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Protein

Protein UXT

Gene

Uxt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chaperone, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UXT
Alternative name(s):
Ubiquitously expressed transcript protein
Gene namesi
Name:Uxt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1359326. Uxt.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003307601 – 157Protein UXTAdd BLAST157

Proteomic databases

PaxDbiQ63ZY7.
PRIDEiQ63ZY7.

PTM databases

PhosphoSitePlusiQ63ZY7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009893.
GenevisibleiQ63ZY7. RN.

Interactioni

Subunit structurei

Homohexamer. Interacts with LRPPRC. Interacts with androgen receptor AR (via N-terminus). Interacts with estrogen receptor ESR1; the interaction relocalizes ESR1 to the cytoplasm. In the nucleus, interacts specifically with RELA (via RHD domain) and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation. Interacts with MECOM. Interacts with URI1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013476.

Structurei

3D structure databases

ProteinModelPortaliQ63ZY7.
SMRiQ63ZY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UXT family.Curated

Phylogenomic databases

eggNOGiKOG3047. Eukaryota.
ENOG4111Q3P. LUCA.
GeneTreeiENSGT00390000018078.
HOGENOMiHOG000005748.
HOVERGENiHBG001087.
InParanoidiQ63ZY7.
OMAiQVNIGSN.
OrthoDBiEOG091G0UOM.
PhylomeDBiQ63ZY7.
TreeFamiTF323827.

Family and domain databases

InterProiView protein in InterPro
IPR004127. Prefoldin_subunit_alpha.
IPR003994. UXT.
PfamiView protein in Pfam
PF02996. Prefoldin. 1 hit.
PRINTSiPR01502. UXTPROTEIN.

Sequencei

Sequence statusi: Complete.

Q63ZY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPPKRRAL DTVGEKVLRY EAFISDVLQR DLQKVLDHRD KVYEQLSVYL
60 70 80 90 100
QLRNVIERLQ ETNHSELYMQ VDLGCNFFVD TMVPDTSRIY VALGYGFFLE
110 120 130 140 150
LTLAEALKFI DRKSSLLTEL SDSLTKDSMN IKANIHMMLE GLRELQGLQN

FPEPSPH
Length:157
Mass (Da):18,166
Last modified:October 25, 2004 - v1
Checksum:iEC681FEE8D97A625
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082752 mRNA. Translation: AAH82752.1.
RefSeqiNP_001006983.1. NM_001006982.1.
XP_006256673.1. XM_006256611.3.
UniGeneiRn.203381.

Genome annotation databases

EnsembliENSRNOT00000013476; ENSRNOP00000013476; ENSRNOG00000009893.
GeneIDi299313.
KEGGirno:299313.
UCSCiRGD:1359326. rat.

Similar proteinsi

Entry informationi

Entry nameiUXT_RAT
AccessioniPrimary (citable) accession number: Q63ZY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 25, 2004
Last modified: October 25, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families