Q64159 (CD3G_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
T-cell surface glycoprotein CD3 gamma chain

Alternative name(s):
T-cell receptor T3 gamma chain
CD_antigen=CD3g

Gene names

Name:

Cd3g

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The CD3 complex mediates signal transduction.
Subunit structure	The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 1 Ig-like (immunoglobulin-like) domain. Contains 1 ITAM domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell surface receptor linked signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB establishment or maintenance of cell polarity Inferred from sequence or structural similarity. Source: UniProtKB protein transport Inferred from sequence or structural similarity. Source: UniProtKB regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein heterodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB transmembrane signaling receptor activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	By similarity
	Chain	23 – 182	160	T-cell surface glycoprotein CD3 gamma chain		PRO_0000014618
Regions
	Topological domain	23 – 116	94	Extracellular Potential
	Transmembrane	117 – 137	21	Helical; Potential
	Topological domain	138 – 182	45	Cytoplasmic Potential
	Domain	37 – 94	58	Ig-like
	Domain	149 – 177	29	ITAM
Amino acid modifications
	Modified residue	145	1	Phosphoserine By similarity
	Modified residue	148	1	Phosphoserine By similarity
	Modified residue	160	1	Phosphotyrosine By similarity
	Modified residue	171	1	Phosphotyrosine By similarity
	Glycosylation	66	1	N-linked (GlcNAc...) Potential
	Disulfide bond	46 ↔ 87		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q64159 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: A4DBA7AA67FACED7	FASTA	182	20,545
	10 20 30 40 50 60 MEQGKGLAGL FLVISLLQGT MAQQKEEKHL VKVDDSQGDG SVLLTCDFNE KTITWLKDGH 70 80 90 100 110 120 RISPPNATKS TWNLGNGAKD PRGMYQCRGA KKKSQLLQVY YRLCENCIEL NMGTVSGFIF 130 140 150 160 170 180 AEIISIFFLA VGVYFIAGQD GVRQSRASDK QTLLQNEQVY QPLKDREYEQ YSRLQGNQVR KK

References

[1]	"The CD3 gamma-chain, transmembrane signalling or recognition?" Levins B., Colaco C.A. Immunogenetics 35:140-143(1992) [PubMed: 1531205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S79711 mRNA. Translation: AAB21286.2.
IPI	IPI00209914.
RefSeq	NP_001071114.1. NM_001077646.1.
UniGene	Rn.106603.
3D structure databases
ProteinModelPortal	Q64159.
SMR	Q64159. Positions 22-103.
ModBase	Search...
Protein-protein interaction databases
STRING	Q64159.
Proteomic databases
PRIDE	Q64159.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	300678.
KEGG	rno:300678.
UCSC	S79711. rat.
Organism-specific databases
CTD	917.
RGD	1307718. Cd3g.
Phylogenomic databases
eggNOG	roNOG16166.
GeneTree	ENSGT00510000046930.
HOVERGEN	HBG005278.
InParanoid	Q64159.
OrthoDB	EOG405S26.
Gene expression databases
ArrayExpress	Q64159.
Genevestigator	Q64159.
GermOnline	ENSRNOG00000015945. Rattus norvegicus.
Family and domain databases
InterPro	IPR015484. CD3_gsu/dsu. IPR013783. Ig-like_fold. IPR003598. Ig_sub2. IPR003110. Phos_immunorcpt_sig_ITAM. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
KO	K06452.
PANTHER	PTHR10570. CD3_gamma_delta. 1 hit.
SMART	SM00408. IGc2. 1 hit. SM00077. ITAM. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. False negative. PS51055. ITAM_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	647298.

Entry information

Entry name

CD3G_RAT

Accession

Primary (citable) accession number: Q64159

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 16, 2011
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program