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Protein

Cell cycle progression protein 1

Gene

Ccpg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42. May be involved in cell cycle regulation.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cell cycle progression protein 1
Gene namesi
Name:Ccpg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1196419. Ccpg1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 218218CytoplasmicSequence analysisAdd
BLAST
Transmembranei219 – 23921Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini240 – 753514LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 753753Cell cycle progression protein 1PRO_0000310539Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei187 – 1871PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ640L3.
MaxQBiQ640L3.
PaxDbiQ640L3.
PRIDEiQ640L3.

PTM databases

iPTMnetiQ640L3.
PhosphoSiteiQ640L3.

Expressioni

Gene expression databases

BgeeiQ640L3.
CleanExiMM_CCPG1.
ExpressionAtlasiQ640L3. baseline and differential.
GenevisibleiQ640L3. MM.

Interactioni

Subunit structurei

Interacts with MCF2L. May interact with MCF2, ARHGEF1, BCR, VAV1 and FGD1, but not with TIAM1. Interacts with GTP-bound CDC42 and SRC.1 Publication

Protein-protein interaction databases

IntActiQ640L3. 1 interaction.
MINTiMINT-1658397.
STRINGi10090.ENSMUSP00000122966.

Structurei

3D structure databases

ProteinModelPortaliQ640L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 307307Interaction with MCF2L and SRCAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili298 – 449152Sequence analysisAdd
BLAST
Coiled coili503 – 52927Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi177 – 1826Poly-Arg

Sequence similaritiesi

Belongs to the CCPG1 family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0Z. Eukaryota.
ENOG4110N7Q. LUCA.
GeneTreeiENSGT00530000063862.
HOGENOMiHOG000013199.
HOVERGENiHBG097118.
InParanoidiQ640L3.
OMAiCSGVFEC.
OrthoDBiEOG76T9R5.
PhylomeDBiQ640L3.
TreeFamiTF333202.

Family and domain databases

InterProiIPR033588. CCPG1.
[Graphical view]
PANTHERiPTHR28638:SF2. PTHR28638:SF2. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q640L3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSESSSDSDS SCGWTVINHE GSDIEIVNSA TASDNCGLTL ECSLVEQEEL
60 70 80 90 100
PVLYVGHGGE ESSANNTSSV GETMLSSMRE TKSAAEVEEA PSPEDNVYFG
110 120 130 140 150
TTSDDSDIVT LEPPKLEEMG NQEVTIQEAP SSDDLNMGSS SSSQYAFCQP
160 170 180 190 200
EPVFSSQPSD EESSSDDTSH EPSPAPRRRR NRKKTVSISE SEEPPLAEPE
210 220 230 240 250
DEPSKEPSKR HFSRGLNKCV ILALVIAVSM GFGHFYGTIQ IQKQLVRKTH
260 270 280 290 300
EDELDGVKGY LSQRKQEQES FLDFKSLKEN LERCWTVTES EKITFETQKK
310 320 330 340 350
NLAAENQYLR ISLEKEEQAL SSLQEELRQL REQIRLLEDK GTSTQLVREN
360 370 380 390 400
QVLKQYLEVE KQKTDSFLRE REMLLEEARM LKRDLEREQL TAMALRAELE
410 420 430 440 450
QFIPGQAQSR AESPSVQTEE KEVGLLQQRL AELEQKLIFE QQRSDLWERL
460 470 480 490 500
YVEAKDQHGK QETDGRKRGS RGSHRAKSKS KETFLGTVKE TFDAMKNSTK
510 520 530 540 550
EFVRHHKEKI KQAKEAVKEN LKKFSDSVKS TFRHFKDTTK NIFDEKGSKR
560 570 580 590 600
FRAPKEAATE KTRTAYSYSS YSQQEAPNQN QNCRRPSAQR DGGREKPSHS
610 620 630 640 650
EEIRKNANSY TYKAKSDCRG THSTRRVCSG MFECAGQEAI SPVNKASPVR
660 670 680 690 700
MNDFKQLIHW YLLNELETFH HWKELDQFIS PFFPNGVFRH DQQLFADFVD
710 720 730 740 750
DVKGYLKSIK EYRVEDGNLE KLDGCIYRHF GHVFALPFGP RSVYIKPCYY

NSF
Length:753
Mass (Da):86,126
Last modified:November 13, 2007 - v2
Checksum:iEBE1C35E53A7CC5F
GO
Isoform 2 (identifier: Q640L3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     741-753: RSVYIKPCYYNSF → SRPDKKQRMV...LGQLPFDPKY

Show »
Length:803
Mass (Da):92,107
Checksum:iB7F2C541ACD15A5E
GO
Isoform 3 (identifier: Q640L3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     630-753: GMFECAGQEA...YIKPCYYNSF → VDLIKSNVW

Note: No experimental confirmation available.
Show »
Length:638
Mass (Da):72,554
Checksum:i8B9EA6572F317988
GO

Sequence cautioni

The sequence AAH06717.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561S → C in BAC36301 (PubMed:16141072).Curated
Sequence conflicti176 – 1761P → R in BAC36301 (PubMed:16141072).Curated
Sequence conflicti227 – 2271A → S in AAH82602 (PubMed:15489334).Curated
Sequence conflicti291 – 2911Missing in AAH82602 (PubMed:15489334).Curated
Sequence conflicti684 – 6841P → S in AAH82602 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei630 – 753124GMFEC…YYNSF → VDLIKSNVW in isoform 3. 1 PublicationVSP_029317Add
BLAST
Alternative sequencei741 – 75313RSVYI…YYNSF → SRPDKKQRMVTIENARHRKQ EQKHLHPQPYEREGKWQKYG RANGRHTANLELELGQLPFD PKY in isoform 2. 1 PublicationVSP_029318Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076325 mRNA. Translation: BAC36301.2.
BC006717 mRNA. Translation: AAH06717.1. Different initiation.
BC043049 mRNA. Translation: AAH43049.1.
BC082602 mRNA. Translation: AAH82602.1.
CCDSiCCDS23334.1. [Q640L3-3]
CCDS52855.1. [Q640L3-1]
CCDS72278.1. [Q640L3-2]
RefSeqiNP_001107800.1. NM_001114328.2. [Q640L3-1]
NP_001273473.1. NM_001286544.1. [Q640L3-2]
NP_001273474.1. NM_001286545.1.
NP_001273475.1. NM_001286546.1.
NP_082457.3. NM_028181.5. [Q640L3-3]
UniGeneiMm.268475.

Genome annotation databases

EnsembliENSMUST00000037977; ENSMUSP00000045669; ENSMUSG00000034563. [Q640L3-3]
ENSMUST00000085350; ENSMUSP00000082458; ENSMUSG00000034563. [Q640L3-2]
ENSMUST00000150826; ENSMUSP00000122966; ENSMUSG00000034563. [Q640L3-1]
GeneIDi72278.
KEGGimmu:72278.
UCSCiuc009qqm.3. mouse. [Q640L3-1]
uc009qqo.3. mouse. [Q640L3-3]
uc009qqp.3. mouse. [Q640L3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076325 mRNA. Translation: BAC36301.2.
BC006717 mRNA. Translation: AAH06717.1. Different initiation.
BC043049 mRNA. Translation: AAH43049.1.
BC082602 mRNA. Translation: AAH82602.1.
CCDSiCCDS23334.1. [Q640L3-3]
CCDS52855.1. [Q640L3-1]
CCDS72278.1. [Q640L3-2]
RefSeqiNP_001107800.1. NM_001114328.2. [Q640L3-1]
NP_001273473.1. NM_001286544.1. [Q640L3-2]
NP_001273474.1. NM_001286545.1.
NP_001273475.1. NM_001286546.1.
NP_082457.3. NM_028181.5. [Q640L3-3]
UniGeneiMm.268475.

3D structure databases

ProteinModelPortaliQ640L3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ640L3. 1 interaction.
MINTiMINT-1658397.
STRINGi10090.ENSMUSP00000122966.

PTM databases

iPTMnetiQ640L3.
PhosphoSiteiQ640L3.

Proteomic databases

EPDiQ640L3.
MaxQBiQ640L3.
PaxDbiQ640L3.
PRIDEiQ640L3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037977; ENSMUSP00000045669; ENSMUSG00000034563. [Q640L3-3]
ENSMUST00000085350; ENSMUSP00000082458; ENSMUSG00000034563. [Q640L3-2]
ENSMUST00000150826; ENSMUSP00000122966; ENSMUSG00000034563. [Q640L3-1]
GeneIDi72278.
KEGGimmu:72278.
UCSCiuc009qqm.3. mouse. [Q640L3-1]
uc009qqo.3. mouse. [Q640L3-3]
uc009qqp.3. mouse. [Q640L3-2]

Organism-specific databases

CTDi9236.
MGIiMGI:1196419. Ccpg1.

Phylogenomic databases

eggNOGiENOG410II0Z. Eukaryota.
ENOG4110N7Q. LUCA.
GeneTreeiENSGT00530000063862.
HOGENOMiHOG000013199.
HOVERGENiHBG097118.
InParanoidiQ640L3.
OMAiCSGVFEC.
OrthoDBiEOG76T9R5.
PhylomeDBiQ640L3.
TreeFamiTF333202.

Miscellaneous databases

ChiTaRSiCcpg1. mouse.
PROiQ640L3.
SOURCEiSearch...

Gene expression databases

BgeeiQ640L3.
CleanExiMM_CCPG1.
ExpressionAtlasiQ640L3. baseline and differential.
GenevisibleiQ640L3. MM.

Family and domain databases

InterProiIPR033588. CCPG1.
[Graphical view]
PANTHERiPTHR28638:SF2. PTHR28638:SF2. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain, Head and Mammary tumor.
  3. "Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs."
    Kostenko E.V., Olabisi O.O., Sahay S., Rodriguez P.L., Whitehead I.P.
    Mol. Cell. Biol. 26:8964-8975(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MCF2; MCF2L; ARHGEF1; BCR; VAV1; FGD1; CDC42 AND SRC, SUBCELLULAR LOCATION, FUNCTION.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Pancreas.

Entry informationi

Entry nameiCCPG1_MOUSE
AccessioniPrimary (citable) accession number: Q640L3
Secondary accession number(s): Q05BJ9, Q8C692, Q922W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: July 6, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.