Q641F1 (UBCP1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-like domain-containing CTD phosphatase 1
EC=3.1.3.16

Alternative name(s):
Nuclear proteasome inhibitor UBLCP1

Gene names

Name:

ublcp1

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Magnesium By similarity.
Subcellular location	Nucleus By similarity. Note: Colocalizes with nuclear proteasomes By similarity.
Domain	The Ubiquitin-like domain mediates interaction with proteasomes By similarity.
Sequence similarities	Contains 1 FCP1 homology domain. Contains 1 ubiquitin-like domain.

Ontologies

Keywords
Cellular component	Nucleus
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Ubiquitin-like domain-containing CTD phosphatase 1		PRO_0000242646
Regions
	Domain	3 – 81	79	Ubiquitin-like
	Domain	133 – 294	162	FCP1 homology
	Region	133 – 294	162	Phosphatase By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q641F1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 170DD5F968C32891	FASTA	318	36,740
	10 20 30 40 50 60 MTLSLIIKWG GQEFPLSALS EEDTVLDLKH SLKSLTGVLP ERMKLLGLKY KGKPAENDVK 70 80 90 100 110 120 LGVLRLKPNT KIMMMGTREE SLEEMMAPPP DNDEVVNDFD IDEEVVEVEN REENLAKISR 130 140 150 160 170 180 RVKDYKVEVL NPPREGKKLL VLDVDYTLFD HRSCAETGQE LMRPYLHEFL SSAYEDYDIV 190 200 210 220 230 240 IWSATSMKWI EAKMKELGVT TNANYKITFM LDSAAMITVH TPRRGLVDVK PLGVIWGKYG 250 260 270 280 290 300 EFYSKNNTIM FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELVKLSQY LKEIAQLDDL 310 SELNHKHWER YLAKKQGQ

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC082386 mRNA. Translation: AAH82386.1.
RefSeq	NP_001087860.1. NM_001094391.1.
UniGene	Xl.15737.
3D structure databases
ProteinModelPortal	Q641F1.
SMR	Q641F1. Positions 3-79.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	447721.
KEGG	xla:447721.
Organism-specific databases
CTD	134510.
Xenbase	XB-GENE-5892757. ublcp1.
Phylogenomic databases
HOVERGEN	HBG080207.
KO	K01090.
Family and domain databases
Gene3D	3.40.50.1000. 1 hit.
InterPro	IPR023214. HAD-like_dom. IPR011943. HAD-SF_hydro_IIID. IPR004274. NIF. IPR000626. Ubiquitin. IPR019955. Ubiquitin_supergroup. [Graphical view]
Pfam	PF03031. NIF. 1 hit. PF00240. ubiquitin. 1 hit. [Graphical view]
SMART	SM00577. CPDc. 1 hit. SM00213. UBQ. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR02245. HAD_IIID1. 1 hit.
PROSITE	PS50969. FCP1. 1 hit. PS00299. UBIQUITIN_1. False negative. PS50053. UBIQUITIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBCP1_XENLA

Accession

Primary (citable) accession number: Q641F1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 25, 2004
Last modified:	March 6, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program