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Q63ZU0 (ADA_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosine deaminase
EC=3.5.4.4
Alternative name(s):
Adenosine aminohydrolase
Gene names
Name:ada
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation By similarity.

Catalytic activity

Adenosine + H2O = inosine + NH3.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein; Extracellular side By similarity. Cell junction By similarity. Cytoplasmic vesicle lumen By similarity. Cytoplasm By similarity.

Sequence similarities

Belongs to the adenosine and AMP deaminases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Adenosine deaminase
PRO_0000194358

Sites

Active site2151Proton donor By similarity
Metal binding141Zinc; catalytic By similarity
Metal binding161Zinc; catalytic By similarity
Metal binding2121Zinc; catalytic By similarity
Metal binding2941Zinc; catalytic By similarity
Binding site161Substrate By similarity
Binding site181Substrate By similarity
Binding site1831Substrate; via amide nitrogen and carbonyl oxygen By similarity
Binding site2951Substrate By similarity
Site2361Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63ZU0 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: FBE993ECF3A080D2

FASTA35840,555
        10         20         30         40         50         60 
MESKAFNKPK VELHVHLDGS IKPETIIHFA KKRQIKLPAD TVEGLLEHVS YKEPLSLTEF 

        70         80         90        100        110        120 
LSKFNHYMPA IAGDREAIKR IAYEFVEMKA KEGVIYVEVR YSPHFLANSK VEPIPWGQKE 

       130        140        150        160        170        180 
GDITPDEVVD LVNQGLRKGE KAFNIKARSI LCCMRHMPSW STEVVELCKK YQNDTVVAID 

       190        200        210        220        230        240 
LAGDESLNCE SYPGHRKAYE EAVKCGIHRT VHAGEVGPSS VVKEAVEVLK AERIGHGYHT 

       250        260        270        280        290        300 
TEDPNLYKEL LEKNMHFEVC PWSSYLTGAC HPDFTKHPAT QFRKDKANYS LNTDDPLIFG 

       310        320        330        340        350 
STLDVDYSIA AKHMGFTEEE FKRVNINAAK SSFLPESEKK ELLYKLYEAY GMILSTGL

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC082820 mRNA. Translation: AAH82820.1.
RefSeqNP_001011025.1. NM_001011025.1.
UniGeneStr.27598.

3D structure databases

ProteinModelPortalQ63ZU0.
SMRQ63ZU0. Positions 3-352.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ63ZU0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID496434.
KEGGxtr:496434.

Organism-specific databases

CTD100.
XenbaseXB-GENE-950501. ada.

Phylogenomic databases

eggNOGveNOG04306.
GeneTreeENSGT00510000047600.
HOGENOMHBG630382.
HOVERGENHBG001718.
InParanoidQ63ZU0.
OrthoDBEOG40K808.

Gene expression databases

BgeeQ63ZU0.

Family and domain databases

InterProIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADA_XENTR
AccessionPrimary (citable) accession number: Q63ZU0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 25, 2004
Last modified: December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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