ID   UXT_RAT                 Reviewed;         157 AA.
AC   Q63ZY7;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   24-JAN-2024, entry version 111.
DE   RecName: Full=Protein UXT;
DE   AltName: Full=Ubiquitously expressed transcript protein;
GN   Name=Uxt;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in gene transcription regulation. Acts in concert
CC       with the corepressor URI1 to regulate androgen receptor AR-mediated
CC       transcription. Together with URI1, associates with chromatin to the
CC       NKX3-1 promoter region. Negatively regulates the transcriptional
CC       activity of the estrogen receptor ESR1 by inducing its translocation
CC       into the cytoplasm. May act as nuclear chaperone that facilitates the
CC       formation of the NF-kappa-B enhanceosome and thus positively regulates
CC       NF-kappa-B transcription activity. Potential component of
CC       mitochondrial-associated LRPPRC, a multidomain organizer that
CC       potentially integrates mitochondria and the microtubular cytoskeleton
CC       with chromosome remodeling. Increasing concentrations of UXT
CC       contributes to progressive aggregation of mitochondria and cell death
CC       potentially through its association with LRPPRC. Suppresses cell
CC       transformation and it might mediate this function by interaction and
CC       inhibition of the biological activity of cell proliferation and
CC       survival stimulatory factors like MECOM.
CC       {ECO:0000250|UniProtKB:Q9UBK9}.
CC   -!- SUBUNIT: Homohexamer. Component of the PAQosome complex which is
CC       responsible for the biogenesis of several protein complexes and which
CC       consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI
CC       complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF,
CC       POLR2E and DNAAF10/WDR92. Interacts with LRPPRC. Interacts with
CC       androgen receptor AR (via N-terminus). Interacts with estrogen receptor
CC       ESR1; the interaction relocalizes ESR1 to the cytoplasm. In the
CC       nucleus, interacts specifically with RELA (via RHD domain) and forms a
CC       dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B
CC       enhanceosome upon stimulation. Interacts with MECOM. Interacts with
CC       URI1. {ECO:0000250|UniProtKB:Q9UBK9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UBK9}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9UBK9}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000250|UniProtKB:Q9UBK9}.
CC       Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9UBK9}.
CC       Note=Predominantly localizes to the nucleus. Localizes to spindle pole
CC       during mitosis. {ECO:0000250|UniProtKB:Q9UBK9}.
CC   -!- SIMILARITY: Belongs to the UXT family. {ECO:0000305}.
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DR   EMBL; BC082752; AAH82752.1; -; mRNA.
DR   RefSeq; NP_001006983.1; NM_001006982.1.
DR   RefSeq; XP_006256673.1; XM_006256611.3.
DR   AlphaFoldDB; Q63ZY7; -.
DR   SMR; Q63ZY7; -.
DR   STRING; 10116.ENSRNOP00000013476; -.
DR   PhosphoSitePlus; Q63ZY7; -.
DR   jPOST; Q63ZY7; -.
DR   PaxDb; 10116-ENSRNOP00000013476; -.
DR   Ensembl; ENSRNOT00000013476.8; ENSRNOP00000013476.4; ENSRNOG00000009893.8.
DR   Ensembl; ENSRNOT00055027734; ENSRNOP00055022266; ENSRNOG00055016355.
DR   Ensembl; ENSRNOT00060033807; ENSRNOP00060027693; ENSRNOG00060019565.
DR   Ensembl; ENSRNOT00065034173; ENSRNOP00065027353; ENSRNOG00065020248.
DR   GeneID; 299313; -.
DR   KEGG; rno:299313; -.
DR   UCSC; RGD:1359326; rat.
DR   AGR; RGD:1359326; -.
DR   CTD; 8409; -.
DR   RGD; 1359326; Uxt.
DR   eggNOG; KOG3047; Eukaryota.
DR   GeneTree; ENSGT00390000018078; -.
DR   HOGENOM; CLU_121199_1_0_1; -.
DR   InParanoid; Q63ZY7; -.
DR   OMA; IPQEPIM; -.
DR   OrthoDB; 73521at2759; -.
DR   PhylomeDB; Q63ZY7; -.
DR   TreeFam; TF323827; -.
DR   PRO; PR:Q63ZY7; -.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000009893; Expressed in ovary and 20 other cell types or tissues.
DR   GO; GO:0005813; C:centrosome; ISS:HGNC-UCL.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005856; C:cytoskeleton; ISS:HGNC-UCL.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:1990062; C:RPAP3/R2TP/prefoldin-like complex; ISO:RGD.
DR   GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR   GO; GO:0048487; F:beta-tubulin binding; ISS:HGNC-UCL.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
DR   GO; GO:0007098; P:centrosome cycle; ISS:HGNC-UCL.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; ISS:HGNC-UCL.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   CDD; cd00584; Prefoldin_alpha; 1.
DR   Gene3D; 1.10.287.370; -; 1.
DR   InterPro; IPR009053; Prefoldin.
DR   InterPro; IPR004127; Prefoldin_subunit_alpha.
DR   InterPro; IPR003994; UXT.
DR   PANTHER; PTHR13345; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10; 1.
DR   PANTHER; PTHR13345:SF12; PROTEIN UXT; 1.
DR   Pfam; PF02996; Prefoldin; 1.
DR   PRINTS; PR01502; UXTPROTEIN.
DR   SUPFAM; SSF46579; Prefoldin; 1.
DR   Genevisible; Q63ZY7; RN.
PE   2: Evidence at transcript level;
KW   Activator; Chaperone; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..157
FT                   /note="Protein UXT"
FT                   /id="PRO_0000330760"
SQ   SEQUENCE   157 AA;  18166 MW;  EC681FEE8D97A625 CRC64;
     MATPPKRRAL DTVGEKVLRY EAFISDVLQR DLQKVLDHRD KVYEQLSVYL QLRNVIERLQ
     ETNHSELYMQ VDLGCNFFVD TMVPDTSRIY VALGYGFFLE LTLAEALKFI DRKSSLLTEL
     SDSLTKDSMN IKANIHMMLE GLRELQGLQN FPEPSPH
//