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Protein

Ubiquitin-like domain-containing CTD phosphatase 1

Gene

ublcp1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)
Alternative name(s):
Nuclear proteasome inhibitor UBLCP1
Gene namesi
Name:ublcp1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5892757. ublcp1.

Subcellular locationi

  • Nucleus By similarity

  • Note: Colocalizes with nuclear proteasomes.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426461 – 318Ubiquitin-like domain-containing CTD phosphatase 1Add BLAST318

Proteomic databases

MaxQBiQ641F1.

Structurei

3D structure databases

ProteinModelPortaliQ641F1.
SMRiQ641F1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 81Ubiquitin-likePROSITE-ProRule annotationAdd BLAST79
Domaini133 – 294FCP1 homologyPROSITE-ProRule annotationAdd BLAST162

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 294PhosphataseBy similarityAdd BLAST162

Domaini

The Ubiquitin-like domain mediates interaction with proteasomes.By similarity

Phylogenomic databases

HOVERGENiHBG080207.
KOiK17618.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
IPR011943. HAD-SF_hydro_IIID.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
SMARTiView protein in SMART
SM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
PROSITEiView protein in PROSITE
PS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q641F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLSLIIKWG GQEFPLSALS EEDTVLDLKH SLKSLTGVLP ERMKLLGLKY
60 70 80 90 100
KGKPAENDVK LGVLRLKPNT KIMMMGTREE SLEEMMAPPP DNDEVVNDFD
110 120 130 140 150
IDEEVVEVEN REENLAKISR RVKDYKVEVL NPPREGKKLL VLDVDYTLFD
160 170 180 190 200
HRSCAETGQE LMRPYLHEFL SSAYEDYDIV IWSATSMKWI EAKMKELGVT
210 220 230 240 250
TNANYKITFM LDSAAMITVH TPRRGLVDVK PLGVIWGKYG EFYSKNNTIM
260 270 280 290 300
FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELVKLSQY LKEIAQLDDL
310
SELNHKHWER YLAKKQGQ
Length:318
Mass (Da):36,740
Last modified:October 25, 2004 - v1
Checksum:i170DD5F968C32891
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082386 mRNA. Translation: AAH82386.1.
RefSeqiNP_001087860.1. NM_001094391.1.
UniGeneiXl.15737.

Genome annotation databases

GeneIDi447721.
KEGGixla:447721.

Similar proteinsi

Entry informationi

Entry nameiUBCP1_XENLA
AccessioniPrimary (citable) accession number: Q641F1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 25, 2004
Last modified: August 30, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program