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Protein

Phosphatidylinositol 3-kinase regulatory subunit gamma

Gene

Pik3r3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_272541. Synthesis of PIPs at the plasma membrane.
REACT_276590. Interleukin-7 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase regulatory subunit gamma
Short name:
PI3-kinase regulatory subunit gamma
Short name:
PI3K regulatory subunit gamma
Short name:
PtdIns-3-kinase regulatory subunit gamma
Alternative name(s):
Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
Short name:
PI3-kinase subunit p55-gamma
Short name:
PtdIns-3-kinase regulatory subunit p55-gamma
p55PIK
Gene namesi
Name:Pik3r3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:109277. Pik3r3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Phosphatidylinositol 3-kinase regulatory subunit gammaPRO_0000080768Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei341 – 3411Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ64143.
PaxDbiQ64143.
PRIDEiQ64143.

PTM databases

PhosphoSiteiQ64143.

Expressioni

Tissue specificityi

Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Barely detectable in liver and spleen.

Gene expression databases

BgeeiQ64143.
ExpressionAtlasiQ64143. baseline and differential.
GenevestigatoriQ64143.

Interactioni

Subunit structurei

Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL (By similarity).By similarity

Protein-protein interaction databases

IntActiQ64143. 3 interactions.
MINTiMINT-1747085.
STRINGi10090.ENSMUSP00000030464.

Structurei

3D structure databases

ProteinModelPortaliQ64143.
SMRiQ64143. Positions 58-455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 16096SH2 1PROSITE-ProRule annotationAdd
BLAST
Domaini358 – 45295SH2 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3K p85 subunit family.Curated
Contains 2 SH2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiNOG263689.
GeneTreeiENSGT00390000010431.
HOGENOMiHOG000008438.
HOVERGENiHBG082100.
InParanoidiQ64143.
KOiK02649.
OMAiETYFINE.
PhylomeDBiQ64143.
TreeFamiTF102033.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
InterProiIPR001720. PI3kinase_P85.
IPR000980. SH2.
[Graphical view]
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiPF00017. SH2. 2 hits.
[Graphical view]
PRINTSiPR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 2 hits.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTPAVT
60 70 80 90 100
NGMKDSFISL QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY
110 120 130 140 150
TLTLRKGGNN KLIKIYHRDG KYGFSEPLTF TSVVELINHY HHESLAQYNP
160 170 180 190 200
KLDVKLTYPV SRFQQDQLVK EDNIDAVGKN LQEFHSQYQE KSKEYDRLYE
210 220 230 240 250
EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKDY IERFRREGNE
260 270 280 290 300
KEIERIMMNY DKLKSRLGEI HDSKLRLEQD LKKQALDNRE IDKKMNSIKP
310 320 330 340 350
DLIQLRKIRD QHLVWLNHRG VRQRRLNAWL GIKNEDSDES YFINEEDENL
360 370 380 390 400
PHYDEKTWFV EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE
410 420 430 440 450
VKHCVIYSTA RGYGFAEPYN LYSSLKELVL HYQQTSLVQH NDSLNVRLAY
460
PVHAQMPTLC R
Length:461
Mass (Da):54,474
Last modified:November 1, 1996 - v1
Checksum:i97A01A0DFAAC661F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79169 mRNA. Translation: AAB34938.1.
BC053102 mRNA. Translation: AAH53102.1.
CCDSiCCDS18509.1.
RefSeqiNP_853616.1. NM_181585.5.
UniGeneiMm.253819.

Genome annotation databases

EnsembliENSMUST00000030464; ENSMUSP00000030464; ENSMUSG00000028698.
GeneIDi18710.
KEGGimmu:18710.
UCSCiuc008ugm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79169 mRNA. Translation: AAB34938.1.
BC053102 mRNA. Translation: AAH53102.1.
CCDSiCCDS18509.1.
RefSeqiNP_853616.1. NM_181585.5.
UniGeneiMm.253819.

3D structure databases

ProteinModelPortaliQ64143.
SMRiQ64143. Positions 58-455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64143. 3 interactions.
MINTiMINT-1747085.
STRINGi10090.ENSMUSP00000030464.

PTM databases

PhosphoSiteiQ64143.

Proteomic databases

MaxQBiQ64143.
PaxDbiQ64143.
PRIDEiQ64143.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030464; ENSMUSP00000030464; ENSMUSG00000028698.
GeneIDi18710.
KEGGimmu:18710.
UCSCiuc008ugm.1. mouse.

Organism-specific databases

CTDi8503.
MGIiMGI:109277. Pik3r3.

Phylogenomic databases

eggNOGiNOG263689.
GeneTreeiENSGT00390000010431.
HOGENOMiHOG000008438.
HOVERGENiHBG082100.
InParanoidiQ64143.
KOiK02649.
OMAiETYFINE.
PhylomeDBiQ64143.
TreeFamiTF102033.

Enzyme and pathway databases

ReactomeiREACT_272541. Synthesis of PIPs at the plasma membrane.
REACT_276590. Interleukin-7 signaling.

Miscellaneous databases

NextBioi294789.
PROiQ64143.
SOURCEiSearch...

Gene expression databases

BgeeiQ64143.
ExpressionAtlasiQ64143. baseline and differential.
GenevestigatoriQ64143.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
InterProiIPR001720. PI3kinase_P85.
IPR000980. SH2.
[Graphical view]
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiPF00017. SH2. 2 hits.
[Graphical view]
PRINTSiPR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 2 hits.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase."
    Pons S., Asano T., Glasheen E., Miralpeix M., Zhang Y., Fisher T.L., Myers M.G. Jr., Sun X.J., White M.F.
    Mol. Cell. Biol. 15:4453-4465(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, PHOSPHORYLATION AT TYR-341.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiP55G_MOUSE
AccessioniPrimary (citable) accession number: Q64143
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.