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Q64133 (AOFA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Amine oxidase [flavin-containing] A

EC=1.4.3.4
Alternative name(s):
Monoamine oxidase type A
Short name=MAO-A
Gene names
Name:Maoa
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine By similarity.

Catalytic activity

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactor

FAD.

Subunit structure

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.

Subcellular location

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.

Sequence similarities

Belongs to the flavin monoamine oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 526526Amine oxidase [flavin-containing] A
PRO_0000099851

Regions

Topological domain1 – 497497Cytoplasmic By similarity
Transmembrane498 – 51821Helical; Anchor for type IV membrane protein; By similarity
Topological domain519 – 5268Mitochondrial intermembrane By similarity
Region520 – 5223Interaction with membrane phospholipid headgroups By similarity

Sites

Site3351Important for substrate specificity By similarity
Site3741Important for catalytic activity By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue4061S-8alpha-FAD cysteine By similarity

Experimental info

Sequence conflict831E → D in AAH29100. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q64133 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 5375D1B0C4C5ACF9

FASTA52659,602
        10         20         30         40         50         60 
MTDLEKPSIT GHMFDVVVIG GGISGLAAAK LLSEYKINVL VLEARDRVGG RTYTVRNEHV 

        70         80         90        100        110        120 
KWVDVGGAYV GPTQNRILRL SKELGIETYK VNVNERLVQY VKGKTYPFRG AFPPVWNPLA 

       130        140        150        160        170        180 
YLDYNNLWRT MDDMGKEIPV DAPWQARHAE EWDKITMKDL IDKICWTKTA REFAYLFVNI 

       190        200        210        220        230        240 
NVTSEPHEVS ALWFLWYVRQ CGGTSRIFSV TNGGQERKFV GGSGQISEQI MVLLGDKVKL 

       250        260        270        280        290        300 
SSPVTYIDQT DDNIIIETLN HEHYECKYVI SAIPPVLTAK IHFKPELPPE RNQLIQRLPM 

       310        320        330        340        350        360 
GAVIKCMVYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSMPAIM GFILARKAER 

       370        380        390        400        410        420 
LAKLHKDIRK RKICELYAKV LGSQEALSPV HYEEKNWCEE QYSGGCYTAY FPPGIMTLYG 

       430        440        450        460        470        480 
RVIRQPVGRI YFAGTETATQ WSGYMEGAVE AGERAAREVL NALGKVAKKD IWVQEPESKD 

       490        500        510        520 
VPALEITHTF LERNLPSVPG LLKITGFSTS VALLCFVLYK FKQPQS 

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[4]"Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA."
Cases O., Seif I., Grimsby J., Gaspar P., Chen K., Pournin S., Mueller U., Aguet M., Babinet C., Shih J.C., de Maeyer E.
Science 268:1763-1766(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-40.
[5]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 137-147; 207-217; 268-280 AND 380-395, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL805907, AL831729 Genomic DNA. Translation: CAM18994.1.
AL831729, AL805907 Genomic DNA. Translation: CAM26634.1.
CH466584 Genomic DNA. Translation: EDL35717.1.
BC029100 mRNA. Translation: AAH29100.1.
S78615, S78606 Genomic DNA. Translation: AAB34677.1.
CCDSCCDS30033.1.
RefSeqNP_776101.3. NM_173740.3.
UniGeneMm.21108.

3D structure databases

ProteinModelPortalQ64133.
SMRQ64133. Positions 11-520.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201307. 2 interactions.
IntActQ64133. 1 interaction.
MINTMINT-4997361.

Chemistry

BindingDBQ64133.
ChEMBLCHEMBL2111442.

PTM databases

PhosphoSiteQ64133.

Proteomic databases

MaxQBQ64133.
PaxDbQ64133.
PRIDEQ64133.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026013; ENSMUSP00000026013; ENSMUSG00000025037.
GeneID17161.
KEGGmmu:17161.
UCSCuc009ssa.2. mouse.

Organism-specific databases

CTD4128.
MGIMGI:96915. Maoa.

Phylogenomic databases

eggNOGCOG1231.
GeneTreeENSGT00730000110903.
HOGENOMHOG000221615.
HOVERGENHBG004255.
InParanoidB1AX52.
KOK00274.
OMAMEITHTF.
OrthoDBEOG7K6PTP.
TreeFamTF313314.

Gene expression databases

ArrayExpressQ64133.
BgeeQ64133.
CleanExMM_MAOA.
GenevestigatorQ64133.

Family and domain databases

InterProIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSPR00757. AMINEOXDASEF.
ProtoNetSearch...

Other

NextBio291438.
PROQ64133.
SOURCESearch...

Entry information

Entry nameAOFA_MOUSE
AccessionPrimary (citable) accession number: Q64133
Secondary accession number(s): B1AX52, Q8K0Z8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot