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Protein

Angiopoietin-related protein 1

Gene

Angptl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • receptor binding Source: MGI

GO - Biological processi

  • transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 1
Alternative name(s):
Angiopoietin-like protein 1
Gene namesi
Name:Angptl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1919963. Angptl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000911923 – 490Angiopoietin-related protein 1Add BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi279 ↔ 308PROSITE-ProRule annotation
Disulfide bondi431 ↔ 444PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ640P2.
PeptideAtlasiQ640P2.
PRIDEiQ640P2.

PTM databases

iPTMnetiQ640P2.
PhosphoSitePlusiQ640P2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033544.
CleanExiMM_ANGPTL1.
GenevisibleiQ640P2. MM.

Interactioni

GO - Molecular functioni

  • receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027885.

Structurei

3D structure databases

ProteinModelPortaliQ640P2.
SMRiQ640P2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini270 – 490Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST221

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili79 – 167Sequence analysisAdd BLAST89

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037129.
HOVERGENiHBG103336.
InParanoidiQ640P2.
OMAiNEGPFKD.
OrthoDBiEOG091G03M1.
PhylomeDBiQ640P2.
TreeFamiTF336658.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q640P2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAFVWTLSV LLFLLGSGHC KGGQLKIKKI TQRRYPRATD GKEEAKKCSY
60 70 80 90 100
TFLVPEQKIT GPICVNTKGQ DAGTIKDMIT RMDLENLKDV LSRQKREIDV
110 120 130 140 150
LQLVVDVDGN IVNEVKLLRK ESRNMNSRVT QLYMQLLHEI IRKRDNSLEL
160 170 180 190 200
SQLENKILNV TTEMLKMATR YRELEVKYAS LTDLVNNQSV TITVLEEQCL
210 220 230 240 250
RMFSRQDPHA SPPLVQVVPR HSPNSHQYTP GLLGGNEIQR DPGYPRDVMP
260 270 280 290 300
PPDLPTAPTK SPFKIPAVTF INEGPFKDCQ QAKEAGHSAS GIYMIKPENS
310 320 330 340 350
NGLMQLWCEN SLDPGGWTVI QKRTDGSVNF FRNWENYKKG FGNIDGEYWL
360 370 380 390 400
GLDNIYKLSN QDNYKLMIEL EDWSEKKVYA EYSSFRLEPE SDYYRLRLGT
410 420 430 440 450
YQGNAGDSMM WHNGKQFTTL DRDKDTYTGN CAHFHKGGWW YNACAHSNLN
460 470 480 490
GVWYRGGHYR SKHQDGIFWA EYRGGSYSLR AVQMMIKPID
Length:490
Mass (Da):56,323
Last modified:October 25, 2004 - v1
Checksum:i1A870A092C96EF97
GO
Isoform 2 (identifier: Q640P2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-323: PFKDCQQAKE...PGGWTVIQKR → ELLLPGQWKN...MSNQNFHFLK
     324-490: Missing.

Note: No experimental confirmation available.
Show »
Length:323
Mass (Da):36,852
Checksum:i36CD2E4FA97633EA
GO

Sequence cautioni

The sequence BAB28537 differs from that shown. Reason: Frameshift at position 26.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013722275 – 323PFKDC…VIQKR → ELLLPGQWKNEAGMLMLYDS RNNTLILVSPTSYVLMPLYM SNQNFHFLK in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_013723324 – 490Missing in isoform 2. 1 PublicationAdd BLAST167

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012888 mRNA. Translation: BAB28537.1. Sequence problems.
AK142319 mRNA. Translation: BAE25028.1.
BC082563 mRNA. Translation: AAH82563.1.
CCDSiCCDS15397.1. [Q640P2-1]
RefSeqiNP_082609.2. NM_028333.2. [Q640P2-1]
UniGeneiMm.389206.

Genome annotation databases

EnsembliENSMUST00000027885; ENSMUSP00000027885; ENSMUSG00000033544. [Q640P2-1]
ENSMUST00000111720; ENSMUSP00000107349; ENSMUSG00000033544. [Q640P2-2]
GeneIDi72713.
KEGGimmu:72713.
UCSCiuc007ddc.1. mouse. [Q640P2-2]
uc007ddd.2. mouse. [Q640P2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012888 mRNA. Translation: BAB28537.1. Sequence problems.
AK142319 mRNA. Translation: BAE25028.1.
BC082563 mRNA. Translation: AAH82563.1.
CCDSiCCDS15397.1. [Q640P2-1]
RefSeqiNP_082609.2. NM_028333.2. [Q640P2-1]
UniGeneiMm.389206.

3D structure databases

ProteinModelPortaliQ640P2.
SMRiQ640P2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027885.

PTM databases

iPTMnetiQ640P2.
PhosphoSitePlusiQ640P2.

Proteomic databases

PaxDbiQ640P2.
PeptideAtlasiQ640P2.
PRIDEiQ640P2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027885; ENSMUSP00000027885; ENSMUSG00000033544. [Q640P2-1]
ENSMUST00000111720; ENSMUSP00000107349; ENSMUSG00000033544. [Q640P2-2]
GeneIDi72713.
KEGGimmu:72713.
UCSCiuc007ddc.1. mouse. [Q640P2-2]
uc007ddd.2. mouse. [Q640P2-1]

Organism-specific databases

CTDi9068.
MGIiMGI:1919963. Angptl1.

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037129.
HOVERGENiHBG103336.
InParanoidiQ640P2.
OMAiNEGPFKD.
OrthoDBiEOG091G03M1.
PhylomeDBiQ640P2.
TreeFamiTF336658.

Miscellaneous databases

PROiQ640P2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033544.
CleanExiMM_ANGPTL1.
GenevisibleiQ640P2. MM.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANGL1_MOUSE
AccessioniPrimary (citable) accession number: Q640P2
Secondary accession number(s): Q3UQL1, Q9CZ81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 25, 2004
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.