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Q640H3

- OTU5B_XENLA

UniProt

Q640H3 - OTU5B_XENLA

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Protein

OTU domain-containing protein 5-B

Gene
otud5-b
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme that may function as negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei179 – 1791 Reviewed prediction
Active sitei182 – 1821Nucleophile By similarity
Active sitei287 – 2871 By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. protein K48-linked deubiquitination Source: UniProtKB
  2. protein K63-linked deubiquitination Source: UniProtKB
  3. response to lipopolysaccharide Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC85.001.

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 5-B (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme A
Short name:
DUBA
Gene namesi
Name:otud5-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6255335. otud5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518OTU domain-containing protein 5-BPRO_0000278228Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ640H3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini171 – 294124OTUAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni176 – 1827Cys-loop By similarity
Regioni231 – 24111Variable-loop By similarityAdd
BLAST
Regioni282 – 2876His-loop By similarity

Sequence similaritiesi

Belongs to the peptidase C85 family.
Contains 1 OTU domain.

Phylogenomic databases

HOVERGENiHBG060214.
KOiK12655.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q640H3-1 [UniParc]FASTAAdd to Basket

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MTILPKKKPP PSSDPEGNGE RSGSGAPDSH SRSGARPRSS PPPRWAYPGN    50
PSSAAERHTQ QVSPPPGSAT SGGAGPLGDG APASSSSSSS SSCNGAGAGG 100
CCSGPGHSKR RRQVLSAGPG ATGNCPDTDD GAGNNSEDEY ETAAQTQHLD 150
PDTAQQQEHW FEKALCEKKG FIIKQMKEDG ACLFRAVADQ VYGDQDMHEV 200
VRKHCMDYLM KNADYFSNYV TEDFTTYINR KRKNNCHGNH IEMQAMAEMY 250
NRPVEVYQYG TEPINTFHGI QQNEDEPIRV SYHRNIHYNS VVNPNKATIG 300
VGLGLPSFKP GHAEQSLMKS AIRTSEESWI EQQMLEDKKR ATDWEATNEA 350
IEEQVARESY LQWLRDQEKQ ARQPRKASAT CSSATAAACS GLEEWSGRSP 400
RQRSTAGSPE QPDVHAELCM KPPSPGAALT LGKPPSPCAP GPSNQMSAGA 450
DRATSPLVSL YPALECRAIM QHMSPTAFGL KDWDDDEILA SVLAASQQEY 500
LDTMKKSTLR RESSPDHS 518
Length:518
Mass (Da):56,209
Last modified:October 25, 2004 - v1
Checksum:i2099AB07C6C93EC1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC082654 mRNA. Translation: AAH82654.1.
RefSeqiNP_001088023.1. NM_001094554.1.
UniGeneiXl.49149.

Genome annotation databases

GeneIDi494714.
KEGGixla:494714.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC082654 mRNA. Translation: AAH82654.1 .
RefSeqi NP_001088023.1. NM_001094554.1.
UniGenei Xl.49149.

3D structure databases

ProteinModelPortali Q640H3.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C85.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 494714.
KEGGi xla:494714.

Organism-specific databases

CTDi 494714.
Xenbasei XB-GENE-6255335. otud5.

Phylogenomic databases

HOVERGENi HBG060214.
KOi K12655.

Family and domain databases

InterProi IPR003323. OTU.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiOTU5B_XENLA
AccessioniPrimary (citable) accession number: Q640H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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