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Q640R3

- HECAM_MOUSE

UniProt

Q640R3 - HECAM_MOUSE

Protein

Hepatocyte cell adhesion molecule

Gene

Hepacam

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. cell cycle arrest Source: UniProtKB-KW
    3. cellular protein localization Source: MGI
    4. regulation of growth Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion, Cell cycle, Growth arrest, Growth regulation

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatocyte cell adhesion molecule
    Short name:
    Protein hepaCAM
    Gene namesi
    Name:HepacamImported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1920177. Hepacam.

    Subcellular locationi

    Cytoplasm. Membrane By similarity; Single-pass type I membrane protein By similarity; Cytoplasmic side By similarity
    Note: Colocalizes with CDH1.By similarity

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cell-cell junction Source: Ensembl
    3. cytoplasm Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW
    5. membrane Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 418385Hepatocyte cell adhesion moleculeSequence AnalysisPRO_0000298778Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi168 ↔ 217PROSITE-ProRule annotation
    Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ640R3.
    PaxDbiQ640R3.
    PRIDEiQ640R3.

    PTM databases

    PhosphoSiteiQ640R3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ640R3.
    BgeeiQ640R3.
    CleanExiMM_HEPACAM.
    GenevestigatoriQ640R3.

    Interactioni

    Subunit structurei

    Homodimer. Dimer formation occurs predominantly through cis interactions on the cell surface By similarity. Part of a complex containing MLC1, TRPV4, AQP4 and ATP1B1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ640R3.
    SMRiQ640R3. Positions 49-235.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini34 – 240207ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini262 – 418157CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei241 – 26121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 142109Ig-like V-typeSequence AnalysisAdd
    BLAST
    Domaini148 – 23487Ig-like C2-typeSequence AnalysisAdd
    BLAST

    Domaini

    The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility.By similarity

    Sequence similaritiesi

    Contains 1 Ig-like V-type (immunoglobulin-like) domain.Sequence Analysis

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG80335.
    GeneTreeiENSGT00530000063550.
    HOGENOMiHOG000060194.
    HOVERGENiHBG107974.
    InParanoidiQ640R3.
    OMAiWKPSKKS.
    OrthoDBiEOG71P2B5.
    PhylomeDBiQ640R3.
    TreeFamiTF331199.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q640R3-1 [UniParc]FASTAAdd to Basket

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    MKRERGALSR ASRALRLSPF VYLLLIQPVP LEGVNITSPV RLIHGTVGKS    50
    ALLSVQYSST SSDKPVVKWQ LKRDKPVTVV QSIGTEVIGT LRPDYRDRIR 100
    LFENGSLLLS DLQLADEGTY EVEISITDDT FTGEKTINLT VDVPISRPQV 150
    LVASTTVLEL SEAFTLNCSH ENGTKPSYTW LKDGKPLLND SRMLLSPDQK 200
    VLTITRVLME DDDLYSCVVE NPISQVRSLP VKITVYRRSS LYIILSTGGI 250
    FLLVTLVTVC ACWKPSKKSR KKRKLEKQNS LEYMDQNDDR LKSEADTLPR 300
    SGEQERKNPM ALYILKDKDS SEPDENPATE PRSTTEPGPP GYSVSPPVPG 350
    RSPGLPIRSA RRYPRSPARS PATGRTHTSP PRAPSSPGRS RSSSRSLRTA 400
    GVQRIREQDE SGQVEISA 418
    Length:418
    Mass (Da):46,367
    Last modified:August 21, 2007 - v2
    Checksum:i39D65EB953A5B933
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC138284 Genomic DNA. No translation available.
    BC082537 mRNA. Translation: AAH82537.1.
    CCDSiCCDS22976.1.
    RefSeqiNP_780398.2. NM_175189.4.
    UniGeneiMm.266133.

    Genome annotation databases

    EnsembliENSMUST00000051839; ENSMUSP00000054105; ENSMUSG00000046240.
    GeneIDi72927.
    KEGGimmu:72927.
    UCSCiuc009our.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC138284 Genomic DNA. No translation available.
    BC082537 mRNA. Translation: AAH82537.1 .
    CCDSi CCDS22976.1.
    RefSeqi NP_780398.2. NM_175189.4.
    UniGenei Mm.266133.

    3D structure databases

    ProteinModelPortali Q640R3.
    SMRi Q640R3. Positions 49-235.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei Q640R3.

    Proteomic databases

    MaxQBi Q640R3.
    PaxDbi Q640R3.
    PRIDEi Q640R3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000051839 ; ENSMUSP00000054105 ; ENSMUSG00000046240 .
    GeneIDi 72927.
    KEGGi mmu:72927.
    UCSCi uc009our.1. mouse.

    Organism-specific databases

    CTDi 220296.
    MGIi MGI:1920177. Hepacam.

    Phylogenomic databases

    eggNOGi NOG80335.
    GeneTreei ENSGT00530000063550.
    HOGENOMi HOG000060194.
    HOVERGENi HBG107974.
    InParanoidi Q640R3.
    OMAi WKPSKKS.
    OrthoDBi EOG71P2B5.
    PhylomeDBi Q640R3.
    TreeFami TF331199.

    Miscellaneous databases

    NextBioi 337151.
    PROi Q640R3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q640R3.
    Bgeei Q640R3.
    CleanExi MM_HEPACAM.
    Genevestigatori Q640R3.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-418.
      Strain: C57BL/6Imported.
      Tissue: BrainImported.
    3. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex1 Publication.

    Entry informationi

    Entry nameiHECAM_MOUSE
    AccessioniPrimary (citable) accession number: Q640R3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3