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Q63ZY7 (UXT_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein UXT
Alternative name(s):
Ubiquitously expressed transcript protein
Gene names
Name:Uxt
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length157 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor (AR) transcription. AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Together with URI1, associates with chromatin to the NKX3-1 promoter region By similarity.

Subunit structure

Homohexamer. Interacts with LRPPRC. Interacts with AR N-terminus. In the nucleus interacts specifically with RELA and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation. Interacts with MECOM and URI1 By similarity.

Subcellular location

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the UXT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 157157Protein UXT
PRO_0000330760

Sequences

Sequence LengthMass (Da)Tools
Q63ZY7 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: EC681FEE8D97A625

FASTA15718,166
        10         20         30         40         50         60 
MATPPKRRAL DTVGEKVLRY EAFISDVLQR DLQKVLDHRD KVYEQLSVYL QLRNVIERLQ 

        70         80         90        100        110        120 
ETNHSELYMQ VDLGCNFFVD TMVPDTSRIY VALGYGFFLE LTLAEALKFI DRKSSLLTEL 

       130        140        150 
SDSLTKDSMN IKANIHMMLE GLRELQGLQN FPEPSPH 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC082752 mRNA. Translation: AAH82752.1.
RefSeqNP_001006983.1. NM_001006982.1.
XP_006256673.1. XM_006256611.1.
UniGeneRn.203381.

3D structure databases

ProteinModelPortalQ63ZY7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000013476.

Proteomic databases

PRIDEQ63ZY7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000013476; ENSRNOP00000013476; ENSRNOG00000009893.
GeneID299313.
KEGGrno:299313.
UCSCRGD:1359326. rat.

Organism-specific databases

CTD8409.
RGD1359326. Uxt.

Phylogenomic databases

eggNOGNOG263764.
GeneTreeENSGT00390000018078.
HOGENOMHOG000005748.
HOVERGENHBG001087.
InParanoidQ63ZY7.
OMADVDLGCN.
OrthoDBEOG7T7GW2.
PhylomeDBQ63ZY7.
TreeFamTF323827.

Gene expression databases

GenevestigatorQ63ZY7.

Family and domain databases

Gene3D1.10.287.370. 1 hit.
InterProIPR003994. PFD_UXT.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view]
PfamPF02996. Prefoldin. 1 hit.
[Graphical view]
PRINTSPR01502. UXTPROTEIN.
SUPFAMSSF46579. SSF46579. 1 hit.
ProtoNetSearch...

Other

NextBio645201.
PROQ63ZY7.

Entry information

Entry nameUXT_RAT
AccessionPrimary (citable) accession number: Q63ZY7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 25, 2004
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families