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Q63ZR6

- UD3A1_XENLA

UniProt

Q63ZR6 - UD3A1_XENLA

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Protein

UDP-glucuronosyltransferase 3A1

Gene

ugt3a1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 3A1 (EC:2.4.1.17)
Short name:
UDPGT 3A1
Gene namesi
Name:ugt3a1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5824808. ugt3a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 483460ExtracellularSequence AnalysisAdd
BLAST
Transmembranei484 – 50421HelicalSequence AnalysisAdd
BLAST
Topological domaini505 – 52319CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 523500UDP-glucuronosyltransferase 3A1PRO_0000299152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ63ZR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106370.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63ZR6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVGRKSLIL SLLIQHFVLL HGAKILTVCF LGGSHYLWMD EISRILHNNG
60 70 80 90 100
QEVTMFLQIA DGLLPDYQMQ ESPYRLITWS LDKNYLKEFS EFFRDSKYNF
110 120 130 140 150
KDCDELSSYL GLMTHFSRQC KMIFNQTSIM NLLKEEKYDL AVIDSFNPCT
160 170 180 190 200
FLVSEKLGIP FIATHPFPVK SPWHSGIPNQ LSYMPVYQSQ LTDHMDFFER
210 220 230 240 250
VKNVFMYIAS AVLERKIYSL FDDVIEEHFP ACSRPSFEEL YKKTALWMYL
260 270 280 290 300
TDFTIEFPHP FFPNVLYIGG VLAKPAKPVS EELEDFIAQS GEHGFIIVTF
310 320 330 340 350
GSMVPSNPLT EFVKEMNDGF SKIPQKVIWR YRISEWPKVL QLAPNVKIMN
360 370 380 390 400
WISQNDLLGH PKARLLVTHG GVNSIQEAIY HGVPMVAIPL FFDQFDNAVR
410 420 430 440 450
IKAKHLGTFI PKDQLKAEKL ANAIRDVIGG ESYKNSAMHL SLIQRSQPFP
460 470 480 490 500
KDQQIVRWVE HIVKVGGTDH LIPYSYQQPL YQQYLLDVFL FVCVCVIGAC
510 520
YLTVKLLKMF IQKLCSFRKL KQN
Length:523
Mass (Da):60,436
Last modified:October 25, 2004 - v1
Checksum:i73B728B7D1CE5CA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082844 mRNA. Translation: AAH82844.1.
RefSeqiNP_001088053.1. NM_001094584.1.
UniGeneiXl.25599.

Genome annotation databases

GeneIDi494747.
KEGGixla:494747.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082844 mRNA. Translation: AAH82844.1 .
RefSeqi NP_001088053.1. NM_001094584.1.
UniGenei Xl.25599.

3D structure databases

ProteinModelPortali Q63ZR6.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 494747.
KEGGi xla:494747.

Organism-specific databases

CTDi 167127.
Xenbasei XB-GENE-5824808. ugt3a2.

Phylogenomic databases

HOVERGENi HBG106370.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiUD3A1_XENLA
AccessioniPrimary (citable) accession number: Q63ZR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 25, 2004
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3