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Q641X3

- HEXA_RAT

UniProt

Q641X3 - HEXA_RAT

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Protein

Beta-hexosaminidase subunit alpha

Gene

Hexa

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei323 – 3231Proton donorBy similarity

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. adult walking behavior Source: Ensembl
  2. carbohydrate metabolic process Source: InterPro
  3. cell morphogenesis involved in neuron differentiation Source: Ensembl
  4. ganglioside catabolic process Source: Ensembl
  5. glycosaminoglycan metabolic process Source: Ensembl
  6. lipid storage Source: Ensembl
  7. lysosome organization Source: Ensembl
  8. myelination Source: Ensembl
  9. neuromuscular process controlling balance Source: Ensembl
  10. neuromuscular process controlling posture Source: Ensembl
  11. sensory perception of sound Source: Ensembl
  12. sexual reproduction Source: Ensembl
  13. skeletal system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiREACT_198577. CS/DS degradation.
REACT_198596. Glycosphingolipid metabolism.
REACT_198617. Keratan sulfate degradation.
REACT_198825. Hyaluronan uptake and degradation.
SABIO-RKQ641X3.

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase subunit alpha (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase subunit alpha
Short name:
Hexosaminidase subunit A
N-acetyl-beta-glucosaminidase subunit alpha
Gene namesi
Name:Hexa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi2792. Hexa.

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-KW
  2. membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 8866By similarityPRO_0000011999Add
BLAST
Chaini89 – 528440Beta-hexosaminidase subunit alphaPRO_0000012000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 104By similarity
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi277 ↔ 328By similarity
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi504 ↔ 521By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ641X3.
PRIDEiQ641X3.

Expressioni

Gene expression databases

GenevestigatoriQ641X3.

Interactioni

Protein-protein interaction databases

IntActiQ641X3. 1 interaction.
STRINGi10116.ENSRNOP00000013747.

Structurei

3D structure databases

ProteinModelPortaliQ641X3.
SMRiQ641X3. Positions 23-527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni422 – 4232Critical for hydrolyzis GM2 gangliosidesBy similarity

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3525.
GeneTreeiENSGT00390000008107.
HOGENOMiHOG000157972.
HOVERGENiHBG005961.
InParanoidiQ641X3.
KOiK12373.
OMAiWHLVDDS.
OrthoDBiEOG7KDFB6.
PhylomeDBiQ641X3.
TreeFamiTF313036.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view]
PfamiPF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view]
PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q641X3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGCRLWVSL LLAAALACLA TALWPWPQYI QTSHRRYTLY PNNFQFRYHA
60 70 80 90 100
GSAAQAGCVV LDEAFRRYRS LLFGSGSWPR PSFSKKQQPL GKNILMVSVV
110 120 130 140 150
TAECNEFPNL ESVENYTLTI NDDQCLLSSE TVWGALRGLE TFSQLVWKSA
160 170 180 190 200
EGTFFINKTK ITDFPRFPHR GILLDTSRHY LPLSSILNTL DVMAYNKFNV
210 220 230 240 250
FHWHLVDDSS FPYESFTFPE LTRKGSFNPV THIYTAQDVK EVIEYARLRG
260 270 280 290 300
IRVLAEFDTP GHTLSWGAGV PGLLTPCYSG SRLSGTYGPV NPSLNSTYDF
310 320 330 340 350
MSTFFLEISS VFPDFYLHLG GDEVDFTCWK SNPNIQAFMK KKGFTDYKQL
360 370 380 390 400
ESFYIQTLLD IVSDYDKGYV VWQEVFDNKV KVRPDTIIQV WREEMPVQYM
410 420 430 440 450
KEIEAITQAG FRALLSAPWY LNRVKYGPDW KEMYKVEPLA FRGTPAQKAL
460 470 480 490 500
VIGGEACMWG EYVDSTNLVP RLWPRAGAIA ERLWSSNLTT NMDFAFKRLS
510 520
HFRCELLRRG IQAQPISVGY CEQEFEHT
Length:528
Mass (Da):60,538
Last modified:October 25, 2004 - v1
Checksum:iB87DD9A21260DCA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC082097 mRNA. Translation: AAH82097.1.
RefSeqiNP_001004443.1. NM_001004443.1.
UniGeneiRn.92939.

Genome annotation databases

EnsembliENSRNOT00000013747; ENSRNOP00000013747; ENSRNOG00000010252.
GeneIDi300757.
KEGGirno:300757.
UCSCiRGD:2792. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC082097 mRNA. Translation: AAH82097.1 .
RefSeqi NP_001004443.1. NM_001004443.1.
UniGenei Rn.92939.

3D structure databases

ProteinModelPortali Q641X3.
SMRi Q641X3. Positions 23-527.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q641X3. 1 interaction.
STRINGi 10116.ENSRNOP00000013747.

Protein family/group databases

CAZyi GH20. Glycoside Hydrolase Family 20.

Proteomic databases

PaxDbi Q641X3.
PRIDEi Q641X3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000013747 ; ENSRNOP00000013747 ; ENSRNOG00000010252 .
GeneIDi 300757.
KEGGi rno:300757.
UCSCi RGD:2792. rat.

Organism-specific databases

CTDi 3073.
RGDi 2792. Hexa.

Phylogenomic databases

eggNOGi COG3525.
GeneTreei ENSGT00390000008107.
HOGENOMi HOG000157972.
HOVERGENi HBG005961.
InParanoidi Q641X3.
KOi K12373.
OMAi WHLVDDS.
OrthoDBi EOG7KDFB6.
PhylomeDBi Q641X3.
TreeFami TF313036.

Enzyme and pathway databases

Reactomei REACT_198577. CS/DS degradation.
REACT_198596. Glycosphingolipid metabolism.
REACT_198617. Keratan sulfate degradation.
REACT_198825. Hyaluronan uptake and degradation.
SABIO-RK Q641X3.

Miscellaneous databases

NextBioi 647448.
PROi Q641X3.

Gene expression databases

Genevestigatori Q641X3.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProi IPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view ]
Pfami PF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view ]
PIRSFi PIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSi PR00738. GLHYDRLASE20.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiHEXA_RAT
AccessioniPrimary (citable) accession number: Q641X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 25, 2004
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3