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Q64143 (P55G_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylinositol 3-kinase regulatory subunit gamma
Short name=PI3-kinase regulatory subunit gamma
Short name=PI3K regulatory subunit gamma
Short name=PtdIns-3-kinase regulatory subunit gamma
Alternative name(s):
Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
Short name=PI3-kinase subunit p55-gamma
Short name=PtdIns-3-kinase regulatory subunit p55-gamma
p55PIK
Gene names
Name:Pik3r3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

Subunit structure

Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL By similarity.

Tissue specificity

Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Barely detectable in liver and spleen.

Sequence similarities

Belongs to the PI3K p85 subunit family.

Contains 2 SH2 domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 461461Phosphatidylinositol 3-kinase regulatory subunit gamma
PRO_0000080768

Regions

Domain65 – 16096SH2 1
Domain358 – 45295SH2 2

Amino acid modifications

Modified residue1991Phosphotyrosine Ref.3
Modified residue3411Phosphotyrosine Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q64143 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 97A01A0DFAAC661F

FASTA46154,474
        10         20         30         40         50         60 
MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTPAVT NGMKDSFISL 

        70         80         90        100        110        120 
QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY TLTLRKGGNN KLIKIYHRDG 

       130        140        150        160        170        180 
KYGFSEPLTF TSVVELINHY HHESLAQYNP KLDVKLTYPV SRFQQDQLVK EDNIDAVGKN 

       190        200        210        220        230        240 
LQEFHSQYQE KSKEYDRLYE EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKDY 

       250        260        270        280        290        300 
IERFRREGNE KEIERIMMNY DKLKSRLGEI HDSKLRLEQD LKKQALDNRE IDKKMNSIKP 

       310        320        330        340        350        360 
DLIQLRKIRD QHLVWLNHRG VRQRRLNAWL GIKNEDSDES YFINEEDENL PHYDEKTWFV 

       370        380        390        400        410        420 
EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE VKHCVIYSTA RGYGFAEPYN 

       430        440        450        460 
LYSSLKELVL HYQQTSLVQH NDSLNVRLAY PVHAQMPTLC R

« Hide

References

« Hide 'large scale' references
[1]"The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase."
Pons S., Asano T., Glasheen E., Miralpeix M., Zhang Y., Fisher T.L., Myers M.G. Jr., Sun X.J., White M.F.
Mol. Cell. Biol. 15:4453-4465(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, PHOSPHORYLATION AT TYR-341.
Tissue: Embryo.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-199, MASS SPECTROMETRY.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		S79169 mRNA. Translation: AAB34938.1.
BC053102 mRNA. Translation: AAH53102.1.
IPIIPI00131170.
RefSeqNP_853616.1. NM_181585.5.
UniGeneMm.253819.

3D structure databases

ProteinModelPortalQ64143.
SMRQ64143. Positions 58-455.
ModBaseSearch...

Protein-protein interaction databases

IntActQ64143. 2 interactions.
STRING10090.ENSMUSP00000030464.

PTM databases

PhosphoSiteQ64143.

Proteomic databases

PaxDbQ64143.
PRIDEQ64143.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030464; ENSMUSP00000030464; ENSMUSG00000028698.
GeneID18710.
KEGGmmu:18710.

Organism-specific databases

CTD8503.
MGIMGI:109277. Pik3r3.

Phylogenomic databases

eggNOGNOG263689.
GeneTreeENSGT00390000010431.
HOGENOMHOG000008438.
HOVERGENHBG082100.
InParanoidQ64143.
KOK02649.
OMAETYFINE.
OrthoDBEOG4QFWD5.

Enzyme and pathway databases

ReactomeREACT_107772. Immune System.

Gene expression databases

ArrayExpressQ64143.
BgeeQ64143.
GenevestigatorQ64143.
GermOnlineENSMUSG00000028698. Mus musculus.

Family and domain databases

Gene3D3.30.505.10. 2 hits.
InterProIPR001720. PI3kinase_P85.
IPR000980. SH2.
[Graphical view]
PANTHERPTHR10155. PTHR10155. 1 hit.
PfamPF00017. SH2. 2 hits.
[Graphical view]
PRINTSPR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTSM00252. SH2. 2 hits.
[Graphical view]
PROSITEPS50001. SH2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio294789.
SOURCESearch...

Entry information

Entry nameP55G_MOUSE
AccessionPrimary (citable) accession number: Q64143
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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