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Protein

Amine oxidase [flavin-containing] A

Gene

Maoa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity).By similarity

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei335Important for substrate specificityBy similarity1
Sitei374Important for catalytic activityBy similarity1

GO - Molecular functioni

  • primary amine oxidase activity Source: MGI

GO - Biological processi

  • dopamine catabolic process Source: MGI
  • neurotransmitter catabolic process Source: UniProtKB-KW

Keywordsi

Molecular functionOxidoreductase
Biological processCatecholamine metabolism, Neurotransmitter degradation
LigandFAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.4.3.4 3474
ReactomeiR-MMU-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle
R-MMU-379397 Enzymatic degradation of dopamine by COMT
R-MMU-379398 Enzymatic degradation of Dopamine by monoamine oxidase
R-MMU-380612 Metabolism of serotonin

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] A (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type A
Short name:
MAO-A
Gene namesi
Name:Maoa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:96915 Maoa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 497CytoplasmicBy similarityAdd BLAST497
Transmembranei498 – 518Helical; Anchor for type IV membrane proteinBy similarityAdd BLAST21
Topological domaini519 – 526Mitochondrial intermembraneBy similarity8

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3681

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000998511 – 526Amine oxidase [flavin-containing] AAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei383PhosphoserineBy similarity1
Modified residuei406S-8alpha-FAD cysteineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ64133
MaxQBiQ64133
PaxDbiQ64133
PRIDEiQ64133
TopDownProteomicsiQ64133

PTM databases

iPTMnetiQ64133
PhosphoSitePlusiQ64133

Expressioni

Gene expression databases

BgeeiENSMUSG00000025037
CleanExiMM_MAOA
GenevisibleiQ64133 MM

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).By similarity

Protein-protein interaction databases

BioGridi201307, 1 interactor
IntActiQ64133, 1 interactor
STRINGi10090.ENSMUSP00000026013

Chemistry databases

BindingDBiQ64133

Structurei

3D structure databases

ProteinModelPortaliQ64133
SMRiQ64133
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni520 – 522Interaction with membrane phospholipid headgroupsBy similarity3

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0029 Eukaryota
ENOG410XSNC LUCA
GeneTreeiENSGT00730000110903
HOGENOMiHOG000221615
HOVERGENiHBG004255
InParanoidiQ64133
KOiK00274
OMAiEWTRGAY
OrthoDBiEOG091G0G7P
TreeFamiTF313314

Family and domain databases

Gene3Di3.50.50.60, 4 hits
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR001613 Flavin_amine_oxidase
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
PRINTSiPR00757 AMINEOXDASEF
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

Q64133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLEKPSIT GHMFDVVVIG GGISGLAAAK LLSEYKINVL VLEARDRVGG
60 70 80 90 100
RTYTVRNEHV KWVDVGGAYV GPTQNRILRL SKELGIETYK VNVNERLVQY
110 120 130 140 150
VKGKTYPFRG AFPPVWNPLA YLDYNNLWRT MDDMGKEIPV DAPWQARHAE
160 170 180 190 200
EWDKITMKDL IDKICWTKTA REFAYLFVNI NVTSEPHEVS ALWFLWYVRQ
210 220 230 240 250
CGGTSRIFSV TNGGQERKFV GGSGQISEQI MVLLGDKVKL SSPVTYIDQT
260 270 280 290 300
DDNIIIETLN HEHYECKYVI SAIPPVLTAK IHFKPELPPE RNQLIQRLPM
310 320 330 340 350
GAVIKCMVYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSMPAIM
360 370 380 390 400
GFILARKAER LAKLHKDIRK RKICELYAKV LGSQEALSPV HYEEKNWCEE
410 420 430 440 450
QYSGGCYTAY FPPGIMTLYG RVIRQPVGRI YFAGTETATQ WSGYMEGAVE
460 470 480 490 500
AGERAAREVL NALGKVAKKD IWVQEPESKD VPALEITHTF LERNLPSVPG
510 520
LLKITGFSTS VALLCFVLYK FKQPQS
Length:526
Mass (Da):59,602
Last modified:July 27, 2011 - v3
Checksum:i5375D1B0C4C5ACF9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83E → D in AAH29100 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL805907, AL831729 Genomic DNA Translation: CAM18994.1
AL831729, AL805907 Genomic DNA Translation: CAM26634.1
CH466584 Genomic DNA Translation: EDL35717.1
BC029100 mRNA Translation: AAH29100.1
S78615, S78606 Genomic DNA Translation: AAB34677.1
CCDSiCCDS30033.1
RefSeqiNP_776101.3, NM_173740.3
UniGeneiMm.21108

Genome annotation databases

EnsembliENSMUST00000026013; ENSMUSP00000026013; ENSMUSG00000025037
GeneIDi17161
KEGGimmu:17161
UCSCiuc009ssa.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAOFA_MOUSE
AccessioniPrimary (citable) accession number: Q64133
Secondary accession number(s): B1AX52, Q8K0Z8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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