Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Angiopoietin-related protein 1

Gene

Angptl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • signaling receptor binding Source: MGI

GO - Biological processi

  • transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 1
Alternative name(s):
Angiopoietin-like protein 1
Gene namesi
Name:Angptl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1919963 Angptl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000911923 – 490Angiopoietin-related protein 1Add BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi279 ↔ 308PROSITE-ProRule annotation
Disulfide bondi431 ↔ 444PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ640P2
PeptideAtlasiQ640P2
PRIDEiQ640P2

PTM databases

iPTMnetiQ640P2
PhosphoSitePlusiQ640P2

Expressioni

Gene expression databases

BgeeiENSMUSG00000033544
CleanExiMM_ANGPTL1
GenevisibleiQ640P2 MM

Interactioni

GO - Molecular functioni

  • signaling receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027885

Structurei

3D structure databases

ProteinModelPortaliQ640P2
SMRiQ640P2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini270 – 490Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST221

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili79 – 167Sequence analysisAdd BLAST89

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00760000118809
HOGENOMiHOG000037129
HOVERGENiHBG103336
InParanoidiQ640P2
OMAiQLWCENS
OrthoDBiEOG091G03M1
PhylomeDBiQ640P2
TreeFamiTF336658

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q640P2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAFVWTLSV LLFLLGSGHC KGGQLKIKKI TQRRYPRATD GKEEAKKCSY
60 70 80 90 100
TFLVPEQKIT GPICVNTKGQ DAGTIKDMIT RMDLENLKDV LSRQKREIDV
110 120 130 140 150
LQLVVDVDGN IVNEVKLLRK ESRNMNSRVT QLYMQLLHEI IRKRDNSLEL
160 170 180 190 200
SQLENKILNV TTEMLKMATR YRELEVKYAS LTDLVNNQSV TITVLEEQCL
210 220 230 240 250
RMFSRQDPHA SPPLVQVVPR HSPNSHQYTP GLLGGNEIQR DPGYPRDVMP
260 270 280 290 300
PPDLPTAPTK SPFKIPAVTF INEGPFKDCQ QAKEAGHSAS GIYMIKPENS
310 320 330 340 350
NGLMQLWCEN SLDPGGWTVI QKRTDGSVNF FRNWENYKKG FGNIDGEYWL
360 370 380 390 400
GLDNIYKLSN QDNYKLMIEL EDWSEKKVYA EYSSFRLEPE SDYYRLRLGT
410 420 430 440 450
YQGNAGDSMM WHNGKQFTTL DRDKDTYTGN CAHFHKGGWW YNACAHSNLN
460 470 480 490
GVWYRGGHYR SKHQDGIFWA EYRGGSYSLR AVQMMIKPID
Length:490
Mass (Da):56,323
Last modified:October 25, 2004 - v1
Checksum:i1A870A092C96EF97
GO
Isoform 2 (identifier: Q640P2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-323: PFKDCQQAKE...PGGWTVIQKR → ELLLPGQWKN...MSNQNFHFLK
     324-490: Missing.

Note: No experimental confirmation available.
Show »
Length:323
Mass (Da):36,852
Checksum:i36CD2E4FA97633EA
GO

Sequence cautioni

The sequence BAB28537 differs from that shown. Reason: Frameshift at position 26.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013722275 – 323PFKDC…VIQKR → ELLLPGQWKNEAGMLMLYDS RNNTLILVSPTSYVLMPLYM SNQNFHFLK in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_013723324 – 490Missing in isoform 2. 1 PublicationAdd BLAST167

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012888 mRNA Translation: BAB28537.1 Sequence problems.
AK142319 mRNA Translation: BAE25028.1
BC082563 mRNA Translation: AAH82563.1
CCDSiCCDS15397.1 [Q640P2-1]
RefSeqiNP_082609.2, NM_028333.2 [Q640P2-1]
UniGeneiMm.389206

Genome annotation databases

EnsembliENSMUST00000027885; ENSMUSP00000027885; ENSMUSG00000033544 [Q640P2-1]
ENSMUST00000111720; ENSMUSP00000107349; ENSMUSG00000033544 [Q640P2-2]
GeneIDi72713
KEGGimmu:72713
UCSCiuc007ddc.1 mouse [Q640P2-2]
uc007ddd.2 mouse [Q640P2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiANGL1_MOUSE
AccessioniPrimary (citable) accession number: Q640P2
Secondary accession number(s): Q3UQL1, Q9CZ81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 25, 2004
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health