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Q64133

- AOFA_MOUSE

UniProt

Q64133 - AOFA_MOUSE

Protein

Amine oxidase [flavin-containing] A

Gene

Maoa

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine By similarity.By similarity

    Catalytic activityi

    RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

    Cofactori

    FAD.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei335 – 3351Important for substrate specificityBy similarity
    Sitei374 – 3741Important for catalytic activityBy similarity

    GO - Molecular functioni

    1. primary amine oxidase activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. dopamine catabolic process Source: MGI
    2. neurotransmitter catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Catecholamine metabolism, Neurotransmitter degradation

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Amine oxidase [flavin-containing] A (EC:1.4.3.4)
    Alternative name(s):
    Monoamine oxidase type A
    Short name:
    MAO-A
    Gene namesi
    Name:Maoa
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:96915. Maoa.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 526526Amine oxidase [flavin-containing] APRO_0000099851Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei406 – 4061S-8alpha-FAD cysteineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ64133.
    PaxDbiQ64133.
    PRIDEiQ64133.

    PTM databases

    PhosphoSiteiQ64133.

    Expressioni

    Gene expression databases

    ArrayExpressiQ64133.
    BgeeiQ64133.
    CleanExiMM_MAOA.
    GenevestigatoriQ64133.

    Interactioni

    Subunit structurei

    Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.By similarity

    Protein-protein interaction databases

    BioGridi201307. 2 interactions.
    IntActiQ64133. 1 interaction.
    MINTiMINT-4997361.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64133.
    SMRiQ64133. Positions 11-520.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 497497CytoplasmicBy similarityAdd
    BLAST
    Topological domaini519 – 5268Mitochondrial intermembraneBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei498 – 51821Helical; Anchor for type IV membrane proteinBy similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni520 – 5223Interaction with membrane phospholipid headgroupsBy similarity

    Sequence similaritiesi

    Belongs to the flavin monoamine oxidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1231.
    GeneTreeiENSGT00730000110903.
    HOGENOMiHOG000221615.
    HOVERGENiHBG004255.
    InParanoidiB1AX52.
    KOiK00274.
    OMAiMEITHTF.
    OrthoDBiEOG7K6PTP.
    TreeFamiTF313314.

    Family and domain databases

    InterProiIPR002937. Amino_oxidase.
    IPR001613. Flavin_amine_oxidase.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    [Graphical view]
    PRINTSiPR00757. AMINEOXDASEF.

    Sequencei

    Sequence statusi: Complete.

    Q64133-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDLEKPSIT GHMFDVVVIG GGISGLAAAK LLSEYKINVL VLEARDRVGG    50
    RTYTVRNEHV KWVDVGGAYV GPTQNRILRL SKELGIETYK VNVNERLVQY 100
    VKGKTYPFRG AFPPVWNPLA YLDYNNLWRT MDDMGKEIPV DAPWQARHAE 150
    EWDKITMKDL IDKICWTKTA REFAYLFVNI NVTSEPHEVS ALWFLWYVRQ 200
    CGGTSRIFSV TNGGQERKFV GGSGQISEQI MVLLGDKVKL SSPVTYIDQT 250
    DDNIIIETLN HEHYECKYVI SAIPPVLTAK IHFKPELPPE RNQLIQRLPM 300
    GAVIKCMVYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSMPAIM 350
    GFILARKAER LAKLHKDIRK RKICELYAKV LGSQEALSPV HYEEKNWCEE 400
    QYSGGCYTAY FPPGIMTLYG RVIRQPVGRI YFAGTETATQ WSGYMEGAVE 450
    AGERAAREVL NALGKVAKKD IWVQEPESKD VPALEITHTF LERNLPSVPG 500
    LLKITGFSTS VALLCFVLYK FKQPQS 526
    Length:526
    Mass (Da):59,602
    Last modified:July 27, 2011 - v3
    Checksum:i5375D1B0C4C5ACF9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti83 – 831E → D in AAH29100. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL805907, AL831729 Genomic DNA. Translation: CAM18994.1.
    AL831729, AL805907 Genomic DNA. Translation: CAM26634.1.
    CH466584 Genomic DNA. Translation: EDL35717.1.
    BC029100 mRNA. Translation: AAH29100.1.
    S78615, S78606 Genomic DNA. Translation: AAB34677.1.
    CCDSiCCDS30033.1.
    RefSeqiNP_776101.3. NM_173740.3.
    UniGeneiMm.21108.

    Genome annotation databases

    EnsembliENSMUST00000026013; ENSMUSP00000026013; ENSMUSG00000025037.
    GeneIDi17161.
    KEGGimmu:17161.
    UCSCiuc009ssa.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL805907 , AL831729 Genomic DNA. Translation: CAM18994.1 .
    AL831729 , AL805907 Genomic DNA. Translation: CAM26634.1 .
    CH466584 Genomic DNA. Translation: EDL35717.1 .
    BC029100 mRNA. Translation: AAH29100.1 .
    S78615 , S78606 Genomic DNA. Translation: AAB34677.1 .
    CCDSi CCDS30033.1.
    RefSeqi NP_776101.3. NM_173740.3.
    UniGenei Mm.21108.

    3D structure databases

    ProteinModelPortali Q64133.
    SMRi Q64133. Positions 11-520.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201307. 2 interactions.
    IntActi Q64133. 1 interaction.
    MINTi MINT-4997361.

    Chemistry

    BindingDBi Q64133.
    ChEMBLi CHEMBL2111442.

    PTM databases

    PhosphoSitei Q64133.

    Proteomic databases

    MaxQBi Q64133.
    PaxDbi Q64133.
    PRIDEi Q64133.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026013 ; ENSMUSP00000026013 ; ENSMUSG00000025037 .
    GeneIDi 17161.
    KEGGi mmu:17161.
    UCSCi uc009ssa.2. mouse.

    Organism-specific databases

    CTDi 4128.
    MGIi MGI:96915. Maoa.

    Phylogenomic databases

    eggNOGi COG1231.
    GeneTreei ENSGT00730000110903.
    HOGENOMi HOG000221615.
    HOVERGENi HBG004255.
    InParanoidi B1AX52.
    KOi K00274.
    OMAi MEITHTF.
    OrthoDBi EOG7K6PTP.
    TreeFami TF313314.

    Miscellaneous databases

    NextBioi 291438.
    PROi Q64133.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q64133.
    Bgeei Q64133.
    CleanExi MM_MAOA.
    Genevestigatori Q64133.

    Family and domain databases

    InterProi IPR002937. Amino_oxidase.
    IPR001613. Flavin_amine_oxidase.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    [Graphical view ]
    PRINTSi PR00757. AMINEOXDASEF.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. "Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA."
      Cases O., Seif I., Grimsby J., Gaspar P., Chen K., Pournin S., Mueller U., Aguet M., Babinet C., Shih J.C., de Maeyer E.
      Science 268:1763-1766(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-40.
    5. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 137-147; 207-217; 268-280 AND 380-395, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiAOFA_MOUSE
    AccessioniPrimary (citable) accession number: Q64133
    Secondary accession number(s): B1AX52, Q8K0Z8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 117 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3