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Q641Q2

- FA21A_HUMAN

UniProt

Q641Q2 - FA21A_HUMAN

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Protein

WASH complex subunit FAM21A

Gene

FAM21A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes (By similarity).By similarity

GO - Biological processi

  1. retrograde transport, endosome to Golgi Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
WASH complex subunit FAM21A
Gene namesi
Name:FAM21A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23416. FAM21A.

Subcellular locationi

GO - Cellular componenti

  1. early endosome Source: UniProtKB
  2. membrane Source: UniProtKB-KW
  3. WASH complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134902481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13411341WASH complex subunit FAM21APRO_0000317299Add
BLAST

Proteomic databases

MaxQBiQ641Q2.
PaxDbiQ641Q2.
PRIDEiQ641Q2.

Expressioni

Gene expression databases

BgeeiQ641Q2.
CleanExiHS_FAM21A.
ExpressionAtlasiQ641Q2. baseline.
GenevestigatoriQ641Q2.

Organism-specific databases

HPAiHPA047844.

Interactioni

Subunit structurei

Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with WASH1; the interaction is direct (By similarity).By similarity

Protein-protein interaction databases

BioGridi132390. 10 interactions.
STRINGi9606.ENSP00000282633.

Structurei

3D structure databases

ProteinModelPortaliQ641Q2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM21 family.Curated

Phylogenomic databases

eggNOGiNOG76301.
GeneTreeiENSGT00510000047694.
HOGENOMiHOG000112469.
HOVERGENiHBG055529.
InParanoidiQ641Q2.
KOiK18462.
OMAiHSDNDQN.
OrthoDBiEOG7GBFWP.
PhylomeDBiQ641Q2.
TreeFamiTF329309.

Family and domain databases

InterProiIPR027308. FAM21.
IPR029341. FAM21/CAPZIP.
[Graphical view]
PANTHERiPTHR21669:SF4. PTHR21669:SF4. 1 hit.
PfamiPF15255. CAP-ZIP_m. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q641Q2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMNRTTPDQE LAPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF
60 70 80 90 100
SQQTISRTHE IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY
110 120 130 140 150
DEEVEEPVLK AEAEKTEQEK TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ
160 170 180 190 200
LDIKAGNSDS EEDDANGRVE LILEPKDLYI DRPLPYLIGS KLFMEQEDVG
210 220 230 240 250
LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN EQNRHTTQMS
260 270 280 290 300
DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD
310 320 330 340 350
AVGRVDEEPT TLPSGEAKPR KTLKEKKERR TPSDDEEDNL FAPPKLTDED
360 370 380 390 400
FSPFGSGGGL FSGGKGLFDD EDEESDLFTE APQDRQAGAS VKEESSSSKP
410 420 430 440 450
GKKIPAGAVS VFLGDTDVFG AASVPSMKEP QKPEQPTPRK SPYGPPPTGL
460 470 480 490 500
FDDDDGDDDD DFFSAPHSKP SKTGKVQSTA DIFGDEEGDL FKEKAVASPE
510 520 530 540 550
ATVSQTDENK ARAEKKVTLS SSKNLKPSSE TKTQKGLFSD EEDSEDLFSS
560 570 580 590 600
QSASKLKGAS LLPGKLPTLV SLFDDEDEED NLFGGTAAKK QTLCLQAQRE
610 620 630 640 650
EKAKASELSK KKASALLFSS DEEDQWNIPA SQTHLASDSR SKGEPRDSGT
660 670 680 690 700
LQSQEAKAVK KTSLFEEDEE DDLFAIAKDS QKKTQRVSLL FEDDVDSGGS
710 720 730 740 750
LFGSPPTSVP PATKKKETVS EAPPLLFSDE EEKEAQLGVK SVDKKVESAK
760 770 780 790 800
ESLKFGRTDV AESEKEGLLT RSAQETVKHS DLFSSSSPWD KGTKPRTKTV
810 820 830 840 850
LSLFDEEEDK MEDQNIIQAP QKEVGKGRDP DAHPKSTGVF QDEELLFSHK
860 870 880 890 900
LQKDNDPDVD LFAGTKKTKL LEPSVGSLFG DDEDDDLFSS AKSQPLVQEK
910 920 930 940 950
KRVVKKDHSV DSFKNQKHPE SIQGSKEKGI WKPETPQDSS GLAPFKTKEP
960 970 980 990 1000
STRIGKIQAN LAINPAALLP TAASQISEVK PVLPELAFPS SEHRRSHGLE
1010 1020 1030 1040 1050
SVPVLPGSGE AGVSFDLPAQ ADTLHSANKS RVKMRGKRRP QTRAARRLAA
1060 1070 1080 1090 1100
QESSETEDMS VPRGPIAQWA DGAISPNGHR PQLRAASGED STEEALAAAA
1110 1120 1130 1140 1150
APWEGGPVPG VDRSPFAKSL GHSRGEADLF DSGDIFSTGT GSQSVERTKP
1160 1170 1180 1190 1200
KAKIAENPAN PPVGGKAKSP MFPALGEASS DDDLFQSAKP KPAKKTNPFP
1210 1220 1230 1240 1250
LLEDEDDLFT DQKVKKNETK SNSQQDVILT TQDIFEDDIF ATEAIKPSQK
1260 1270 1280 1290 1300
TREKEKTLES NLFDDNIDIF ADLTVKPKEK SKKKVEAKSI FDDDMDDIFS
1310 1320 1330 1340
SGIQAKTTKP KSRSAQAAPE PRFEHKVSNI FDDPLNAFGG Q
Length:1,341
Mass (Da):147,184
Last modified:February 5, 2008 - v3
Checksum:i8F0F755EB1493EA7
GO
Isoform 2 (identifier: Q641Q2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     938-958: Missing.

Show »
Length:1,320
Mass (Da):144,941
Checksum:i64417D36898CFFBF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti444 – 4441G → E in AAH75815. (PubMed:15489334)Curated
Sequence conflicti816 – 8161I → T in AAH75815. (PubMed:15489334)Curated
Sequence conflicti997 – 9971H → Y in AAH82258. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei938 – 95821Missing in isoform 2. 1 PublicationVSP_030948Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL442003, AL450382 Genomic DNA. Translation: CAM17004.1.
AL450382, AL442003 Genomic DNA. Translation: CAM22317.1.
BC075815 mRNA. Translation: AAH75815.1.
BC082258 mRNA. Translation: AAH82258.2.
CCDSiCCDS41527.1. [Q641Q2-1]
RefSeqiNP_001005751.1. NM_001005751.2. [Q641Q2-1]
NP_001278327.1. NM_001291398.1. [Q641Q2-2]
UniGeneiHs.365286.
Hs.449662.
Hs.645272.

Genome annotation databases

EnsembliENST00000282633; ENSP00000282633; ENSG00000099290. [Q641Q2-1]
ENST00000351071; ENSP00000344037; ENSG00000099290. [Q641Q2-2]
GeneIDi387680.
KEGGihsa:387680.
UCSCiuc001jjb.3. human. [Q641Q2-1]
uc010qhi.2. human. [Q641Q2-2]

Polymorphism databases

DMDMi166971555.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL442003 , AL450382 Genomic DNA. Translation: CAM17004.1 .
AL450382 , AL442003 Genomic DNA. Translation: CAM22317.1 .
BC075815 mRNA. Translation: AAH75815.1 .
BC082258 mRNA. Translation: AAH82258.2 .
CCDSi CCDS41527.1. [Q641Q2-1 ]
RefSeqi NP_001005751.1. NM_001005751.2. [Q641Q2-1 ]
NP_001278327.1. NM_001291398.1. [Q641Q2-2 ]
UniGenei Hs.365286.
Hs.449662.
Hs.645272.

3D structure databases

ProteinModelPortali Q641Q2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 132390. 10 interactions.
STRINGi 9606.ENSP00000282633.

Polymorphism databases

DMDMi 166971555.

Proteomic databases

MaxQBi Q641Q2.
PaxDbi Q641Q2.
PRIDEi Q641Q2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000282633 ; ENSP00000282633 ; ENSG00000099290 . [Q641Q2-1 ]
ENST00000351071 ; ENSP00000344037 ; ENSG00000099290 . [Q641Q2-2 ]
GeneIDi 387680.
KEGGi hsa:387680.
UCSCi uc001jjb.3. human. [Q641Q2-1 ]
uc010qhi.2. human. [Q641Q2-2 ]

Organism-specific databases

CTDi 387680.
GeneCardsi GC10P051827.
H-InvDB HIX0008825.
HGNCi HGNC:23416. FAM21A.
HPAi HPA047844.
neXtProti NX_Q641Q2.
PharmGKBi PA134902481.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG76301.
GeneTreei ENSGT00510000047694.
HOGENOMi HOG000112469.
HOVERGENi HBG055529.
InParanoidi Q641Q2.
KOi K18462.
OMAi HSDNDQN.
OrthoDBi EOG7GBFWP.
PhylomeDBi Q641Q2.
TreeFami TF329309.

Miscellaneous databases

GenomeRNAii 387680.
NextBioi 101504.
PROi Q641Q2.

Gene expression databases

Bgeei Q641Q2.
CleanExi HS_FAM21A.
ExpressionAtlasi Q641Q2. baseline.
Genevestigatori Q641Q2.

Family and domain databases

InterProi IPR027308. FAM21.
IPR029341. FAM21/CAPZIP.
[Graphical view ]
PANTHERi PTHR21669:SF4. PTHR21669:SF4. 1 hit.
Pfami PF15255. CAP-ZIP_m. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Eye and Spleen.

Entry informationi

Entry nameiFA21A_HUMAN
AccessioniPrimary (citable) accession number: Q641Q2
Secondary accession number(s): A2A3S2, A2A3U6, Q6DHY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3