Q640U4 (CYC1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c, somatic

Gene names

Name:	cycs
ORF Names:	TTpA002h20.1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	105 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Post-translational modification	Binds 1 heme group per subunit By similarity.
Sequence similarities	Belongs to the cytochrome c family.
Sequence caution	The sequence CAJ83237.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	Heme Iron Metal-binding
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 105	104	Cytochrome c, somatic		PRO_0000108257
Sites
	Metal binding	19	1	Iron (heme axial ligand) By similarity
	Metal binding	81	1	Iron (heme axial ligand) By similarity
	Binding site	15	1	Heme (covalent) By similarity
	Binding site	18	1	Heme (covalent) By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylglycine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q640U4 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 1B6EE9163A497CA7	FASTA	105	11,758
	10 20 30 40 50 60 MGDVEKGKKI FVQKCAQCHT VEKTGKHKTG PNLWGLFGRK TGQAPGFSYT DANKSKGIVW 70 80 90 100 GEDTLFEYLE NPKKYIPGTK MIFAGIKKKN ERADLIAYLK KSTSE

References

[1]	Sanger Xenopus tropicalis EST/cDNA project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Tadpole.
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR760771 mRNA. Translation: CAJ83237.1. Different initiation. BC082495 mRNA. Translation: AAH82495.1.
RefSeq	NP_001008176.1. NM_001008175.1.
UniGene	Str.46288.
3D structure databases
ProteinModelPortal	Q640U4.
SMR	Q640U4. Positions 2-105.
ModBase	Search...
Protein-protein interaction databases
STRING	Q640U4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	493538.
KEGG	xtr:493538.
Organism-specific databases
CTD	13067.
Xenbase	XB-GENE-5931974. cyct.
Phylogenomic databases
eggNOG	veNOG20062.
GeneTree	ENSGT00390000009405.
HOVERGEN	HBG003023.
InParanoid	Q640U4.
OMA	WDAQTLD.
OrthoDB	EOG45DWQX.
PhylomeDB	Q640U4.
Gene expression databases
Bgee	Q640U4.
Family and domain databases
InterPro	IPR002327. Cyt_c_1A/1B. IPR009056. Cyt_c_dom. IPR003088. Cyt_c_I. [Graphical view]
Gene3D	G3DSA:1.10.760.10. Cytochrome_c_R. 1 hit.
KO	K08738.
PANTHER	PTHR11961. Cyt_CIAB. 1 hit.
Pfam	PF00034. Cytochrom_C. 1 hit. [Graphical view]
PRINTS	PR00604. CYTCHRMECIAB.
SUPFAM	SSF46626. Cytochrome_c. 1 hit.
PROSITE	PS51007. CYTC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYC1_XENTR

Accession

Primary (citable) accession number: Q640U4
Secondary accession number(s): Q28HR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 60 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program