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Q641X3

- HEXA_RAT

UniProt

Q641X3 - HEXA_RAT

Protein

Beta-hexosaminidase subunit alpha

Gene

Hexa

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.By similarity

    Catalytic activityi

    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei323 – 3231Proton donorBy similarity

    GO - Molecular functioni

    1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. adult walking behavior Source: Ensembl
    2. carbohydrate metabolic process Source: InterPro
    3. cell morphogenesis involved in neuron differentiation Source: Ensembl
    4. ganglioside catabolic process Source: Ensembl
    5. glycosaminoglycan metabolic process Source: Ensembl
    6. lipid storage Source: Ensembl
    7. lysosome organization Source: Ensembl
    8. myelination Source: Ensembl
    9. neuromuscular process controlling balance Source: Ensembl
    10. neuromuscular process controlling posture Source: Ensembl
    11. sensory perception of sound Source: Ensembl
    12. sexual reproduction Source: Ensembl
    13. skeletal system development Source: Ensembl

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_198577. CS/DS degradation.
    REACT_198596. Glycosphingolipid metabolism.
    REACT_198617. Keratan sulfate degradation.
    REACT_198825. Hyaluronan uptake and degradation.
    SABIO-RKQ641X3.

    Protein family/group databases

    CAZyiGH20. Glycoside Hydrolase Family 20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-hexosaminidase subunit alpha (EC:3.2.1.52)
    Alternative name(s):
    Beta-N-acetylhexosaminidase subunit alpha
    Short name:
    Hexosaminidase subunit A
    N-acetyl-beta-glucosaminidase subunit alpha
    Gene namesi
    Name:Hexa
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi2792. Hexa.

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell
    2. membrane Source: Ensembl

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 8866By similarityPRO_0000011999Add
    BLAST
    Chaini89 – 528440Beta-hexosaminidase subunit alphaPRO_0000012000Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi58 ↔ 104By similarity
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi277 ↔ 328By similarity
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi504 ↔ 521By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ641X3.
    PRIDEiQ641X3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ641X3.

    Interactioni

    Protein-protein interaction databases

    IntActiQ641X3. 1 interaction.
    STRINGi10116.ENSRNOP00000013747.

    Structurei

    3D structure databases

    ProteinModelPortaliQ641X3.
    SMRiQ641X3. Positions 23-527.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni422 – 4232Critical for hydrolyzis GM2 gangliosidesBy similarity

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 20 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3525.
    GeneTreeiENSGT00390000008107.
    HOGENOMiHOG000157972.
    HOVERGENiHBG005961.
    InParanoidiQ641X3.
    KOiK12373.
    OMAiWHLVDDS.
    OrthoDBiEOG7KDFB6.
    PhylomeDBiQ641X3.
    TreeFamiTF313036.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    3.30.379.10. 1 hit.
    InterProiIPR025705. Beta_hexosaminidase_sua/sub.
    IPR029018. Chitobiase/Hex_dom_2-like.
    IPR015883. Glyco_hydro_20_cat-core.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR029019. HEX_eukaryotic_N.
    [Graphical view]
    PfamiPF00728. Glyco_hydro_20. 1 hit.
    PF14845. Glycohydro_20b2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
    PRINTSiPR00738. GLHYDRLASE20.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF55545. SSF55545. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q641X3-1 [UniParc]FASTAAdd to Basket

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    MAGCRLWVSL LLAAALACLA TALWPWPQYI QTSHRRYTLY PNNFQFRYHA    50
    GSAAQAGCVV LDEAFRRYRS LLFGSGSWPR PSFSKKQQPL GKNILMVSVV 100
    TAECNEFPNL ESVENYTLTI NDDQCLLSSE TVWGALRGLE TFSQLVWKSA 150
    EGTFFINKTK ITDFPRFPHR GILLDTSRHY LPLSSILNTL DVMAYNKFNV 200
    FHWHLVDDSS FPYESFTFPE LTRKGSFNPV THIYTAQDVK EVIEYARLRG 250
    IRVLAEFDTP GHTLSWGAGV PGLLTPCYSG SRLSGTYGPV NPSLNSTYDF 300
    MSTFFLEISS VFPDFYLHLG GDEVDFTCWK SNPNIQAFMK KKGFTDYKQL 350
    ESFYIQTLLD IVSDYDKGYV VWQEVFDNKV KVRPDTIIQV WREEMPVQYM 400
    KEIEAITQAG FRALLSAPWY LNRVKYGPDW KEMYKVEPLA FRGTPAQKAL 450
    VIGGEACMWG EYVDSTNLVP RLWPRAGAIA ERLWSSNLTT NMDFAFKRLS 500
    HFRCELLRRG IQAQPISVGY CEQEFEHT 528
    Length:528
    Mass (Da):60,538
    Last modified:October 25, 2004 - v1
    Checksum:iB87DD9A21260DCA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC082097 mRNA. Translation: AAH82097.1.
    RefSeqiNP_001004443.1. NM_001004443.1.
    UniGeneiRn.92939.

    Genome annotation databases

    EnsembliENSRNOT00000013747; ENSRNOP00000013747; ENSRNOG00000010252.
    GeneIDi300757.
    KEGGirno:300757.
    UCSCiRGD:2792. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC082097 mRNA. Translation: AAH82097.1 .
    RefSeqi NP_001004443.1. NM_001004443.1.
    UniGenei Rn.92939.

    3D structure databases

    ProteinModelPortali Q641X3.
    SMRi Q641X3. Positions 23-527.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q641X3. 1 interaction.
    STRINGi 10116.ENSRNOP00000013747.

    Protein family/group databases

    CAZyi GH20. Glycoside Hydrolase Family 20.

    Proteomic databases

    PaxDbi Q641X3.
    PRIDEi Q641X3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000013747 ; ENSRNOP00000013747 ; ENSRNOG00000010252 .
    GeneIDi 300757.
    KEGGi rno:300757.
    UCSCi RGD:2792. rat.

    Organism-specific databases

    CTDi 3073.
    RGDi 2792. Hexa.

    Phylogenomic databases

    eggNOGi COG3525.
    GeneTreei ENSGT00390000008107.
    HOGENOMi HOG000157972.
    HOVERGENi HBG005961.
    InParanoidi Q641X3.
    KOi K12373.
    OMAi WHLVDDS.
    OrthoDBi EOG7KDFB6.
    PhylomeDBi Q641X3.
    TreeFami TF313036.

    Enzyme and pathway databases

    Reactomei REACT_198577. CS/DS degradation.
    REACT_198596. Glycosphingolipid metabolism.
    REACT_198617. Keratan sulfate degradation.
    REACT_198825. Hyaluronan uptake and degradation.
    SABIO-RK Q641X3.

    Miscellaneous databases

    NextBioi 647448.
    PROi Q641X3.

    Gene expression databases

    Genevestigatori Q641X3.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    3.30.379.10. 1 hit.
    InterProi IPR025705. Beta_hexosaminidase_sua/sub.
    IPR029018. Chitobiase/Hex_dom_2-like.
    IPR015883. Glyco_hydro_20_cat-core.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR029019. HEX_eukaryotic_N.
    [Graphical view ]
    Pfami PF00728. Glyco_hydro_20. 1 hit.
    PF14845. Glycohydro_20b2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
    PRINTSi PR00738. GLHYDRLASE20.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF55545. SSF55545. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiHEXA_RAT
    AccessioniPrimary (citable) accession number: Q641X3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3