Amine oxidase [flavin-containing] A

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Q64133 (AOFA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 105. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Amine oxidase [flavin-containing] A
EC=1.4.3.4

Alternative name(s):
Monoamine oxidase type A
Short name=MAO-A

Gene names

Name:

Maoa

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	526 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine By similarity.
Catalytic activity	RCH₂NHR' + H₂O + O₂ = RCHO + R'NH₂ + H₂O₂.
Cofactor	FAD.
Subunit structure	Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.
Subcellular location	Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
Sequence similarities	Belongs to the flavin monoamine oxidase family.

Ontologies

Keywords
Biological process	Catecholamine metabolism Neurotransmitter degradation
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
Domain	Transmembrane Transmembrane helix
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	dopamine catabolic process Inferred from direct assay PubMed 9520487. Source: MGI neurotransmitter catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from direct assay PubMed 14651853 PubMed 18614015. Source: MGI
Molecular_function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 526

526

Amine oxidase [flavin-containing] A

PRO_0000099851

Regions

Topological domain

1 – 497

497

Cytoplasmic By similarity

Transmembrane

498 – 518

Helical; Anchor for type IV membrane protein; By similarity

Topological domain

519 – 526

Mitochondrial intermembrane By similarity

Region

520 – 522

Interaction with membrane phospholipid headgroups By similarity

Sites

Site

335

Important for substrate specificity By similarity

Site

374

Important for catalytic activity By similarity

Amino acid modifications

Modified residue

N-acetylmethionine By similarity

Modified residue

406

S-8alpha-FAD cysteine By similarity

Experimental info

Sequence conflict

E → D in AAH29100. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

Q64133 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 5375D1B0C4C5ACF9
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FASTA

526

59,602

        10         20         30         40         50         60 
MTDLEKPSIT GHMFDVVVIG GGISGLAAAK LLSEYKINVL VLEARDRVGG RTYTVRNEHV 

        70         80         90        100        110        120 
KWVDVGGAYV GPTQNRILRL SKELGIETYK VNVNERLVQY VKGKTYPFRG AFPPVWNPLA 

       130        140        150        160        170        180 
YLDYNNLWRT MDDMGKEIPV DAPWQARHAE EWDKITMKDL IDKICWTKTA REFAYLFVNI 

       190        200        210        220        230        240 
NVTSEPHEVS ALWFLWYVRQ CGGTSRIFSV TNGGQERKFV GGSGQISEQI MVLLGDKVKL 

       250        260        270        280        290        300 
SSPVTYIDQT DDNIIIETLN HEHYECKYVI SAIPPVLTAK IHFKPELPPE RNQLIQRLPM 

       310        320        330        340        350        360 
GAVIKCMVYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSMPAIM GFILARKAER 

       370        380        390        400        410        420 
LAKLHKDIRK RKICELYAKV LGSQEALSPV HYEEKNWCEE QYSGGCYTAY FPPGIMTLYG 

       430        440        450        460        470        480 
RVIRQPVGRI YFAGTETATQ WSGYMEGAVE AGERAAREVL NALGKVAKKD IWVQEPESKD 

       490        500        510        520 
VPALEITHTF LERNLPSVPG LLKITGFSTS VALLCFVLYK FKQPQS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
[4]	"Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA." Cases O., Seif I., Grimsby J., Gaspar P., Chen K., Pournin S., Mueller U., Aguet M., Babinet C., Shih J.C., de Maeyer E. Science 268:1763-1766(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-40.
[5]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 137-147; 207-217; 268-280 AND 380-395, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL805907, AL831729 Genomic DNA. Translation: CAM18994.1. AL831729, AL805907 Genomic DNA. Translation: CAM26634.1. CH466584 Genomic DNA. Translation: EDL35717.1. BC029100 mRNA. Translation: AAH29100.1. S78615, S78606 Genomic DNA. Translation: AAB34677.1.
IPI	IPI00169711.
RefSeq	NP_776101.3. NM_173740.3.
UniGene	Mm.21108.
3D structure databases
ProteinModelPortal	Q64133.
SMR	Q64133. Positions 11-520.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q64133. 1 interaction.
PTM databases
PhosphoSite	Q64133.
Proteomic databases
PaxDb	Q64133.
PRIDE	Q64133.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000026013; ENSMUSP00000026013; ENSMUSG00000025037.
GeneID	17161.
KEGG	mmu:17161.
Organism-specific databases
CTD	4128.
MGI	MGI:96915. Maoa.
Phylogenomic databases
eggNOG	COG1231.
GeneTree	ENSGT00530000063101.
HOGENOM	HOG000221615.
HOVERGEN	HBG004255.
InParanoid	B1AX52.
KO	K00274.
OrthoDB	EOG412M55.
Gene expression databases
ArrayExpress	Q64133.
Bgee	Q64133.
CleanEx	MM_MAOA.
Genevestigator	Q64133.
GermOnline	ENSMUSG00000025037. Mus musculus.
Family and domain databases
InterPro	IPR002937. Amino_oxidase. IPR001613. Flavin_amine_oxidase. [Graphical view]
Pfam	PF01593. Amino_oxidase. 1 hit. [Graphical view]
PRINTS	PR00757. AMINEOXDASEF.
ProtoNet	Search...
Other
BindingDB	Q64133.
ChEMBL	CHEMBL3681.
NextBio	291438.
SOURCE	Search...

Entry information

Entry name

AOFA_MOUSE

Accession

Primary (citable) accession number: Q64133
Secondary accession number(s): B1AX52, Q8K0Z8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 105 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents