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Protein

Actin-like protein 7A

Gene

Actl7a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-like protein 7A
Gene namesi
Name:Actl7a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1304697. Actl7a.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Golgi apparatus By similarity
  • Cytoplasm 1 Publication
  • Nucleus By similarity

  • Note: Detected at the Golgi apparatus during acrosome biogenesis. Detected at the subacrosomal layer in round spermatids. Detected in sperm head and tail.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB-SubCell
  • male germ cell nucleus Source: Ensembl
  • motile cilium Source: Ensembl
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002828291 – 440Actin-like protein 7AAdd BLAST440

Proteomic databases

PaxDbiQ641W9.
PRIDEiQ641W9.

PTM databases

PhosphoSitePlusiQ641W9.

Expressioni

Tissue specificityi

Detected in testis. Detected at the acrosome of round spermatids (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000016641.

Interactioni

Subunit structurei

Interacts (via N-terminus) with TES (via LIM domain 2). Heterodimer with TES; the heterodimer interacts with ENAH to form a heterotrimer.1 Publication

Protein-protein interaction databases

IntActiQ641W9. 1 interactor.
STRINGi10116.ENSRNOP00000022395.

Structurei

3D structure databases

ProteinModelPortaliQ641W9.
SMRiQ641W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni36 – 56Required for interaction with TESBy similarityAdd BLAST21

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiQ641W9.
OMAiIWEYLFH.
OrthoDBiEOG091G07GC.
PhylomeDBiQ641W9.
TreeFamiTF354237.

Family and domain databases

InterProiIPR004000. Actin.
IPR027679. ACTL7A.
IPR031769. ACTL7A_N.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF167. PTHR11937:SF167. 1 hit.
PfamiPF00022. Actin. 1 hit.
PF16840. ACTL7A_N. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q641W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLDAVWAPQ TANIGDGPAK KASDQTSMQT QVLQTASLRD GPAKRAVWVR
60 70 80 90 100
RDNAEKEEPV KSAVSKDRPR LEVTKAVVVD LGTGFCKCGF AGLPKPTHKI
110 120 130 140 150
STTVGKPYME TAKTGDNRKE TFVGRELFNP DIHLKLVNPL RHGIIVDWDT
160 170 180 190 200
VQDIWEYLFR QEMKIAPEEH AVLVSDPPLS PHTNREKYAE MLFETFNTPA
210 220 230 240 250
MHIAYQSRLS MYSYGRTSGL VVEVGHGVSY VVPIYEGYPL PSITGRLDYA
260 270 280 290 300
GSDLTNYLMN LMNNCGKHFS EDHLSIVEDI KTKCCFVALD PIEEKKIPPS
310 320 330 340 350
EHEIHYTLPD GKEIRLGQER FLCSEMFFKP SLIKSMQLGL HTQTVSCLNK
360 370 380 390 400
CDIALKRDLM GNILLCGGST MLRGFPNRLQ KELSSMCPND TPQVNVLPER
410 420 430 440
DTAVWTGGSI LASLQGFQPL WVHRLEYEEH GPFFLYRRCF
Length:440
Mass (Da):49,568
Last modified:October 25, 2004 - v1
Checksum:iEE38C1EA8098D653
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082101 mRNA. Translation: AAH82101.1.
RefSeqiNP_001011973.1. NM_001011973.1.
XP_008761929.1. XM_008763707.2.
UniGeneiRn.103609.

Genome annotation databases

EnsembliENSRNOT00000022395; ENSRNOP00000022395; ENSRNOG00000016641.
GeneIDi298017.
KEGGirno:298017.
UCSCiRGD:1304697. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082101 mRNA. Translation: AAH82101.1.
RefSeqiNP_001011973.1. NM_001011973.1.
XP_008761929.1. XM_008763707.2.
UniGeneiRn.103609.

3D structure databases

ProteinModelPortaliQ641W9.
SMRiQ641W9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ641W9. 1 interactor.
STRINGi10116.ENSRNOP00000022395.

PTM databases

PhosphoSitePlusiQ641W9.

Proteomic databases

PaxDbiQ641W9.
PRIDEiQ641W9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022395; ENSRNOP00000022395; ENSRNOG00000016641.
GeneIDi298017.
KEGGirno:298017.
UCSCiRGD:1304697. rat.

Organism-specific databases

CTDi10881.
RGDi1304697. Actl7a.

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiQ641W9.
OMAiIWEYLFH.
OrthoDBiEOG091G07GC.
PhylomeDBiQ641W9.
TreeFamiTF354237.

Miscellaneous databases

PROiQ641W9.

Gene expression databases

BgeeiENSRNOG00000016641.

Family and domain databases

InterProiIPR004000. Actin.
IPR027679. ACTL7A.
IPR031769. ACTL7A_N.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF167. PTHR11937:SF167. 1 hit.
PfamiPF00022. Actin. 1 hit.
PF16840. ACTL7A_N. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACL7A_RAT
AccessioniPrimary (citable) accession number: Q641W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 25, 2004
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.