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Q640R3 (HECAM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hepatocyte cell adhesion molecule

Short name=Protein hepaCAM
Gene names
Name:Hepacam
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation By similarity. UniProtKB Q14CZ8

Subunit structure

Homodimer. Dimer formation occurs predominantly through cis interactions on the cell surface By similarity. Part of a complex containing MLC1, TRPV4, AQP4 and ATP1B1 By similarity. UniProtKB Q14CZ8

Subcellular location

Cytoplasm. Membrane; Single-pass type I membrane protein; Cytoplasmic side By similarity. Note: Colocalizes with CDH1 By similarity.

Domain

The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility By similarity. UniProtKB Q14CZ8

Post-translational modification

N-glycosylated By similarity. UniProtKB Q14CZ8

Sequence similarities

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 418385Hepatocyte cell adhesion molecule
PRO_0000298778

Regions

Topological domain34 – 240207Extracellular Potential
Transmembrane241 – 26121Helical; Potential
Topological domain262 – 418157Cytoplasmic Potential
Domain34 – 142109Ig-like V-type
Domain148 – 23487Ig-like C2-type

Amino acid modifications

Glycosylation351N-linked (GlcNAc...) Potential
Glycosylation1381N-linked (GlcNAc...) Potential
Glycosylation1671N-linked (GlcNAc...) Potential
Glycosylation1891N-linked (GlcNAc...) Potential
Disulfide bond168 ↔ 217 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q640R3 [UniParc].

Last modified August 21, 2007. Version 2.
Checksum: 39D65EB953A5B933

FASTA41846,367
        10         20         30         40         50         60 
MKRERGALSR ASRALRLSPF VYLLLIQPVP LEGVNITSPV RLIHGTVGKS ALLSVQYSST 

        70         80         90        100        110        120 
SSDKPVVKWQ LKRDKPVTVV QSIGTEVIGT LRPDYRDRIR LFENGSLLLS DLQLADEGTY 

       130        140        150        160        170        180 
EVEISITDDT FTGEKTINLT VDVPISRPQV LVASTTVLEL SEAFTLNCSH ENGTKPSYTW 

       190        200        210        220        230        240 
LKDGKPLLND SRMLLSPDQK VLTITRVLME DDDLYSCVVE NPISQVRSLP VKITVYRRSS 

       250        260        270        280        290        300 
LYIILSTGGI FLLVTLVTVC ACWKPSKKSR KKRKLEKQNS LEYMDQNDDR LKSEADTLPR 

       310        320        330        340        350        360 
SGEQERKNPM ALYILKDKDS SEPDENPATE PRSTTEPGPP GYSVSPPVPG RSPGLPIRSA 

       370        380        390        400        410 
RRYPRSPARS PATGRTHTSP PRAPSSPGRS RSSSRSLRTA GVQRIREQDE SGQVEISA 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-418.
Strain: C57BL/6.
Tissue: Brain.
[3]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain cortex.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC138284 Genomic DNA. No translation available.
BC082537 mRNA. Translation: AAH82537.1.
CCDSCCDS22976.1.
RefSeqNP_780398.2. NM_175189.4.
UniGeneMm.266133.

3D structure databases

ProteinModelPortalQ640R3.
SMRQ640R3. Positions 49-235.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI43.001.

PTM databases

PhosphoSiteQ640R3.

Proteomic databases

MaxQBQ640R3.
PaxDbQ640R3.
PRIDEQ640R3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000051839; ENSMUSP00000054105; ENSMUSG00000046240.
GeneID72927.
KEGGmmu:72927.
UCSCuc009our.1. mouse.

Organism-specific databases

CTD220296.
MGIMGI:1920177. Hepacam.

Phylogenomic databases

eggNOGNOG80335.
GeneTreeENSGT00530000063550.
HOGENOMHOG000060194.
HOVERGENHBG107974.
InParanoidQ640R3.
OMAWKPSKKS.
OrthoDBEOG71P2B5.
PhylomeDBQ640R3.
TreeFamTF331199.

Gene expression databases

ArrayExpressQ640R3.
BgeeQ640R3.
CleanExMM_HEPACAM.
GenevestigatorQ640R3.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio337151.
PROQ640R3.
SOURCESearch...

Entry information

Entry nameHECAM_MOUSE
AccessionPrimary (citable) accession number: Q640R3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot