Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q64057 (AL7A1_RAT)

Last modified January 19, 2010. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Alpha-aminoadipic semialdehyde dehydrogenase
      Short name=Alpha-AASA dehydrogenase
    EC=1.2.1.31
Alternative name(s):
    Delta1-piperideine-6-carboxylate dehydrogenease
      Short name=P6c dehydrogenase
    Aldehyde dehydrogenase family 7 member A1
    Antiquitin-1
Gene names
Name: Aldh7a1
Synonyms: Ald7a1
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length228 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.

Subunit structure

Homotetramer By similarity. UniProtKB P83402

Tissue specificity

Abundant in kidney, liver, cochlea and outer hair cells but not inner hair cells or vestibular type I hair cells. Very low levels in lung, brain, intestine and pancreas. Ref.1 Ref.3

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionL-aminoadipate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 228›228Alpha-aminoadipic semialdehyde dehydrogenase
PRO_0000056492

Sites

Active site191 By similarity UniProtKB Q56694

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q64057-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F5DA69254AF35C16

FASTA22825,158
        10         20         30         40         50         60 
SLVLPSALFA AVGTAGQRCT TVRRLFLHES IHDEVVDRLK NDYSQIRVGN PWDPNILYGP 

        70         80         90        100        110        120 
LHTKQAVSMF VQAVEEAKKE GGTVVYGGKV MDHPGNYVEP TIVTGLVHDA PIVHKETFAP 

       130        140        150        160        170        180 
ILYVFKFKNE EEVFEWNNKV KQELSSSIFT KDLGRIFRWL GPKGSDCGIV NVNIPTSGAE 

       190        200        210        220 
IGGAFGGEKH TGSGRESGSD AWKQYMRRST CTINYSTALP LAQGIKFQ 

« Hide

References

[1]"Homology between a human protein and a protein of the green garden pea."
Lee P., Kuhl W., Gelbart T., Kamimura T., West C., Beutler E.
Genomics 21:371-378(1994) [PubMed: 8088832] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Intestinal mucosa.
[2]Lubec G., Afjehi-Sadat L.
Submitted (NOV-2006) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 25-38 AND 116-126, MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Spinal cord.
[3]"An ancient conserved gene expressed in the human inner ear: identification, expression analysis, and chromosomal mapping of human and mouse antiquitin (ATQ1)."
Skvorak A.B., Robertson N.G., Yin Y., Weremowicz S., Her H., Bieber F.R., Beisel K.W., Lynch E.D., Beier D.R., Morton C.C.
Genomics 46:191-199(1997) [PubMed: 9417906] [Abstract]
Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S75019 mRNA. Translation: AAB31967.2.
IPIIPI00208917.
PIRB54676.
UniGeneRn.7330

3D structure databases

SMRQ64057. Positions 1-216.
ModBaseSearch...

Genome annotation databases

EnsemblENSRNOT00000020325; ENSRNOP00000020325; ENSRNOG00000014645; Rattus norvegicus. [Genome view]

Organism-specific databases

RGD1308614. Aldh7a1.

Phylogenomic databases

eggNOGroNOG09457.
HOVERGENQ64057.
InParanoidQ64057.

Enzyme and pathway databases

BRENDA1.2.1.31. 248.

Gene expression databases

ArrayExpressQ64057.
GenevestigatorQ64057.
GermOnlineENSRNOG00000014645. Rattus norvegicus.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR015590. Aldehyde_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. Partial match.
PS00687. ALDEHYDE_DEHYDR_GLU. Partial match.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAL7A1_RAT
AccessionPrimary (citable) accession number: Q64057
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1996
Last modified: January 19, 2010
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents