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Protein

Cell cycle progression protein 1

Gene

Ccpg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42. May be involved in cell cycle regulation.1 Publication

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cell cycle progression protein 1
Gene namesi
Name:Ccpg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1196419 Ccpg1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 218CytoplasmicSequence analysisAdd BLAST218
Transmembranei219 – 239Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini240 – 753LumenalSequence analysisAdd BLAST514

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003105391 – 753Cell cycle progression protein 1Add BLAST753

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei187PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ640L3
PRIDEiQ640L3

PTM databases

iPTMnetiQ640L3
PhosphoSitePlusiQ640L3

Expressioni

Gene expression databases

BgeeiENSMUSG00000034563
CleanExiMM_CCPG1
ExpressionAtlasiQ640L3 baseline and differential
GenevisibleiQ640L3 MM

Interactioni

Subunit structurei

Interacts with MCF2L. May interact with MCF2, ARHGEF1, BCR, VAV1 and FGD1, but not with TIAM1. Interacts with GTP-bound CDC42 and SRC.1 Publication

Protein-protein interaction databases

IntActiQ640L3, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ640L3
SMRiQ640L3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 307Interaction with MCF2L and SRC1 PublicationAdd BLAST307

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili298 – 449Sequence analysisAdd BLAST152
Coiled coili503 – 529Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi177 – 182Poly-Arg6

Sequence similaritiesi

Belongs to the CCPG1 family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0Z Eukaryota
ENOG4110N7Q LUCA
GeneTreeiENSGT00530000063862
HOGENOMiHOG000013199
HOVERGENiHBG097118
InParanoidiQ640L3
OMAiFHHWKEL
OrthoDBiEOG091G02B9
PhylomeDBiQ640L3
TreeFamiTF333202

Family and domain databases

InterProiView protein in InterPro
IPR033588 CCPG1
PANTHERiPTHR28638:SF2 PTHR28638:SF2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q640L3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSESSSDSDS SCGWTVINHE GSDIEIVNSA TASDNCGLTL ECSLVEQEEL
60 70 80 90 100
PVLYVGHGGE ESSANNTSSV GETMLSSMRE TKSAAEVEEA PSPEDNVYFG
110 120 130 140 150
TTSDDSDIVT LEPPKLEEMG NQEVTIQEAP SSDDLNMGSS SSSQYAFCQP
160 170 180 190 200
EPVFSSQPSD EESSSDDTSH EPSPAPRRRR NRKKTVSISE SEEPPLAEPE
210 220 230 240 250
DEPSKEPSKR HFSRGLNKCV ILALVIAVSM GFGHFYGTIQ IQKQLVRKTH
260 270 280 290 300
EDELDGVKGY LSQRKQEQES FLDFKSLKEN LERCWTVTES EKITFETQKK
310 320 330 340 350
NLAAENQYLR ISLEKEEQAL SSLQEELRQL REQIRLLEDK GTSTQLVREN
360 370 380 390 400
QVLKQYLEVE KQKTDSFLRE REMLLEEARM LKRDLEREQL TAMALRAELE
410 420 430 440 450
QFIPGQAQSR AESPSVQTEE KEVGLLQQRL AELEQKLIFE QQRSDLWERL
460 470 480 490 500
YVEAKDQHGK QETDGRKRGS RGSHRAKSKS KETFLGTVKE TFDAMKNSTK
510 520 530 540 550
EFVRHHKEKI KQAKEAVKEN LKKFSDSVKS TFRHFKDTTK NIFDEKGSKR
560 570 580 590 600
FRAPKEAATE KTRTAYSYSS YSQQEAPNQN QNCRRPSAQR DGGREKPSHS
610 620 630 640 650
EEIRKNANSY TYKAKSDCRG THSTRRVCSG MFECAGQEAI SPVNKASPVR
660 670 680 690 700
MNDFKQLIHW YLLNELETFH HWKELDQFIS PFFPNGVFRH DQQLFADFVD
710 720 730 740 750
DVKGYLKSIK EYRVEDGNLE KLDGCIYRHF GHVFALPFGP RSVYIKPCYY

NSF
Length:753
Mass (Da):86,126
Last modified:November 13, 2007 - v2
Checksum:iEBE1C35E53A7CC5F
GO
Isoform 2 (identifier: Q640L3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     741-753: RSVYIKPCYYNSF → SRPDKKQRMV...LGQLPFDPKY

Show »
Length:803
Mass (Da):92,107
Checksum:iB7F2C541ACD15A5E
GO
Isoform 3 (identifier: Q640L3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     630-753: GMFECAGQEA...YIKPCYYNSF → VDLIKSNVW

Note: No experimental confirmation available.
Show »
Length:638
Mass (Da):72,554
Checksum:i8B9EA6572F317988
GO

Sequence cautioni

The sequence AAH06717 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156S → C in BAC36301 (PubMed:16141072).Curated1
Sequence conflicti176P → R in BAC36301 (PubMed:16141072).Curated1
Sequence conflicti227A → S in AAH82602 (PubMed:15489334).Curated1
Sequence conflicti291Missing in AAH82602 (PubMed:15489334).Curated1
Sequence conflicti684P → S in AAH82602 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029317630 – 753GMFEC…YYNSF → VDLIKSNVW in isoform 3. 1 PublicationAdd BLAST124
Alternative sequenceiVSP_029318741 – 753RSVYI…YYNSF → SRPDKKQRMVTIENARHRKQ EQKHLHPQPYEREGKWQKYG RANGRHTANLELELGQLPFD PKY in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076325 mRNA Translation: BAC36301.2
BC006717 mRNA Translation: AAH06717.1 Different initiation.
BC043049 mRNA Translation: AAH43049.1
BC082602 mRNA Translation: AAH82602.1
CCDSiCCDS23334.1 [Q640L3-3]
CCDS52855.1 [Q640L3-1]
CCDS72278.1 [Q640L3-2]
RefSeqiNP_001107800.1, NM_001114328.2 [Q640L3-1]
NP_001273473.1, NM_001286544.1 [Q640L3-2]
NP_001273474.1, NM_001286545.1
NP_001273475.1, NM_001286546.1
NP_082457.3, NM_028181.5 [Q640L3-3]
UniGeneiMm.268475

Genome annotation databases

EnsembliENSMUST00000037977; ENSMUSP00000045669; ENSMUSG00000034563 [Q640L3-3]
ENSMUST00000085350; ENSMUSP00000082458; ENSMUSG00000034563 [Q640L3-2]
ENSMUST00000150826; ENSMUSP00000122966; ENSMUSG00000034563 [Q640L3-1]
GeneIDi72278
KEGGimmu:72278
UCSCiuc009qqm.3 mouse [Q640L3-1]
uc009qqo.3 mouse [Q640L3-3]
uc009qqp.3 mouse [Q640L3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCCPG1_MOUSE
AccessioniPrimary (citable) accession number: Q640L3
Secondary accession number(s): Q05BJ9, Q8C692, Q922W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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