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Protein

Dynein light chain 1, axonemal

Gene

dnal1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity).By similarity

Miscellaneous

Outer (ODAs) and inner (IDAs) dynein arms contain the molecular motors that generate the force to move cilia by ATP-dependent reactions. There are two mechanosensory systems that monitor and respond to the mechanical state (curvature) of the axoneme. One system involves the central pair microtubule complex and radial spokes and the second system involves the outer dynein arms.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionMotor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 1, axonemal
Gene namesi
Name:dnal1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-983797. dnal1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002811331 – 192Dynein light chain 1, axonemalAdd BLAST192

Proteomic databases

MaxQBiQ641R9.

Interactioni

Subunit structurei

Interacts with DNAH5, a outer arm dynein heavy chain. Interacts with tubulin located within the A-tubule of the outer doublets in a ATP-independent manner.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ641R9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati49 – 70LRR 1Add BLAST22
Repeati71 – 92LRR 2Add BLAST22
Repeati94 – 115LRR 3Add BLAST22
Repeati116 – 137LRR 4Add BLAST22
Domaini150 – 192LRRCTAdd BLAST43

Sequence similaritiesi

Belongs to the dynein light chain LC1-type family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

HOVERGENiHBG081457.
KOiK10411.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR001611. Leu-rich_rpt.
IPR032675. LRR_dom_sf.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 4 hits.

Sequencei

Sequence statusi: Complete.

Q641R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKATTIKEA LAKWEERTGQ KAGEAKEVKL YAQIPPLEKM DASLSTLVNC
60 70 80 90 100
EKLSLSTNCI EKIANLNGLK YLKILSLGRN NIKNLNGLEA VGETLEELWI
110 120 130 140 150
SYNLIEKLKG IHVMKKLKVL YMSNNLVKDW AEFSKLGELP LLGDIVFVGN
160 170 180 190
PLEEKHTAEG NWMEEAVKRL PKLKKLDGNP VIKQEEEEGD ES
Length:192
Mass (Da):21,562
Last modified:October 25, 2004 - v1
Checksum:i29A37B357B2F1513
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082218 mRNA. Translation: AAH82218.1.
RefSeqiNP_001087953.1. NM_001094484.1.
UniGeneiXl.49781.

Genome annotation databases

GeneIDi494635.
KEGGixla:494635.

Similar proteinsi

Entry informationi

Entry nameiDNAL1_XENLA
AccessioniPrimary (citable) accession number: Q641R9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 25, 2004
Last modified: November 22, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families