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Protein

Nuclear fragile X mental retardation-interacting protein 1

Gene

Nufip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds RNA.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri167 – 18923C2H2-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear fragile X mental retardation-interacting protein 1
Alternative name(s):
Nuclear FMRP-interacting protein 1
Gene namesi
Name:Nufip1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1359440. Nufip1.

Subcellular locationi

  • Nucleus By similarity

  • Note: Distributed in the nucleus in a dot-like pattern.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Nuclear fragile X mental retardation-interacting protein 1PRO_0000245520Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei331 – 3311PhosphoserineBy similarity
Modified residuei333 – 3331PhosphoserineBy similarity
Modified residuei335 – 3351PhosphoserineBy similarity
Modified residuei396 – 3961PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ641W3.
PRIDEiQ641W3.

Expressioni

Gene expression databases

GenevisibleiQ641W3. RN.

Interactioni

Subunit structurei

Interacts with FMR1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001366.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi236 – 25217Bipartite nuclear localization signalBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 9289Pro-richAdd
BLAST
Compositional biasi154 – 1618Poly-Lys

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri167 – 18923C2H2-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IJ6R. Eukaryota.
ENOG4111GKG. LUCA.
GeneTreeiENSGT00390000003758.
HOGENOMiHOG000113888.
HOVERGENiHBG059841.
InParanoidiQ641W3.
OMAiKEPVFHY.
OrthoDBiEOG77T15S.
PhylomeDBiQ641W3.
TreeFamiTF329804.

Family and domain databases

InterProiIPR019496. NUFIP1_cons_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF10453. NUFIP1. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q641W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPTPAGWP SAPELTPAPG TPSEAAPPQD NWVYWAMLPP PPPPLSSPVA
60 70 80 90 100
GTEPCQKEQP HVEPQPTSGA FPPFDAQILP AAQPPFDAQA PPDGQSQFND
110 120 130 140 150
QQAWNFQAST PWYWGLSPNG FPTYNTSFHS PATHSYFPQS YANYNDFNLP
160 170 180 190 200
QNRKQKKKKR KEPVFHFFCD TCDRGFKNQE KYDIHMSEHK KCPEVDCSFS
210 220 230 240 250
AHEKIVQFHW RNMHAPGMKK IKLDTPEDIA RWREERRKNY PTLANIERKK
260 270 280 290 300
LLQLEKEKRG EVLTTTQYGK MKGMSRHSQM AKIRSPGKHY KWKSGGARQR
310 320 330 340 350
AVLGLGNRAR DLKPEIPTKV NVDPLGVLIH SDSESDKDEK SQRAIVPKEV
360 370 380 390 400
TPALCSLMSS YGNVSGSESE PEEAPIKTEA EVLAENRVLP SSPPKSPRHN
410 420 430 440 450
VRTTARTVLR AKWKAQRSGL RKITLKQKKS PCHPLFEPRT RHPHLLEMLL
460 470 480
APDIRHERNV ILQCVRYIIK KDFFGLTAGS VKTEDV
Length:486
Mass (Da):55,090
Last modified:October 25, 2004 - v1
Checksum:i59C76B6BDAD06D5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082111 mRNA. Translation: AAH82111.1.
RefSeqiNP_001007759.1. NM_001007758.1.
UniGeneiRn.154742.

Genome annotation databases

EnsembliENSRNOT00000001366; ENSRNOP00000001366; ENSRNOG00000001033.
GeneIDi364430.
KEGGirno:364430.
UCSCiRGD:1359440. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082111 mRNA. Translation: AAH82111.1.
RefSeqiNP_001007759.1. NM_001007758.1.
UniGeneiRn.154742.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001366.

Proteomic databases

PaxDbiQ641W3.
PRIDEiQ641W3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001366; ENSRNOP00000001366; ENSRNOG00000001033.
GeneIDi364430.
KEGGirno:364430.
UCSCiRGD:1359440. rat.

Organism-specific databases

CTDi26747.
RGDi1359440. Nufip1.

Phylogenomic databases

eggNOGiENOG410IJ6R. Eukaryota.
ENOG4111GKG. LUCA.
GeneTreeiENSGT00390000003758.
HOGENOMiHOG000113888.
HOVERGENiHBG059841.
InParanoidiQ641W3.
OMAiKEPVFHY.
OrthoDBiEOG77T15S.
PhylomeDBiQ641W3.
TreeFamiTF329804.

Miscellaneous databases

NextBioi685397.
PROiQ641W3.

Gene expression databases

GenevisibleiQ641W3. RN.

Family and domain databases

InterProiIPR019496. NUFIP1_cons_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF10453. NUFIP1. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNUFP1_RAT
AccessioniPrimary (citable) accession number: Q641W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 25, 2004
Last modified: May 11, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.