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Protein

Nuclear fragile X mental retardation-interacting protein 1

Gene

Nufip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds RNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri167 – 189C2H2-typeAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear fragile X mental retardation-interacting protein 1
Alternative name(s):
Nuclear FMRP-interacting protein 1
Gene namesi
Name:Nufip1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1359440 Nufip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455201 – 486Nuclear fragile X mental retardation-interacting protein 1Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei331PhosphoserineBy similarity1
Modified residuei333PhosphoserineBy similarity1
Modified residuei335PhosphoserineBy similarity1
Modified residuei396PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ641W3
PRIDEiQ641W3

PTM databases

iPTMnetiQ641W3
PhosphoSitePlusiQ641W3

Expressioni

Gene expression databases

BgeeiENSRNOG00000001033
GenevisibleiQ641W3 RN

Interactioni

Subunit structurei

Interacts with FMR1 (By similarity). Interacts with ZNHIT3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001366

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi236 – 252Bipartite nuclear localization signalBy similarityAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 92Pro-richAdd BLAST89
Compositional biasi154 – 161Poly-Lys8

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri167 – 189C2H2-typeAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IJ6R Eukaryota
ENOG4111GKG LUCA
GeneTreeiENSGT00390000003758
HOGENOMiHOG000113888
HOVERGENiHBG059841
InParanoidiQ641W3
OMAiCDFAALH
OrthoDBiEOG091G0OE9
PhylomeDBiQ641W3
TreeFamiTF329804

Family and domain databases

InterProiView protein in InterPro
IPR019496 NUFIP1_cons_dom
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF10453 NUFIP1, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q641W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPTPAGWP SAPELTPAPG TPSEAAPPQD NWVYWAMLPP PPPPLSSPVA
60 70 80 90 100
GTEPCQKEQP HVEPQPTSGA FPPFDAQILP AAQPPFDAQA PPDGQSQFND
110 120 130 140 150
QQAWNFQAST PWYWGLSPNG FPTYNTSFHS PATHSYFPQS YANYNDFNLP
160 170 180 190 200
QNRKQKKKKR KEPVFHFFCD TCDRGFKNQE KYDIHMSEHK KCPEVDCSFS
210 220 230 240 250
AHEKIVQFHW RNMHAPGMKK IKLDTPEDIA RWREERRKNY PTLANIERKK
260 270 280 290 300
LLQLEKEKRG EVLTTTQYGK MKGMSRHSQM AKIRSPGKHY KWKSGGARQR
310 320 330 340 350
AVLGLGNRAR DLKPEIPTKV NVDPLGVLIH SDSESDKDEK SQRAIVPKEV
360 370 380 390 400
TPALCSLMSS YGNVSGSESE PEEAPIKTEA EVLAENRVLP SSPPKSPRHN
410 420 430 440 450
VRTTARTVLR AKWKAQRSGL RKITLKQKKS PCHPLFEPRT RHPHLLEMLL
460 470 480
APDIRHERNV ILQCVRYIIK KDFFGLTAGS VKTEDV
Length:486
Mass (Da):55,090
Last modified:October 25, 2004 - v1
Checksum:i59C76B6BDAD06D5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082111 mRNA Translation: AAH82111.1
RefSeqiNP_001007759.1, NM_001007758.1
UniGeneiRn.154742

Genome annotation databases

EnsembliENSRNOT00000001366; ENSRNOP00000001366; ENSRNOG00000001033
GeneIDi364430
KEGGirno:364430
UCSCiRGD:1359440 rat

Similar proteinsi

Entry informationi

Entry nameiNUFP1_RAT
AccessioniPrimary (citable) accession number: Q641W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 25, 2004
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health