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Q64092

- TFE3_MOUSE

UniProt

Q64092 - TFE3_MOUSE

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Protein

Transcription factor E3

Gene
Tfe3, Tcfe3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.1 Publication

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. protein heterodimerization activity Source: UniProtKB
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  4. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. humoral immune response Source: UniProtKB
  2. positive regulation of cell adhesion Source: UniProtKB
  3. positive regulation of transcription, DNA-templated Source: MGI
  4. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  5. regulation of osteoclast differentiation Source: MGI
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Adaptive immunity, Immunity, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor E3
Gene namesi
Name:Tfe3
Synonyms:Tcfe3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:98511. Tfe3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Transcription factor E3PRO_0000127472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei545 – 5451Phosphoserine By similarity
Modified residuei553 – 5531Phosphoserine By similarity
Modified residuei557 – 5571Phosphoserine By similarity
Modified residuei565 – 5651Phosphoserine By similarity

Post-translational modificationi

Sumoylated; does not affect dimerization with MITF By similarity.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ64092.
PRIDEiQ64092.

PTM databases

PhosphoSiteiQ64092.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ64092.
CleanExiMM_TCFE3.
GenevestigatoriQ64092.

Interactioni

Subunit structurei

Homodimer and heterodimer; with TFEB or MITF By similarity.

Protein-protein interaction databases

BioGridi229078. 1 interaction.
IntActiQ64092. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ64092.
SMRiQ64092. Positions 346-436.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini345 – 39854bHLHAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni259 – 27012Strong transcription activation domain Reviewed predictionAdd
BLAST
Regioni408 – 42922Leucine-zipperAdd
BLAST

Sequence similaritiesi

Belongs to the MiT/TFE family.

Phylogenomic databases

eggNOGiNOG251286.
GeneTreeiENSGT00390000004402.
HOVERGENiHBG006768.
InParanoidiA2AEW3.
KOiK09105.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR021802. bHLH_ZIP_TF_MiT/TFE.
IPR024100. TFE3.
[Graphical view]
PANTHERiPTHR10014:SF37. PTHR10014:SF37. 1 hit.
PfamiPF11851. DUF3371. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q64092-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSHAAEPARD AVEASAEGPR AVFLLLEERR PAESAQLLSL NSLLPESGIV    50
ADIELENILD PDSFYELKSQ PLFLRSSLPI SLQATPTTPA TLSASSSAGG 100
SRTPAMSSSS SRVLLRQQLM RAQAQEQERR ERREQAAAAP FPSPAPASPA 150
ISVIGVSAGG HTLSRPPPAQ VPREVLKVQT HLENPTRYHL QQARRQQVKQ 200
YLSTTLGPKL ASQALTPPPG PSSAQPLPAP ETAHATGPTG SAPNSPMALL 250
TIGSSSEKEI DDVIDEIISL ESSYNDEMLS YLPGGTAGLQ LPSTLPVSGN 300
LLDVYSSQGV ATPAITVSNS CPAELPNIKR EISETEAKAL LKERQKKDNH 350
NLIERRRRFN INDRIKELGT LIPKSNDPEM RWNKGTILKA SVDYIRKLQK 400
EQQRSKDLES RQRSLEQANR SLQLRIQELE LQAQIHGLPV PPNPGLLSLT 450
TSSVSDSLKP EQLDIEEEGR PSTTFHVSGG PAQNAPPQQP PAPPSDALLD 500
LHFPSDHLGD LGDPFHLGLE DILMEEEGMV GGLSGGALSP LRAASDPLLS 550
SVSPAVSKAS SRRSSFSMEE ES 572
Length:572
Mass (Da):61,536
Last modified:January 9, 2007 - v2
Checksum:iDAB0487EC0F6E92D
GO
Isoform 2 (identifier: Q64092-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.

Note: No experimental confirmation available.

Show »
Length:467
Mass (Da):50,509
Checksum:i2353472086F2A3A0
GO
Isoform 3 (identifier: Q64092-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.
     260-294: Missing.

Note: No experimental confirmation available.

Show »
Length:432
Mass (Da):46,770
Checksum:i24EE10757C31E2CC
GO
Isoform 4 (identifier: Q64092-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-294: Missing.

Note: No experimental confirmation available.

Show »
Length:537
Mass (Da):57,797
Checksum:i8E063275FBFC4F7A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 105105Missing in isoform 2 and isoform 3. VSP_022143Add
BLAST
Alternative sequencei260 – 29435Missing in isoform 3 and isoform 4. VSP_022144Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731F → S in BAE24128. 1 Publication
Sequence conflicti73 – 731F → S in BAE25994. 1 Publication
Sequence conflicti127 – 1315QERRE → TSGTR in AAB21130. 1 Publication
Sequence conflicti143 – 1431S → G in BAE25994. 1 Publication
Sequence conflicti558 – 5581K → N in AAB21130. 1 Publication
Sequence conflicti568 – 5681M → I in AAB21130. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK089762 mRNA. Translation: BAC40955.1.
AK139756 mRNA. Translation: BAE24128.1.
AK144657 mRNA. Translation: BAE25994.1.
AK152221 mRNA. Translation: BAE31048.1.
AL671995 Genomic DNA. Translation: CAM13597.1.
AL671995 Genomic DNA. Translation: CAM13598.1.
BC056358 mRNA. Translation: AAH56358.1.
BC063047 mRNA. Translation: AAH63047.1.
S76673 mRNA. Translation: AAB21130.1.
CCDSiCCDS52984.1. [Q64092-1]
CCDS52985.1. [Q64092-4]
CCDS72332.1. [Q64092-2]
CCDS72333.1. [Q64092-3]
PIRiA42029.
RefSeqiNP_001098666.1. NM_001105196.1.
NP_001098667.1. NM_001105197.1. [Q64092-2]
NP_001258418.1. NM_001271489.1. [Q64092-2]
NP_001258419.1. NM_001271490.1. [Q64092-2]
NP_001258420.1. NM_001271491.1. [Q64092-3]
NP_766060.2. NM_172472.3.
XP_006527641.1. XM_006527578.1. [Q64092-2]
UniGeneiMm.249142.

Genome annotation databases

EnsembliENSMUST00000101695; ENSMUSP00000099219; ENSMUSG00000000134. [Q64092-2]
ENSMUST00000115677; ENSMUSP00000111341; ENSMUSG00000000134. [Q64092-2]
ENSMUST00000115678; ENSMUSP00000111342; ENSMUSG00000000134. [Q64092-3]
ENSMUST00000115679; ENSMUSP00000111343; ENSMUSG00000000134. [Q64092-2]
ENSMUST00000137467; ENSMUSP00000134125; ENSMUSG00000000134. [Q64092-2]
GeneIDi209446.
KEGGimmu:209446.
UCSCiuc009smg.2. mouse. [Q64092-1]
uc009smk.2. mouse. [Q64092-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK089762 mRNA. Translation: BAC40955.1 .
AK139756 mRNA. Translation: BAE24128.1 .
AK144657 mRNA. Translation: BAE25994.1 .
AK152221 mRNA. Translation: BAE31048.1 .
AL671995 Genomic DNA. Translation: CAM13597.1 .
AL671995 Genomic DNA. Translation: CAM13598.1 .
BC056358 mRNA. Translation: AAH56358.1 .
BC063047 mRNA. Translation: AAH63047.1 .
S76673 mRNA. Translation: AAB21130.1 .
CCDSi CCDS52984.1. [Q64092-1 ]
CCDS52985.1. [Q64092-4 ]
CCDS72332.1. [Q64092-2 ]
CCDS72333.1. [Q64092-3 ]
PIRi A42029.
RefSeqi NP_001098666.1. NM_001105196.1.
NP_001098667.1. NM_001105197.1. [Q64092-2 ]
NP_001258418.1. NM_001271489.1. [Q64092-2 ]
NP_001258419.1. NM_001271490.1. [Q64092-2 ]
NP_001258420.1. NM_001271491.1. [Q64092-3 ]
NP_766060.2. NM_172472.3.
XP_006527641.1. XM_006527578.1. [Q64092-2 ]
UniGenei Mm.249142.

3D structure databases

ProteinModelPortali Q64092.
SMRi Q64092. Positions 346-436.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 229078. 1 interaction.
IntActi Q64092. 1 interaction.

PTM databases

PhosphoSitei Q64092.

Proteomic databases

PaxDbi Q64092.
PRIDEi Q64092.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000101695 ; ENSMUSP00000099219 ; ENSMUSG00000000134 . [Q64092-2 ]
ENSMUST00000115677 ; ENSMUSP00000111341 ; ENSMUSG00000000134 . [Q64092-2 ]
ENSMUST00000115678 ; ENSMUSP00000111342 ; ENSMUSG00000000134 . [Q64092-3 ]
ENSMUST00000115679 ; ENSMUSP00000111343 ; ENSMUSG00000000134 . [Q64092-2 ]
ENSMUST00000137467 ; ENSMUSP00000134125 ; ENSMUSG00000000134 . [Q64092-2 ]
GeneIDi 209446.
KEGGi mmu:209446.
UCSCi uc009smg.2. mouse. [Q64092-1 ]
uc009smk.2. mouse. [Q64092-3 ]

Organism-specific databases

CTDi 7030.
MGIi MGI:98511. Tfe3.

Phylogenomic databases

eggNOGi NOG251286.
GeneTreei ENSGT00390000004402.
HOVERGENi HBG006768.
InParanoidi A2AEW3.
KOi K09105.

Miscellaneous databases

NextBioi 372667.
PROi Q64092.
SOURCEi Search...

Gene expression databases

Bgeei Q64092.
CleanExi MM_TCFE3.
Genevestigatori Q64092.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
IPR021802. bHLH_ZIP_TF_MiT/TFE.
IPR024100. TFE3.
[Graphical view ]
PANTHERi PTHR10014:SF37. PTHR10014:SF37. 1 hit.
Pfami PF11851. DUF3371. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Egg, Lung and Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  4. "mTFE3, an X-linked transcriptional activator containing basic helix-loop-helix and zipper domains, utilizes the zipper to stabilize both DNA binding and multimerization."
    Roman C., Matera A.G., Cooper C., Artandi S., Blain S., Ward D.C., Calame K.
    Mol. Cell. Biol. 12:817-827(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 127-572.
  5. "Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity."
    Huan C., Kelly M.L., Steele R., Shapira I., Gottesman S.R.S., Roman C.A.J.
    Nat. Immunol. 7:1082-1091(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTFE3_MOUSE
AccessioniPrimary (citable) accession number: Q64092
Secondary accession number(s): A2AEW3
, A2AEW4, Q3U8H0, Q3UMV4, Q3UT52, Q7TNC1, Q8BN29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 9, 2007
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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