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Protein

Cytochrome c, somatic

Gene

cycs

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151Heme (covalent)PROSITE-ProRule annotation
Binding sitei18 – 181Heme (covalent)PROSITE-ProRule annotation
Metal bindingi19 – 191Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi81 – 811Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c, somatic
Gene namesi
Name:cycs
ORF Names:TTpA002h20.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5931974. cyct.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 105104Cytochrome c, somaticPRO_0000108257Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycineBy similarity

Post-translational modificationi

Binds 1 heme group per subunit.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ640U4.
PRIDEiQ640U4.

Expressioni

Gene expression databases

BgeeiQ640U4.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000018532.

Structurei

3D structure databases

ProteinModelPortaliQ640U4.
SMRiQ640U4. Positions 2-105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiKOG3453. Eukaryota.
COG3474. LUCA.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
InParanoidiQ640U4.
KOiK08738.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q640U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDVEKGKKI FVQKCAQCHT VEKTGKHKTG PNLWGLFGRK TGQAPGFSYT
60 70 80 90 100
DANKSKGIVW GEDTLFEYLE NPKKYIPGTK MIFAGIKKKN ERADLIAYLK

KSTSE
Length:105
Mass (Da):11,758
Last modified:January 23, 2007 - v3
Checksum:i1B6EE9163A497CA7
GO

Sequence cautioni

The sequence CAJ83237.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR760771 mRNA. Translation: CAJ83237.1. Different initiation.
BC082495 mRNA. Translation: AAH82495.1.
RefSeqiNP_001008176.1. NM_001008175.1.
XP_012825804.1. XM_012970350.1.
UniGeneiStr.46288.

Genome annotation databases

GeneIDi493538.
KEGGixtr:493538.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR760771 mRNA. Translation: CAJ83237.1. Different initiation.
BC082495 mRNA. Translation: AAH82495.1.
RefSeqiNP_001008176.1. NM_001008175.1.
XP_012825804.1. XM_012970350.1.
UniGeneiStr.46288.

3D structure databases

ProteinModelPortaliQ640U4.
SMRiQ640U4. Positions 2-105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000018532.

Proteomic databases

PaxDbiQ640U4.
PRIDEiQ640U4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi493538.
KEGGixtr:493538.

Organism-specific databases

CTDi13067.
XenbaseiXB-GENE-5931974. cyct.

Phylogenomic databases

eggNOGiKOG3453. Eukaryota.
COG3474. LUCA.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
InParanoidiQ640U4.
KOiK08738.

Gene expression databases

BgeeiQ640U4.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tadpole.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCYC1_XENTR
AccessioniPrimary (citable) accession number: Q640U4
Secondary accession number(s): Q28HR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: January 23, 2007
Last modified: February 17, 2016
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.