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Q63ZY3

- KANK2_HUMAN

UniProt

Q63ZY3 - KANK2_HUMAN

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Protein
KN motif and ankyrin repeat domain-containing protein 2
Gene
KANK2, ANKRD25, KIAA1518, MXRA3, SIP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation.3 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
  3. negative regulation of cell proliferation Source: UniProtKB
  4. negative regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
  5. negative regulation of programmed cell death Source: UniProtKB
  6. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
KN motif and ankyrin repeat domain-containing protein 2
Alternative name(s):
Ankyrin repeat domain-containing protein 25
Matrix-remodeling-associated protein 3
SRC-1-interacting protein
Short name:
SIP
Short name:
SRC-interacting protein
Short name:
SRC1-interacting protein
Gene namesi
Name:KANK2
Synonyms:ANKRD25, KIAA1518, MXRA3, SIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:29300. KANK2.

Subcellular locationi

Cytoplasm. Mitochondrion 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi510 – 5123SSS → AAA: Impairs phosphorylation; when associated with A-515. 1 Publication
Mutagenesisi515 – 5151S → A: Impairs phosphorylation; when associated with 510-A--A-512. 1 Publication

Organism-specific databases

PharmGKBiPA162392581.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 851851KN motif and ankyrin repeat domain-containing protein 2
PRO_0000240840Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Phosphoserine1 Publication
Modified residuei356 – 3561Phosphoserine1 Publication
Modified residuei375 – 3751Phosphoserine3 Publications
Modified residuei472 – 4721Phosphothreonine1 Publication

Post-translational modificationi

Phosphorylated by CaMK2 upon estrogen stimulation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ63ZY3.
PaxDbiQ63ZY3.
PRIDEiQ63ZY3.

PTM databases

PhosphoSiteiQ63ZY3.

Expressioni

Tissue specificityi

Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level).2 Publications

Gene expression databases

ArrayExpressiQ63ZY3.
BgeeiQ63ZY3.
CleanExiHS_KANK2.
GenevestigatoriQ63ZY3.

Organism-specific databases

HPAiHPA015643.

Interactioni

Subunit structurei

Interacts (phosphorylated) with NCOA1; NCOA2 AND NCOA3. Interacts with AIFM1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AIFM1O958314EBI-6244894,EBI-356440
NCOA1Q157884EBI-2556193,EBI-455189

Protein-protein interaction databases

BioGridi117449. 13 interactions.
IntActiQ63ZY3. 15 interactions.
MINTiMINT-4540700.
STRINGi9606.ENSP00000347276.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi592 – 60615
Helixi613 – 63220
Helixi638 – 65114
Helixi653 – 6608
Helixi670 – 6767
Helixi680 – 6889
Helixi704 – 7074
Helixi708 – 7103
Helixi716 – 72813
Turni736 – 7383
Helixi742 – 7487
Helixi752 – 7609
Helixi775 – 7828
Helixi785 – 7928
Helixi809 – 8168
Helixi819 – 82810

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HBDX-ray1.72A578-832[»]
ProteinModelPortaliQ63ZY3.
SMRiQ63ZY3. Positions 588-832.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati666 – 69631ANK 1
Add
BLAST
Repeati700 – 73334ANK 2
Add
BLAST
Repeati738 – 76730ANK 3
Add
BLAST
Repeati771 – 80131ANK 4
Add
BLAST
Repeati805 – 83531ANK 5
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7272Interaction with AIFM1
Add
BLAST
Regioni669 – 835167Interaction with NCOA1
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili183 – 23452 Reviewed prediction
Add
BLAST
Coiled coili282 – 31231 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi425 – 4284Poly-Ser

Sequence similaritiesi

Contains 5 ANK repeats.

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0666.
HOVERGENiHBG062256.
InParanoidiQ63ZY3.
OMAiSVGTWVR.
OrthoDBiEOG7NW687.
PhylomeDBiQ63ZY3.
TreeFamiTF324499.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021939. KN_motif.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF12075. KN_motif. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q63ZY3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAQVLHVPAP FPGTPGPASP PAFPAKDPDP PYSVETPYGY RLDLDFLKYV    50
DDIEKGHTLR RVAVQRRPRL SSLPRGPGSW WTSTESLCSN ASGDSRHSAY 100
SYCGRGFYPQ YGALETRGGF NPRVERTLLD ARRRLEDQAA TPTGLGSLTP 150
SAAGSTASLV GVGLPPPTPR SSGLSTPVPP SAGHLAHVRE QMAGALRKLR 200
QLEEQVKLIP VLQVKLSVLQ EEKRQLTVQL KSQKFLGHPT AGRGRSELCL 250
DLPDPPEDPV ALETRSVGTW VRERDLGMPD GEAALAAKVA VLETQLKKAL 300
QELQAAQARQ ADPQPQAWPP PDSPVRVDTV RVVEGPREVE VVASTAAGAP 350
AQRAQSLEPY GTGLRALAMP GRPESPPVFR SQEVVETMCP VPAAATSNVH 400
MVKKISITER SCDGAAGLPE VPAESSSSPP GSEVASLTQP EKSTGRVPTQ 450
EPTHREPTRQ AASQESEEAG GTGGPPAGVR SIMKRKEEVA DPTAHRRSLQ 500
FVGVNGGYES SSEDSSTAEN ISDNDSTENE APEPRERVPS VAEAPQLRPA 550
GTAAAKTSRQ ECQLSRESQH IPTAEGASGS NTEEEIRMEL SPDLISACLA 600
LEKYLDNPNA LTERELKVAY TTVLQEWLRL ACRSDAHPEL VRRHLVTFRA 650
MSARLLDYVV NIADSNGNTA LHYSVSHANF PVVQQLLDSG VCKVDKQNRA 700
GYSPIMLTAL ATLKTQDDIE TVLQLFRLGN INAKASQAGQ TALMLAVSHG 750
RVDVVKALLA CEADVNVQDD DGSTALMCAC EHGHKEIAGL LLAVPSCDIS 800
LTDRDGSTAL MVALDAGQSE IASMLYSRMN IKCSFAPMSD DESPTSSSAE 850
E 851
Length:851
Mass (Da):91,174
Last modified:October 25, 2004 - v1
Checksum:iC14CD8B937A7B6E8
GO
Isoform 2 (identifier: Q63ZY3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     472-472: T → TAPPLSSPP

Note: No experimental confirmation available.

Show »
Length:859
Mass (Da):91,921
Checksum:i0629BE4E0E29FCEE
GO
Isoform 3 (identifier: Q63ZY3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     835-841: FAPMSDD → VSLNPAG
     842-851: Missing.

Note: No experimental confirmation available.

Show »
Length:841
Mass (Da):90,044
Checksum:iD82155CD26E514F1
GO

Sequence cautioni

The sequence BAA92081.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA96042.2 differs from that shown. Reason: Erroneous initiation.
The sequence BAB14531.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1181G → S.
Corresponds to variant rs755237 [ dbSNP | Ensembl ].
VAR_048304
Natural varianti401 – 4011M → T.
Corresponds to variant rs17616661 [ dbSNP | Ensembl ].
VAR_048305

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei472 – 4721T → TAPPLSSPP in isoform 2.
VSP_019427
Alternative sequencei835 – 8417FAPMSDD → VSLNPAG in isoform 3.
VSP_019428
Alternative sequencei842 – 85110Missing in isoform 3.
VSP_019429

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti525 – 5251D → N in BAA96042. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY639929 mRNA. Translation: AAT57879.1.
AB284125 mRNA. Translation: BAG06864.1.
AB040951 mRNA. Translation: BAA96042.2. Different initiation.
CH471106 Genomic DNA. Translation: EAW84177.1.
BC082762 mRNA. Translation: AAH82762.1.
BC098105 mRNA. Translation: AAH98105.1.
BC098286 mRNA. Translation: AAH98286.1.
BC098312 mRNA. Translation: AAH98312.1.
BC105989 mRNA. Translation: AAI05990.1.
AK002094 mRNA. Translation: BAA92081.1. Different initiation.
AK023332 mRNA. Translation: BAB14531.1. Different initiation.
CCDSiCCDS12255.1. [Q63ZY3-1]
CCDS54219.1. [Q63ZY3-2]
RefSeqiNP_001129663.1. NM_001136191.2. [Q63ZY3-1]
NP_056308.3. NM_015493.6. [Q63ZY3-2]
UniGeneiHs.284208.
Hs.723365.
Hs.744940.

Genome annotation databases

EnsembliENST00000355150; ENSP00000347276; ENSG00000197256. [Q63ZY3-1]
ENST00000432929; ENSP00000395650; ENSG00000197256. [Q63ZY3-2]
ENST00000586659; ENSP00000465650; ENSG00000197256. [Q63ZY3-1]
ENST00000589359; ENSP00000468002; ENSG00000197256. [Q63ZY3-2]
ENST00000589894; ENSP00000467029; ENSG00000197256. [Q63ZY3-3]
GeneIDi25959.
KEGGihsa:25959.
UCSCiuc002mqm.3. human. [Q63ZY3-2]
uc002mqo.4. human. [Q63ZY3-1]
uc002mqp.1. human. [Q63ZY3-3]

Polymorphism databases

DMDMi74757262.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY639929 mRNA. Translation: AAT57879.1 .
AB284125 mRNA. Translation: BAG06864.1 .
AB040951 mRNA. Translation: BAA96042.2 . Different initiation.
CH471106 Genomic DNA. Translation: EAW84177.1 .
BC082762 mRNA. Translation: AAH82762.1 .
BC098105 mRNA. Translation: AAH98105.1 .
BC098286 mRNA. Translation: AAH98286.1 .
BC098312 mRNA. Translation: AAH98312.1 .
BC105989 mRNA. Translation: AAI05990.1 .
AK002094 mRNA. Translation: BAA92081.1 . Different initiation.
AK023332 mRNA. Translation: BAB14531.1 . Different initiation.
CCDSi CCDS12255.1. [Q63ZY3-1 ]
CCDS54219.1. [Q63ZY3-2 ]
RefSeqi NP_001129663.1. NM_001136191.2. [Q63ZY3-1 ]
NP_056308.3. NM_015493.6. [Q63ZY3-2 ]
UniGenei Hs.284208.
Hs.723365.
Hs.744940.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HBD X-ray 1.72 A 578-832 [» ]
ProteinModelPortali Q63ZY3.
SMRi Q63ZY3. Positions 588-832.
ModBasei Search...

Protein-protein interaction databases

BioGridi 117449. 13 interactions.
IntActi Q63ZY3. 15 interactions.
MINTi MINT-4540700.
STRINGi 9606.ENSP00000347276.

PTM databases

PhosphoSitei Q63ZY3.

Polymorphism databases

DMDMi 74757262.

Proteomic databases

MaxQBi Q63ZY3.
PaxDbi Q63ZY3.
PRIDEi Q63ZY3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355150 ; ENSP00000347276 ; ENSG00000197256 . [Q63ZY3-1 ]
ENST00000432929 ; ENSP00000395650 ; ENSG00000197256 . [Q63ZY3-2 ]
ENST00000586659 ; ENSP00000465650 ; ENSG00000197256 . [Q63ZY3-1 ]
ENST00000589359 ; ENSP00000468002 ; ENSG00000197256 . [Q63ZY3-2 ]
ENST00000589894 ; ENSP00000467029 ; ENSG00000197256 . [Q63ZY3-3 ]
GeneIDi 25959.
KEGGi hsa:25959.
UCSCi uc002mqm.3. human. [Q63ZY3-2 ]
uc002mqo.4. human. [Q63ZY3-1 ]
uc002mqp.1. human. [Q63ZY3-3 ]

Organism-specific databases

CTDi 25959.
GeneCardsi GC19M011274.
HGNCi HGNC:29300. KANK2.
HPAi HPA015643.
MIMi 614610. gene.
neXtProti NX_Q63ZY3.
PharmGKBi PA162392581.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
HOVERGENi HBG062256.
InParanoidi Q63ZY3.
OMAi SVGTWVR.
OrthoDBi EOG7NW687.
PhylomeDBi Q63ZY3.
TreeFami TF324499.

Miscellaneous databases

GeneWikii ANKRD25.
GenomeRNAii 25959.
NextBioi 47574.
PROi Q63ZY3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q63ZY3.
Bgeei Q63ZY3.
CleanExi HS_KANK2.
Genevestigatori Q63ZY3.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021939. KN_motif.
[Graphical view ]
Pfami PF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF12075. KN_motif. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 5 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm."
    Zhang Y., Zhang H., Liang J., Yu W., Shang Y.
    EMBO J. 26:2645-2657(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH NCOA1; NCOA2 AND NCOA3, SUBCELLULAR LOCATION, PHOSPHORYLATION, MUTAGENESIS OF 510-SER--SER-512 AND SER-515.
  2. Zhu Y., Kakinuma N., Wang Y., Kiyama R.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Spleen.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix and Lung.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 386-841 (ISOFORM 3).
    Tissue: Ovary and Placenta.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19 AND SER-375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  9. "Kank proteins: a new family of ankyrin-repeat domain-containing proteins."
    Zhu Y., Kakinuma N., Wang Y., Kiyama R.
    Biochim. Biophys. Acta 1780:128-133(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356 AND THR-472, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Expression of novel podocyte-associated proteins sult1b1 and ankrd25."
    Xu X., Patrakka J., Sistani L., Uhlen M., Jalanko H., Betsholtz C., Tryggvason K.
    Nephron Exp. Nephrol. 117:E39-E46(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  14. "Steroid receptor coactivator-interacting protein (SIP) inhibits caspase-independent apoptosis by preventing apoptosis-inducing factor (AIF) from being released from mitochondria."
    Wang D., Liang J., Zhang Y., Gui B., Wang F., Yi X., Sun L., Yao Z., Shang Y.
    J. Biol. Chem. 287:12612-12621(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH AIFM1.
  15. "Crystal structure of KANK2 ankyrin repeats."
    Structural genomics consortium (SGC)
    Submitted (DEC-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) OF 578-832.

Entry informationi

Entry nameiKANK2_HUMAN
AccessioniPrimary (citable) accession number: Q63ZY3
Secondary accession number(s): B0I1P4
, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 25, 2004
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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