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Protein

Properdin

Gene

CFP

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement alternate pathway, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Properdin
Alternative name(s):
Complement factor P
Gene namesi
Name:CFP
Synonyms:PFC
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 470444ProperdinPRO_0000035862Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 71PROSITE-ProRule annotation
Disulfide bondi42 ↔ 74PROSITE-ProRule annotation
Disulfide bondi88 ↔ 126PROSITE-ProRule annotation
Disulfide bondi92 ↔ 132PROSITE-ProRule annotation
Disulfide bondi103 ↔ 110PROSITE-ProRule annotation
Disulfide bondi147 ↔ 183PROSITE-ProRule annotation
Disulfide bondi151 ↔ 189PROSITE-ProRule annotation
Disulfide bondi162 ↔ 173PROSITE-ProRule annotation
Disulfide bondi204 ↔ 247PROSITE-ProRule annotation
Disulfide bondi208 ↔ 253PROSITE-ProRule annotation
Disulfide bondi223 ↔ 237PROSITE-ProRule annotation
Disulfide bondi268 ↔ 305PROSITE-ProRule annotation
Disulfide bondi272 ↔ 311PROSITE-ProRule annotation
Disulfide bondi283 ↔ 295PROSITE-ProRule annotation
Disulfide bondi326 ↔ 369PROSITE-ProRule annotation
Disulfide bondi336 ↔ 375PROSITE-ProRule annotation
Disulfide bondi349 ↔ 359PROSITE-ProRule annotation
Disulfide bondi392 ↔ 456PROSITE-ProRule annotation
Disulfide bondi396 ↔ 462PROSITE-ProRule annotation
Disulfide bondi408 ↔ 440PROSITE-ProRule annotation
Glycosylationi429 – 4291N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

In plasma, properdin exists as dimers, trimers or tetramers in the relative proportions of 26:54:20.By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000006537.

Structurei

3D structure databases

ProteinModelPortaliQ64181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 7549TSP type-1 0PROSITE-ProRule annotationAdd
BLAST
Domaini76 – 13358TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini135 – 19056TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini192 – 25463TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini256 – 31257TSP type-1 4PROSITE-ProRule annotationAdd
BLAST
Domaini314 – 37663TSP type-1 5PROSITE-ProRule annotationAdd
BLAST
Domaini380 – 46384TSP type-1 6PROSITE-ProRule annotationAdd
BLAST

Domaini

TSP type-1 domains 0 and 6 bind to each other and mediate multimerization.By similarity

Sequence similaritiesi

Contains 7 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IUGK. Eukaryota.
ENOG410ZHSM. LUCA.
HOGENOMiHOG000231326.
HOVERGENiHBG008263.
InParanoidiQ64181.

Family and domain databases

InterProiIPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00090. TSP_1. 6 hits.
[Graphical view]
SMARTiSM00209. TSP1. 6 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 6 hits.
PROSITEiPS50092. TSP1. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAPVQVPQS LLLLLMLLLT LPATGSDPVL CFSQYEDSSS KCKDLLGKDV
60 70 80 90 100
SLEDCCLNAA YAFKERDNGH CQACRSPRWS PWSSWAPCSV SCSEGSQLRH
110 120 130 140 150
RRCIGWGGQC SENKAPGTLE WQLQACEEQQ CCPEMGGWSN WEPWGPCTVT
160 170 180 190 200
CSKGTRIRRR VCNNPAPKCG GHCPGVAQES EACDTQQVCP THGAWGPWGP
210 220 230 240 250
WSSCLSSCHG GPHKPVETRS RTCSAPEPSK NPPGNPCPGT AYEQQSCAGL
260 270 280 290 300
PPCPVAGGWG PWGSVSPCSV TCGLGQILEQ RKCDNPVPQH GGSFCTGDDT
310 320 330 340 350
RAHICNTAVP CPVDGEWEPW GDWSTCTRPH LSAIRCKEIV GQQTRVRICK
360 370 380 390 400
GRKFNGQRCP GKHQEIRHCY NIQNCIFGEK GSWSQWTPWG LCTPPCGANP
410 420 430 440 450
TRVRQRRCMA SLPKFSPTVS VVEGQGEKNV TFWGKPLAQC EELQGQKVLL
460 470
EEKRPCLHVP ACKDPEEEEP
Length:470
Mass (Da):51,431
Last modified:November 1, 1996 - v1
Checksum:iFDC2B393DC7EC15F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81116 mRNA. Translation: AAB35918.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81116 mRNA. Translation: AAB35918.1.

3D structure databases

ProteinModelPortaliQ64181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000006537.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IUGK. Eukaryota.
ENOG410ZHSM. LUCA.
HOGENOMiHOG000231326.
HOVERGENiHBG008263.
InParanoidiQ64181.

Family and domain databases

InterProiIPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00090. TSP_1. 6 hits.
[Graphical view]
SMARTiSM00209. TSP1. 6 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 6 hits.
PROSITEiPS50092. TSP1. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of the cDNA encoding guinea-pig properdin: a comparison of properdin from three species."
    Maves K.K., Guenthner S.T., Densen P., Moser D.R., Weiler J.M.
    Immunology 86:475-479(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiPROP_CAVPO
AccessioniPrimary (citable) accession number: Q64181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.