Hepatocyte cell adhesion molecule precursor

Contribute

Send feedback

Read comments (?) or add your own

Q640R3 (HECAM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 71. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Hepatocyte cell adhesion molecule
Short name=Protein hepaCAM

Gene names

Name:

Hepacam

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation By similarity. UniProtKB Q14CZ8
Subunit structure	Homodimer. Dimer formation occurs predominantly through cis interactions on the cell surface By similarity. Part of a complex containing MLC1, TRPV4, AQP4 and ATP1B1 By similarity. UniProtKB Q14CZ8
Subcellular location	Cytoplasm. Membrane; Single-pass type I membrane protein; Cytoplasmic side By similarity. Note: Colocalizes with CDH1 By similarity.
Domain	The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility By similarity. UniProtKB Q14CZ8
Post-translational modification	N-glycosylated By similarity. UniProtKB Q14CZ8
Sequence similarities	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Cell adhesion Cell cycle Growth arrest Growth regulation
Cellular component	Cytoplasm Membrane
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW cell cycle arrest Inferred from electronic annotation. Source: UniProtKB-KW cellular protein localization Inferred from direct assay PubMed 21419380. Source: MGI regulation of growth Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	axon Inferred from electronic annotation. Source: Compara cell-cell junction Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from direct assay PubMed 21419380. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 33

Potential

Chain

34 – 418

385

Hepatocyte cell adhesion molecule

PRO_0000298778

Regions

Topological domain

34 – 240

207

Extracellular Potential

Transmembrane

241 – 261

Helical; Potential

Topological domain

262 – 418

157

Cytoplasmic Potential

Domain

34 – 142

109

Ig-like V-type

Domain

148 – 234

Ig-like C2-type

Amino acid modifications

Modified residue

280

Phosphoserine Ref.3

Modified residue

320

Phosphoserine Ref.3

Modified residue

352

Phosphoserine Ref.3

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

138

N-linked (GlcNAc...) Potential

Glycosylation

167

N-linked (GlcNAc...) Potential

Glycosylation

189

N-linked (GlcNAc...) Potential

Disulfide bond

168 ↔ 217

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q640R3 [UniParc].

Last modified August 21, 2007. Version 2.
Checksum: 39D65EB953A5B933
Show »

FASTA

418

46,367

        10         20         30         40         50         60 
MKRERGALSR ASRALRLSPF VYLLLIQPVP LEGVNITSPV RLIHGTVGKS ALLSVQYSST 

        70         80         90        100        110        120 
SSDKPVVKWQ LKRDKPVTVV QSIGTEVIGT LRPDYRDRIR LFENGSLLLS DLQLADEGTY 

       130        140        150        160        170        180 
EVEISITDDT FTGEKTINLT VDVPISRPQV LVASTTVLEL SEAFTLNCSH ENGTKPSYTW 

       190        200        210        220        230        240 
LKDGKPLLND SRMLLSPDQK VLTITRVLME DDDLYSCVVE NPISQVRSLP VKITVYRRSS 

       250        260        270        280        290        300 
LYIILSTGGI FLLVTLVTVC ACWKPSKKSR KKRKLEKQNS LEYMDQNDDR LKSEADTLPR 

       310        320        330        340        350        360 
SGEQERKNPM ALYILKDKDS SEPDENPATE PRSTTEPGPP GYSVSPPVPG RSPGLPIRSA 

       370        380        390        400        410 
RRYPRSPARS PATGRTHTSP PRAPSSPGRS RSSSRSLRTA GVQRIREQDE SGQVEISA

« Hide

References

[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-418. Strain: C57BL/6. Tissue: Brain.
[3]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280; SER-320 AND SER-352, MASS SPECTROMETRY. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC138284 Genomic DNA. No translation available. BC082537 mRNA. Translation: AAH82537.1.
IPI	IPI00471176.
RefSeq	NP_780398.2. NM_175189.4.
UniGene	Mm.266133.
3D structure databases
ProteinModelPortal	Q640R3.
SMR	Q640R3. Positions 49-235.
ModBase	Search...
Protein family/group databases
MEROPS	I43.001.
PTM databases
PhosphoSite	Q640R3.
Proteomic databases
PaxDb	Q640R3.
PRIDE	Q640R3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000051839; ENSMUSP00000054105; ENSMUSG00000046240.
GeneID	72927.
KEGG	mmu:72927.
Organism-specific databases
CTD	220296.
MGI	MGI:1920177. Hepacam.
Phylogenomic databases
eggNOG	NOG80335.
GeneTree	ENSGT00530000063550.
HOGENOM	HOG000060194.
HOVERGEN	HBG107974.
InParanoid	Q640R3.
OMA	WKPSKKS.
OrthoDB	EOG49W2FV.
Gene expression databases
ArrayExpress	Q640R3.
Bgee	Q640R3.
CleanEx	MM_HEPACAM.
Genevestigator	Q640R3.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR013106. Ig_V-set. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. SM00408. IGc2. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	337151.
SOURCE	Search...

Entry information

Entry name

HECAM_MOUSE

Accession

Primary (citable) accession number: Q640R3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	May 1, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents