Q64077 (NK2R_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Substance-K receptor
Short name=SKR

Alternative name(s):
NK-2 receptor
Short name=NK-2R
Neurokinin A receptor
Tachykinin receptor 2

Gene names

Name:

TACR2

Organism

Cavia porcellus (Guinea pig) [Reference proteome]

Taxonomic identifier

10141 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tachykinin receptor signaling pathway Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	tachykinin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 402	402	Substance-K receptor		PRO_0000069892
Regions
	Topological domain	1 – 32	32	Extracellular Potential
	Transmembrane	33 – 56	24	Helical; Name=1; Potential
	Topological domain	57 – 69	13	Cytoplasmic Potential
	Transmembrane	70 – 90	21	Helical; Name=2; Potential
	Topological domain	91 – 107	17	Extracellular Potential
	Transmembrane	108 – 129	22	Helical; Name=3; Potential
	Topological domain	130 – 149	20	Cytoplasmic Potential
	Transmembrane	150 – 170	21	Helical; Name=4; Potential
	Topological domain	171 – 196	26	Extracellular Potential
	Transmembrane	197 – 218	22	Helical; Name=5; Potential
	Topological domain	219 – 251	33	Cytoplasmic Potential
	Transmembrane	252 – 272	21	Helical; Name=6; Potential
	Topological domain	273 – 290	18	Extracellular Potential
	Transmembrane	291 – 310	20	Helical; Name=7; Potential
	Topological domain	311 – 402	92	Cytoplasmic Potential
Amino acid modifications
	Lipidation	324	1	S-palmitoyl cysteine Potential
	Glycosylation	11	1	N-linked (GlcNAc...) Potential
	Glycosylation	19	1	N-linked (GlcNAc...) Potential
	Disulfide bond	106 ↔ 181		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q64077 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: D4FA803E4363376F	FASTA	402	45,092
	10 20 30 40 50 60 MGACVIVTNT NISSGLESNT TGITAFSMPT WQLALWATAY LALVLVAVTG NATVTWIILA 70 80 90 100 110 120 HQRMRTVTNY FIVNLALADL CMAAFNAAFN FVYASHNIWY FGRAFCYFQN LFPITAMFVS 130 140 150 160 170 180 IYSMTAIAID RYMAIVHPFQ PRLSAPSTKA VIGGIWLVAL ALAFPQCFYS TITEDEGATK 190 200 210 220 230 240 CVVAWPEDSR DKSLLLYHLV VIVLIYLLPL TVMFVAYSII GLTLWRRAVP RHQAHGANLR 250 260 270 280 290 300 HLQAKKKFVK TMVLVVVTFA ICWLPYHLYF ILGSFQEDIY CHKFIQQVYL ALFWLAMSST 310 320 330 340 350 360 MYNPIIYCCL NRRFRSGFRL AFRCCPWVTP TEEDKLELTH TPSFSLRVNR CHTKEILFMA 370 380 390 400 GDTVPSEATN GQAGGPQDRE SVELSSLPGC RAGPSILAKA SS

References

[1]

"Isolation and characterization of neurokinin A receptor cDNAs from guinea-pig lung and rabbit pulmonary artery." Aharony D., Little J., Thomas C., Powell S., Downey-Jones M., Graham A. J. Recept. Res. 14:399-421(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Dunkin-Hartley. Tissue: Lung.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S76253 mRNA. Translation: AAB33553.1.
PIR	I56595.
RefSeq	XP_003473635.1. XM_003473587.1.
3D structure databases
ProteinModelPortal	Q64077.
ModBase	Search...
Protein-protein interaction databases
STRING	10141.ENSCPOP00000005425.
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100720631.
Phylogenomic databases
eggNOG	NOG331485.
HOGENOM	HOG000013018.
HOVERGEN	HBG103412.
InParanoid	Q64077.
OrthoDB	EOG4C5CJT.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001681. Neurokn_rcpt. IPR000913. NK2_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01025. NEUROKININ2R. PR00244. NEUROKININR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q64077.
ChEMBL	CHEMBL2647.

Entry information

Entry name

NK2R_CAVPO

Accession

Primary (citable) accession number: Q64077

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program