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Q64133

- AOFA_MOUSE

UniProt

Q64133 - AOFA_MOUSE

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Protein

Amine oxidase [flavin-containing] A

Gene

Maoa

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine By similarity.By similarity

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FAD.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei335 – 3351Important for substrate specificityBy similarity
Sitei374 – 3741Important for catalytic activityBy similarity

GO - Molecular functioni

  1. primary amine oxidase activity Source: MGI

GO - Biological processi

  1. dopamine catabolic process Source: MGI
  2. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Catecholamine metabolism, Neurotransmitter degradation

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] A (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type A
Short name:
MAO-A
Gene namesi
Name:Maoa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:96915. Maoa.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-KW
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Amine oxidase [flavin-containing] APRO_0000099851Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei406 – 4061S-8alpha-FAD cysteineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ64133.
PaxDbiQ64133.
PRIDEiQ64133.

PTM databases

PhosphoSiteiQ64133.

Expressioni

Gene expression databases

BgeeiQ64133.
CleanExiMM_MAOA.
ExpressionAtlasiQ64133. baseline and differential.
GenevestigatoriQ64133.

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.By similarity

Protein-protein interaction databases

BioGridi201307. 2 interactions.
IntActiQ64133. 1 interaction.
MINTiMINT-4997361.

Structurei

3D structure databases

ProteinModelPortaliQ64133.
SMRiQ64133. Positions 11-520.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 497497CytoplasmicBy similarityAdd
BLAST
Topological domaini519 – 5268Mitochondrial intermembraneBy similarity

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei498 – 51821Helical; Anchor for type IV membrane proteinBy similarityAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni520 – 5223Interaction with membrane phospholipid headgroupsBy similarity

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1231.
GeneTreeiENSGT00730000110903.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
InParanoidiQ64133.
KOiK00274.
OMAiMEITHTF.
OrthoDBiEOG7K6PTP.
TreeFamiTF313314.

Family and domain databases

InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

Q64133-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDLEKPSIT GHMFDVVVIG GGISGLAAAK LLSEYKINVL VLEARDRVGG
60 70 80 90 100
RTYTVRNEHV KWVDVGGAYV GPTQNRILRL SKELGIETYK VNVNERLVQY
110 120 130 140 150
VKGKTYPFRG AFPPVWNPLA YLDYNNLWRT MDDMGKEIPV DAPWQARHAE
160 170 180 190 200
EWDKITMKDL IDKICWTKTA REFAYLFVNI NVTSEPHEVS ALWFLWYVRQ
210 220 230 240 250
CGGTSRIFSV TNGGQERKFV GGSGQISEQI MVLLGDKVKL SSPVTYIDQT
260 270 280 290 300
DDNIIIETLN HEHYECKYVI SAIPPVLTAK IHFKPELPPE RNQLIQRLPM
310 320 330 340 350
GAVIKCMVYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSMPAIM
360 370 380 390 400
GFILARKAER LAKLHKDIRK RKICELYAKV LGSQEALSPV HYEEKNWCEE
410 420 430 440 450
QYSGGCYTAY FPPGIMTLYG RVIRQPVGRI YFAGTETATQ WSGYMEGAVE
460 470 480 490 500
AGERAAREVL NALGKVAKKD IWVQEPESKD VPALEITHTF LERNLPSVPG
510 520
LLKITGFSTS VALLCFVLYK FKQPQS
Length:526
Mass (Da):59,602
Last modified:July 27, 2011 - v3
Checksum:i5375D1B0C4C5ACF9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831E → D in AAH29100. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL805907, AL831729 Genomic DNA. Translation: CAM18994.1.
AL831729, AL805907 Genomic DNA. Translation: CAM26634.1.
CH466584 Genomic DNA. Translation: EDL35717.1.
BC029100 mRNA. Translation: AAH29100.1.
S78615, S78606 Genomic DNA. Translation: AAB34677.1.
CCDSiCCDS30033.1.
RefSeqiNP_776101.3. NM_173740.3.
UniGeneiMm.21108.

Genome annotation databases

EnsembliENSMUST00000026013; ENSMUSP00000026013; ENSMUSG00000025037.
GeneIDi17161.
KEGGimmu:17161.
UCSCiuc009ssa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL805907 , AL831729 Genomic DNA. Translation: CAM18994.1 .
AL831729 , AL805907 Genomic DNA. Translation: CAM26634.1 .
CH466584 Genomic DNA. Translation: EDL35717.1 .
BC029100 mRNA. Translation: AAH29100.1 .
S78615 , S78606 Genomic DNA. Translation: AAB34677.1 .
CCDSi CCDS30033.1.
RefSeqi NP_776101.3. NM_173740.3.
UniGenei Mm.21108.

3D structure databases

ProteinModelPortali Q64133.
SMRi Q64133. Positions 11-520.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201307. 2 interactions.
IntActi Q64133. 1 interaction.
MINTi MINT-4997361.

Chemistry

BindingDBi Q64133.
ChEMBLi CHEMBL3681.

PTM databases

PhosphoSitei Q64133.

Proteomic databases

MaxQBi Q64133.
PaxDbi Q64133.
PRIDEi Q64133.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026013 ; ENSMUSP00000026013 ; ENSMUSG00000025037 .
GeneIDi 17161.
KEGGi mmu:17161.
UCSCi uc009ssa.2. mouse.

Organism-specific databases

CTDi 4128.
MGIi MGI:96915. Maoa.

Phylogenomic databases

eggNOGi COG1231.
GeneTreei ENSGT00730000110903.
HOGENOMi HOG000221615.
HOVERGENi HBG004255.
InParanoidi Q64133.
KOi K00274.
OMAi MEITHTF.
OrthoDBi EOG7K6PTP.
TreeFami TF313314.

Miscellaneous databases

NextBioi 291438.
PROi Q64133.
SOURCEi Search...

Gene expression databases

Bgeei Q64133.
CleanExi MM_MAOA.
ExpressionAtlasi Q64133. baseline and differential.
Genevestigatori Q64133.

Family and domain databases

InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA."
    Cases O., Seif I., Grimsby J., Gaspar P., Chen K., Pournin S., Mueller U., Aguet M., Babinet C., Shih J.C., de Maeyer E.
    Science 268:1763-1766(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-40.
  5. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 137-147; 207-217; 268-280 AND 380-395, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiAOFA_MOUSE
AccessioniPrimary (citable) accession number: Q64133
Secondary accession number(s): B1AX52, Q8K0Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3