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Protein

Prolactin-releasing peptide receptor

Gene

Prlhr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD
  • neuropeptide Y receptor activity Source: InterPro
  • peptide hormone binding Source: RGD

GO - Biological processi

  • feeding behavior Source: RGD
  • G-protein coupled receptor signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin-releasing peptide receptor
Short name:
PrRP receptor
Short name:
PrRPR
Alternative name(s):
G-protein coupled receptor 10
UHR-1
Gene namesi
Name:Prlhr
Synonyms:Gpr10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi71037. Prlhr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262ExtracellularSequence analysisAdd
BLAST
Transmembranei63 – 8321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini84 – 10118CytoplasmicSequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini123 – 1264ExtracellularSequence analysis
Transmembranei127 – 14721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini148 – 17528CytoplasmicSequence analysisAdd
BLAST
Transmembranei176 – 19621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini197 – 22327ExtracellularSequence analysisAdd
BLAST
Transmembranei224 – 24421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini245 – 27632CytoplasmicSequence analysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini298 – 31720ExtracellularSequence analysisAdd
BLAST
Transmembranei318 – 33821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini339 – 37032CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Prolactin-releasing peptide receptorPRO_0000069526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence analysis
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi134 ↔ 211PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ64121.

PTM databases

PhosphoSiteiQ64121.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in pituitary, cerebellum, and hypothalamus.1 Publication

Interactioni

Subunit structurei

Interacts through its C-terminal region with the PDZ domain-containing proteins GRIP1, GRIP2 and PICK1. Interacts with PDZ domains 4 and 5 of GRIP1 and with the PDZ domain of PICK1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013170.

Structurei

3D structure databases

ProteinModelPortaliQ64121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni365 – 3706Required for interaction with GRIP1, GRIP2 and PICK1By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000050229.
HOVERGENiHBG101109.
InParanoidiQ64121.
KOiK04314.
PhylomeDBiQ64121.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001402. Prolrel_pep_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01018. PRPRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64121-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSLPPGTTG DPDLFSGPSP AGSTPANQSA EASESNVSAT VPRAAAVTPF
60 70 80 90 100
QSLQLVHQLK GLIVMLYSIV VVVGLVGNCL LVLVIARVRR LHNVTNFLIG
110 120 130 140 150
NLALSDVLMC AACVPLTLAY AFEPRGWVFG GGLCHLVFFL QPVTVYVSVF
160 170 180 190 200
TLTTIAVDRY VVLVHPLRRR ISLKLSAYAV LGIWALSAVL ALPAAVHTYH
210 220 230 240 250
VELKPHDVRL CEEFWGSQER QRQIYAWGLL LGTYLLPLLA ILLSYVRVSV
260 270 280 290 300
KLRNRVVPGS VTQSQADWDR ARRRRTFCLL VVVVVVFALC WLPLHIFNLL
310 320 330 340 350
RDLDPRAIDP YAFGLVQLLC HWLAMSSACY NPFIYAWLHD SFREELRKML
360 370
LSWPRKIVPH GQNMTVSVVI
Length:370
Mass (Da):41,161
Last modified:November 1, 1996 - v1
Checksum:i8EE5E689D127CB2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77867 mRNA. Translation: AAB34129.1.
RefSeqiNP_631932.3. NM_139193.3.
UniGeneiRn.138127.

Genome annotation databases

GeneIDi246075.
KEGGirno:246075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77867 mRNA. Translation: AAB34129.1.
RefSeqiNP_631932.3. NM_139193.3.
UniGeneiRn.138127.

3D structure databases

ProteinModelPortaliQ64121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013170.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ64121.

Proteomic databases

PaxDbiQ64121.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi246075.
KEGGirno:246075.

Organism-specific databases

CTDi2834.
RGDi71037. Prlhr.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000050229.
HOVERGENiHBG101109.
InParanoidiQ64121.
KOiK04314.
PhylomeDBiQ64121.

Miscellaneous databases

NextBioi623360.
PROiQ64121.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001402. Prolrel_pep_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01018. PRPRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence and tissue distribution of a candidate G-coupled receptor cloned from rat hypothalamus."
    Welch S.K., O'Hara B.F., Kilduff T.S., Heller H.C.
    Biochem. Biophys. Res. Commun. 209:606-613(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hypothalamus.
  2. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPRLHR_RAT
AccessioniPrimary (citable) accession number: Q64121
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.