Reviewed,
UniProtKB/Swiss-Prot Q641X3 (HEXA_RAT)
Last modified
November 3, 2009.
Version 42.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Beta-hexosaminidase subunit alpha EC=3.2.1.52 Alternative name(s): N-acetyl-beta-glucosaminidase subunit alpha Beta-N-acetylhexosaminidase subunit alpha Short name=Hexosaminidase subunit A | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 528 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues By similarity. |
| Catalytic activity | Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. |
| Subcellular location | Lysosome By similarity. |
| Sequence similarities | Belongs to the glycosyl hydrolase 20 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Lysosome |
| Domain | Signal |
| Molecular function | Glycosidase Hydrolase |
| PTM | Disulfide bond Glycoprotein Zymogen |
| Gene Ontology (GO) | |
| Cellular component | lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: EC cation bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | Potential | ||||||||
| Propeptide | 23 – 88 | 66 | By similarity | PRO_0000011999 | |||||||
| Chain | 89 – 528 | 440 | Beta-hexosaminidase subunit alpha | PRO_0000012000 | |||||||
Sites | |||||||||||
| Active site | 323 | 1 | Proton donor By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 115 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 157 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 295 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 487 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 58 ↔ 104 | By similarity | |||||||||
| Disulfide bond | 277 ↔ 328 | By similarity | |||||||||
| Disulfide bond | 504 ↔ 521 | By similarity | |||||||||
Sequences
| ||||||||||||||||||
References
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| BC082097 mRNA. Translation: AAH82097.1. | |
| IPI | IPI00394353. |
| RefSeq | NP_001004443.1. |
| UniGene | Rn.92939 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q641X3. |
Protein family/group databases | |
| CAZy | GH20. Glycoside Hydrolase Family 20. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000013747; ENSRNOP00000013747; ENSRNOG00000010252; Rattus norvegicus. [Genome view] |
| GeneID | 300757. |
| KEGG | rno:300757. |
| NMPDR | fig|10116.3.peg.28740. |
| UCSC | NM_001004443. rat. |
Organism-specific databases | |
| CTD | 300757. |
| RGD | 2792. Hexa. |
Phylogenomic databases | |
| HOVERGEN | Q641X3. |
| OMA | TNLVPRL. |
Enzyme and pathway databases | |
| BRENDA | 3.2.1.52. 248. |
Gene expression databases | |
| ArrayExpress | Q641X3. |
| Genevestigator | Q641X3. |
| GermOnline | ENSRNOG00000010252. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR001540. Glyco_hydro_20. IPR015883. Glyco_hydro_20_cat-core. IPR013781. Glyco_hydro_sg_catalytic. IPR015882. HexNAc-like_b. [Graphical view] |
| Gene3D | G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit. |
| PANTHER | PTHR22600. Glyco_hydro_20. 1 hit. |
| Pfam | PF00728. Glyco_hydro_20. 1 hit. PF02838. Glyco_hydro_20b. 1 hit. [Graphical view] |
| PRINTS | PR00738. GLHYDRLASE20. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 647448. |
Entry information
| Entry name | HEXA_RAT | ||||||||
| Accession | Primary (citable) accession number: Q641X3 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Glycosyl hydrolases Classification of glycosyl hydrolase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


