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Protein

F-box only protein 25

Gene

Fbxo25

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 25
Gene namesi
Name:Fbxo25
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359105. Fbxo25.

Subcellular locationi

  • Nucleus By similarity

  • Note: In the nucleus, associates with a specific and novel subnuclear dot-like structure.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199131 – 357F-box only protein 25Add BLAST357

PTM databases

iPTMnetiQ641X7.
PhosphoSitePlusiQ641X7.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly with SKP1 and CUL1 (By similarity). Interacts (via C-terminus) with actin (via N-terminus) (By similarity).By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini224 – 271F-boxAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 83Interaction with beta-actinBy similarityAdd BLAST83

Domaini

The F-box is necessary for the interaction with SKP1.By similarity

Sequence similaritiesi

Contains 1 F-box domain.Curated

Phylogenomic databases

HOVERGENiHBG051572.
InParanoidiQ641X7.
KOiK10305.
PhylomeDBiQ641X7.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q641X7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFLGQDWRS PGWSWIKTED GWKRCDPCSH EIRSEDNQYP VNHSIILNSG
60 70 80 90 100
EEEIFNNDCE YAAKKRKKQH FGNDTAAHSF YREKWIYVHK ESTKERHGYC
110 120 130 140 150
TLGEAFNRLD FSSAIQDIRR FTYVVKLLQL IAKSQLTSLS GVAQKNYFNI
160 170 180 190 200
LDKIVQKVLD DHQNPRLIKD LLQDLSSTLC ILVRGVGKSV LVGNINIWIC
210 220 230 240 250
RLETVLNWQE KLQNLQMTKQ VNTGLTLSDL PLHMLNNILY RFSDGWDIVT
260 270 280 290 300
LGQVTPTLYM LSEDRRLWKR LCQYHFAEKQ FCRHLILSEK GHIEWKLMYF
310 320 330 340 350
TLQKYYPTKE QYGDTLHFCR HCSILFWKDS GHPCTAADPD SCFTPVSPEH

FIDLFKF
Length:357
Mass (Da):41,984
Last modified:October 25, 2004 - v1
Checksum:i0AB159D60CFCED42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082088 mRNA. Translation: AAH82088.1.
RefSeqiNP_001014261.1. NM_001014239.1.
UniGeneiRn.234327.

Genome annotation databases

GeneIDi364637.
KEGGirno:364637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082088 mRNA. Translation: AAH82088.1.
RefSeqiNP_001014261.1. NM_001014239.1.
UniGeneiRn.234327.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ641X7.
PhosphoSitePlusiQ641X7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi364637.
KEGGirno:364637.

Organism-specific databases

CTDi26260.
RGDi1359105. Fbxo25.

Phylogenomic databases

HOVERGENiHBG051572.
InParanoidiQ641X7.
KOiK10305.
PhylomeDBiQ641X7.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ641X7.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFBX25_RAT
AccessioniPrimary (citable) accession number: Q641X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 25, 2004
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.