Q63ZY3 (KANK2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
KN motif and ankyrin repeat domain-containing protein 2

Alternative name(s):
Ankyrin repeat domain-containing protein 25
Matrix-remodeling-associated protein 3
SRC-1-interacting protein
Short name=SIP
Short name=SRC-interacting protein
Short name=SRC1-interacting protein

Gene names

Name:	KANK2
Synonyms:	ANKRD25, KIAA1518, MXRA3, SIP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	851 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation. Ref.1 Ref.9 Ref.14
Subunit structure	Interacts (phosphorylated) with NCOA1; NCOA2 AND NCOA3. Interacts with AIFM1. Ref.1 Ref.14
Subcellular location	Cytoplasm. Mitochondrion Ref.1 Ref.9.
Tissue specificity	Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level). Ref.9 Ref.13
Post-translational modification	Phosphorylated by CaMK2 upon estrogen stimulation. Ref.1
Sequence similarities	Contains 5 ANK repeats.
Sequence caution	The sequence BAA92081.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA96042.2 differs from that shown. Reason: Erroneous initiation. The sequence BAB14531.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Apoptosis Transcription Transcription regulation
Cellular component	Cytoplasm Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Coiled coil Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of G1/S transition of mitotic cell cycle Inferred from direct assay Ref.1. Source: UniProtKB negative regulation of cell proliferation Inferred from direct assay Ref.1. Source: UniProtKB negative regulation of intracellular estrogen receptor signaling pathway Inferred from direct assay Ref.1. Source: UniProtKB negative regulation of programmed cell death Inferred from direct assay Ref.14. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay Ref.1. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from direct assay Ref.14. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
AIFM1	O95831	4	EBI-6244894,EBI-356440

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q63ZY3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q63ZY3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     472-472: T → TAPPLSSPP

Note: No experimental confirmation available.

Isoform 3 (identifier: Q63ZY3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     835-841: FAPMSDD → VSLNPAG
     842-851: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 851

851

KN motif and ankyrin repeat domain-containing protein 2

PRO_0000240840

Regions

Repeat

666 – 696

31

ANK 1

Repeat

700 – 733

34

ANK 2

Repeat

738 – 767

30

ANK 3

Repeat

771 – 801

31

ANK 4

Repeat

805 – 835

31

ANK 5

Region

1 – 72

72

Interaction with AIFM1

Region

669 – 835

167

Interaction with NCOA1

Coiled coil

183 – 234

52

Potential

Coiled coil

282 – 312

31

Potential

Compositional bias

425 – 428

4

Poly-Ser

Amino acid modifications

Modified residue

19

1

Phosphoserine Ref.7

Modified residue

246

1

Phosphoserine By similarity

Modified residue

356

1

Phosphoserine Ref.10

Modified residue

375

1

Phosphoserine Ref.7 Ref.11 Ref.12

Modified residue

472

1

Phosphothreonine Ref.10

Natural variations

Alternative sequence

472

1

T → TAPPLSSPP in isoform 2.

VSP_019427

Alternative sequence

835 – 841

7

FAPMSDD → VSLNPAG in isoform 3.

VSP_019428

Alternative sequence

842 – 851

10

Missing in isoform 3.

VSP_019429

Natural variant

118

1

G → S.
Corresponds to variant rs755237 [ dbSNP | Ensembl ].

VAR_048304

Natural variant

401

1

M → T.
Corresponds to variant rs17616661 [ dbSNP | Ensembl ].

VAR_048305

Experimental info

Mutagenesis

510 – 512

3

SSS → AAA: Impairs phosphorylation; when associated with A-515. Ref.1

Mutagenesis

515

1

S → A: Impairs phosphorylation; when associated with 510-A--A-512. Ref.1

Sequence conflict

525

1

D → N in BAA96042. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

851

Helix Strand Turn

Details...

Helix

592 – 606

15

Helix

613 – 632

20

Helix

638 – 651

14

Helix

653 – 660

8

Helix

670 – 676

7

Helix

680 – 688

9

Helix

704 – 707

4

Helix

708 – 710

3

Helix

716 – 728

13

Turn

736 – 738

3

Helix

742 – 748

7

Helix

752 – 760

9

Helix

775 – 782

8

Helix

785 – 792

8

Helix

809 – 816

8

Helix

819 – 828

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: C14CD8B937A7B6E8	FASTA	851	91,174
	10 20 30 40 50 60 MAQVLHVPAP FPGTPGPASP PAFPAKDPDP PYSVETPYGY RLDLDFLKYV DDIEKGHTLR 70 80 90 100 110 120 RVAVQRRPRL SSLPRGPGSW WTSTESLCSN ASGDSRHSAY SYCGRGFYPQ YGALETRGGF 130 140 150 160 170 180 NPRVERTLLD ARRRLEDQAA TPTGLGSLTP SAAGSTASLV GVGLPPPTPR SSGLSTPVPP 190 200 210 220 230 240 SAGHLAHVRE QMAGALRKLR QLEEQVKLIP VLQVKLSVLQ EEKRQLTVQL KSQKFLGHPT 250 260 270 280 290 300 AGRGRSELCL DLPDPPEDPV ALETRSVGTW VRERDLGMPD GEAALAAKVA VLETQLKKAL 310 320 330 340 350 360 QELQAAQARQ ADPQPQAWPP PDSPVRVDTV RVVEGPREVE VVASTAAGAP AQRAQSLEPY 370 380 390 400 410 420 GTGLRALAMP GRPESPPVFR SQEVVETMCP VPAAATSNVH MVKKISITER SCDGAAGLPE 430 440 450 460 470 480 VPAESSSSPP GSEVASLTQP EKSTGRVPTQ EPTHREPTRQ AASQESEEAG GTGGPPAGVR 490 500 510 520 530 540 SIMKRKEEVA DPTAHRRSLQ FVGVNGGYES SSEDSSTAEN ISDNDSTENE APEPRERVPS 550 560 570 580 590 600 VAEAPQLRPA GTAAAKTSRQ ECQLSRESQH IPTAEGASGS NTEEEIRMEL SPDLISACLA 610 620 630 640 650 660 LEKYLDNPNA LTERELKVAY TTVLQEWLRL ACRSDAHPEL VRRHLVTFRA MSARLLDYVV 670 680 690 700 710 720 NIADSNGNTA LHYSVSHANF PVVQQLLDSG VCKVDKQNRA GYSPIMLTAL ATLKTQDDIE 730 740 750 760 770 780 TVLQLFRLGN INAKASQAGQ TALMLAVSHG RVDVVKALLA CEADVNVQDD DGSTALMCAC 790 800 810 820 830 840 EHGHKEIAGL LLAVPSCDIS LTDRDGSTAL MVALDAGQSE IASMLYSRMN IKCSFAPMSD 850 DESPTSSSAE E
	Isoform 2 [UniParc]. Checksum: 0629BE4E0E29FCEE	FASTA	859	91,921
	10 20 30 40 50 60 MAQVLHVPAP FPGTPGPASP PAFPAKDPDP PYSVETPYGY RLDLDFLKYV DDIEKGHTLR 70 80 90 100 110 120 RVAVQRRPRL SSLPRGPGSW WTSTESLCSN ASGDSRHSAY SYCGRGFYPQ YGALETRGGF 130 140 150 160 170 180 NPRVERTLLD ARRRLEDQAA TPTGLGSLTP SAAGSTASLV GVGLPPPTPR SSGLSTPVPP 190 200 210 220 230 240 SAGHLAHVRE QMAGALRKLR QLEEQVKLIP VLQVKLSVLQ EEKRQLTVQL KSQKFLGHPT 250 260 270 280 290 300 AGRGRSELCL DLPDPPEDPV ALETRSVGTW VRERDLGMPD GEAALAAKVA VLETQLKKAL 310 320 330 340 350 360 QELQAAQARQ ADPQPQAWPP PDSPVRVDTV RVVEGPREVE VVASTAAGAP AQRAQSLEPY 370 380 390 400 410 420 GTGLRALAMP GRPESPPVFR SQEVVETMCP VPAAATSNVH MVKKISITER SCDGAAGLPE 430 440 450 460 470 480 VPAESSSSPP GSEVASLTQP EKSTGRVPTQ EPTHREPTRQ AASQESEEAG GTAPPLSSPP 490 500 510 520 530 540 GGPPAGVRSI MKRKEEVADP TAHRRSLQFV GVNGGYESSS EDSSTAENIS DNDSTENEAP 550 560 570 580 590 600 EPRERVPSVA EAPQLRPAGT AAAKTSRQEC QLSRESQHIP TAEGASGSNT EEEIRMELSP 610 620 630 640 650 660 DLISACLALE KYLDNPNALT ERELKVAYTT VLQEWLRLAC RSDAHPELVR RHLVTFRAMS 670 680 690 700 710 720 ARLLDYVVNI ADSNGNTALH YSVSHANFPV VQQLLDSGVC KVDKQNRAGY SPIMLTALAT 730 740 750 760 770 780 LKTQDDIETV LQLFRLGNIN AKASQAGQTA LMLAVSHGRV DVVKALLACE ADVNVQDDDG 790 800 810 820 830 840 STALMCACEH GHKEIAGLLL AVPSCDISLT DRDGSTALMV ALDAGQSEIA SMLYSRMNIK 850 CSFAPMSDDE SPTSSSAEE
	Isoform 3 [UniParc]. Checksum: D82155CD26E514F1	FASTA	841	90,044
	10 20 30 40 50 60 MAQVLHVPAP FPGTPGPASP PAFPAKDPDP PYSVETPYGY RLDLDFLKYV DDIEKGHTLR 70 80 90 100 110 120 RVAVQRRPRL SSLPRGPGSW WTSTESLCSN ASGDSRHSAY SYCGRGFYPQ YGALETRGGF 130 140 150 160 170 180 NPRVERTLLD ARRRLEDQAA TPTGLGSLTP SAAGSTASLV GVGLPPPTPR SSGLSTPVPP 190 200 210 220 230 240 SAGHLAHVRE QMAGALRKLR QLEEQVKLIP VLQVKLSVLQ EEKRQLTVQL KSQKFLGHPT 250 260 270 280 290 300 AGRGRSELCL DLPDPPEDPV ALETRSVGTW VRERDLGMPD GEAALAAKVA VLETQLKKAL 310 320 330 340 350 360 QELQAAQARQ ADPQPQAWPP PDSPVRVDTV RVVEGPREVE VVASTAAGAP AQRAQSLEPY 370 380 390 400 410 420 GTGLRALAMP GRPESPPVFR SQEVVETMCP VPAAATSNVH MVKKISITER SCDGAAGLPE 430 440 450 460 470 480 VPAESSSSPP GSEVASLTQP EKSTGRVPTQ EPTHREPTRQ AASQESEEAG GTGGPPAGVR 490 500 510 520 530 540 SIMKRKEEVA DPTAHRRSLQ FVGVNGGYES SSEDSSTAEN ISDNDSTENE APEPRERVPS 550 560 570 580 590 600 VAEAPQLRPA GTAAAKTSRQ ECQLSRESQH IPTAEGASGS NTEEEIRMEL SPDLISACLA 610 620 630 640 650 660 LEKYLDNPNA LTERELKVAY TTVLQEWLRL ACRSDAHPEL VRRHLVTFRA MSARLLDYVV 670 680 690 700 710 720 NIADSNGNTA LHYSVSHANF PVVQQLLDSG VCKVDKQNRA GYSPIMLTAL ATLKTQDDIE 730 740 750 760 770 780 TVLQLFRLGN INAKASQAGQ TALMLAVSHG RVDVVKALLA CEADVNVQDD DGSTALMCAC 790 800 810 820 830 840 EHGHKEIAGL LLAVPSCDIS LTDRDGSTAL MVALDAGQSE IASMLYSRMN IKCSVSLNPA G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm." Zhang Y., Zhang H., Liang J., Yu W., Shang Y. EMBO J. 26:2645-2657(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH NCOA1; NCOA2 AND NCOA3, SUBCELLULAR LOCATION, PHOSPHORYLATION, MUTAGENESIS OF 510-SER--SER-512 AND SER-515.
[2]	Zhu Y., Kakinuma N., Wang Y., Kiyama R. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Spleen.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cervix and Lung.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 386-841 (ISOFORM 3). Tissue: Ovary and Placenta.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19 AND SER-375, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Embryonic kidney.
[9]	"Kank proteins: a new family of ankyrin-repeat domain-containing proteins." Zhu Y., Kakinuma N., Wang Y., Kiyama R. Biochim. Biophys. Acta 1780:128-133(2008) [PubMed] [Europe PMC] [Abstract] Cited for: POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356 AND THR-472, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375, MASS SPECTROMETRY.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Expression of novel podocyte-associated proteins sult1b1 and ankrd25." Xu X., Patrakka J., Sistani L., Uhlen M., Jalanko H., Betsholtz C., Tryggvason K. Nephron Exp. Nephrol. 117:E39-E46(2011) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[14]	"Steroid receptor coactivator-interacting protein (SIP) inhibits caspase-independent apoptosis by preventing apoptosis-inducing factor (AIF) from being released from mitochondria." Wang D., Liang J., Zhang Y., Gui B., Wang F., Yi X., Sun L., Yao Z., Shang Y. J. Biol. Chem. 287:12612-12621(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH AIFM1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY639929 mRNA. Translation: AAT57879.1.
AB284125 mRNA. Translation: BAG06864.1.
AB040951 mRNA. Translation: BAA96042.2. Different initiation.
CH471106 Genomic DNA. Translation: EAW84177.1.
BC082762 mRNA. Translation: AAH82762.1.
BC098105 mRNA. Translation: AAH98105.1.
BC098286 mRNA. Translation: AAH98286.1.
BC098312 mRNA. Translation: AAH98312.1.
BC105989 mRNA. Translation: AAI05990.1.
AK002094 mRNA. Translation: BAA92081.1. Different initiation.
AK023332 mRNA. Translation: BAB14531.1. Different initiation.

IPI

IPI00470559.
IPI00760928.
IPI00760962.

RefSeq

NP_001129663.1. NM_001136191.2.
NP_056308.3. NM_015493.6.

UniGene

Hs.284208.
Hs.723365.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4HBD	X-ray	1.72	A	578-832	[»]

ProteinModelPortal

Q63ZY3.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q63ZY3. 10 interactions.

MINT

MINT-4540700.

STRING

9606.ENSP00000347276.

PTM databases

PhosphoSite

Q63ZY3.

Polymorphism databases

DMDM

74757262.

Proteomic databases

PaxDb

Q63ZY3.

PRIDE

Q63ZY3.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000355150; ENSP00000347276; ENSG00000197256.
ENST00000432929; ENSP00000395650; ENSG00000197256.
ENST00000586659; ENSP00000465650; ENSG00000197256.
ENST00000589359; ENSP00000468002; ENSG00000197256.
ENST00000589894; ENSP00000467029; ENSG00000197256.

GeneID

25959.

KEGG

hsa:25959.

UCSC

uc002mqm.3. human.
uc002mqo.4. human.
uc002mqp.1. human.

Organism-specific databases

CTD

25959.

GeneCards

GC19M011274.

HGNC

HGNC:29300. KANK2.

HPA

HPA015643.

MIM

614610. gene.

neXtProt

NX_Q63ZY3.

PharmGKB

PA162392581.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0666.

HOVERGEN

HBG062256.

InParanoid

Q63ZY3.

OMA

SVGTWVR.

OrthoDB

EOG4HQDHX.

Gene expression databases

ArrayExpress

Q63ZY3.

Bgee

Q63ZY3.

CleanEx

HS_KANK2.

Genevestigator

Q63ZY3.

GermOnline

ENSG00000197256. Homo sapiens.

Family and domain databases

Gene3D

1.25.40.20. 1 hit.

InterPro

IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021939. KN_motif.
[Graphical view]

Pfam

PF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF12075. KN_motif. 1 hit.
[Graphical view]

SMART

SM00248. ANK. 5 hits.
[Graphical view]

SUPFAM

SSF48403. ANK. 1 hit.

PROSITE

PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

25959.

NextBio

47574.

SOURCE

Search...

Entry information

Entry name

KANK2_HUMAN

Accession

Primary (citable) accession number: Q63ZY3
Secondary accession number(s): B0I1P4 , Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 25, 2004
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.