Q640C5 (DOPDB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-dopachrome decarboxylase-B
EC=4.1.1.84

Alternative name(s):
D-dopachrome tautomerase-B

Gene names

Name:

ddt-b

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) By similarity.
Catalytic activity	D-dopachrome = 5,6-dihydroxyindole + CO2.
Subunit structure	Homotrimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the MIF family.

Ontologies

Keywords
Biological process	Melanin biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
PTM	Acetylation
Gene Ontology (GO)
Biological_process	melanin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	D-dopachrome decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 118	117	D-dopachrome decarboxylase-B		PRO_0000337236
Amino acid modifications
	Modified residue	2	1	N-acetylproline By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q640C5 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 8FBB4BCC2B8FAC57	FASTA	118	12,902
	10 20 30 40 50 60 MPFVELDTNL QQQEVPQDLA EKLCSATATI LGKPRERVNV TVRTGVSMVV GGSSAPCTQL 70 80 90 100 110 IISSIGVVGT AEQNKEHSAK FFNFLTEQLG LAQDRILLRF VPLEPWQIGK NGTVMTFL

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC082705 mRNA. Translation: AAH82705.1.
RefSeq	NP_001088035.1. NM_001094566.1.
UniGene	Xl.45032.
3D structure databases
HSSP	HSSP built from PDB template 1DPT based on UniProtKB P30046.
ProteinModelPortal	Q640C5.
SMR	Q640C5. Positions 2-118.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	494727.
KEGG	xla:494727.
Organism-specific databases
CTD	494727.
Xenbase	XB-GENE-6255328. ddt.
Phylogenomic databases
HOVERGEN	HBG003240.
KO	K10028.
Family and domain databases
InterPro	IPR001398. Macrophage_inhib_fac. IPR014347. Tautomerase/MIF_sf. [Graphical view]
PANTHER	PTHR11954. PTHR11954. 1 hit.
Pfam	PF01187. MIF. 1 hit. [Graphical view]
ProDom	PD004816. Macrophage_inhib_fac. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF55331. SSF55331. 1 hit.
PROSITE	PS01158. MIF. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DOPDB_XENLA

Accession

Primary (citable) accession number: Q640C5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	October 25, 2004
Last modified:	March 6, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program