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Q641F1

- UBCP1_XENLA

UniProt

Q641F1 - UBCP1_XENLA

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Protein
Ubiquitin-like domain-containing CTD phosphatase 1
Gene
ublcp1
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)
    Alternative name(s):
    Nuclear proteasome inhibitor UBLCP1
    Gene namesi
    Name:ublcp1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-5892757. ublcp1.

    Subcellular locationi

    Nucleus By similarity
    Note: Colocalizes with nuclear proteasomes By similarity.

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Ubiquitin-like domain-containing CTD phosphatase 1
    PRO_0000242646Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ641F1.
    SMRiQ641F1. Positions 3-79.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 8179Ubiquitin-like
    Add
    BLAST
    Domaini133 – 294162FCP1 homology
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni133 – 294162Phosphatase By similarity
    Add
    BLAST

    Domaini

    The Ubiquitin-like domain mediates interaction with proteasomes By similarity.

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG080207.
    KOiK17618.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR023214. HAD-like_dom.
    IPR011943. HAD-SF_hydro_IIID.
    IPR004274. NIF.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF03031. NIF. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view]
    SMARTiSM00577. CPDc. 1 hit.
    SM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
    PROSITEiPS50969. FCP1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q641F1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLSLIIKWG GQEFPLSALS EEDTVLDLKH SLKSLTGVLP ERMKLLGLKY    50
    KGKPAENDVK LGVLRLKPNT KIMMMGTREE SLEEMMAPPP DNDEVVNDFD 100
    IDEEVVEVEN REENLAKISR RVKDYKVEVL NPPREGKKLL VLDVDYTLFD 150
    HRSCAETGQE LMRPYLHEFL SSAYEDYDIV IWSATSMKWI EAKMKELGVT 200
    TNANYKITFM LDSAAMITVH TPRRGLVDVK PLGVIWGKYG EFYSKNNTIM 250
    FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELVKLSQY LKEIAQLDDL 300
    SELNHKHWER YLAKKQGQ 318
    Length:318
    Mass (Da):36,740
    Last modified:October 25, 2004 - v1
    Checksum:i170DD5F968C32891
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC082386 mRNA. Translation: AAH82386.1.
    RefSeqiNP_001087860.1. NM_001094391.1.
    UniGeneiXl.15737.

    Genome annotation databases

    GeneIDi447721.
    KEGGixla:447721.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC082386 mRNA. Translation: AAH82386.1 .
    RefSeqi NP_001087860.1. NM_001094391.1.
    UniGenei Xl.15737.

    3D structure databases

    ProteinModelPortali Q641F1.
    SMRi Q641F1. Positions 3-79.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 447721.
    KEGGi xla:447721.

    Organism-specific databases

    CTDi 134510.
    Xenbasei XB-GENE-5892757. ublcp1.

    Phylogenomic databases

    HOVERGENi HBG080207.
    KOi K17618.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR023214. HAD-like_dom.
    IPR011943. HAD-SF_hydro_IIID.
    IPR004274. NIF.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF03031. NIF. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    SMARTi SM00577. CPDc. 1 hit.
    SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02245. HAD_IIID1. 1 hit.
    PROSITEi PS50969. FCP1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiUBCP1_XENLA
    AccessioniPrimary (citable) accession number: Q641F1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: October 25, 2004
    Last modified: June 11, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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