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Q63ZY7

- UXT_RAT

UniProt

Q63ZY7 - UXT_RAT

Protein

Protein UXT

Gene

Uxt

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor (AR) transcription. AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Together with URI1, associates with chromatin to the NKX3-1 promoter region By similarity.By similarity

    GO - Molecular functioni

    1. beta-tubulin binding Source: HGNC
    2. chromatin binding Source: UniProtKB
    3. RNA polymerase II transcription corepressor activity Source: UniProtKB

    GO - Biological processi

    1. centrosome organization Source: HGNC
    2. microtubule cytoskeleton organization Source: HGNC
    3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. protein folding Source: InterPro

    Keywords - Molecular functioni

    Activator, Chaperone, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein UXT
    Alternative name(s):
    Ubiquitously expressed transcript protein
    Gene namesi
    Name:Uxt
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi1359326. Uxt.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. centrosome Source: HGNC
    2. cytoplasm Source: UniProtKB
    3. cytoskeleton Source: HGNC
    4. gamma-tubulin complex Source: Ensembl
    5. nucleus Source: UniProtKB
    6. prefoldin complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 157157Protein UXTPRO_0000330760Add
    BLAST

    Proteomic databases

    PRIDEiQ63ZY7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ63ZY7.

    Interactioni

    Subunit structurei

    Homohexamer. Interacts with LRPPRC. Interacts with AR N-terminus. In the nucleus interacts specifically with RELA and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation. Interacts with MECOM and URI1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000013476.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63ZY7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UXT family.Curated

    Phylogenomic databases

    eggNOGiNOG263764.
    GeneTreeiENSGT00390000018078.
    HOGENOMiHOG000005748.
    HOVERGENiHBG001087.
    InParanoidiQ63ZY7.
    OMAiDVDLGCN.
    OrthoDBiEOG7T7GW2.
    PhylomeDBiQ63ZY7.
    TreeFamiTF323827.

    Family and domain databases

    Gene3Di1.10.287.370. 1 hit.
    InterProiIPR003994. PFD_UXT.
    IPR009053. Prefoldin.
    IPR004127. Prefoldin_subunit_alpha.
    [Graphical view]
    PfamiPF02996. Prefoldin. 1 hit.
    [Graphical view]
    PRINTSiPR01502. UXTPROTEIN.
    SUPFAMiSSF46579. SSF46579. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q63ZY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATPPKRRAL DTVGEKVLRY EAFISDVLQR DLQKVLDHRD KVYEQLSVYL    50
    QLRNVIERLQ ETNHSELYMQ VDLGCNFFVD TMVPDTSRIY VALGYGFFLE 100
    LTLAEALKFI DRKSSLLTEL SDSLTKDSMN IKANIHMMLE GLRELQGLQN 150
    FPEPSPH 157
    Length:157
    Mass (Da):18,166
    Last modified:October 25, 2004 - v1
    Checksum:iEC681FEE8D97A625
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC082752 mRNA. Translation: AAH82752.1.
    RefSeqiNP_001006983.1. NM_001006982.1.
    XP_006256673.1. XM_006256611.1.
    UniGeneiRn.203381.

    Genome annotation databases

    EnsembliENSRNOT00000013476; ENSRNOP00000013476; ENSRNOG00000009893.
    GeneIDi299313.
    KEGGirno:299313.
    UCSCiRGD:1359326. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC082752 mRNA. Translation: AAH82752.1 .
    RefSeqi NP_001006983.1. NM_001006982.1.
    XP_006256673.1. XM_006256611.1.
    UniGenei Rn.203381.

    3D structure databases

    ProteinModelPortali Q63ZY7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000013476.

    Proteomic databases

    PRIDEi Q63ZY7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000013476 ; ENSRNOP00000013476 ; ENSRNOG00000009893 .
    GeneIDi 299313.
    KEGGi rno:299313.
    UCSCi RGD:1359326. rat.

    Organism-specific databases

    CTDi 8409.
    RGDi 1359326. Uxt.

    Phylogenomic databases

    eggNOGi NOG263764.
    GeneTreei ENSGT00390000018078.
    HOGENOMi HOG000005748.
    HOVERGENi HBG001087.
    InParanoidi Q63ZY7.
    OMAi DVDLGCN.
    OrthoDBi EOG7T7GW2.
    PhylomeDBi Q63ZY7.
    TreeFami TF323827.

    Miscellaneous databases

    NextBioi 645201.
    PROi Q63ZY7.

    Gene expression databases

    Genevestigatori Q63ZY7.

    Family and domain databases

    Gene3Di 1.10.287.370. 1 hit.
    InterProi IPR003994. PFD_UXT.
    IPR009053. Prefoldin.
    IPR004127. Prefoldin_subunit_alpha.
    [Graphical view ]
    Pfami PF02996. Prefoldin. 1 hit.
    [Graphical view ]
    PRINTSi PR01502. UXTPROTEIN.
    SUPFAMi SSF46579. SSF46579. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiUXT_RAT
    AccessioniPrimary (citable) accession number: Q63ZY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3