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Q63ZY7

- UXT_RAT

UniProt

Q63ZY7 - UXT_RAT

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Protein

Protein UXT

Gene

Uxt

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor (AR) transcription. AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Together with URI1, associates with chromatin to the NKX3-1 promoter region (By similarity).By similarity

GO - Molecular functioni

  1. beta-tubulin binding Source: HGNC
  2. chromatin binding Source: UniProtKB
  3. RNA polymerase II transcription corepressor activity Source: UniProtKB

GO - Biological processi

  1. centrosome organization Source: HGNC
  2. microtubule cytoskeleton organization Source: HGNC
  3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chaperone, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UXT
Alternative name(s):
Ubiquitously expressed transcript protein
Gene namesi
Name:Uxt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi1359326. Uxt.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Nucleus By similarity

GO - Cellular componenti

  1. centrosome Source: HGNC
  2. cytoplasm Source: UniProtKB
  3. cytoskeleton Source: HGNC
  4. gamma-tubulin complex Source: Ensembl
  5. nucleus Source: UniProtKB
  6. prefoldin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 157157Protein UXTPRO_0000330760Add
BLAST

Proteomic databases

PRIDEiQ63ZY7.

Expressioni

Gene expression databases

GenevestigatoriQ63ZY7.

Interactioni

Subunit structurei

Homohexamer. Interacts with LRPPRC. Interacts with AR N-terminus. In the nucleus interacts specifically with RELA and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation. Interacts with MECOM and URI1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013476.

Structurei

3D structure databases

ProteinModelPortaliQ63ZY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UXT family.Curated

Phylogenomic databases

eggNOGiNOG263764.
GeneTreeiENSGT00390000018078.
HOGENOMiHOG000005748.
HOVERGENiHBG001087.
InParanoidiQ63ZY7.
OMAiDVDLGCN.
OrthoDBiEOG7T7GW2.
PhylomeDBiQ63ZY7.
TreeFamiTF323827.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR003994. PFD_UXT.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view]
PfamiPF02996. Prefoldin. 1 hit.
[Graphical view]
PRINTSiPR01502. UXTPROTEIN.
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63ZY7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATPPKRRAL DTVGEKVLRY EAFISDVLQR DLQKVLDHRD KVYEQLSVYL
60 70 80 90 100
QLRNVIERLQ ETNHSELYMQ VDLGCNFFVD TMVPDTSRIY VALGYGFFLE
110 120 130 140 150
LTLAEALKFI DRKSSLLTEL SDSLTKDSMN IKANIHMMLE GLRELQGLQN

FPEPSPH
Length:157
Mass (Da):18,166
Last modified:October 25, 2004 - v1
Checksum:iEC681FEE8D97A625
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082752 mRNA. Translation: AAH82752.1.
RefSeqiNP_001006983.1. NM_001006982.1.
XP_006256673.1. XM_006256611.2.
UniGeneiRn.203381.

Genome annotation databases

EnsembliENSRNOT00000013476; ENSRNOP00000013476; ENSRNOG00000009893.
GeneIDi299313.
KEGGirno:299313.
UCSCiRGD:1359326. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082752 mRNA. Translation: AAH82752.1 .
RefSeqi NP_001006983.1. NM_001006982.1.
XP_006256673.1. XM_006256611.2.
UniGenei Rn.203381.

3D structure databases

ProteinModelPortali Q63ZY7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000013476.

Proteomic databases

PRIDEi Q63ZY7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000013476 ; ENSRNOP00000013476 ; ENSRNOG00000009893 .
GeneIDi 299313.
KEGGi rno:299313.
UCSCi RGD:1359326. rat.

Organism-specific databases

CTDi 8409.
RGDi 1359326. Uxt.

Phylogenomic databases

eggNOGi NOG263764.
GeneTreei ENSGT00390000018078.
HOGENOMi HOG000005748.
HOVERGENi HBG001087.
InParanoidi Q63ZY7.
OMAi DVDLGCN.
OrthoDBi EOG7T7GW2.
PhylomeDBi Q63ZY7.
TreeFami TF323827.

Miscellaneous databases

NextBioi 645201.
PROi Q63ZY7.

Gene expression databases

Genevestigatori Q63ZY7.

Family and domain databases

Gene3Di 1.10.287.370. 1 hit.
InterProi IPR003994. PFD_UXT.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view ]
Pfami PF02996. Prefoldin. 1 hit.
[Graphical view ]
PRINTSi PR01502. UXTPROTEIN.
SUPFAMi SSF46579. SSF46579. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiUXT_RAT
AccessioniPrimary (citable) accession number: Q63ZY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 25, 2004
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3