Reviewed,
UniProtKB/Swiss-Prot Q64191 (ASPG_MOUSE)
Last modified
January 19, 2010.
Version 71.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase EC=3.5.1.26 Alternative name(s): Glycosylasparaginase Aspartylglucosaminidase Short name=AGA N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase Cleaved into the following 2 chains: 1- Recommended name: Glycosylasparaginase alpha chain 2- Recommended name: Glycosylasparaginase beta chain | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 346 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. |
| Catalytic activity | N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate. |
| Subunit structure | Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the Ntn-hydrolase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Lysosome |
| Domain | Signal |
| Molecular function | Hydrolase |
| PTM | Disulfide bond Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | protein maturation Ref.1 Inferred from direct assay. Source: MGI |
| Cellular component | lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity Ref.1 Inferred from direct assay. Source: MGI |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 23 | 23 | Potential | ||||||||
| Chain | 24 – 205 | 182 | Glycosylasparaginase alpha chain | PRO_0000002335 | |||||||
| Chain | 206 – 346 | 141 | Glycosylasparaginase beta chain | PRO_0000002336 | |||||||
Sites | |||||||||||
| Active site | 206 | 1 | Nucleophile By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 38 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 310 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 64 ↔ 69 | By similarity | |||||||||
| Disulfide bond | 163 ↔ 179 | By similarity | |||||||||
| Disulfide bond | 286 ↔ 306 | By similarity | |||||||||
| Disulfide bond | 317 ↔ 345 | By similarity | |||||||||
Sequences
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References
| [1] | "Molecular cloning, chromosomal assignment, and expression of the mouse aspartylglucosaminidase gene." Tenhunen K., Laan M., Manninen T., Palotie A., Peltonen L., Jalanko A. Genomics 30:244-250(1995) [PubMed: 8586423] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | S81393 mRNA. Translation: AAB36101.1. |
| IPI | IPI00131231. |
| RefSeq | NP_001005847.1. |
| UniGene | Mm.334535 |
3D structure databases | |
| SMR | Q64191. Positions 25-184, 206-346. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q64191. |
Protein family/group databases | |
| MEROPS | T02.001. |
PTM databases | |
| PhosphoSite | Q64191. |
Proteomic databases | |
| PRIDE | Q64191. |
Genome annotation databases | |
| Ensembl | ENSMUST00000033920; ENSMUSP00000033920; ENSMUSG00000031521; Mus musculus. [Genome view] |
| GeneID | 11593. |
| KEGG | mmu:11593. |
| UCSC | uc009lrz.1. mouse. |
Organism-specific databases | |
| CTD | 11593. |
| MGI | MGI:104873. Aga. |
Phylogenomic databases | |
| HOGENOM | HBG735787. |
| HOVERGEN | Q64191. |
| InParanoid | Q64191. |
| OMA | PSKYCGP. |
| OrthoDB | EOG95QKZR. |
| PhylomeDB | Q64191. |
Enzyme and pathway databases | |
| BRENDA | 3.5.1.26. 244. |
Gene expression databases | |
| ArrayExpress | Q64191. |
| Bgee | Q64191. |
| CleanEx | MM_AGA. |
| Genevestigator | Q64191. |
| GermOnline | ENSMUSG00000031521. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000246. Peptidase_T2. [Graphical view] |
| PANTHER | PTHR10188. Peptidase_T2. 1 hit. |
| Pfam | PF01112. Asparaginase_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 279104. |
| SOURCE | Search... |
Entry information
| Entry name | ASPG_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q64191 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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