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Q641Q2

- FA21A_HUMAN

UniProt

Q641Q2 - FA21A_HUMAN

Protein

WASH complex subunit FAM21A

Gene

FAM21A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 3 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes By similarity.By similarity

    GO - Biological processi

    1. retrograde transport, endosome to Golgi Source: UniProtKB

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WASH complex subunit FAM21A
    Gene namesi
    Name:FAM21A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23416. FAM21A.

    Subcellular locationi

    GO - Cellular componenti

    1. early endosome Source: UniProtKB
    2. early endosome membrane Source: UniProtKB-SubCell
    3. WASH complex Source: UniProtKB

    Keywords - Cellular componenti

    Endosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134902481.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13411341WASH complex subunit FAM21APRO_0000317299Add
    BLAST

    Proteomic databases

    MaxQBiQ641Q2.
    PaxDbiQ641Q2.
    PRIDEiQ641Q2.

    Expressioni

    Gene expression databases

    BgeeiQ641Q2.
    CleanExiHS_FAM21A.
    GenevestigatoriQ641Q2.

    Organism-specific databases

    HPAiHPA047844.

    Interactioni

    Subunit structurei

    Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with WASH1; the interaction is direct By similarity.By similarity

    Protein-protein interaction databases

    BioGridi132390. 9 interactions.
    STRINGi9606.ENSP00000282633.

    Structurei

    3D structure databases

    ProteinModelPortaliQ641Q2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM21 family.Curated

    Phylogenomic databases

    eggNOGiNOG76301.
    HOGENOMiHOG000112469.
    HOVERGENiHBG055529.
    InParanoidiQ641Q2.
    OMAiHSDNDQN.
    OrthoDBiEOG7GBFWP.
    PhylomeDBiQ641Q2.
    TreeFamiTF329309.

    Family and domain databases

    InterProiIPR027308. FAM21.
    IPR029341. FAM21/CAPZIP.
    [Graphical view]
    PANTHERiPTHR21669:SF4. PTHR21669:SF4. 1 hit.
    PfamiPF15255. CAP-ZIP_m. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q641Q2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMNRTTPDQE LAPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF     50
    SQQTISRTHE IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY 100
    DEEVEEPVLK AEAEKTEQEK TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ 150
    LDIKAGNSDS EEDDANGRVE LILEPKDLYI DRPLPYLIGS KLFMEQEDVG 200
    LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN EQNRHTTQMS 250
    DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD 300
    AVGRVDEEPT TLPSGEAKPR KTLKEKKERR TPSDDEEDNL FAPPKLTDED 350
    FSPFGSGGGL FSGGKGLFDD EDEESDLFTE APQDRQAGAS VKEESSSSKP 400
    GKKIPAGAVS VFLGDTDVFG AASVPSMKEP QKPEQPTPRK SPYGPPPTGL 450
    FDDDDGDDDD DFFSAPHSKP SKTGKVQSTA DIFGDEEGDL FKEKAVASPE 500
    ATVSQTDENK ARAEKKVTLS SSKNLKPSSE TKTQKGLFSD EEDSEDLFSS 550
    QSASKLKGAS LLPGKLPTLV SLFDDEDEED NLFGGTAAKK QTLCLQAQRE 600
    EKAKASELSK KKASALLFSS DEEDQWNIPA SQTHLASDSR SKGEPRDSGT 650
    LQSQEAKAVK KTSLFEEDEE DDLFAIAKDS QKKTQRVSLL FEDDVDSGGS 700
    LFGSPPTSVP PATKKKETVS EAPPLLFSDE EEKEAQLGVK SVDKKVESAK 750
    ESLKFGRTDV AESEKEGLLT RSAQETVKHS DLFSSSSPWD KGTKPRTKTV 800
    LSLFDEEEDK MEDQNIIQAP QKEVGKGRDP DAHPKSTGVF QDEELLFSHK 850
    LQKDNDPDVD LFAGTKKTKL LEPSVGSLFG DDEDDDLFSS AKSQPLVQEK 900
    KRVVKKDHSV DSFKNQKHPE SIQGSKEKGI WKPETPQDSS GLAPFKTKEP 950
    STRIGKIQAN LAINPAALLP TAASQISEVK PVLPELAFPS SEHRRSHGLE 1000
    SVPVLPGSGE AGVSFDLPAQ ADTLHSANKS RVKMRGKRRP QTRAARRLAA 1050
    QESSETEDMS VPRGPIAQWA DGAISPNGHR PQLRAASGED STEEALAAAA 1100
    APWEGGPVPG VDRSPFAKSL GHSRGEADLF DSGDIFSTGT GSQSVERTKP 1150
    KAKIAENPAN PPVGGKAKSP MFPALGEASS DDDLFQSAKP KPAKKTNPFP 1200
    LLEDEDDLFT DQKVKKNETK SNSQQDVILT TQDIFEDDIF ATEAIKPSQK 1250
    TREKEKTLES NLFDDNIDIF ADLTVKPKEK SKKKVEAKSI FDDDMDDIFS 1300
    SGIQAKTTKP KSRSAQAAPE PRFEHKVSNI FDDPLNAFGG Q 1341
    Length:1,341
    Mass (Da):147,184
    Last modified:February 5, 2008 - v3
    Checksum:i8F0F755EB1493EA7
    GO
    Isoform 2 (identifier: Q641Q2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         938-958: Missing.

    Show »
    Length:1,320
    Mass (Da):144,941
    Checksum:i64417D36898CFFBF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti444 – 4441G → E in AAH75815. (PubMed:15489334)Curated
    Sequence conflicti816 – 8161I → T in AAH75815. (PubMed:15489334)Curated
    Sequence conflicti997 – 9971H → Y in AAH82258. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei938 – 95821Missing in isoform 2. 1 PublicationVSP_030948Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL442003, AL450382 Genomic DNA. Translation: CAM17004.1.
    AL450382, AL442003 Genomic DNA. Translation: CAM22317.1.
    BC075815 mRNA. Translation: AAH75815.1.
    BC082258 mRNA. Translation: AAH82258.2.
    CCDSiCCDS41527.1. [Q641Q2-1]
    RefSeqiNP_001005751.1. NM_001005751.2. [Q641Q2-1]
    NP_001278327.1. NM_001291398.1. [Q641Q2-2]
    UniGeneiHs.365286.
    Hs.449662.
    Hs.645272.

    Genome annotation databases

    EnsembliENST00000282633; ENSP00000282633; ENSG00000099290. [Q641Q2-1]
    ENST00000351071; ENSP00000344037; ENSG00000099290. [Q641Q2-2]
    GeneIDi387680.
    KEGGihsa:387680.
    UCSCiuc001jjb.3. human. [Q641Q2-1]
    uc010qhi.2. human. [Q641Q2-2]

    Polymorphism databases

    DMDMi166971555.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL442003 , AL450382 Genomic DNA. Translation: CAM17004.1 .
    AL450382 , AL442003 Genomic DNA. Translation: CAM22317.1 .
    BC075815 mRNA. Translation: AAH75815.1 .
    BC082258 mRNA. Translation: AAH82258.2 .
    CCDSi CCDS41527.1. [Q641Q2-1 ]
    RefSeqi NP_001005751.1. NM_001005751.2. [Q641Q2-1 ]
    NP_001278327.1. NM_001291398.1. [Q641Q2-2 ]
    UniGenei Hs.365286.
    Hs.449662.
    Hs.645272.

    3D structure databases

    ProteinModelPortali Q641Q2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 132390. 9 interactions.
    STRINGi 9606.ENSP00000282633.

    Polymorphism databases

    DMDMi 166971555.

    Proteomic databases

    MaxQBi Q641Q2.
    PaxDbi Q641Q2.
    PRIDEi Q641Q2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000282633 ; ENSP00000282633 ; ENSG00000099290 . [Q641Q2-1 ]
    ENST00000351071 ; ENSP00000344037 ; ENSG00000099290 . [Q641Q2-2 ]
    GeneIDi 387680.
    KEGGi hsa:387680.
    UCSCi uc001jjb.3. human. [Q641Q2-1 ]
    uc010qhi.2. human. [Q641Q2-2 ]

    Organism-specific databases

    CTDi 387680.
    GeneCardsi GC10P051827.
    H-InvDB HIX0008825.
    HGNCi HGNC:23416. FAM21A.
    HPAi HPA047844.
    neXtProti NX_Q641Q2.
    PharmGKBi PA134902481.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG76301.
    HOGENOMi HOG000112469.
    HOVERGENi HBG055529.
    InParanoidi Q641Q2.
    OMAi HSDNDQN.
    OrthoDBi EOG7GBFWP.
    PhylomeDBi Q641Q2.
    TreeFami TF329309.

    Miscellaneous databases

    GenomeRNAii 387680.
    NextBioi 101504.
    PROi Q641Q2.

    Gene expression databases

    Bgeei Q641Q2.
    CleanExi HS_FAM21A.
    Genevestigatori Q641Q2.

    Family and domain databases

    InterProi IPR027308. FAM21.
    IPR029341. FAM21/CAPZIP.
    [Graphical view ]
    PANTHERi PTHR21669:SF4. PTHR21669:SF4. 1 hit.
    Pfami PF15255. CAP-ZIP_m. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Eye and Spleen.

    Entry informationi

    Entry nameiFA21A_HUMAN
    AccessioniPrimary (citable) accession number: Q641Q2
    Secondary accession number(s): A2A3S2, A2A3U6, Q6DHY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 76 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3