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Q64143

- P55G_MOUSE

UniProt

Q64143 - P55G_MOUSE

Protein

Phosphatidylinositol 3-kinase regulatory subunit gamma

Gene

Pik3r3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

    GO - Molecular functioni

    1. phosphatidylinositol 3-kinase regulator activity Source: InterPro

    Enzyme and pathway databases

    ReactomeiREACT_198701. Interleukin-7 signaling.
    REACT_198973. Synthesis of PIPs at the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 3-kinase regulatory subunit gamma
    Short name:
    PI3-kinase regulatory subunit gamma
    Short name:
    PI3K regulatory subunit gamma
    Short name:
    PtdIns-3-kinase regulatory subunit gamma
    Alternative name(s):
    Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
    Short name:
    PI3-kinase subunit p55-gamma
    Short name:
    PtdIns-3-kinase regulatory subunit p55-gamma
    p55PIK
    Gene namesi
    Name:Pik3r3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:109277. Pik3r3.

    Subcellular locationi

    GO - Cellular componenti

    1. phosphatidylinositol 3-kinase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 461461Phosphatidylinositol 3-kinase regulatory subunit gammaPRO_0000080768Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei341 – 3411Phosphotyrosine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ64143.
    PaxDbiQ64143.
    PRIDEiQ64143.

    PTM databases

    PhosphoSiteiQ64143.

    Expressioni

    Tissue specificityi

    Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Barely detectable in liver and spleen.

    Gene expression databases

    BgeeiQ64143.
    GenevestigatoriQ64143.

    Interactioni

    Subunit structurei

    Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ64143. 3 interactions.
    MINTiMINT-1747085.
    STRINGi10090.ENSMUSP00000030464.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64143.
    SMRiQ64143. Positions 58-455.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 16096SH2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini358 – 45295SH2 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PI3K p85 subunit family.Curated
    Contains 2 SH2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH2 domain

    Phylogenomic databases

    eggNOGiNOG263689.
    GeneTreeiENSGT00390000010431.
    HOGENOMiHOG000008438.
    HOVERGENiHBG082100.
    InParanoidiQ64143.
    KOiK02649.
    OMAiETYFINE.
    PhylomeDBiQ64143.
    TreeFamiTF102033.

    Family and domain databases

    Gene3Di3.30.505.10. 2 hits.
    InterProiIPR001720. PI3kinase_P85.
    IPR000980. SH2.
    [Graphical view]
    PANTHERiPTHR10155. PTHR10155. 1 hit.
    PfamiPF00017. SH2. 2 hits.
    [Graphical view]
    PRINTSiPR00678. PI3KINASEP85.
    PR00401. SH2DOMAIN.
    SMARTiSM00252. SH2. 2 hits.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 2 hits.
    PROSITEiPS50001. SH2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64143-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTPAVT    50
    NGMKDSFISL QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY 100
    TLTLRKGGNN KLIKIYHRDG KYGFSEPLTF TSVVELINHY HHESLAQYNP 150
    KLDVKLTYPV SRFQQDQLVK EDNIDAVGKN LQEFHSQYQE KSKEYDRLYE 200
    EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKDY IERFRREGNE 250
    KEIERIMMNY DKLKSRLGEI HDSKLRLEQD LKKQALDNRE IDKKMNSIKP 300
    DLIQLRKIRD QHLVWLNHRG VRQRRLNAWL GIKNEDSDES YFINEEDENL 350
    PHYDEKTWFV EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE 400
    VKHCVIYSTA RGYGFAEPYN LYSSLKELVL HYQQTSLVQH NDSLNVRLAY 450
    PVHAQMPTLC R 461
    Length:461
    Mass (Da):54,474
    Last modified:November 1, 1996 - v1
    Checksum:i97A01A0DFAAC661F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S79169 mRNA. Translation: AAB34938.1.
    BC053102 mRNA. Translation: AAH53102.1.
    CCDSiCCDS18509.1.
    RefSeqiNP_853616.1. NM_181585.5.
    UniGeneiMm.253819.

    Genome annotation databases

    EnsembliENSMUST00000030464; ENSMUSP00000030464; ENSMUSG00000028698.
    GeneIDi18710.
    KEGGimmu:18710.
    UCSCiuc008ugm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S79169 mRNA. Translation: AAB34938.1 .
    BC053102 mRNA. Translation: AAH53102.1 .
    CCDSi CCDS18509.1.
    RefSeqi NP_853616.1. NM_181585.5.
    UniGenei Mm.253819.

    3D structure databases

    ProteinModelPortali Q64143.
    SMRi Q64143. Positions 58-455.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q64143. 3 interactions.
    MINTi MINT-1747085.
    STRINGi 10090.ENSMUSP00000030464.

    PTM databases

    PhosphoSitei Q64143.

    Proteomic databases

    MaxQBi Q64143.
    PaxDbi Q64143.
    PRIDEi Q64143.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030464 ; ENSMUSP00000030464 ; ENSMUSG00000028698 .
    GeneIDi 18710.
    KEGGi mmu:18710.
    UCSCi uc008ugm.1. mouse.

    Organism-specific databases

    CTDi 8503.
    MGIi MGI:109277. Pik3r3.

    Phylogenomic databases

    eggNOGi NOG263689.
    GeneTreei ENSGT00390000010431.
    HOGENOMi HOG000008438.
    HOVERGENi HBG082100.
    InParanoidi Q64143.
    KOi K02649.
    OMAi ETYFINE.
    PhylomeDBi Q64143.
    TreeFami TF102033.

    Enzyme and pathway databases

    Reactomei REACT_198701. Interleukin-7 signaling.
    REACT_198973. Synthesis of PIPs at the plasma membrane.

    Miscellaneous databases

    NextBioi 294789.
    PROi Q64143.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q64143.
    Genevestigatori Q64143.

    Family and domain databases

    Gene3Di 3.30.505.10. 2 hits.
    InterProi IPR001720. PI3kinase_P85.
    IPR000980. SH2.
    [Graphical view ]
    PANTHERi PTHR10155. PTHR10155. 1 hit.
    Pfami PF00017. SH2. 2 hits.
    [Graphical view ]
    PRINTSi PR00678. PI3KINASEP85.
    PR00401. SH2DOMAIN.
    SMARTi SM00252. SH2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 2 hits.
    PROSITEi PS50001. SH2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase."
      Pons S., Asano T., Glasheen E., Miralpeix M., Zhang Y., Fisher T.L., Myers M.G. Jr., Sun X.J., White M.F.
      Mol. Cell. Biol. 15:4453-4465(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, PHOSPHORYLATION AT TYR-341.
      Tissue: Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiP55G_MOUSE
    AccessioniPrimary (citable) accession number: Q64143
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3