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Protein

Hepatocyte cell adhesion molecule

Gene

Hepacam

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (By similarity).By similarity

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cell cycle arrest Source: UniProtKB-KW
  3. cellular protein localization Source: MGI
  4. regulation of growth Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Cell cycle, Growth arrest, Growth regulation

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte cell adhesion molecule
Short name:
Protein hepaCAM
Gene namesi
Name:HepacamImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1920177. Hepacam.

Subcellular locationi

Cytoplasm. Membrane By similarity; Single-pass type I membrane protein By similarity; Cytoplasmic side By similarity
Note: Colocalizes with CDH1.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 240207ExtracellularSequence AnalysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence AnalysisAdd
BLAST
Topological domaini262 – 418157CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. axon Source: MGI
  2. cell-cell junction Source: MGI
  3. cytoplasm Source: UniProtKB-SubCell
  4. integral component of membrane Source: UniProtKB-KW
  5. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 418385Hepatocyte cell adhesion moleculeSequence AnalysisPRO_0000298778Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi168 ↔ 217PROSITE-ProRule annotation
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ640R3.
PaxDbiQ640R3.
PRIDEiQ640R3.

PTM databases

PhosphoSiteiQ640R3.

Expressioni

Gene expression databases

BgeeiQ640R3.
CleanExiMM_HEPACAM.
ExpressionAtlasiQ640R3. baseline and differential.
GenevestigatoriQ640R3.

Interactioni

Subunit structurei

Homodimer. Dimer formation occurs predominantly through cis interactions on the cell surface (By similarity). Part of a complex containing MLC1, TRPV4, AQP4 and ATP1B1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ640R3.
SMRiQ640R3. Positions 49-235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 142109Ig-like V-typeSequence AnalysisAdd
BLAST
Domaini148 – 23487Ig-like C2-typeSequence AnalysisAdd
BLAST

Domaini

The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility.By similarity

Sequence similaritiesi

Contains 1 Ig-like V-type (immunoglobulin-like) domain.Sequence Analysis

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG80335.
GeneTreeiENSGT00530000063550.
HOGENOMiHOG000060194.
HOVERGENiHBG107974.
InParanoidiQ640R3.
OMAiPIKITVY.
OrthoDBiEOG71P2B5.
PhylomeDBiQ640R3.
TreeFamiTF331199.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q640R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRERGALSR ASRALRLSPF VYLLLIQPVP LEGVNITSPV RLIHGTVGKS
60 70 80 90 100
ALLSVQYSST SSDKPVVKWQ LKRDKPVTVV QSIGTEVIGT LRPDYRDRIR
110 120 130 140 150
LFENGSLLLS DLQLADEGTY EVEISITDDT FTGEKTINLT VDVPISRPQV
160 170 180 190 200
LVASTTVLEL SEAFTLNCSH ENGTKPSYTW LKDGKPLLND SRMLLSPDQK
210 220 230 240 250
VLTITRVLME DDDLYSCVVE NPISQVRSLP VKITVYRRSS LYIILSTGGI
260 270 280 290 300
FLLVTLVTVC ACWKPSKKSR KKRKLEKQNS LEYMDQNDDR LKSEADTLPR
310 320 330 340 350
SGEQERKNPM ALYILKDKDS SEPDENPATE PRSTTEPGPP GYSVSPPVPG
360 370 380 390 400
RSPGLPIRSA RRYPRSPARS PATGRTHTSP PRAPSSPGRS RSSSRSLRTA
410
GVQRIREQDE SGQVEISA
Length:418
Mass (Da):46,367
Last modified:August 21, 2007 - v2
Checksum:i39D65EB953A5B933
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138284 Genomic DNA. No translation available.
BC082537 mRNA. Translation: AAH82537.1.
CCDSiCCDS22976.1.
RefSeqiNP_780398.2. NM_175189.4.
UniGeneiMm.266133.

Genome annotation databases

EnsembliENSMUST00000051839; ENSMUSP00000054105; ENSMUSG00000046240.
GeneIDi72927.
KEGGimmu:72927.
UCSCiuc009our.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138284 Genomic DNA. No translation available.
BC082537 mRNA. Translation: AAH82537.1.
CCDSiCCDS22976.1.
RefSeqiNP_780398.2. NM_175189.4.
UniGeneiMm.266133.

3D structure databases

ProteinModelPortaliQ640R3.
SMRiQ640R3. Positions 49-235.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI43.001.

PTM databases

PhosphoSiteiQ640R3.

Proteomic databases

MaxQBiQ640R3.
PaxDbiQ640R3.
PRIDEiQ640R3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051839; ENSMUSP00000054105; ENSMUSG00000046240.
GeneIDi72927.
KEGGimmu:72927.
UCSCiuc009our.1. mouse.

Organism-specific databases

CTDi220296.
MGIiMGI:1920177. Hepacam.

Phylogenomic databases

eggNOGiNOG80335.
GeneTreeiENSGT00530000063550.
HOGENOMiHOG000060194.
HOVERGENiHBG107974.
InParanoidiQ640R3.
OMAiPIKITVY.
OrthoDBiEOG71P2B5.
PhylomeDBiQ640R3.
TreeFamiTF331199.

Miscellaneous databases

NextBioi337151.
PROiQ640R3.
SOURCEiSearch...

Gene expression databases

BgeeiQ640R3.
CleanExiMM_HEPACAM.
ExpressionAtlasiQ640R3. baseline and differential.
GenevestigatoriQ640R3.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-418.
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  3. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.

Entry informationi

Entry nameiHECAM_MOUSE
AccessioniPrimary (citable) accession number: Q640R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: March 4, 2015
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.