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Protein

Ras-related protein Rab-34

Gene

Rab34

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein transport. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes (By similarity). Involved in the redistribution of lysosomes to the peri-Golgi region (PubMed:12475955). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (PubMed:29290584).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 66GTPBy similarity8
Nucleotide bindingi107 – 111GTPBy similarity5
Nucleotide bindingi166 – 169GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: MGI
  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: MGI
  • guanyl nucleotide binding Source: MGI
  • Ral GTPase binding Source: MGI

GO - Biological processi

  • antigen processing and presentation Source: MGI
  • endocytosis Source: MGI
  • Golgi to plasma membrane protein transport Source: UniProtKB
  • lysosomal transport Source: ParkinsonsUK-UCL
  • lysosome localization Source: MGI
  • phagosome-lysosome fusion Source: ParkinsonsUK-UCL
  • phagosome maturation Source: UniProtKB
  • positive regulation of defense response to bacterium Source: ParkinsonsUK-UCL
  • positive regulation of protein localization to phagocytic vesicle Source: ParkinsonsUK-UCL
  • positive regulation of smoothened signaling pathway Source: UniProtKB
  • protein localization to plasma membrane Source: MGI

Keywordsi

Biological processCilium biogenesis/degradation, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-34
Alternative name(s):
Ras-related homolog
Ras-related protein Rab-39
Ras-related protein Rah
Gene namesi
Name:Rab34
Synonyms:Rab39, Rah, Rah1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104606 Rab34

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi82K → Q: Abolishes interaction with RILP and localization to the peri-Golgi region. 1 Publication1
Mutagenesisi82K → Y: Does not abolish interaction with RILP and localization to the peri-Golgi region. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212441 – 259Ras-related protein Rab-34Add BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei241PhosphoserineCombined sources1
Lipidationi257S-geranylgeranyl cysteineSequence analysis1
Lipidationi258S-geranylgeranyl cysteineSequence analysis1

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ64008
PaxDbiQ64008
PRIDEiQ64008

PTM databases

iPTMnetiQ64008
PhosphoSitePlusiQ64008
SwissPalmiQ64008

Expressioni

Gene expression databases

CleanExiMM_RAB34
MM_RAB39

Interactioni

Subunit structurei

Interacts with RILP.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202576, 3 interactors
IntActiQ64008, 7 interactors
STRINGi10090.ENSMUSP00000002128

Structurei

3D structure databases

ProteinModelPortaliQ64008
SMRiQ64008
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 89Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094 Eukaryota
ENOG410XPBI LUCA
HOVERGENiHBG106693
InParanoidiQ64008
KOiK07921
PhylomeDBiQ64008

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q64008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILAPVRRD RVLAELPQCL KKEAALHVRK DFHPRVTCAC QEHRTGTVGF
60 70 80 90 100
KISKVIVVGD LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGVP
110 120 130 140 150
FSLQLWDTAG QERFKCIAST YYRGAQAIII VFNLNDVASL EHTKQWLTDA
160 170 180 190 200
LKENDPSNVL LFLVGSKKDL STPAQYSLME KDALKVAQEI KAEYWAVSSL
210 220 230 240 250
TGENVREFFF RVAALTFEAN VLADVEKSGA RHIADVVRIN SDDKNLYLTA

SKKKATCCP
Length:259
Mass (Da):29,101
Last modified:January 31, 2002 - v2
Checksum:i158F5132F0DDE808
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52I → N in AAB20669 (PubMed:1752434).Curated1
Sequence conflicti224 – 225DV → EL (Ref. 3) Curated2
Sequence conflicti224 – 225DV → EL (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322068 mRNA Translation: AAK09398.1
AF327929 mRNA Translation: AAK11241.1
AB082927 mRNA Translation: BAC16803.1
BC038638 mRNA Translation: AAH38638.1
S72304 mRNA Translation: AAB20669.1
CCDSiCCDS25094.1
PIRiA41636
RefSeqiNP_001152954.1, NM_001159482.1
NP_258436.2, NM_033475.3
UniGeneiMm.275864

Genome annotation databases

GeneIDi19376
KEGGimmu:19376

Similar proteinsi

Entry informationi

Entry nameiRAB34_MOUSE
AccessioniPrimary (citable) accession number: Q64008
Secondary accession number(s): Q8BHJ0, Q99P59, Q99P90
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 31, 2002
Last modified: April 25, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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