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Q640R3

- HECAM_MOUSE

UniProt

Q640R3 - HECAM_MOUSE

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Protein
Hepatocyte cell adhesion molecule
Gene
Hepacam
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation By similarity.By similarity

GO - Molecular functioni

  1. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cell cycle arrest Source: UniProtKB-KW
  3. cellular protein localization Source: MGI
  4. regulation of growth Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Cell cycle, Growth arrest, Growth regulation

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte cell adhesion molecule
Short name:
Protein hepaCAM
Gene namesi
Name:Hepacam
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1920177. Hepacam.

Subcellular locationi

Cytoplasm. Membrane; Single-pass type I membrane protein; Cytoplasmic side By similarity
Note: Colocalizes with CDH1 By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 240207Extracellular Reviewed prediction
Add
BLAST
Transmembranei241 – 26121Helical; Reviewed prediction
Add
BLAST
Topological domaini262 – 418157Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cell-cell junction Source: Ensembl
  3. cytoplasm Source: UniProtKB-SubCell
  4. integral component of membrane Source: UniProtKB-KW
  5. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed prediction
Add
BLAST
Chaini34 – 418385Hepatocyte cell adhesion molecule
PRO_0000298778Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi138 – 1381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi167 – 1671N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi168 ↔ 217 By similarity
Glycosylationi189 – 1891N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ640R3.
PaxDbiQ640R3.
PRIDEiQ640R3.

PTM databases

PhosphoSiteiQ640R3.

Expressioni

Gene expression databases

ArrayExpressiQ640R3.
BgeeiQ640R3.
CleanExiMM_HEPACAM.
GenevestigatoriQ640R3.

Interactioni

Subunit structurei

Homodimer. Dimer formation occurs predominantly through cis interactions on the cell surface By similarity. Part of a complex containing MLC1, TRPV4, AQP4 and ATP1B1 By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ640R3.
SMRiQ640R3. Positions 49-235.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 142109Ig-like V-type
Add
BLAST
Domaini148 – 23487Ig-like C2-type
Add
BLAST

Domaini

The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility By similarity.By similarity

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG80335.
GeneTreeiENSGT00530000063550.
HOGENOMiHOG000060194.
HOVERGENiHBG107974.
InParanoidiQ640R3.
OMAiWKPSKKS.
OrthoDBiEOG71P2B5.
PhylomeDBiQ640R3.
TreeFamiTF331199.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q640R3-1 [UniParc]FASTAAdd to Basket

« Hide

MKRERGALSR ASRALRLSPF VYLLLIQPVP LEGVNITSPV RLIHGTVGKS    50
ALLSVQYSST SSDKPVVKWQ LKRDKPVTVV QSIGTEVIGT LRPDYRDRIR 100
LFENGSLLLS DLQLADEGTY EVEISITDDT FTGEKTINLT VDVPISRPQV 150
LVASTTVLEL SEAFTLNCSH ENGTKPSYTW LKDGKPLLND SRMLLSPDQK 200
VLTITRVLME DDDLYSCVVE NPISQVRSLP VKITVYRRSS LYIILSTGGI 250
FLLVTLVTVC ACWKPSKKSR KKRKLEKQNS LEYMDQNDDR LKSEADTLPR 300
SGEQERKNPM ALYILKDKDS SEPDENPATE PRSTTEPGPP GYSVSPPVPG 350
RSPGLPIRSA RRYPRSPARS PATGRTHTSP PRAPSSPGRS RSSSRSLRTA 400
GVQRIREQDE SGQVEISA 418
Length:418
Mass (Da):46,367
Last modified:August 21, 2007 - v2
Checksum:i39D65EB953A5B933
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC138284 Genomic DNA. No translation available.
BC082537 mRNA. Translation: AAH82537.1.
CCDSiCCDS22976.1.
RefSeqiNP_780398.2. NM_175189.4.
UniGeneiMm.266133.

Genome annotation databases

EnsembliENSMUST00000051839; ENSMUSP00000054105; ENSMUSG00000046240.
GeneIDi72927.
KEGGimmu:72927.
UCSCiuc009our.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC138284 Genomic DNA. No translation available.
BC082537 mRNA. Translation: AAH82537.1 .
CCDSi CCDS22976.1.
RefSeqi NP_780398.2. NM_175189.4.
UniGenei Mm.266133.

3D structure databases

ProteinModelPortali Q640R3.
SMRi Q640R3. Positions 49-235.
ModBasei Search...

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei Q640R3.

Proteomic databases

MaxQBi Q640R3.
PaxDbi Q640R3.
PRIDEi Q640R3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000051839 ; ENSMUSP00000054105 ; ENSMUSG00000046240 .
GeneIDi 72927.
KEGGi mmu:72927.
UCSCi uc009our.1. mouse.

Organism-specific databases

CTDi 220296.
MGIi MGI:1920177. Hepacam.

Phylogenomic databases

eggNOGi NOG80335.
GeneTreei ENSGT00530000063550.
HOGENOMi HOG000060194.
HOVERGENi HBG107974.
InParanoidi Q640R3.
OMAi WKPSKKS.
OrthoDBi EOG71P2B5.
PhylomeDBi Q640R3.
TreeFami TF331199.

Miscellaneous databases

NextBioi 337151.
PROi Q640R3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q640R3.
Bgeei Q640R3.
CleanExi MM_HEPACAM.
Genevestigatori Q640R3.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-418.
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.

Entry informationi

Entry nameiHECAM_MOUSE
AccessioniPrimary (citable) accession number: Q640R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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