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Reviewed, UniProtKB/Swiss-Prot Q63ZT8 (FTHFD_XENTR)

Last modified June 16, 2009. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    10-formyltetrahydrofolate dehydrogenase
      Short name=10-FTHFDH
    EC=1.5.1.6
Alternative name(s):
    Aldehyde dehydrogenase family 1 member L1
Gene names
Name: aldh1l1
ORF Names: TNeu011l01.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

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Protein attributes

Sequence length902 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

In the N-terminal section; belongs to the GART family.

In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.

Contains 1 acyl carrier domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 90290210-formyltetrahydrofolate dehydrogenase
PRO_0000316000

Regions

Domain323 – 39270Acyl carrier
Region1 – 203203GART
Region417 – 902486Aldehyde dehydrogenase

Sites

Active site1061Proton donor By similarity
Active site6731 By similarity
Active site7071 By similarity
Site1421Essential for catalytic activity By similarity

Amino acid modifications

Modified residue3541O-(pantetheine 4'-phosphoryl)serine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q63ZT8-1 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 120CFF8CD10474BE

FASTA90299,658
        10         20         30         40         50         60 
MKIAVIGQSL FGREVYRELL KEGHQVVGVF TIPDKNGKAD PLGADAEKDG IPVFKFPRWR 

        70         80         90        100        110        120 
VKGQAIPEVV EKYKALEAEL NVLPFCSQFI PMEVIDCPKH GSIIYHPSIL PRHRGASAIN 

       130        140        150        160        170        180 
WTLMQGDKIG GFTIFWADDG LDTGDILLQR ECEVLPDDTV NTIYNRFLFP EGVKGMVEAV 

       190        200        210        220        230        240 
RLIAEGNAPR IKQATEGATY DPMQKKENAK INWDQPAEAI HNFIRGNDKV PGAWTVVGDQ 

       250        260        270        280        290        300 
QLTFFGSSFI SNGPAPDGQP LEIPGAFRPA VVTKTGLVLF GNDGQKLSVK NIQFEDGKMI 

       310        320        330        340        350        360 
PASQYYKTAD SAALQLSDEE KKFSEEIRAA WKRILTNVSE IEDSTDFFKA GAASMDVVRL 

       370        380        390        400        410        420 
VEEVKLKCNG LQLQNEDVYM ATKFEEFIQM VVRRLRGEDG EEELVVDYVE KEINNMTVKI 

       430        440        450        460        470        480 
PHQLFINGQF IDAEGGKTYD TVNPTDGTAI CKVSLAQVSD IDRAVAAAKE AFENGEWGKM 

       490        500        510        520        530        540 
NPRDRGRILY RLADIMEEHQ EELATIESID SGAVYTLALK THVGMSIQTF RYFAGWCDKI 

       550        560        570        580        590        600 
QGSTIPINQA RPNRNLTFTR REPIGVCGIV IPWNYPLMML AWKTAACLAA GNTVVLKPAQ 

       610        620        630        640        650        660 
VTPLTALKFA ELSVKAGIPK GVINILPGAG SLIGQRLSDH PDVRKIGFTG STPIGKHIMK 

       670        680        690        700        710        720 
SCAVGNVKKV SLELGGKSPL IIFQDCDLDK AVRMGMSSVF FNKGENCIAA GRLFLEESIH 

       730        740        750        760        770        780 
DEFVKRVVGE VKKMKIGDPL DRSTDHGPQN HKAHLDKLIE YCQTGVKEGA KLVYGGKQVE 

       790        800        810        820        830        840 
RPGFFFEPTI FTDVTDEMFI AKEESFGPIM IISKFKDGDV DEVLKRANNT EFGLASGVFT 

       850        860        870        880        890        900 
KDISKALYVS EKLQAGTVFV NTYNKTDVAA PFGGFKQSGF GKDLGEEALN EYLKTKAVTI 


EY

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References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Neurula.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tail bud.

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Cross-references

Sequence databases

CR926185 mRNA. Translation: CAJ82649.1.
CR926221 mRNA. Translation: CAJ83333.1.
BC082822 mRNA. Translation: AAH82822.1.
RefSeqNP_001011027.1.
UniGeneStr.2604

3D structure databases

SMRQ63ZT8. Positions 1-307, 405-902.
ModBaseSearch...

Genome annotation databases

EnsemblENSXETG00000011551. Xenopus tropicalis. [Contig view]
GeneID496436.
KEGGxtr:496436.

Organism-specific databases

XenbaseXB-FEAT-1016236. aldh1l1.

Phylogenomic databases

HOGENOMQ63ZT8.
HOVERGENQ63ZT8.

Enzyme and pathway databases

BRENDA1.5.1.6. 279072.

Family and domain databases

InterProIPR011407. 10_FTHF_DH.
IPR009081. Acyl_carrier_prot-like.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR001555. GART_AS.
IPR006162. Ppantne_S.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
G3DSA:3.10.25.10. Formyl_trans_C. 1 hit.
G3DSA:3.40.50.170. Formyl_transf_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
PIRSFPIRSF036489. 10-FTHFDH. 1 hit.
PROSITEPS50075. ACP_DOMAIN. 1 hit.
PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
PS00373. GART. 1 hit.
PS00012. PHOSPHOPANTETHEINE. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameFTHFD_XENTR
AccessionPrimary (citable) accession number: Q63ZT8
Secondary accession number(s): Q28CS4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectXenopus annotation project

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents