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Protein

Probable G-protein coupled receptor 176

Gene

Gpr176

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 176
Alternative name(s):
G-protein coupled receptor AGR9
RBU-15
Gene namesi
Name:Gpr176
Synonyms:Agr9, Gm1012
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi621718. Gpr176.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence analysisAdd
BLAST
Transmembranei42 – 6423Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini65 – 7713CytoplasmicSequence analysisAdd
BLAST
Transmembranei78 – 9821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini99 – 10810ExtracellularSequence analysis
Transmembranei109 – 12921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini130 – 15728CytoplasmicSequence analysisAdd
BLAST
Transmembranei158 – 17720Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini178 – 20427ExtracellularSequence analysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini226 – 26439CytoplasmicSequence analysisAdd
BLAST
Transmembranei265 – 28521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini286 – 30116ExtracellularSequence analysisAdd
BLAST
Transmembranei302 – 32221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini323 – 513191CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Probable G-protein coupled receptor 176PRO_0000069658Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ64017.

PTM databases

PhosphoSiteiQ64017.

Expressioni

Tissue specificityi

Expressed in brain, lung, heart, stomach, intestine, cultured aortic smooth muscle cells and cardiac myocytes.1 Publication

Gene expression databases

BgeeiENSRNOG00000005971.
GenevisibleiQ64017. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007882.

Structurei

3D structure databases

ProteinModelPortaliQ64017.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123027.
HOGENOMiHOG000231854.
HOVERGENiHBG080463.
InParanoidiQ64017.
KOiK08442.
OMAiIWAHAVV.
OrthoDBiEOG091G032V.
PhylomeDBiQ64017.
TreeFamiTF331506.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHNGSWVSP NTSHPRNTSG AQAGANSSAF GELSEAQLYR QFTTTVQVVI
60 70 80 90 100
FIGSLLGNFT VLWSTCRTTV FKSVTNRFIK NLACSGICAS VVCVPFDIIL
110 120 130 140 150
STSPHCCWWI YTMLFCKVLK FLHKVFCSVT VLSFPAIALD RYYSVLYPLE
160 170 180 190 200
RKISDAKSRE LVMYIWAHAV VASVPVFAVT NVADIYATST CTEVWSNSLG
210 220 230 240 250
HLVYVLIYNV TTVIVPVAVV FLFLILIRRA LSASQKKKVI IAALRTPQNT
260 270 280 290 300
ISIPYASQRE AELHATLLSM VTVFILCSVP YATLVVYQTV LNVPNTSVFL
310 320 330 340 350
LLTAIWLPKV SLLANPVLFL TVNRSVRKCL VGTLVQLHHR YSRRNVVSTG
360 370 380 390 400
SGVVEPSLEP SMRSGSQLLE MFHIGQQQIF KPSEDEEESE AKYLGSTDFQ
410 420 430 440 450
AKEVLTSSPE GEESQLAPSV PPPGTVDSVS RVSPVAPVEP GIFPDKYSLQ
460 470 480 490 500
FGFGPFELPP QWLSETRNSK KRLLPPLGNT PEELIQTKVP RVSRVERKMS
510
RNNKVSIFPK VDS
Length:513
Mass (Da):56,785
Last modified:November 22, 2005 - v2
Checksum:iEF191707F723FE2E
GO

Sequence cautioni

The sequence AAB31153 differs from that shown. Reason: Frameshift at positions 159, 170, 478 and 506. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti210 – 2101V → I in AAB31153 (PubMed:8018717).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73608 mRNA. Translation: AAB31153.1. Frameshift.
D38450 mRNA. Translation: BAA07482.1.
RefSeqiNP_001257915.1. NM_001270986.1.
UniGeneiRn.44656.

Genome annotation databases

EnsembliENSRNOT00000007882; ENSRNOP00000007882; ENSRNOG00000005971.
GeneIDi117257.
KEGGirno:117257.
UCSCiRGD:621718. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73608 mRNA. Translation: AAB31153.1. Frameshift.
D38450 mRNA. Translation: BAA07482.1.
RefSeqiNP_001257915.1. NM_001270986.1.
UniGeneiRn.44656.

3D structure databases

ProteinModelPortaliQ64017.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007882.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ64017.

Proteomic databases

PaxDbiQ64017.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007882; ENSRNOP00000007882; ENSRNOG00000005971.
GeneIDi117257.
KEGGirno:117257.
UCSCiRGD:621718. rat.

Organism-specific databases

CTDi11245.
RGDi621718. Gpr176.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123027.
HOGENOMiHOG000231854.
HOVERGENiHBG080463.
InParanoidiQ64017.
KOiK08442.
OMAiIWAHAVV.
OrthoDBiEOG091G032V.
PhylomeDBiQ64017.
TreeFamiTF331506.

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ64017.

Gene expression databases

BgeeiENSRNOG00000005971.
GenevisibleiQ64017. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP176_RAT
AccessioniPrimary (citable) accession number: Q64017
Secondary accession number(s): Q63231
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.