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Q64057

- AL7A1_RAT

UniProt

Q64057 - AL7A1_RAT

Protein

Alpha-aminoadipic semialdehyde dehydrogenase

Gene

Aldh7a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism By similarity.By similarity

    Catalytic activityi

    (S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.
    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei195 – 1951Transition state stabilizerBy similarity
    Active sitei296 – 2961Proton acceptorPROSITE-ProRule annotation
    Active sitei330 – 3301NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi274 – 2796NADBy similarity

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. L-aminoadipate-semialdehyde dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    ReactomeiREACT_220761. Lysine catabolism.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-aminoadipic semialdehyde dehydrogenase (EC:1.2.1.31)
    Short name:
    Alpha-AASA dehydrogenase
    Alternative name(s):
    Aldehyde dehydrogenase family 7 member A1 (EC:1.2.1.3)
    Antiquitin-1
    Betaine aldehyde dehydrogenase (EC:1.2.1.8)
    Delta1-piperideine-6-carboxylate dehydrogenase
    Short name:
    P6c dehydrogenase
    Gene namesi
    Name:Aldh7a1
    Synonyms:Ald7a1
    OrganismiRattus norvegicus (Rat)Curated
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 18

    Organism-specific databases

    RGDi1308614. Aldh7a1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasmcytosol By similarity. Mitochondrion By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell
    2. mitochondrion Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2626MitochondrionSequence AnalysisAdd
    BLAST
    Chaini27 – 539513Alpha-aminoadipic semialdehyde dehydrogenasePRO_0000056492Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei86 – 861N6-acetyllysine; alternateBy similarity
    Modified residuei86 – 861N6-succinyllysine; alternateBy similarity
    Modified residuei94 – 941N6-acetyllysine; alternateBy similarity
    Modified residuei94 – 941N6-succinyllysine; alternateBy similarity
    Modified residuei97 – 971N6-acetyllysine; alternateBy similarity
    Modified residuei97 – 971N6-succinyllysine; alternateBy similarity
    Modified residuei462 – 4621N6-acetyllysineBy similarity
    Modified residuei500 – 5001N6-acetyllysineBy similarity
    Modified residuei537 – 5371N6-succinyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ64057.
    PRIDEiQ64057.

    Expressioni

    Tissue specificityi

    Abundant in kidney, liver, cochlea and outer hair cells but not inner hair cells or vestibular type I hair cells. Very low levels in lung, brain, intestine and pancreas.2 Publications

    Gene expression databases

    GenevestigatoriQ64057.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    MINTiMINT-4574870.
    STRINGi10116.ENSRNOP00000020325.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64057.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1012.
    GeneTreeiENSGT00720000108597.
    HOGENOMiHOG000271511.
    HOVERGENiHBG050485.
    InParanoidiQ64057.
    KOiK14085.
    OMAiNAIIVFE.
    OrthoDBiEOG78D7JV.
    PhylomeDBiQ64057.
    TreeFamiTF300388.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q64057-1 [UniParc]FASTAAdd to Basket

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    MLRLARPLCV QTVKASKLSR LWSRPAALMS TLLIHHPQYA WLQDLGLRED    50
    NEGVFNGSWG GRGEVITTYC PANNEPIARV RQASMKDYEE TIGKAKKAWN 100
    IWADIPAPKR GEIVRKIGDA LREKIQLLGR LVSLEMGKIL VEGIGEVQEY 150
    VDVCDYAAGL SRMIGGPTLP SERPGHALME QWNPLGLVGI ITAFNFPVAV 200
    FGWNNAIALI TGNVCLWKGA PTTSLVSIAV TKIIAKVLED NLLPGAICSL 250
    TCGGADMGTA MARDERVNLL SFTGSTQVGK QVALMVQERF GKSLLELGGN 300
    NAIIAFEDAD LSLVLPSALF AAVGTAGQRC TTVRRLFLHE SIHDEVVDRL 350
    KNAYSQIRVG NPWDPNILYG PLHTKQAVSM FVQAVEEAKK EGGTVVYGGK 400
    VMDHPGNYVE PTIVTGLVHD APIVHKETFA PILYVFKFKN EEEVFEWNNE 450
    VKQGLSSSIF TKDLGRIFRW LGPKGSDCGI VNVNIPTSGA EIGGAFGGEK 500
    HTGGGRESGS DAWKQYMRRS TCTINYSTAL PLAQGIKFQ 539
    Length:539
    Mass (Da):58,749
    Last modified:April 20, 2010 - v2
    Checksum:i90F355B926582E77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03109709 Genomic DNA. No translation available.
    S75019 mRNA. Translation: AAB31967.2.
    PIRiB54676.
    RefSeqiNP_001258034.1. NM_001271105.1.
    UniGeneiRn.7330.

    Genome annotation databases

    EnsembliENSRNOT00000020325; ENSRNOP00000020325; ENSRNOG00000014645.
    GeneIDi291450.
    KEGGirno:291450.
    UCSCiRGD:1308614. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03109709 Genomic DNA. No translation available.
    S75019 mRNA. Translation: AAB31967.2 .
    PIRi B54676.
    RefSeqi NP_001258034.1. NM_001271105.1.
    UniGenei Rn.7330.

    3D structure databases

    ProteinModelPortali Q64057.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4574870.
    STRINGi 10116.ENSRNOP00000020325.

    Proteomic databases

    PaxDbi Q64057.
    PRIDEi Q64057.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000020325 ; ENSRNOP00000020325 ; ENSRNOG00000014645 .
    GeneIDi 291450.
    KEGGi rno:291450.
    UCSCi RGD:1308614. rat.

    Organism-specific databases

    CTDi 501.
    RGDi 1308614. Aldh7a1.

    Phylogenomic databases

    eggNOGi COG1012.
    GeneTreei ENSGT00720000108597.
    HOGENOMi HOG000271511.
    HOVERGENi HBG050485.
    InParanoidi Q64057.
    KOi K14085.
    OMAi NAIIVFE.
    OrthoDBi EOG78D7JV.
    PhylomeDBi Q64057.
    TreeFami TF300388.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    Reactomei REACT_220761. Lysine catabolism.

    Miscellaneous databases

    NextBioi 632620.
    PROi Q64057.

    Gene expression databases

    Genevestigatori Q64057.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. Lubec G., Afjehi-Sadat L.
      Submitted (NOV-2006) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 53-66 AND 144-154, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Spinal cord.
    3. "Homology between a human protein and a protein of the green garden pea."
      Lee P., Kuhl W., Gelbart T., Kamimura T., West C., Beutler E.
      Genomics 21:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 312-539, TISSUE SPECIFICITY.
      Tissue: Intestinal mucosa.
    4. "An ancient conserved gene expressed in the human inner ear: identification, expression analysis, and chromosomal mapping of human and mouse antiquitin (ATQ1)."
      Skvorak A.B., Robertson N.G., Yin Y., Weremowicz S., Her H., Bieber F.R., Beisel K.W., Lynch E.D., Beier D.R., Morton C.C.
      Genomics 46:191-199(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiAL7A1_RAT
    AccessioniPrimary (citable) accession number: Q64057
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3