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Q640H3 (OTU5B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
OTU domain-containing protein 5-B

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme A
Short name=DUBA
Gene names
Name:otud5-b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinating enzyme that may function as negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C85 family.

Contains 1 OTU domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518OTU domain-containing protein 5-B
PRO_0000278228

Regions

Domain171 – 294124OTU
Region176 – 1827Cys-loop By similarity
Region231 – 24111Variable-loop By similarity
Region282 – 2876His-loop By similarity

Sites

Active site1791 Potential
Active site1821Nucleophile By similarity
Active site2871 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q640H3 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 2099AB07C6C93EC1

FASTA51856,209
        10         20         30         40         50         60 
MTILPKKKPP PSSDPEGNGE RSGSGAPDSH SRSGARPRSS PPPRWAYPGN PSSAAERHTQ 

        70         80         90        100        110        120 
QVSPPPGSAT SGGAGPLGDG APASSSSSSS SSCNGAGAGG CCSGPGHSKR RRQVLSAGPG 

       130        140        150        160        170        180 
ATGNCPDTDD GAGNNSEDEY ETAAQTQHLD PDTAQQQEHW FEKALCEKKG FIIKQMKEDG 

       190        200        210        220        230        240 
ACLFRAVADQ VYGDQDMHEV VRKHCMDYLM KNADYFSNYV TEDFTTYINR KRKNNCHGNH 

       250        260        270        280        290        300 
IEMQAMAEMY NRPVEVYQYG TEPINTFHGI QQNEDEPIRV SYHRNIHYNS VVNPNKATIG 

       310        320        330        340        350        360 
VGLGLPSFKP GHAEQSLMKS AIRTSEESWI EQQMLEDKKR ATDWEATNEA IEEQVARESY 

       370        380        390        400        410        420 
LQWLRDQEKQ ARQPRKASAT CSSATAAACS GLEEWSGRSP RQRSTAGSPE QPDVHAELCM 

       430        440        450        460        470        480 
KPPSPGAALT LGKPPSPCAP GPSNQMSAGA DRATSPLVSL YPALECRAIM QHMSPTAFGL 

       490        500        510 
KDWDDDEILA SVLAASQQEY LDTMKKSTLR RESSPDHS 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC082654 mRNA. Translation: AAH82654.1.
RefSeqNP_001088023.1. NM_001094554.1.
UniGeneXl.49149.

3D structure databases

ProteinModelPortalQ640H3.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC85.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID494714.
KEGGxla:494714.

Organism-specific databases

CTD494714.
XenbaseXB-GENE-6255335. otud5.

Phylogenomic databases

HOVERGENHBG060214.
KOK12655.

Family and domain databases

InterProIPR003323. OTU.
[Graphical view]
PfamPF02338. OTU. 1 hit.
[Graphical view]
PROSITEPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTU5B_XENLA
AccessionPrimary (citable) accession number: Q640H3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 25, 2004
Last modified: February 19, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries