Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q63ZY3

- KANK2_HUMAN

UniProt

Q63ZY3 - KANK2_HUMAN

Protein

KN motif and ankyrin repeat domain-containing protein 2

Gene

KANK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. negative regulation of cell proliferation Source: UniProtKB
    3. negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
    4. negative regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
    5. negative regulation of programmed cell death Source: UniProtKB
    6. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KN motif and ankyrin repeat domain-containing protein 2
    Alternative name(s):
    Ankyrin repeat domain-containing protein 25
    Matrix-remodeling-associated protein 3
    SRC-1-interacting protein
    Short name:
    SIP
    Short name:
    SRC-interacting protein
    Short name:
    SRC1-interacting protein
    Gene namesi
    Name:KANK2
    Synonyms:ANKRD25, KIAA1518, MXRA3, SIP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:29300. KANK2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi510 – 5123SSS → AAA: Impairs phosphorylation; when associated with A-515.
    Mutagenesisi515 – 5151S → A: Impairs phosphorylation; when associated with 510-A--A-512. 1 Publication

    Organism-specific databases

    PharmGKBiPA162392581.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 851851KN motif and ankyrin repeat domain-containing protein 2PRO_0000240840Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei19 – 191Phosphoserine2 Publications
    Modified residuei356 – 3561Phosphoserine2 Publications
    Modified residuei375 – 3751Phosphoserine4 Publications
    Modified residuei472 – 4721Phosphothreonine2 Publications

    Post-translational modificationi

    Phosphorylated by CaMK2 upon estrogen stimulation.5 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ63ZY3.
    PaxDbiQ63ZY3.
    PRIDEiQ63ZY3.

    PTM databases

    PhosphoSiteiQ63ZY3.

    Expressioni

    Tissue specificityi

    Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level).2 Publications

    Gene expression databases

    ArrayExpressiQ63ZY3.
    BgeeiQ63ZY3.
    CleanExiHS_KANK2.
    GenevestigatoriQ63ZY3.

    Organism-specific databases

    HPAiHPA015643.

    Interactioni

    Subunit structurei

    Interacts (phosphorylated) with NCOA1; NCOA2 AND NCOA3. Interacts with AIFM1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AIFM1O958314EBI-6244894,EBI-356440
    NCOA1Q157884EBI-2556193,EBI-455189

    Protein-protein interaction databases

    BioGridi117449. 13 interactions.
    IntActiQ63ZY3. 15 interactions.
    MINTiMINT-4540700.
    STRINGi9606.ENSP00000347276.

    Structurei

    Secondary structure

    1
    851
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi592 – 60615
    Helixi613 – 63220
    Helixi638 – 65114
    Helixi653 – 6608
    Helixi670 – 6767
    Helixi680 – 6889
    Helixi704 – 7074
    Helixi708 – 7103
    Helixi716 – 72813
    Turni736 – 7383
    Helixi742 – 7487
    Helixi752 – 7609
    Helixi775 – 7828
    Helixi785 – 7928
    Helixi809 – 8168
    Helixi819 – 82810

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HBDX-ray1.72A578-832[»]
    ProteinModelPortaliQ63ZY3.
    SMRiQ63ZY3. Positions 588-832.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati666 – 69631ANK 1Add
    BLAST
    Repeati700 – 73334ANK 2Add
    BLAST
    Repeati738 – 76730ANK 3Add
    BLAST
    Repeati771 – 80131ANK 4Add
    BLAST
    Repeati805 – 83531ANK 5Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 7272Interaction with AIFM1Add
    BLAST
    Regioni669 – 835167Interaction with NCOA1Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili183 – 23452Sequence AnalysisAdd
    BLAST
    Coiled coili282 – 31231Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi425 – 4284Poly-Ser

    Sequence similaritiesi

    Contains 5 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOVERGENiHBG062256.
    InParanoidiQ63ZY3.
    OMAiSVGTWVR.
    OrthoDBiEOG7NW687.
    PhylomeDBiQ63ZY3.
    TreeFamiTF324499.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR021939. KN_motif.
    [Graphical view]
    PfamiPF00023. Ank. 1 hit.
    PF12796. Ank_2. 1 hit.
    PF12075. KN_motif. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 5 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q63ZY3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQVLHVPAP FPGTPGPASP PAFPAKDPDP PYSVETPYGY RLDLDFLKYV    50
    DDIEKGHTLR RVAVQRRPRL SSLPRGPGSW WTSTESLCSN ASGDSRHSAY 100
    SYCGRGFYPQ YGALETRGGF NPRVERTLLD ARRRLEDQAA TPTGLGSLTP 150
    SAAGSTASLV GVGLPPPTPR SSGLSTPVPP SAGHLAHVRE QMAGALRKLR 200
    QLEEQVKLIP VLQVKLSVLQ EEKRQLTVQL KSQKFLGHPT AGRGRSELCL 250
    DLPDPPEDPV ALETRSVGTW VRERDLGMPD GEAALAAKVA VLETQLKKAL 300
    QELQAAQARQ ADPQPQAWPP PDSPVRVDTV RVVEGPREVE VVASTAAGAP 350
    AQRAQSLEPY GTGLRALAMP GRPESPPVFR SQEVVETMCP VPAAATSNVH 400
    MVKKISITER SCDGAAGLPE VPAESSSSPP GSEVASLTQP EKSTGRVPTQ 450
    EPTHREPTRQ AASQESEEAG GTGGPPAGVR SIMKRKEEVA DPTAHRRSLQ 500
    FVGVNGGYES SSEDSSTAEN ISDNDSTENE APEPRERVPS VAEAPQLRPA 550
    GTAAAKTSRQ ECQLSRESQH IPTAEGASGS NTEEEIRMEL SPDLISACLA 600
    LEKYLDNPNA LTERELKVAY TTVLQEWLRL ACRSDAHPEL VRRHLVTFRA 650
    MSARLLDYVV NIADSNGNTA LHYSVSHANF PVVQQLLDSG VCKVDKQNRA 700
    GYSPIMLTAL ATLKTQDDIE TVLQLFRLGN INAKASQAGQ TALMLAVSHG 750
    RVDVVKALLA CEADVNVQDD DGSTALMCAC EHGHKEIAGL LLAVPSCDIS 800
    LTDRDGSTAL MVALDAGQSE IASMLYSRMN IKCSFAPMSD DESPTSSSAE 850
    E 851
    Length:851
    Mass (Da):91,174
    Last modified:October 25, 2004 - v1
    Checksum:iC14CD8B937A7B6E8
    GO
    Isoform 2 (identifier: Q63ZY3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         472-472: T → TAPPLSSPP

    Note: No experimental confirmation available.

    Show »
    Length:859
    Mass (Da):91,921
    Checksum:i0629BE4E0E29FCEE
    GO
    Isoform 3 (identifier: Q63ZY3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         835-841: FAPMSDD → VSLNPAG
         842-851: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:841
    Mass (Da):90,044
    Checksum:iD82155CD26E514F1
    GO

    Sequence cautioni

    The sequence BAA92081.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA96042.2 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB14531.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti525 – 5251D → N in BAA96042. (PubMed:10819331)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti118 – 1181G → S.
    Corresponds to variant rs755237 [ dbSNP | Ensembl ].
    VAR_048304
    Natural varianti401 – 4011M → T.
    Corresponds to variant rs17616661 [ dbSNP | Ensembl ].
    VAR_048305

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei472 – 4721T → TAPPLSSPP in isoform 2. 1 PublicationVSP_019427
    Alternative sequencei835 – 8417FAPMSDD → VSLNPAG in isoform 3. 1 PublicationVSP_019428
    Alternative sequencei842 – 85110Missing in isoform 3. 1 PublicationVSP_019429

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY639929 mRNA. Translation: AAT57879.1.
    AB284125 mRNA. Translation: BAG06864.1.
    AB040951 mRNA. Translation: BAA96042.2. Different initiation.
    CH471106 Genomic DNA. Translation: EAW84177.1.
    BC082762 mRNA. Translation: AAH82762.1.
    BC098105 mRNA. Translation: AAH98105.1.
    BC098286 mRNA. Translation: AAH98286.1.
    BC098312 mRNA. Translation: AAH98312.1.
    BC105989 mRNA. Translation: AAI05990.1.
    AK002094 mRNA. Translation: BAA92081.1. Different initiation.
    AK023332 mRNA. Translation: BAB14531.1. Different initiation.
    CCDSiCCDS12255.1. [Q63ZY3-1]
    CCDS54219.1. [Q63ZY3-2]
    RefSeqiNP_001129663.1. NM_001136191.2. [Q63ZY3-1]
    NP_056308.3. NM_015493.6. [Q63ZY3-2]
    UniGeneiHs.284208.
    Hs.723365.
    Hs.744940.

    Genome annotation databases

    EnsembliENST00000586659; ENSP00000465650; ENSG00000197256. [Q63ZY3-1]
    ENST00000589359; ENSP00000468002; ENSG00000197256. [Q63ZY3-2]
    ENST00000589894; ENSP00000467029; ENSG00000197256. [Q63ZY3-3]
    GeneIDi25959.
    KEGGihsa:25959.
    UCSCiuc002mqm.3. human. [Q63ZY3-2]
    uc002mqo.4. human. [Q63ZY3-1]
    uc002mqp.1. human. [Q63ZY3-3]

    Polymorphism databases

    DMDMi74757262.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY639929 mRNA. Translation: AAT57879.1 .
    AB284125 mRNA. Translation: BAG06864.1 .
    AB040951 mRNA. Translation: BAA96042.2 . Different initiation.
    CH471106 Genomic DNA. Translation: EAW84177.1 .
    BC082762 mRNA. Translation: AAH82762.1 .
    BC098105 mRNA. Translation: AAH98105.1 .
    BC098286 mRNA. Translation: AAH98286.1 .
    BC098312 mRNA. Translation: AAH98312.1 .
    BC105989 mRNA. Translation: AAI05990.1 .
    AK002094 mRNA. Translation: BAA92081.1 . Different initiation.
    AK023332 mRNA. Translation: BAB14531.1 . Different initiation.
    CCDSi CCDS12255.1. [Q63ZY3-1 ]
    CCDS54219.1. [Q63ZY3-2 ]
    RefSeqi NP_001129663.1. NM_001136191.2. [Q63ZY3-1 ]
    NP_056308.3. NM_015493.6. [Q63ZY3-2 ]
    UniGenei Hs.284208.
    Hs.723365.
    Hs.744940.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HBD X-ray 1.72 A 578-832 [» ]
    ProteinModelPortali Q63ZY3.
    SMRi Q63ZY3. Positions 588-832.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117449. 13 interactions.
    IntActi Q63ZY3. 15 interactions.
    MINTi MINT-4540700.
    STRINGi 9606.ENSP00000347276.

    PTM databases

    PhosphoSitei Q63ZY3.

    Polymorphism databases

    DMDMi 74757262.

    Proteomic databases

    MaxQBi Q63ZY3.
    PaxDbi Q63ZY3.
    PRIDEi Q63ZY3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000586659 ; ENSP00000465650 ; ENSG00000197256 . [Q63ZY3-1 ]
    ENST00000589359 ; ENSP00000468002 ; ENSG00000197256 . [Q63ZY3-2 ]
    ENST00000589894 ; ENSP00000467029 ; ENSG00000197256 . [Q63ZY3-3 ]
    GeneIDi 25959.
    KEGGi hsa:25959.
    UCSCi uc002mqm.3. human. [Q63ZY3-2 ]
    uc002mqo.4. human. [Q63ZY3-1 ]
    uc002mqp.1. human. [Q63ZY3-3 ]

    Organism-specific databases

    CTDi 25959.
    GeneCardsi GC19M011274.
    HGNCi HGNC:29300. KANK2.
    HPAi HPA015643.
    MIMi 614610. gene.
    neXtProti NX_Q63ZY3.
    PharmGKBi PA162392581.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOVERGENi HBG062256.
    InParanoidi Q63ZY3.
    OMAi SVGTWVR.
    OrthoDBi EOG7NW687.
    PhylomeDBi Q63ZY3.
    TreeFami TF324499.

    Miscellaneous databases

    GeneWikii ANKRD25.
    GenomeRNAii 25959.
    NextBioi 47574.
    PROi Q63ZY3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q63ZY3.
    Bgeei Q63ZY3.
    CleanExi HS_KANK2.
    Genevestigatori Q63ZY3.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR021939. KN_motif.
    [Graphical view ]
    Pfami PF00023. Ank. 1 hit.
    PF12796. Ank_2. 1 hit.
    PF12075. KN_motif. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 5 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm."
      Zhang Y., Zhang H., Liang J., Yu W., Shang Y.
      EMBO J. 26:2645-2657(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH NCOA1; NCOA2 AND NCOA3, SUBCELLULAR LOCATION, PHOSPHORYLATION, MUTAGENESIS OF 510-SER--SER-512 AND SER-515.
    2. Zhu Y., Kakinuma N., Wang Y., Kiyama R.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Spleen.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cervix and Lung.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 386-841 (ISOFORM 3).
      Tissue: Ovary and Placenta.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19 AND SER-375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    9. "Kank proteins: a new family of ankyrin-repeat domain-containing proteins."
      Zhu Y., Kakinuma N., Wang Y., Kiyama R.
      Biochim. Biophys. Acta 1780:128-133(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356 AND THR-472, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Expression of novel podocyte-associated proteins sult1b1 and ankrd25."
      Xu X., Patrakka J., Sistani L., Uhlen M., Jalanko H., Betsholtz C., Tryggvason K.
      Nephron Exp. Nephrol. 117:E39-E46(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    14. "Steroid receptor coactivator-interacting protein (SIP) inhibits caspase-independent apoptosis by preventing apoptosis-inducing factor (AIF) from being released from mitochondria."
      Wang D., Liang J., Zhang Y., Gui B., Wang F., Yi X., Sun L., Yao Z., Shang Y.
      J. Biol. Chem. 287:12612-12621(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH AIFM1.
    15. "Crystal structure of KANK2 ankyrin repeats."
      Structural genomics consortium (SGC)
      Submitted (DEC-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) OF 578-832.

    Entry informationi

    Entry nameiKANK2_HUMAN
    AccessioniPrimary (citable) accession number: Q63ZY3
    Secondary accession number(s): B0I1P4
    , Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3