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Protein

Replication factor C subunit 2

Gene

Rfc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 78ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-110312 Translesion synthesis by REV1
R-RNO-110314 Recognition of DNA damage by PCNA-containing replication complex
R-RNO-110320 Translesion Synthesis by POLH
R-RNO-174411 Polymerase switching on the C-strand of the telomere
R-RNO-176187 Activation of ATR in response to replication stress
R-RNO-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-RNO-5655862 Translesion synthesis by POLK
R-RNO-5656121 Translesion synthesis by POLI
R-RNO-5656169 Termination of translesion DNA synthesis
R-RNO-5685938 HDR through Single Strand Annealing (SSA)
R-RNO-5685942 HDR through Homologous Recombination (HRR)
R-RNO-5693607 Processing of DNA double-strand break ends
R-RNO-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-RNO-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-RNO-5696400 Dual Incision in GG-NER
R-RNO-6782135 Dual incision in TC-NER
R-RNO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-RNO-6804756 Regulation of TP53 Activity through Phosphorylation
R-RNO-69091 Polymerase switching
R-RNO-69473 G2/M DNA damage checkpoint

Names & Taxonomyi

Protein namesi
Recommended name:
Replication factor C subunit 2
Alternative name(s):
Activator 1 subunit C2
Gene namesi
Name:Rfc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi621198 Rfc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003304621 – 349Replication factor C subunit 2Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei158N6-acetyllysineBy similarity1
Modified residuei299N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ641W4
PRIDEiQ641W4

Expressioni

Gene expression databases

BgeeiENSRNOG00000001457
GenevisibleiQ641W4 RN

Interactioni

Subunit structurei

Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA. RFC2 also interacts with PRKAR1A; the complex may be involved in cell survival. Interacts with DDX11.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001989

Structurei

3D structure databases

ProteinModelPortaliQ641W4
SMRiQ641W4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the activator 1 small subunits family.Curated

Phylogenomic databases

eggNOGiKOG0991 Eukaryota
COG0470 LUCA
GeneTreeiENSGT00550000075050
HOGENOMiHOG000224155
HOVERGENiHBG002053
InParanoidiQ641W4
KOiK10755
OMAiQSTWSGF
OrthoDBiEOG091G0CKT
PhylomeDBiQ641W4
TreeFamiTF300585

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR008921 DNA_pol3_clamp-load_cplx_C
IPR027417 P-loop_NTPase
IPR013748 Rep_factorC_C
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF08542 Rep_fac_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF48019 SSF48019, 1 hit
SSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q641W4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVQESGSGS AESGTQEPSP VPSKTTGHYE LPWVEKYRPV KLNEIVGNED
60 70 80 90 100
TVSRLEVFAR EGNVPNIIIA GPPGTGKTTS ILCLARALLG PALKDAVLEL
110 120 130 140 150
NASNDRGIDV VRNKIKMFAQ QKVTLPKGRH KIIILDEADS MTDGAQQALR
160 170 180 190 200
RTMEIYSKTT RFALACNASD KIIEPIQSRC AVLRYTKLTD AQVLSRLMNV
210 220 230 240 250
IEKEKVPYTD DGLEAIIFTA QGDMRQALNN LQSTFSGFGY INSENVFKVC
260 270 280 290 300
DEPHPLLVKE MIQHCVDANI DEAYKILAHL WHLGYSPEDV IGNIFRVCKT
310 320 330 340
FPMAEYLKLE FIKEIGYTHM KVAEGVNSLL QMAGLLARLC QKTMAPVAS
Length:349
Mass (Da):38,657
Last modified:October 25, 2004 - v1
Checksum:i0E9EDF01AFDB2092
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082110 mRNA Translation: AAH82110.1
RefSeqiNP_446238.1, NM_053786.1
UniGeneiRn.113319

Genome annotation databases

EnsembliENSRNOT00000001989; ENSRNOP00000001989; ENSRNOG00000001457
GeneIDi116468
KEGGirno:116468
UCSCiRGD:621198 rat

Similar proteinsi

Entry informationi

Entry nameiRFC2_RAT
AccessioniPrimary (citable) accession number: Q641W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 25, 2004
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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