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Protein
Submitted name:

Enzymatic glycosylation-regulating gene protein

Gene

Gcnt1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_289902. O-linked glycosylation of mucins.

Protein family/group databases

CAZyiGT14. Glycosyltransferase Family 14.

Names & Taxonomyi

Protein namesi
Submitted name:
Enzymatic glycosylation-regulating gene proteinImported
Submitted name:
Protein Gcnt1Imported
Submitted name:
RCG47510Imported
Gene namesi
Name:Gcnt1Imported
ORF Names:rCG_47510Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621370. Gcnt1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • Golgi cisterna Source: Ensembl
  • membrane Source: InterPro
  • trans-Golgi network Source: Ensembl
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066013.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG253565.
GeneTreeiENSGT00760000119183.
HOGENOMiHOG000293251.
HOVERGENiHBG051711.
KOiK00727.
OMAiNCMQDLY.
OrthoDBiEOG74N5HW.
TreeFamiTF315534.

Family and domain databases

InterProiIPR003406. Glyco_trans_14.
[Graphical view]
PfamiPF02485. Branch. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNLFRRRL FSYPTKYYFM VLVLSLITFS VVRIHQKPEF VSVSHLELSG
60 70 80 90 100
DDPNSNVNCT KVLQGDPEEI QKVKLEILTV QFKKRPRRTP HDYINMTRDC
110 120 130 140 150
ASFIRTRKYI MEPLTKEEVG FPIAYSIVVH HKIDMLDRLL RAIYMPQNFY
160 170 180 190 200
CIHVDRKAEE SFLAAVQGIA SCFDNVFVAS QLESVVYASW SRVKADLNCM
210 220 230 240 250
KDLYRMNANW KYLINLCGMD FPIKTNLEIV RKLKSFTGEN SLETEKMPPN
260 270 280 290 300
KEERWKKRYT VVDGKLTNTG VVKAQPPLKT PLFSGSAYFV VTREYVGYVL
310 320 330 340 350
ENKNIQKFME WAQDTYSPDE FLWATIQRIP EVPGSLPSSH KYDLSDMNAV
360 370 380 390 400
ARFVKWQYFE GDVSNGAPYP PCSGVHVRSV CVFGVGDLSW MLRKHHFFAN
410 420
KFDMDVDPFA LQCLEEHLRH KALETLER
Length:428
Mass (Da):49,827
Last modified:November 1, 1996 - v1
Checksum:iAE25A18172897AA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006475 Genomic DNA. No translation available.
S79797 mRNA. Translation: AAB35697.2.
CH473953 Genomic DNA. Translation: EDM12976.1.
RefSeqiNP_071612.1. NM_022276.1.
XP_006231209.1. XM_006231147.2.
XP_006231212.1. XM_006231150.2.
UniGeneiRn.162516.

Genome annotation databases

EnsembliENSRNOT00000074939; ENSRNOP00000066013; ENSRNOG00000050534.
GeneIDi64043.
KEGGirno:64043.
UCSCiRGD:621370. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006475 Genomic DNA. No translation available.
S79797 mRNA. Translation: AAB35697.2.
CH473953 Genomic DNA. Translation: EDM12976.1.
RefSeqiNP_071612.1. NM_022276.1.
XP_006231209.1. XM_006231147.2.
XP_006231212.1. XM_006231150.2.
UniGeneiRn.162516.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066013.

Protein family/group databases

CAZyiGT14. Glycosyltransferase Family 14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074939; ENSRNOP00000066013; ENSRNOG00000050534.
GeneIDi64043.
KEGGirno:64043.
UCSCiRGD:621370. rat.

Organism-specific databases

CTDi2650.
RGDi621370. Gcnt1.

Phylogenomic databases

eggNOGiNOG253565.
GeneTreeiENSGT00760000119183.
HOGENOMiHOG000293251.
HOVERGENiHBG051711.
KOiK00727.
OMAiNCMQDLY.
OrthoDBiEOG74N5HW.
TreeFamiTF315534.

Enzyme and pathway databases

ReactomeiREACT_289902. O-linked glycosylation of mucins.

Miscellaneous databases

NextBioi612697.
PROiQ64165.

Family and domain databases

InterProiIPR003406. Glyco_trans_14.
[Graphical view]
PfamiPF02485. Branch. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue."
    Nishio Y., Warren C.E., Buczek-Thomas J.A., Rulfs J., Koya D., Aiello L.P., Feener E.P., Miller T.B. Jr, Dennis J.W., King G.L.
    J. Clin. Invest. 96:1759-1767(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: HeartImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Ensembl
    Submitted (FEB-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ64165_RAT
AccessioniPrimary (citable) accession number: Q64165
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 22, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.