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Q640H3

- OTU5B_XENLA

UniProt

Q640H3 - OTU5B_XENLA

Protein

OTU domain-containing protein 5-B

Gene

otud5-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that may function as negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei179 – 1791Sequence Analysis
    Active sitei182 – 1821NucleophileBy similarity
    Active sitei287 – 2871By similarity

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. protein K48-linked deubiquitination Source: UniProtKB
    2. protein K63-linked deubiquitination Source: UniProtKB
    3. response to lipopolysaccharide Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC85.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OTU domain-containing protein 5-B (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme A
    Short name:
    DUBA
    Gene namesi
    Name:otud5-b
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6255335. otud5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 518518OTU domain-containing protein 5-BPRO_0000278228Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ640H3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini171 – 294124OTUPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni176 – 1827Cys-loopBy similarity
    Regioni231 – 24111Variable-loopBy similarityAdd
    BLAST
    Regioni282 – 2876His-loopBy similarity

    Sequence similaritiesi

    Belongs to the peptidase C85 family.Curated
    Contains 1 OTU domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG060214.
    KOiK12655.

    Family and domain databases

    InterProiIPR003323. OTU.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q640H3-1 [UniParc]FASTAAdd to Basket

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    MTILPKKKPP PSSDPEGNGE RSGSGAPDSH SRSGARPRSS PPPRWAYPGN    50
    PSSAAERHTQ QVSPPPGSAT SGGAGPLGDG APASSSSSSS SSCNGAGAGG 100
    CCSGPGHSKR RRQVLSAGPG ATGNCPDTDD GAGNNSEDEY ETAAQTQHLD 150
    PDTAQQQEHW FEKALCEKKG FIIKQMKEDG ACLFRAVADQ VYGDQDMHEV 200
    VRKHCMDYLM KNADYFSNYV TEDFTTYINR KRKNNCHGNH IEMQAMAEMY 250
    NRPVEVYQYG TEPINTFHGI QQNEDEPIRV SYHRNIHYNS VVNPNKATIG 300
    VGLGLPSFKP GHAEQSLMKS AIRTSEESWI EQQMLEDKKR ATDWEATNEA 350
    IEEQVARESY LQWLRDQEKQ ARQPRKASAT CSSATAAACS GLEEWSGRSP 400
    RQRSTAGSPE QPDVHAELCM KPPSPGAALT LGKPPSPCAP GPSNQMSAGA 450
    DRATSPLVSL YPALECRAIM QHMSPTAFGL KDWDDDEILA SVLAASQQEY 500
    LDTMKKSTLR RESSPDHS 518
    Length:518
    Mass (Da):56,209
    Last modified:October 25, 2004 - v1
    Checksum:i2099AB07C6C93EC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC082654 mRNA. Translation: AAH82654.1.
    RefSeqiNP_001088023.1. NM_001094554.1.
    UniGeneiXl.49149.

    Genome annotation databases

    GeneIDi494714.
    KEGGixla:494714.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC082654 mRNA. Translation: AAH82654.1 .
    RefSeqi NP_001088023.1. NM_001094554.1.
    UniGenei Xl.49149.

    3D structure databases

    ProteinModelPortali Q640H3.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C85.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 494714.
    KEGGi xla:494714.

    Organism-specific databases

    CTDi 494714.
    Xenbasei XB-GENE-6255335. otud5.

    Phylogenomic databases

    HOVERGENi HBG060214.
    KOi K12655.

    Family and domain databases

    InterProi IPR003323. OTU.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiOTU5B_XENLA
    AccessioniPrimary (citable) accession number: Q640H3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3