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Q64165

- Q64165_RAT

UniProt

Q64165 - Q64165_RAT

Protein
Submitted name:

Enzymatic glycosylation-regulating gene protein

Gene

Gcnt1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Source: RGD

    GO - Biological processi

    1. cell adhesion molecule production Source: Ensembl
    2. glycoprotein biosynthetic process Source: Ensembl
    3. kidney morphogenesis Source: Ensembl
    4. leukocyte tethering or rolling Source: Ensembl
    5. response to insulin Source: RGD
    6. tissue morphogenesis Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_196259. O-linked glycosylation of mucins.

    Protein family/group databases

    CAZyiGT14. Glycosyltransferase Family 14.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Enzymatic glycosylation-regulating gene proteinImported
    Submitted name:
    Protein Gcnt1Imported
    Submitted name:
    RCG47510Imported
    Gene namesi
    Name:Gcnt1Imported
    ORF Names:rCG_47510Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi621370. Gcnt1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RGD
    2. Golgi cisterna Source: Ensembl
    3. membrane Source: InterPro
    4. trans-Golgi network Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ64165.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000020736.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG253565.
    GeneTreeiENSGT00750000117608.
    HOGENOMiHOG000293251.
    HOVERGENiHBG051711.
    InParanoidiQ64165.
    KOiK00727.
    OMAiGIHVRSV.
    OrthoDBiEOG74N5HW.
    TreeFamiTF315534.

    Family and domain databases

    InterProiIPR003406. Glyco_trans_14.
    [Graphical view]
    PfamiPF02485. Branch. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64165-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRNLFRRRL FSYPTKYYFM VLVLSLITFS VVRIHQKPEF VSVSHLELSG    50
    DDPNSNVNCT KVLQGDPEEI QKVKLEILTV QFKKRPRRTP HDYINMTRDC 100
    ASFIRTRKYI MEPLTKEEVG FPIAYSIVVH HKIDMLDRLL RAIYMPQNFY 150
    CIHVDRKAEE SFLAAVQGIA SCFDNVFVAS QLESVVYASW SRVKADLNCM 200
    KDLYRMNANW KYLINLCGMD FPIKTNLEIV RKLKSFTGEN SLETEKMPPN 250
    KEERWKKRYT VVDGKLTNTG VVKAQPPLKT PLFSGSAYFV VTREYVGYVL 300
    ENKNIQKFME WAQDTYSPDE FLWATIQRIP EVPGSLPSSH KYDLSDMNAV 350
    ARFVKWQYFE GDVSNGAPYP PCSGVHVRSV CVFGVGDLSW MLRKHHFFAN 400
    KFDMDVDPFA LQCLEEHLRH KALETLER 428
    Length:428
    Mass (Da):49,827
    Last modified:November 1, 1996 - v1
    Checksum:iAE25A18172897AA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06010123 Genomic DNA. No translation available.
    S79797 mRNA. Translation: AAB35697.2.
    CH473953 Genomic DNA. Translation: EDM12976.1.
    RefSeqiNP_071612.1. NM_022276.1.
    XP_006231209.1. XM_006231147.1.
    XP_006231210.1. XM_006231148.1.
    XP_006231211.1. XM_006231149.1.
    XP_006231212.1. XM_006231150.1.
    XP_006231213.1. XM_006231151.1.
    UniGeneiRn.162516.

    Genome annotation databases

    EnsembliENSRNOT00000074939; ENSRNOP00000066013; ENSRNOG00000050534.
    GeneIDi64043.
    KEGGirno:64043.
    UCSCiRGD:621370. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06010123 Genomic DNA. No translation available.
    S79797 mRNA. Translation: AAB35697.2 .
    CH473953 Genomic DNA. Translation: EDM12976.1 .
    RefSeqi NP_071612.1. NM_022276.1.
    XP_006231209.1. XM_006231147.1.
    XP_006231210.1. XM_006231148.1.
    XP_006231211.1. XM_006231149.1.
    XP_006231212.1. XM_006231150.1.
    XP_006231213.1. XM_006231151.1.
    UniGenei Rn.162516.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000020736.

    Protein family/group databases

    CAZyi GT14. Glycosyltransferase Family 14.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000074939 ; ENSRNOP00000066013 ; ENSRNOG00000050534 .
    GeneIDi 64043.
    KEGGi rno:64043.
    UCSCi RGD:621370. rat.

    Organism-specific databases

    CTDi 2650.
    RGDi 621370. Gcnt1.

    Phylogenomic databases

    eggNOGi NOG253565.
    GeneTreei ENSGT00750000117608.
    HOGENOMi HOG000293251.
    HOVERGENi HBG051711.
    InParanoidi Q64165.
    KOi K00727.
    OMAi GIHVRSV.
    OrthoDBi EOG74N5HW.
    TreeFami TF315534.

    Enzyme and pathway databases

    Reactomei REACT_196259. O-linked glycosylation of mucins.

    Miscellaneous databases

    NextBioi 612697.
    PROi Q64165.

    Gene expression databases

    Genevestigatori Q64165.

    Family and domain databases

    InterProi IPR003406. Glyco_trans_14.
    [Graphical view ]
    Pfami PF02485. Branch. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue."
      Nishio Y., Warren C.E., Buczek-Thomas J.A., Rulfs J., Koya D., Aiello L.P., Feener E.P., Miller T.B. Jr, Dennis J.W., King G.L.
      J. Clin. Invest. 96:1759-1767(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.
      Tissue: HeartImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Ensembl
      Submitted (FEB-2013) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ64165_RAT
    AccessioniPrimary (citable) accession number: Q64165
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3