Reviewed,
UniProtKB/Swiss-Prot Q64133 (AOFA_MOUSE)
Last modified
November 3, 2009.
Version 75.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Amine oxidase [flavin-containing] A EC=1.4.3.4 Alternative name(s): Monoamine oxidase type A Short name=MAO-A | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 526 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine By similarity. |
| Catalytic activity | RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2. |
| Cofactor | FAD. |
| Subunit structure | Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity. |
| Subcellular location | Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. |
| Sequence similarities | Belongs to the flavin monoamine oxidase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Catecholamine metabolism Neurotransmitter degradation |
| Cellular component | Membrane Mitochondrion Mitochondrion outer membrane |
| Domain | Transmembrane |
| Ligand | FAD Flavoprotein |
| Molecular function | Oxidoreductase |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | dopamine catabolic process Inferred from direct assay. Source: MGI neurotransmitter catabolic processInferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW internal side of plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial outer membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | amine oxidase activity Inferred from electronic annotation. Source: EC electron carrier activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 526 | 526 | Amine oxidase [flavin-containing] A | PRO_0000099851 | |||||
Regions | |||||||||
| Topological domain | 1 – 497 | 497 | Cytoplasmic By similarity | ||||||
| Transmembrane | 498 – 518 | 21 | Anchor for type IV membrane protein By similarity | ||||||
| Topological domain | 519 – 526 | 8 | Mitochondrial intermembrane By similarity | ||||||
| Region | 520 – 522 | 3 | Interaction with membrane phospholipid headgroups By similarity | ||||||
Sites | |||||||||
| Site | 335 | 1 | Important for substrate specificity By similarity | ||||||
| Site | 374 | 1 | Important for catalytic activity By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 406 | 1 | S-8alpha-FAD cysteine By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor. |
| [2] | "Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA." Cases O., Seif I., Grimsby J., Gaspar P., Chen K., Pournin S., Mueller U., Aguet M., Babinet C., Shih J.C., de Maeyer E. Science 268:1763-1766(1995) [PubMed: 7792602] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-40. |
| [3] | Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 137-147; 207-217; 268-280 AND 380-395, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| BC029100 mRNA. Translation: AAH29100.1. S78615, S78606 Genomic DNA. Translation: AAB34677.1. | |
| IPI | IPI00169711. |
| UniGene | Mm.21108 |
3D structure databases | |
| SMR | Q64133. Positions 23-509. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q64133. |
PTM databases | |
| PhosphoSite | Q64133. |
Proteomic databases | |
| PRIDE | Q64133. |
Genome annotation databases | |
| Ensembl | ENSMUST00000026013; ENSMUSP00000026013; ENSMUSG00000025037; Mus musculus. [Genome view] |
Organism-specific databases | |
| MGI | MGI:96915. Maoa. |
Phylogenomic databases | |
| HOGENOM | Q64133. |
| HOVERGEN | Q64133. |
Enzyme and pathway databases | |
| BRENDA | 1.4.3.4. 244. |
Gene expression databases | |
| ArrayExpress | Q64133. |
| Bgee | Q64133. |
| CleanEx | MM_MAOA. |
| Genevestigator | Q64133. |
| GermOnline | ENSMUSG00000025037. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001613. Amineoxid_fl. IPR002937. Amino_oxidase. [Graphical view] |
| Pfam | PF01593. Amino_oxidase. 1 hit. [Graphical view] |
| PRINTS | PR00757. AMINEOXDASEF. |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | AOFA_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q64133 Secondary accession number(s): Q8K0Z8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


