SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q641Q2

- FA21A_HUMAN

UniProt

Q641Q2 - FA21A_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

WASH complex subunit FAM21A

Gene
FAM21A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes By similarity.

GO - Biological processi

  1. retrograde transport, endosome to Golgi Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
WASH complex subunit FAM21A
Gene namesi
Name:FAM21A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23416. FAM21A.

Subcellular locationi

GO - Cellular componenti

  1. early endosome Source: UniProtKB
  2. early endosome membrane Source: UniProtKB-SubCell
  3. WASH complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134902481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13411341WASH complex subunit FAM21APRO_0000317299Add
BLAST

Proteomic databases

MaxQBiQ641Q2.
PaxDbiQ641Q2.
PRIDEiQ641Q2.

Expressioni

Gene expression databases

BgeeiQ641Q2.
CleanExiHS_FAM21A.
GenevestigatoriQ641Q2.

Organism-specific databases

HPAiHPA047844.

Interactioni

Subunit structurei

Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with WASH1; the interaction is direct By similarity.

Protein-protein interaction databases

BioGridi132390. 9 interactions.
STRINGi9606.ENSP00000282633.

Structurei

3D structure databases

ProteinModelPortaliQ641Q2.

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM21 family.

Phylogenomic databases

eggNOGiNOG76301.
HOGENOMiHOG000112469.
HOVERGENiHBG055529.
InParanoidiQ641Q2.
OMAiHSDNDQN.
OrthoDBiEOG7GBFWP.
PhylomeDBiQ641Q2.
TreeFamiTF329309.

Family and domain databases

InterProiIPR027308. FAM21.
IPR029341. FAM21/CAPZIP.
[Graphical view]
PANTHERiPTHR21669:SF4. PTHR21669:SF4. 1 hit.
PfamiPF15255. CAP-ZIP_m. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q641Q2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMNRTTPDQE LAPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF     50
SQQTISRTHE IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY 100
DEEVEEPVLK AEAEKTEQEK TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ 150
LDIKAGNSDS EEDDANGRVE LILEPKDLYI DRPLPYLIGS KLFMEQEDVG 200
LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN EQNRHTTQMS 250
DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD 300
AVGRVDEEPT TLPSGEAKPR KTLKEKKERR TPSDDEEDNL FAPPKLTDED 350
FSPFGSGGGL FSGGKGLFDD EDEESDLFTE APQDRQAGAS VKEESSSSKP 400
GKKIPAGAVS VFLGDTDVFG AASVPSMKEP QKPEQPTPRK SPYGPPPTGL 450
FDDDDGDDDD DFFSAPHSKP SKTGKVQSTA DIFGDEEGDL FKEKAVASPE 500
ATVSQTDENK ARAEKKVTLS SSKNLKPSSE TKTQKGLFSD EEDSEDLFSS 550
QSASKLKGAS LLPGKLPTLV SLFDDEDEED NLFGGTAAKK QTLCLQAQRE 600
EKAKASELSK KKASALLFSS DEEDQWNIPA SQTHLASDSR SKGEPRDSGT 650
LQSQEAKAVK KTSLFEEDEE DDLFAIAKDS QKKTQRVSLL FEDDVDSGGS 700
LFGSPPTSVP PATKKKETVS EAPPLLFSDE EEKEAQLGVK SVDKKVESAK 750
ESLKFGRTDV AESEKEGLLT RSAQETVKHS DLFSSSSPWD KGTKPRTKTV 800
LSLFDEEEDK MEDQNIIQAP QKEVGKGRDP DAHPKSTGVF QDEELLFSHK 850
LQKDNDPDVD LFAGTKKTKL LEPSVGSLFG DDEDDDLFSS AKSQPLVQEK 900
KRVVKKDHSV DSFKNQKHPE SIQGSKEKGI WKPETPQDSS GLAPFKTKEP 950
STRIGKIQAN LAINPAALLP TAASQISEVK PVLPELAFPS SEHRRSHGLE 1000
SVPVLPGSGE AGVSFDLPAQ ADTLHSANKS RVKMRGKRRP QTRAARRLAA 1050
QESSETEDMS VPRGPIAQWA DGAISPNGHR PQLRAASGED STEEALAAAA 1100
APWEGGPVPG VDRSPFAKSL GHSRGEADLF DSGDIFSTGT GSQSVERTKP 1150
KAKIAENPAN PPVGGKAKSP MFPALGEASS DDDLFQSAKP KPAKKTNPFP 1200
LLEDEDDLFT DQKVKKNETK SNSQQDVILT TQDIFEDDIF ATEAIKPSQK 1250
TREKEKTLES NLFDDNIDIF ADLTVKPKEK SKKKVEAKSI FDDDMDDIFS 1300
SGIQAKTTKP KSRSAQAAPE PRFEHKVSNI FDDPLNAFGG Q 1341
Length:1,341
Mass (Da):147,184
Last modified:February 5, 2008 - v3
Checksum:i8F0F755EB1493EA7
GO
Isoform 2 (identifier: Q641Q2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     938-958: Missing.

Show »
Length:1,320
Mass (Da):144,941
Checksum:i64417D36898CFFBF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei938 – 95821Missing in isoform 2. VSP_030948Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti444 – 4441G → E in AAH75815. 1 Publication
Sequence conflicti816 – 8161I → T in AAH75815. 1 Publication
Sequence conflicti997 – 9971H → Y in AAH82258. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL442003, AL450382 Genomic DNA. Translation: CAM17004.1.
AL450382, AL442003 Genomic DNA. Translation: CAM22317.1.
BC075815 mRNA. Translation: AAH75815.1.
BC082258 mRNA. Translation: AAH82258.2.
CCDSiCCDS41527.1. [Q641Q2-1]
RefSeqiNP_001005751.1. NM_001005751.2. [Q641Q2-1]
NP_001278327.1. NM_001291398.1. [Q641Q2-2]
UniGeneiHs.365286.
Hs.449662.
Hs.645272.

Genome annotation databases

EnsembliENST00000282633; ENSP00000282633; ENSG00000099290. [Q641Q2-1]
ENST00000351071; ENSP00000344037; ENSG00000099290. [Q641Q2-2]
ENST00000606580; ENSP00000475905; ENSG00000272064. [Q641Q2-1]
ENST00000606663; ENSP00000475601; ENSG00000272064. [Q641Q2-2]
GeneIDi387680.
KEGGihsa:387680.
UCSCiuc001jjb.3. human. [Q641Q2-1]
uc010qhi.2. human. [Q641Q2-2]

Polymorphism databases

DMDMi166971555.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL442003 , AL450382 Genomic DNA. Translation: CAM17004.1 .
AL450382 , AL442003 Genomic DNA. Translation: CAM22317.1 .
BC075815 mRNA. Translation: AAH75815.1 .
BC082258 mRNA. Translation: AAH82258.2 .
CCDSi CCDS41527.1. [Q641Q2-1 ]
RefSeqi NP_001005751.1. NM_001005751.2. [Q641Q2-1 ]
NP_001278327.1. NM_001291398.1. [Q641Q2-2 ]
UniGenei Hs.365286.
Hs.449662.
Hs.645272.

3D structure databases

ProteinModelPortali Q641Q2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 132390. 9 interactions.
STRINGi 9606.ENSP00000282633.

Polymorphism databases

DMDMi 166971555.

Proteomic databases

MaxQBi Q641Q2.
PaxDbi Q641Q2.
PRIDEi Q641Q2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000282633 ; ENSP00000282633 ; ENSG00000099290 . [Q641Q2-1 ]
ENST00000351071 ; ENSP00000344037 ; ENSG00000099290 . [Q641Q2-2 ]
ENST00000606580 ; ENSP00000475905 ; ENSG00000272064 . [Q641Q2-1 ]
ENST00000606663 ; ENSP00000475601 ; ENSG00000272064 . [Q641Q2-2 ]
GeneIDi 387680.
KEGGi hsa:387680.
UCSCi uc001jjb.3. human. [Q641Q2-1 ]
uc010qhi.2. human. [Q641Q2-2 ]

Organism-specific databases

CTDi 387680.
GeneCardsi GC10P051827.
H-InvDB HIX0008825.
HGNCi HGNC:23416. FAM21A.
HPAi HPA047844.
neXtProti NX_Q641Q2.
PharmGKBi PA134902481.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG76301.
HOGENOMi HOG000112469.
HOVERGENi HBG055529.
InParanoidi Q641Q2.
OMAi HSDNDQN.
OrthoDBi EOG7GBFWP.
PhylomeDBi Q641Q2.
TreeFami TF329309.

Miscellaneous databases

GenomeRNAii 387680.
NextBioi 101504.
PROi Q641Q2.

Gene expression databases

Bgeei Q641Q2.
CleanExi HS_FAM21A.
Genevestigatori Q641Q2.

Family and domain databases

InterProi IPR027308. FAM21.
IPR029341. FAM21/CAPZIP.
[Graphical view ]
PANTHERi PTHR21669:SF4. PTHR21669:SF4. 1 hit.
Pfami PF15255. CAP-ZIP_m. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Eye and Spleen.

Entry informationi

Entry nameiFA21A_HUMAN
AccessioniPrimary (citable) accession number: Q641Q2
Secondary accession number(s): A2A3S2, A2A3U6, Q6DHY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 9, 2014
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi