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Protein

Ras-related protein Rab-34

Gene

Rab34

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes (By similarity). Involved in the redistribution of lysosomes to the peri-Golgi region.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 66GTPBy similarity8
Nucleotide bindingi107 – 111GTPBy similarity5
Nucleotide bindingi166 – 169GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: MGI
  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: MGI
  • guanyl nucleotide binding Source: MGI
  • Ral GTPase binding Source: MGI

GO - Biological processi

  • antigen processing and presentation Source: MGI
  • endocytosis Source: MGI
  • Golgi to plasma membrane protein transport Source: UniProtKB
  • lysosomal transport Source: ParkinsonsUK-UCL
  • lysosome localization Source: MGI
  • phagosome-lysosome fusion Source: UniProtKB
  • phagosome maturation Source: UniProtKB
  • positive regulation of defense response to bacterium Source: ParkinsonsUK-UCL
  • positive regulation of protein localization to phagocytic vesicle Source: ParkinsonsUK-UCL
  • protein localization to plasma membrane Source: MGI
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-34
Alternative name(s):
Ras-related homolog
Ras-related protein Rab-39
Ras-related protein Rah
Gene namesi
Name:Rab34
Synonyms:Rab39, Rah, Rah1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104606. Rab34.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Golgi apparatus 1 Publication
  • Cytoplasmic vesiclephagosome By similarity
  • Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

  • Note: Recruited to phagosomes containing S.aureus or Mycobacterium.By similarity

GO - Cellular componenti

  • cytoplasmic vesicle Source: ParkinsonsUK-UCL
  • early endosome Source: MGI
  • extracellular exosome Source: MGI
  • Golgi apparatus Source: ParkinsonsUK-UCL
  • Golgi cisterna Source: MGI
  • Golgi stack Source: MGI
  • late endosome Source: ParkinsonsUK-UCL
  • perinuclear region of cytoplasm Source: MGI
  • phagocytic vesicle Source: UniProtKB
  • phagocytic vesicle membrane Source: UniProtKB-SubCell
  • ruffle Source: MGI
  • vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi82K → Q: Abolishes interaction with RILP and localization to the peri-Golgi region. 1 Publication1
Mutagenesisi82K → Y: Does not abolish interaction with RILP and localization to the peri-Golgi region. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212441 – 259Ras-related protein Rab-34Add BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei241PhosphoserineCombined sources1
Lipidationi257S-geranylgeranyl cysteineSequence analysis1
Lipidationi258S-geranylgeranyl cysteineSequence analysis1

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ64008.
PaxDbiQ64008.
PRIDEiQ64008.

PTM databases

iPTMnetiQ64008.
PhosphoSitePlusiQ64008.
SwissPalmiQ64008.

Expressioni

Gene expression databases

CleanExiMM_RAB34.
MM_RAB39.

Interactioni

Subunit structurei

Interacts with RILP.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202576. 3 interactors.
IntActiQ64008. 7 interactors.
STRINGi10090.ENSMUSP00000002128.

Structurei

3D structure databases

ProteinModelPortaliQ64008.
SMRiQ64008.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 89Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
HOVERGENiHBG106693.
InParanoidiQ64008.
KOiK07921.
PhylomeDBiQ64008.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILAPVRRD RVLAELPQCL KKEAALHVRK DFHPRVTCAC QEHRTGTVGF
60 70 80 90 100
KISKVIVVGD LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGVP
110 120 130 140 150
FSLQLWDTAG QERFKCIAST YYRGAQAIII VFNLNDVASL EHTKQWLTDA
160 170 180 190 200
LKENDPSNVL LFLVGSKKDL STPAQYSLME KDALKVAQEI KAEYWAVSSL
210 220 230 240 250
TGENVREFFF RVAALTFEAN VLADVEKSGA RHIADVVRIN SDDKNLYLTA

SKKKATCCP
Length:259
Mass (Da):29,101
Last modified:January 31, 2002 - v2
Checksum:i158F5132F0DDE808
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52I → N in AAB20669 (PubMed:1752434).Curated1
Sequence conflicti224 – 225DV → EL (Ref. 3) Curated2
Sequence conflicti224 – 225DV → EL (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322068 mRNA. Translation: AAK09398.1.
AF327929 mRNA. Translation: AAK11241.1.
AB082927 mRNA. Translation: BAC16803.1.
BC038638 mRNA. Translation: AAH38638.1.
S72304 mRNA. Translation: AAB20669.1.
CCDSiCCDS25094.1.
PIRiA41636.
RefSeqiNP_001152954.1. NM_001159482.1.
NP_258436.2. NM_033475.3.
UniGeneiMm.275864.

Genome annotation databases

GeneIDi19376.
KEGGimmu:19376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322068 mRNA. Translation: AAK09398.1.
AF327929 mRNA. Translation: AAK11241.1.
AB082927 mRNA. Translation: BAC16803.1.
BC038638 mRNA. Translation: AAH38638.1.
S72304 mRNA. Translation: AAB20669.1.
CCDSiCCDS25094.1.
PIRiA41636.
RefSeqiNP_001152954.1. NM_001159482.1.
NP_258436.2. NM_033475.3.
UniGeneiMm.275864.

3D structure databases

ProteinModelPortaliQ64008.
SMRiQ64008.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202576. 3 interactors.
IntActiQ64008. 7 interactors.
STRINGi10090.ENSMUSP00000002128.

PTM databases

iPTMnetiQ64008.
PhosphoSitePlusiQ64008.
SwissPalmiQ64008.

Proteomic databases

MaxQBiQ64008.
PaxDbiQ64008.
PRIDEiQ64008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19376.
KEGGimmu:19376.

Organism-specific databases

CTDi83871.
MGIiMGI:104606. Rab34.

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
HOVERGENiHBG106693.
InParanoidiQ64008.
KOiK07921.
PhylomeDBiQ64008.

Miscellaneous databases

PROiQ64008.
SOURCEiSearch...

Gene expression databases

CleanExiMM_RAB34.
MM_RAB39.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB34_MOUSE
AccessioniPrimary (citable) accession number: Q64008
Secondary accession number(s): Q8BHJ0, Q99P59, Q99P90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 31, 2002
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.