Q63ZY7 (UXT_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein UXT

Alternative name(s):
Ubiquitously expressed transcript protein

Gene names

Name:

Uxt

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	157 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor (AR) transcription. AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Together with URI1, associates with chromatin to the NKX3-1 promoter region By similarity.
Subunit structure	Homohexamer. Interacts with LRPPRC. Interacts with AR N-terminus. In the nucleus interacts specifically with RELA and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation. Interacts with MECOM and URI1 By similarity.
Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton By similarity. Cytoplasm › cytoskeleton › centrosome By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the UXT family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Cytoskeleton Nucleus
Molecular function	Activator Chaperone Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	centrosome organization Inferred from sequence or structural similarity. Source: HGNC protein folding Inferred from electronic annotation. Source: InterPro
Cellular_component	centrosome Inferred from sequence or structural similarity. Source: HGNC cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB gamma-tubulin complex Inferred from electronic annotation. Source: Compara nucleus Inferred from sequence or structural similarity. Source: UniProtKB prefoldin complex Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA polymerase II transcription corepressor activity Inferred from sequence or structural similarity. Source: UniProtKB beta-tubulin binding Inferred from sequence or structural similarity. Source: HGNC chromatin binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 157	157	Protein UXT		PRO_0000330760

Sequences

	Sequence		Length	Mass (Da)
	Q63ZY7 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: EC681FEE8D97A625	FASTA	157	18,166
	10 20 30 40 50 60 MATPPKRRAL DTVGEKVLRY EAFISDVLQR DLQKVLDHRD KVYEQLSVYL QLRNVIERLQ 70 80 90 100 110 120 ETNHSELYMQ VDLGCNFFVD TMVPDTSRIY VALGYGFFLE LTLAEALKFI DRKSSLLTEL 130 140 150 SDSLTKDSMN IKANIHMMLE GLRELQGLQN FPEPSPH

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC082752 mRNA. Translation: AAH82752.1.
IPI	IPI00365895.
RefSeq	NP_001006983.1. NM_001006982.1.
UniGene	Rn.203381.
3D structure databases
ProteinModelPortal	Q63ZY7.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000013476.
Proteomic databases
PRIDE	Q63ZY7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000013476; ENSRNOP00000013476; ENSRNOG00000009893.
GeneID	299313.
KEGG	rno:299313.
UCSC	RGD:1359326. rat.
Organism-specific databases
CTD	8409.
RGD	1359326. Uxt.
Phylogenomic databases
eggNOG	NOG263764.
GeneTree	ENSGT00390000018078.
HOGENOM	HOG000005748.
HOVERGEN	HBG001087.
InParanoid	Q63ZY7.
OMA	DVDLGCN.
OrthoDB	EOG4Z36G3.
Gene expression databases
Genevestigator	Q63ZY7.
Family and domain databases
InterPro	IPR003994. PFD_UXT. IPR009053. Prefoldin. IPR004127. Prefoldin_subunit. [Graphical view]
Pfam	PF02996. Prefoldin. 1 hit. [Graphical view]
PRINTS	PR01502. UXTPROTEIN.
SUPFAM	SSF46579. Prefoldin. 1 hit.
ProtoNet	Search...
Other
NextBio	645201.

Entry information

Entry name

UXT_RAT

Accession

Primary (citable) accession number: Q63ZY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	October 25, 2004
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program