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Protein

Sodium- and chloride-dependent transporter XTRP3

Gene

Slc6a20

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids.1 Publication

GO - Molecular functioni

GO - Biological processi

  • amino acid transmembrane transport Source: GOC
  • amino acid transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Symport, Transport

Protein family/group databases

TCDBi2.A.22.6.1. the neurotransmitter:sodium symporter (nss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent transporter XTRP3
Alternative name(s):
Sodium/imino-acid transporter 1
Solute carrier family 6 member 20
Transporter rB21A
Gene namesi
Name:Slc6a20
Synonyms:Sit1, Xtrp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621651. Slc6a20.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737CytoplasmicSequence analysisAdd
BLAST
Transmembranei38 – 5821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini59 – 668ExtracellularSequence analysis
Transmembranei67 – 8721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini88 – 10316CytoplasmicSequence analysisAdd
BLAST
Transmembranei104 – 12421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini125 – 18965ExtracellularSequence analysisAdd
BLAST
Transmembranei190 – 21021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini211 – 2188CytoplasmicSequence analysis
Transmembranei219 – 23921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini240 – 26526ExtracellularSequence analysisAdd
BLAST
Transmembranei266 – 28621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini287 – 30014CytoplasmicSequence analysisAdd
BLAST
Transmembranei301 – 32121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini322 – 41392ExtracellularSequence analysisAdd
BLAST
Transmembranei414 – 43421Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini435 – 45521CytoplasmicSequence analysisAdd
BLAST
Transmembranei456 – 47621Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini477 – 48913ExtracellularSequence analysisAdd
BLAST
Transmembranei490 – 51021Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini511 – 53323CytoplasmicSequence analysisAdd
BLAST
Transmembranei534 – 55421Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini555 – 57824ExtracellularSequence analysisAdd
BLAST
Transmembranei579 – 59921Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini600 – 61617CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 616616Sodium- and chloride-dependent transporter XTRP3PRO_0000214814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ64093.
PRIDEiQ64093.

Expressioni

Tissue specificityi

Highly expressed in epithelial cells of duodenum, jejunum, ileum, stomach, cecum, colon and kidney proximal tubule. Also expressed in the choroid plexus, microglia and meniges of the brain and in the ovary.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007467.

Structurei

3D structure databases

ProteinModelPortaliQ64093.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ64093.
KOiK05048.
PhylomeDBiQ64093.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLAIKRRAS RGQRPGPDEK RARDMEKARP QWGNPLQFVF ACISYAVGLG
60 70 80 90 100
NVWRFPYLCQ MYGGGSFLVP YLIMLIVEGM PLLYLELAVG QRMRQGSIGA
110 120 130 140 150
WRTISPYLSG VGVASVVVSF FLSMYYNVIN AWGFWYLFHS FQDPLPWSVC
160 170 180 190 200
PLNSNRTGYD EECEKASSTQ YFWYRKTLNI SPSIQENGGV QWEPALCLTL
210 220 230 240 250
AWLMVYLCIL RGTESTGKVV YFTALMPYCV LIIYLVRGLT LHGATNGLMY
260 270 280 290 300
MFTPKIEQLA NPKAWINAAT QIFFSLGLGF GSLIAFASYN EPSNDCQKHA
310 320 330 340 350
VIVSVINSST SIFASIVTFS IYGFKATFNY ENCLNKVILL LTNSFDLEDG
360 370 380 390 400
FLTASNLEEV KDYLASTYPN KYSEVFPHIR NCSLESELNT AVQGTGLAFI
410 420 430 440 450
VYAEAIKNME VSQLWSVLYF FMLLMLGMGS MLGNTAAILT PLTDSKVISS
460 470 480 490 500
YLPKEAISGL VCLINCAVGM VFTMEAGNYW FDIFNDYAAT LSLLLIVLVE
510 520 530 540 550
TIAVCYVYGL RRFESDLRAM TGRPLNWYWK AMWAFVSPLL IIGLFIFYLS
560 570 580 590 600
DYILTGTLQY QAWDATQGQL VTKDYPPHAL AVIGLLVASS TMCIPLVALG
610
TFIRNRLKRG GSSPVA
Length:616
Mass (Da):68,971
Last modified:November 1, 1996 - v1
Checksum:i6B0DAB04315CE829
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76742 mRNA. Translation: AAB32806.1.
PIRiS50998.
RefSeqiNP_579830.1. NM_133296.1.
UniGeneiRn.161982.

Genome annotation databases

GeneIDi113918.
KEGGirno:113918.
UCSCiRGD:621651. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76742 mRNA. Translation: AAB32806.1.
PIRiS50998.
RefSeqiNP_579830.1. NM_133296.1.
UniGeneiRn.161982.

3D structure databases

ProteinModelPortaliQ64093.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007467.

Protein family/group databases

TCDBi2.A.22.6.1. the neurotransmitter:sodium symporter (nss) family.

Proteomic databases

PaxDbiQ64093.
PRIDEiQ64093.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi113918.
KEGGirno:113918.
UCSCiRGD:621651. rat.

Organism-specific databases

CTDi54716.
RGDi621651. Slc6a20.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ64093.
KOiK05048.
PhylomeDBiQ64093.

Miscellaneous databases

NextBioi618023.
PROiQ64093.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of an orphan transporter. A new member of the neurotransmitter transporter family."
    Smith K.E., Fried S.G., Durkin M.M., Gustafson E.L., Borden L.A., Branchek T.A., Weinshank R.L.
    FEBS Lett. 357:86-92(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino."
    Takanaga H., Mackenzie B., Suzuki Y., Hediger M.A.
    J. Biol. Chem. 280:8974-8984(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiS6A20_RAT
AccessioniPrimary (citable) accession number: Q64093
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.