
PROSITEi PS00535. COMPLEX1_49K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Brown Norway1 Publication.
    Tissue: TestisImported.
  2. "Proteome profile of the mature rat olfactory bulb."
    Maurya D.K., Sundaram C.S., Bhargava P.
    Proteomics 9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiNDUS2_RAT
AccessioniPrimary (citable) accession number: Q641Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 25, 2004
Last modified: November 26, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3