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Q641X3 (HEXA_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase subunit alpha

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase subunit alpha
Short name=Hexosaminidase subunit A
N-acetyl-beta-glucosaminidase subunit alpha
Gene names
Name:Hexa
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 20 family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadult walking behavior

Inferred from electronic annotation. Source: Ensembl

carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

cell morphogenesis involved in neuron differentiation

Inferred from electronic annotation. Source: Ensembl

ganglioside catabolic process

Inferred from electronic annotation. Source: Ensembl

glycosaminoglycan metabolic process

Inferred from electronic annotation. Source: Ensembl

lipid storage

Inferred from electronic annotation. Source: Ensembl

lysosome organization

Inferred from electronic annotation. Source: Ensembl

myelination

Inferred from electronic annotation. Source: Ensembl

neuromuscular process controlling balance

Inferred from electronic annotation. Source: Ensembl

neuromuscular process controlling posture

Inferred from electronic annotation. Source: Ensembl

sensory perception of sound

Inferred from electronic annotation. Source: Ensembl

sexual reproduction

Inferred from electronic annotation. Source: Ensembl

skeletal system development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionbeta-N-acetylhexosaminidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Propeptide23 – 8866 By similarity
PRO_0000011999
Chain89 – 528440Beta-hexosaminidase subunit alpha
PRO_0000012000

Regions

Region422 – 4232Critical for hydrolyzis GM2 gangliosides By similarity

Sites

Active site3231Proton donor By similarity

Amino acid modifications

Glycosylation1151N-linked (GlcNAc...) Potential
Glycosylation1571N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential
Glycosylation4871N-linked (GlcNAc...) Potential
Disulfide bond58 ↔ 104 By similarity
Disulfide bond277 ↔ 328 By similarity
Disulfide bond504 ↔ 521 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q641X3 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: B87DD9A21260DCA3

FASTA52860,538
        10         20         30         40         50         60 
MAGCRLWVSL LLAAALACLA TALWPWPQYI QTSHRRYTLY PNNFQFRYHA GSAAQAGCVV 

        70         80         90        100        110        120 
LDEAFRRYRS LLFGSGSWPR PSFSKKQQPL GKNILMVSVV TAECNEFPNL ESVENYTLTI 

       130        140        150        160        170        180 
NDDQCLLSSE TVWGALRGLE TFSQLVWKSA EGTFFINKTK ITDFPRFPHR GILLDTSRHY 

       190        200        210        220        230        240 
LPLSSILNTL DVMAYNKFNV FHWHLVDDSS FPYESFTFPE LTRKGSFNPV THIYTAQDVK 

       250        260        270        280        290        300 
EVIEYARLRG IRVLAEFDTP GHTLSWGAGV PGLLTPCYSG SRLSGTYGPV NPSLNSTYDF 

       310        320        330        340        350        360 
MSTFFLEISS VFPDFYLHLG GDEVDFTCWK SNPNIQAFMK KKGFTDYKQL ESFYIQTLLD 

       370        380        390        400        410        420 
IVSDYDKGYV VWQEVFDNKV KVRPDTIIQV WREEMPVQYM KEIEAITQAG FRALLSAPWY 

       430        440        450        460        470        480 
LNRVKYGPDW KEMYKVEPLA FRGTPAQKAL VIGGEACMWG EYVDSTNLVP RLWPRAGAIA 

       490        500        510        520 
ERLWSSNLTT NMDFAFKRLS HFRCELLRRG IQAQPISVGY CEQEFEHT 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC082097 mRNA. Translation: AAH82097.1.
RefSeqNP_001004443.1. NM_001004443.1.
UniGeneRn.92939.

3D structure databases

ProteinModelPortalQ641X3.
SMRQ641X3. Positions 23-527.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ641X3. 1 interaction.
STRING10116.ENSRNOP00000013747.

Protein family/group databases

CAZyGH20. Glycoside Hydrolase Family 20.

Proteomic databases

PaxDbQ641X3.
PRIDEQ641X3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000013747; ENSRNOP00000013747; ENSRNOG00000010252.
GeneID300757.
KEGGrno:300757.
UCSCRGD:2792. rat.

Organism-specific databases

CTD3073.
RGD2792. Hexa.

Phylogenomic databases

eggNOGCOG3525.
GeneTreeENSGT00390000008107.
HOGENOMHOG000157972.
HOVERGENHBG005961.
InParanoidQ641X3.
KOK12373.
OMAWHLVDDS.
OrthoDBEOG7KDFB6.
PhylomeDBQ641X3.
TreeFamTF313036.

Enzyme and pathway databases

SABIO-RKQ641X3.

Gene expression databases

GenevestigatorQ641X3.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProIPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view]
PfamPF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view]
PIRSFPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSPR00738. GLHYDRLASE20.
SUPFAMSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
ProtoNetSearch...

Other

NextBio647448.
PROQ641X3.

Entry information

Entry nameHEXA_RAT
AccessionPrimary (citable) accession number: Q641X3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 25, 2004
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries