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Q641Y2 (NDUS2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
Complex I-49kD
Short name=CI-49kD
NADH-ubiquinone oxidoreductase 49 kDa subunit
Gene names
Name:Ndufs2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. HAMAP-Rule MF_01358

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out). HAMAP-Rule MF_01358

NADH + acceptor = NAD+ + reduced acceptor. HAMAP-Rule MF_01358

Cofactor

Binds 1 4Fe-4S cluster.

Subunit structure

Complex I is composed of 45 different subunits. Component of the iron-sulfur (IP) fragment of the enzyme By similarity. Interacts with NDUFAF3 By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side Ref.2.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3333Mitochondrion By similarity
Chain34 – 463430NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial HAMAP-Rule MF_01358
PRO_0000342702

Sites

Metal binding3261Iron-sulfur (4Fe-4S) Potential
Metal binding3321Iron-sulfur (4Fe-4S) Potential
Metal binding3471Iron-sulfur (4Fe-4S) Potential

Amino acid modifications

Modified residue621N6-acetyllysine By similarity
Modified residue1181Symmetric dimethylarginine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q641Y2 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: B9919E581C229C19

FASTA46352,562
        10         20         30         40         50         60 
MAALRAVCSL RGVGAQVLRA GSGIRLPSQP SRGARRWQPD IEWAEQFSGA VMYPSKETAH 

        70         80         90        100        110        120 
WKPPPWNDVD VLKEKVVTNV TLNFGPQHPA AHGVLRLVLE LSGEMVRKCD PHIGLLHRGT 

       130        140        150        160        170        180 
EKLIEYKTYL QALPYFDRLD YVSMMCNEQA YSLAVEKLLN IQPPPRAQWI RVLFGEITRI 

       190        200        210        220        230        240 
LNHIMAVTTH ALDIGAMTPF FWMFEEREKM FEFYERVSGA RMHAAYIRPG GVHQDLPLGL 

       250        260        270        280        290        300 
MDDIYEFSKN FSLRIDEVEE MLTNNRIWRN RTVDIGVVSA EDALNYGFSG VMLRGSGIQW 

       310        320        330        340        350        360 
DLRKTQPYDV YDQVEFDVPI GSRGDCYDRY LCRVEEMRQS LRIIEQCLNK MPPGEIKVDD 

       370        380        390        400        410        420 
AKVSPPKRAE MKTSMESLIH HFKLYTEGYQ VPPGATYTAI EAPKGEFGVY LVSDGSSRPY 

       430        440        450        460 
RCKIKAPGFA HLAGLDKMSK GHMLADVVAI IGTQDIVFGE IDR 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Brown Norway.
Tissue: Testis.
[2]"Proteome profile of the mature rat olfactory bulb."
Maurya D.K., Sundaram C.S., Bhargava P.
Proteomics 9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC082067 mRNA. Translation: AAH82067.1.
RefSeqNP_001011907.1. NM_001011907.1.
XP_003751325.1. XM_003751277.2.
UniGeneRn.99666.

3D structure databases

ProteinModelPortalQ641Y2.
ModBaseSearch...
MobiDBSearch...

2D gel databases

World-2DPAGE0004:Q641Y2.

Proteomic databases

PRIDEQ641Y2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000058423; ENSRNOP00000055224; ENSRNOG00000038372.
GeneID289218.
KEGGrno:289218.
UCSCRGD:1307109. rat.

Organism-specific databases

CTD4720.
RGD1307109. Ndufs2.

Phylogenomic databases

GeneTreeENSGT00390000009529.
HOVERGENHBG000760.
KOK03935.
OMAARFTINY.
OrthoDBEOG7WT411.
PhylomeDBQ641Y2.

Gene expression databases

GenevestigatorQ641Y2.

Family and domain databases

Gene3D1.10.645.10. 1 hit.
HAMAPMF_01358. NDH1_NuoD.
InterProIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMSSF56762. SSF56762. 1 hit.
TIGRFAMsTIGR01962. NuoD. 1 hit.
PROSITEPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio629400.
PROQ641Y2.

Entry information

Entry nameNDUS2_RAT
AccessionPrimary (citable) accession number: Q641Y2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 25, 2004
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families