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Protein

Alpha-aminoadipic semialdehyde dehydrogenase

Gene

Aldh7a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity).By similarity

Catalytic activityi

(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.
Betaine aldehyde + NAD+ + H2O = betaine + NADH.
An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei195 – 1951Transition state stabilizerBy similarity
Active sitei296 – 2961Proton acceptorPROSITE-ProRule annotation
Active sitei330 – 3301NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi274 – 2796NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: GO_Central
  2. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  3. L-aminoadipate-semialdehyde dehydrogenase activity Source: GO_Central

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_346799. Lysine catabolism.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-aminoadipic semialdehyde dehydrogenase (EC:1.2.1.31)
Short name:
Alpha-AASA dehydrogenase
Alternative name(s):
Aldehyde dehydrogenase family 7 member A1 (EC:1.2.1.3)
Antiquitin-1
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Delta1-piperideine-6-carboxylate dehydrogenase
Short name:
P6c dehydrogenase
Gene namesi
Name:Aldh7a1
Synonyms:Ald7a1
OrganismiRattus norvegicus (Rat)Curated
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1308614. Aldh7a1.

Subcellular locationi

Nucleus By similarity. Cytoplasmcytosol By similarity. Mitochondrion By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB-SubCell
  2. extracellular vesicular exosome Source: Ensembl
  3. mitochondrion Source: UniProtKB-SubCell
  4. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2626MitochondrionSequence AnalysisAdd
BLAST
Chaini27 – 539513Alpha-aminoadipic semialdehyde dehydrogenasePRO_0000056492Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei86 – 861N6-acetyllysine; alternateBy similarity
Modified residuei86 – 861N6-succinyllysine; alternateBy similarity
Modified residuei94 – 941N6-acetyllysine; alternateBy similarity
Modified residuei94 – 941N6-succinyllysine; alternateBy similarity
Modified residuei97 – 971N6-acetyllysine; alternateBy similarity
Modified residuei97 – 971N6-succinyllysine; alternateBy similarity
Modified residuei462 – 4621N6-acetyllysineBy similarity
Modified residuei500 – 5001N6-acetyllysineBy similarity
Modified residuei537 – 5371N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ64057.
PRIDEiQ64057.

Expressioni

Tissue specificityi

Abundant in kidney, liver, cochlea and outer hair cells but not inner hair cells or vestibular type I hair cells. Very low levels in lung, brain, intestine and pancreas.2 Publications

Gene expression databases

GenevestigatoriQ64057.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

MINTiMINT-4574870.
STRINGi10116.ENSRNOP00000020325.

Structurei

3D structure databases

ProteinModelPortaliQ64057.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00780000121975.
HOGENOMiHOG000271511.
HOVERGENiHBG050485.
InParanoidiQ64057.
KOiK14085.
OMAiNAIIVFE.
OrthoDBiEOG78D7JV.
PhylomeDBiQ64057.
TreeFamiTF300388.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLARPLCV QTVKASKLSR LWSRPAALMS TLLIHHPQYA WLQDLGLRED
60 70 80 90 100
NEGVFNGSWG GRGEVITTYC PANNEPIARV RQASMKDYEE TIGKAKKAWN
110 120 130 140 150
IWADIPAPKR GEIVRKIGDA LREKIQLLGR LVSLEMGKIL VEGIGEVQEY
160 170 180 190 200
VDVCDYAAGL SRMIGGPTLP SERPGHALME QWNPLGLVGI ITAFNFPVAV
210 220 230 240 250
FGWNNAIALI TGNVCLWKGA PTTSLVSIAV TKIIAKVLED NLLPGAICSL
260 270 280 290 300
TCGGADMGTA MARDERVNLL SFTGSTQVGK QVALMVQERF GKSLLELGGN
310 320 330 340 350
NAIIAFEDAD LSLVLPSALF AAVGTAGQRC TTVRRLFLHE SIHDEVVDRL
360 370 380 390 400
KNAYSQIRVG NPWDPNILYG PLHTKQAVSM FVQAVEEAKK EGGTVVYGGK
410 420 430 440 450
VMDHPGNYVE PTIVTGLVHD APIVHKETFA PILYVFKFKN EEEVFEWNNE
460 470 480 490 500
VKQGLSSSIF TKDLGRIFRW LGPKGSDCGI VNVNIPTSGA EIGGAFGGEK
510 520 530
HTGGGRESGS DAWKQYMRRS TCTINYSTAL PLAQGIKFQ
Length:539
Mass (Da):58,749
Last modified:April 20, 2010 - v2
Checksum:i90F355B926582E77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03109709 Genomic DNA. No translation available.
S75019 mRNA. Translation: AAB31967.2.
PIRiB54676.
RefSeqiNP_001258034.1. NM_001271105.1.
UniGeneiRn.7330.

Genome annotation databases

EnsembliENSRNOT00000020325; ENSRNOP00000020325; ENSRNOG00000014645.
GeneIDi291450.
KEGGirno:291450.
UCSCiRGD:1308614. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03109709 Genomic DNA. No translation available.
S75019 mRNA. Translation: AAB31967.2.
PIRiB54676.
RefSeqiNP_001258034.1. NM_001271105.1.
UniGeneiRn.7330.

3D structure databases

ProteinModelPortaliQ64057.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4574870.
STRINGi10116.ENSRNOP00000020325.

Proteomic databases

PaxDbiQ64057.
PRIDEiQ64057.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020325; ENSRNOP00000020325; ENSRNOG00000014645.
GeneIDi291450.
KEGGirno:291450.
UCSCiRGD:1308614. rat.

Organism-specific databases

CTDi501.
RGDi1308614. Aldh7a1.

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00780000121975.
HOGENOMiHOG000271511.
HOVERGENiHBG050485.
InParanoidiQ64057.
KOiK14085.
OMAiNAIIVFE.
OrthoDBiEOG78D7JV.
PhylomeDBiQ64057.
TreeFamiTF300388.

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.
ReactomeiREACT_346799. Lysine catabolism.

Miscellaneous databases

NextBioi632620.
PROiQ64057.

Gene expression databases

GenevestigatoriQ64057.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. Lubec G., Afjehi-Sadat L.
    Submitted (OCT-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 53-66 AND 144-154, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.
  3. "Homology between a human protein and a protein of the green garden pea."
    Lee P., Kuhl W., Gelbart T., Kamimura T., West C., Beutler E.
    Genomics 21:371-378(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 312-539, TISSUE SPECIFICITY.
    Tissue: Intestinal mucosa.
  4. "An ancient conserved gene expressed in the human inner ear: identification, expression analysis, and chromosomal mapping of human and mouse antiquitin (ATQ1)."
    Skvorak A.B., Robertson N.G., Yin Y., Weremowicz S., Her H., Bieber F.R., Beisel K.W., Lynch E.D., Beier D.R., Morton C.C.
    Genomics 46:191-199(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiAL7A1_RAT
AccessioniPrimary (citable) accession number: Q64057
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: April 20, 2010
Last modified: April 1, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.