Reviewed, UniProtKB/Swiss-Prot Q64057 (AL7A1_RAT)

Names and origin

Protein names

Recommended name:
    Alpha-aminoadipic semialdehyde dehydrogenase
      Short name=Alpha-AASA dehydrogenase
    EC=1.2.1.31
Alternative name(s):
    Delta1-piperideine-6-carboxylate dehydrogenease
      Short name=P6c dehydrogenase
    Aldehyde dehydrogenase family 7 member A1
    Antiquitin-1

Gene names

Name:	Aldh7a1
Synonyms:	Ald7a1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	228 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.
Subunit structure	Homotetramer By similarity. UniProtKB P83402
Tissue specificity	Abundant in kidney, liver, cochlea and outer hair cells but not inner hair cells or vestibular type I hair cells. Very low levels in lung, brain, intestine and pancreas. Ref.1 Ref.3
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-aminoadipate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 228	›228	Alpha-aminoadipic semialdehyde dehydrogenase		PRO_0000056492
Sites
	Active site	19	1	By similarity UniProtKB Q56694
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q64057-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: F5DA69254AF35C16	FASTA	228	25,158
	10 20 30 40 50 60 SLVLPSALFA AVGTAGQRCT TVRRLFLHES IHDEVVDRLK NDYSQIRVGN PWDPNILYGP 70 80 90 100 110 120 LHTKQAVSMF VQAVEEAKKE GGTVVYGGKV MDHPGNYVEP TIVTGLVHDA PIVHKETFAP 130 140 150 160 170 180 ILYVFKFKNE EEVFEWNNKV KQELSSSIFT KDLGRIFRWL GPKGSDCGIV NVNIPTSGAE 190 200 210 220 IGGAFGGEKH TGSGRESGSD AWKQYMRRST CTINYSTALP LAQGIKFQ

References

[1]	"Homology between a human protein and a protein of the green garden pea." Lee P., Kuhl W., Gelbart T., Kamimura T., West C., Beutler E. Genomics 21:371-378(1994) [PubMed: 8088832] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Intestinal mucosa.
[2]	Lubec G., Afjehi-Sadat L. Submitted (NOV-2006) to UniProtKB Cited for: PROTEIN SEQUENCE OF 25-38 AND 116-126, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Spinal cord.
[3]	"An ancient conserved gene expressed in the human inner ear: identification, expression analysis, and chromosomal mapping of human and mouse antiquitin (ATQ1)." Skvorak A.B., Robertson N.G., Yin Y., Weremowicz S., Her H., Bieber F.R., Beisel K.W., Lynch E.D., Beier D.R., Morton C.C. Genomics 46:191-199(1997) [PubMed: 9417906] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S75019 mRNA. Translation: AAB31967.2.
IPI	IPI00208917.
PIR	B54676.
UniGene	Rn.7330
3D structure databases
SMR	Q64057. Positions 1-216.
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000020325; ENSRNOP00000020325; ENSRNOG00000014645; Rattus norvegicus. [Genome view]
Organism-specific databases
RGD	1308614. Aldh7a1.
Phylogenomic databases
eggNOG	roNOG09457.
HOVERGEN	Q64057.
InParanoid	Q64057.
Enzyme and pathway databases
BRENDA	1.2.1.31. 248.
Gene expression databases
ArrayExpress	Q64057.
Genevestigator	Q64057.
GermOnline	ENSRNOG00000014645. Rattus norvegicus.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. Partial match. PS00687. ALDEHYDE_DEHYDR_GLU. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL7A1_RAT

Accession

Primary (citable) accession number: Q64057

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	November 1, 1996
Last modified:	January 19, 2010
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)