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Q640R3

- HECAM_MOUSE

UniProt

Q640R3 - HECAM_MOUSE

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Protein

Hepatocyte cell adhesion molecule

Gene

Hepacam

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (By similarity).By similarity

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cell cycle arrest Source: UniProtKB-KW
  3. cellular protein localization Source: MGI
  4. regulation of growth Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Cell cycle, Growth arrest, Growth regulation

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte cell adhesion molecule
Short name:
Protein hepaCAM
Gene namesi
Name:HepacamImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1920177. Hepacam.

Subcellular locationi

Cytoplasm. Membrane By similarity; Single-pass type I membrane protein By similarity; Cytoplasmic side By similarity
Note: Colocalizes with CDH1.By similarity

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cell-cell junction Source: Ensembl
  3. cytoplasm Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 418385Hepatocyte cell adhesion moleculeSequence AnalysisPRO_0000298778Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi168 ↔ 217PROSITE-ProRule annotation
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ640R3.
PaxDbiQ640R3.
PRIDEiQ640R3.

PTM databases

PhosphoSiteiQ640R3.

Expressioni

Gene expression databases

BgeeiQ640R3.
CleanExiMM_HEPACAM.
ExpressionAtlasiQ640R3. baseline and differential.
GenevestigatoriQ640R3.

Interactioni

Subunit structurei

Homodimer. Dimer formation occurs predominantly through cis interactions on the cell surface (By similarity). Part of a complex containing MLC1, TRPV4, AQP4 and ATP1B1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ640R3.
SMRiQ640R3. Positions 49-235.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 240207ExtracellularSequence AnalysisAdd
BLAST
Topological domaini262 – 418157CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei241 – 26121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 142109Ig-like V-typeSequence AnalysisAdd
BLAST
Domaini148 – 23487Ig-like C2-typeSequence AnalysisAdd
BLAST

Domaini

The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility.By similarity

Sequence similaritiesi

Contains 1 Ig-like V-type (immunoglobulin-like) domain.Sequence Analysis

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG80335.
GeneTreeiENSGT00530000063550.
HOGENOMiHOG000060194.
HOVERGENiHBG107974.
InParanoidiQ640R3.
OMAiWKPSKKS.
OrthoDBiEOG71P2B5.
PhylomeDBiQ640R3.
TreeFamiTF331199.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q640R3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRERGALSR ASRALRLSPF VYLLLIQPVP LEGVNITSPV RLIHGTVGKS
60 70 80 90 100
ALLSVQYSST SSDKPVVKWQ LKRDKPVTVV QSIGTEVIGT LRPDYRDRIR
110 120 130 140 150
LFENGSLLLS DLQLADEGTY EVEISITDDT FTGEKTINLT VDVPISRPQV
160 170 180 190 200
LVASTTVLEL SEAFTLNCSH ENGTKPSYTW LKDGKPLLND SRMLLSPDQK
210 220 230 240 250
VLTITRVLME DDDLYSCVVE NPISQVRSLP VKITVYRRSS LYIILSTGGI
260 270 280 290 300
FLLVTLVTVC ACWKPSKKSR KKRKLEKQNS LEYMDQNDDR LKSEADTLPR
310 320 330 340 350
SGEQERKNPM ALYILKDKDS SEPDENPATE PRSTTEPGPP GYSVSPPVPG
360 370 380 390 400
RSPGLPIRSA RRYPRSPARS PATGRTHTSP PRAPSSPGRS RSSSRSLRTA
410
GVQRIREQDE SGQVEISA
Length:418
Mass (Da):46,367
Last modified:August 21, 2007 - v2
Checksum:i39D65EB953A5B933
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC138284 Genomic DNA. No translation available.
BC082537 mRNA. Translation: AAH82537.1.
CCDSiCCDS22976.1.
RefSeqiNP_780398.2. NM_175189.4.
UniGeneiMm.266133.

Genome annotation databases

EnsembliENSMUST00000051839; ENSMUSP00000054105; ENSMUSG00000046240.
GeneIDi72927.
KEGGimmu:72927.
UCSCiuc009our.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC138284 Genomic DNA. No translation available.
BC082537 mRNA. Translation: AAH82537.1 .
CCDSi CCDS22976.1.
RefSeqi NP_780398.2. NM_175189.4.
UniGenei Mm.266133.

3D structure databases

ProteinModelPortali Q640R3.
SMRi Q640R3. Positions 49-235.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei Q640R3.

Proteomic databases

MaxQBi Q640R3.
PaxDbi Q640R3.
PRIDEi Q640R3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000051839 ; ENSMUSP00000054105 ; ENSMUSG00000046240 .
GeneIDi 72927.
KEGGi mmu:72927.
UCSCi uc009our.1. mouse.

Organism-specific databases

CTDi 220296.
MGIi MGI:1920177. Hepacam.

Phylogenomic databases

eggNOGi NOG80335.
GeneTreei ENSGT00530000063550.
HOGENOMi HOG000060194.
HOVERGENi HBG107974.
InParanoidi Q640R3.
OMAi WKPSKKS.
OrthoDBi EOG71P2B5.
PhylomeDBi Q640R3.
TreeFami TF331199.

Miscellaneous databases

NextBioi 337151.
PROi Q640R3.
SOURCEi Search...

Gene expression databases

Bgeei Q640R3.
CleanExi MM_HEPACAM.
ExpressionAtlasi Q640R3. baseline and differential.
Genevestigatori Q640R3.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-418.
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  3. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex1 Publication.

Entry informationi

Entry nameiHECAM_MOUSE
AccessioniPrimary (citable) accession number: Q640R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3