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Q64133

- AOFA_MOUSE

UniProt

Q64133 - AOFA_MOUSE

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Protein
Amine oxidase [flavin-containing] A
Gene
Maoa
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine By similarity.

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FAD.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei335 – 3351Important for substrate specificity By similarity
Sitei374 – 3741Important for catalytic activity By similarity

GO - Molecular functioni

  1. primary amine oxidase activity Source: MGI
  2. protein binding Source: MGI

GO - Biological processi

  1. dopamine catabolic process Source: MGI
  2. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Catecholamine metabolism, Neurotransmitter degradation

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] A (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type A
Short name:
MAO-A
Gene namesi
Name:Maoa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:96915. Maoa.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 497497Cytoplasmic By similarity
Add
BLAST
Transmembranei498 – 51821Helical; Anchor for type IV membrane protein; By similarity
Add
BLAST
Topological domaini519 – 5268Mitochondrial intermembrane By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Amine oxidase [flavin-containing] A
PRO_0000099851Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei406 – 4061S-8alpha-FAD cysteine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ64133.
PaxDbiQ64133.
PRIDEiQ64133.

PTM databases

PhosphoSiteiQ64133.

Expressioni

Gene expression databases

ArrayExpressiQ64133.
BgeeiQ64133.
CleanExiMM_MAOA.
GenevestigatoriQ64133.

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.

Protein-protein interaction databases

BioGridi201307. 2 interactions.
IntActiQ64133. 1 interaction.
MINTiMINT-4997361.

Structurei

3D structure databases

ProteinModelPortaliQ64133.
SMRiQ64133. Positions 11-520.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni520 – 5223Interaction with membrane phospholipid headgroups By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1231.
GeneTreeiENSGT00730000110903.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
InParanoidiB1AX52.
KOiK00274.
OMAiMEITHTF.
OrthoDBiEOG7K6PTP.
TreeFamiTF313314.

Family and domain databases

InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

Q64133-1 [UniParc]FASTAAdd to Basket

« Hide

MTDLEKPSIT GHMFDVVVIG GGISGLAAAK LLSEYKINVL VLEARDRVGG    50
RTYTVRNEHV KWVDVGGAYV GPTQNRILRL SKELGIETYK VNVNERLVQY 100
VKGKTYPFRG AFPPVWNPLA YLDYNNLWRT MDDMGKEIPV DAPWQARHAE 150
EWDKITMKDL IDKICWTKTA REFAYLFVNI NVTSEPHEVS ALWFLWYVRQ 200
CGGTSRIFSV TNGGQERKFV GGSGQISEQI MVLLGDKVKL SSPVTYIDQT 250
DDNIIIETLN HEHYECKYVI SAIPPVLTAK IHFKPELPPE RNQLIQRLPM 300
GAVIKCMVYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSMPAIM 350
GFILARKAER LAKLHKDIRK RKICELYAKV LGSQEALSPV HYEEKNWCEE 400
QYSGGCYTAY FPPGIMTLYG RVIRQPVGRI YFAGTETATQ WSGYMEGAVE 450
AGERAAREVL NALGKVAKKD IWVQEPESKD VPALEITHTF LERNLPSVPG 500
LLKITGFSTS VALLCFVLYK FKQPQS 526
Length:526
Mass (Da):59,602
Last modified:July 27, 2011 - v3
Checksum:i5375D1B0C4C5ACF9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831E → D in AAH29100. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL805907, AL831729 Genomic DNA. Translation: CAM18994.1.
AL831729, AL805907 Genomic DNA. Translation: CAM26634.1.
CH466584 Genomic DNA. Translation: EDL35717.1.
BC029100 mRNA. Translation: AAH29100.1.
S78615, S78606 Genomic DNA. Translation: AAB34677.1.
CCDSiCCDS30033.1.
RefSeqiNP_776101.3. NM_173740.3.
UniGeneiMm.21108.

Genome annotation databases

EnsembliENSMUST00000026013; ENSMUSP00000026013; ENSMUSG00000025037.
GeneIDi17161.
KEGGimmu:17161.
UCSCiuc009ssa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL805907 , AL831729 Genomic DNA. Translation: CAM18994.1 .
AL831729 , AL805907 Genomic DNA. Translation: CAM26634.1 .
CH466584 Genomic DNA. Translation: EDL35717.1 .
BC029100 mRNA. Translation: AAH29100.1 .
S78615 , S78606 Genomic DNA. Translation: AAB34677.1 .
CCDSi CCDS30033.1.
RefSeqi NP_776101.3. NM_173740.3.
UniGenei Mm.21108.

3D structure databases

ProteinModelPortali Q64133.
SMRi Q64133. Positions 11-520.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201307. 2 interactions.
IntActi Q64133. 1 interaction.
MINTi MINT-4997361.

Chemistry

BindingDBi Q64133.
ChEMBLi CHEMBL2111442.

PTM databases

PhosphoSitei Q64133.

Proteomic databases

MaxQBi Q64133.
PaxDbi Q64133.
PRIDEi Q64133.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026013 ; ENSMUSP00000026013 ; ENSMUSG00000025037 .
GeneIDi 17161.
KEGGi mmu:17161.
UCSCi uc009ssa.2. mouse.

Organism-specific databases

CTDi 4128.
MGIi MGI:96915. Maoa.

Phylogenomic databases

eggNOGi COG1231.
GeneTreei ENSGT00730000110903.
HOGENOMi HOG000221615.
HOVERGENi HBG004255.
InParanoidi B1AX52.
KOi K00274.
OMAi MEITHTF.
OrthoDBi EOG7K6PTP.
TreeFami TF313314.

Miscellaneous databases

NextBioi 291438.
PROi Q64133.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q64133.
Bgeei Q64133.
CleanExi MM_MAOA.
Genevestigatori Q64133.

Family and domain databases

InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA."
    Cases O., Seif I., Grimsby J., Gaspar P., Chen K., Pournin S., Mueller U., Aguet M., Babinet C., Shih J.C., de Maeyer E.
    Science 268:1763-1766(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-40.
  5. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 137-147; 207-217; 268-280 AND 380-395, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiAOFA_MOUSE
AccessioniPrimary (citable) accession number: Q64133
Secondary accession number(s): B1AX52, Q8K0Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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