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Reviewed, UniProtKB/Swiss-Prot Q640B3 (PLD3_XENTR)

Last modified November 3, 2009. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Phospholipase D3
      Short name=PLD 3
    EC=3.1.4.4
Alternative name(s):
    Choline phosphatase 3
    Phosphatidylcholine-hydrolyzing phospholipase D3
Gene names
Name: pld3
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

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Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

A phosphatidylcholine + H2O = choline + a phosphatidate.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the phospholipase D family.

Contains 2 PLD phosphodiesterase domains.

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Ontologies

Keywords
   Biological processLipid degradation
   Cellular componentEndoplasmic reticulum
Membrane
   DomainRepeat
Signal-anchor
Transmembrane
   Molecular functionHydrolase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-KW

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAPE-specific phospholipase D activity

Inferred from electronic annotation. Source: EC

phospholipase D activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Phospholipase D3
PRO_0000280332

Regions

Topological domain1 – 3737Cytoplasmic Potential
Transmembrane38 – 5821Signal-anchor for type II membrane protein Potential
Topological domain59 – 494436Lumenal Potential
Domain198 – 22528PLD phosphodiesterase 1
Domain413 – 43927PLD phosphodiesterase 2

Sites

Active site2031 Potential
Active site2051 Potential
Active site2101 Potential
Active site4181 Potential
Active site4201 Potential
Active site4251 Potential

Amino acid modifications

Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation2381N-linked (GlcNAc...) Potential
Glycosylation2601N-linked (GlcNAc...) Potential
Glycosylation2701N-linked (GlcNAc...) Potential
Glycosylation2861N-linked (GlcNAc...) Potential
Glycosylation3891N-linked (GlcNAc...) Potential
Glycosylation4341N-linked (GlcNAc...) Potential
Glycosylation4511N-linked (GlcNAc...) Potential
Glycosylation4771N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q640B3-1 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: EACEA360F7437F18

FASTA49456,213
        10         20         30         40         50         60 
MNPKVEYKQI QSHDEAENQV LQHECHQAKA RKYYRCAVVI AIIITLLFCV LASQLLLFPL 

        70         80         90        100        110        120 
FSITSQTTTE IVLNKDIQCD DQCRFVLVES IPEGLVYDAN ATINPSIFQS WLNILTSAKS 

       130        140        150        160        170        180 
SVDIASFYWT LTNEDTQTQE PSAHQGELIL QELLNLKQRG VSVRVAVNPP DSPLRAKDIS 

       190        200        210        220        230        240 
ALKDSGADVR VVDLPKLTDG VLHTKFWVVD SEHFYIGSAN MDWRSLTQVK ELGATIYNCS 

       250        260        270        280        290        300 
CLAEDLKKIF EAYWILGLPN ATLPSPWPVN YSTPYNKDTP MQVMLNSTAS QVYISSSPPP 

       310        320        330        340        350        360 
LSATGRTDDL QSIINIIDDA KKFVYISVMD YSPTEEFSHP RRYWPYIDNH LRKAVYERNV 

       370        380        390        400        410        420 
NVRLLISCWQ NSRPSMFTFL RSLAALHSNK SHYNIEVKIF VVPATEVQKK IPYARVNHNK 

       430        440        450        460        470        480 
YMVTDRVAYI GTSNWSGDYF IHTAGSALIV NQTQSVGTSD TIQMQLQAVF ERDWNSNYSR 

       490 
TFNTLSSWKE KCIF

« Hide

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References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

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Cross-references

Sequence databases

BC082717 mRNA. Translation: AAH82717.1.
RefSeqNP_001011023.1.
UniGeneStr.4390

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID496432.
KEGGxtr:496432.

Organism-specific databases

CTD496432.
XenbaseXB-FEAT-1006823. pld3.

Phylogenomic databases

HOVERGENQ640B3.
OMAVFERDWN.

Enzyme and pathway databases

BRENDA3.1.4.4. 279072.

Family and domain databases

InterProIPR013582. PLD_envelope.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamPF08371. PLD_envelope. 1 hit.
PF00614. PLDc. 2 hits.
[Graphical view]
SMARTSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePLD3_XENTR
AccessionPrimary (citable) accession number: Q640B3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 25, 2004
Last modified: November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectXenopus annotation project

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents