Reviewed, UniProtKB/Swiss-Prot Q63ZR6 (UD3A1_XENLA)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 3A1
      Short name=UDPGT 3A1
    EC=2.4.1.17

Gene names

Name:

ugt3a1

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	523 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 523	500	UDP-glucuronosyltransferase 3A1		PRO_0000299152
Regions
	Topological domain	24 – 483	460	Extracellular Potential
	Transmembrane	484 – 504	21	Potential
	Topological domain	505 – 523	19	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	125	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q63ZR6-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 73B728B7D1CE5CA0	FASTA	523	60,436
	10 20 30 40 50 60 MAVGRKSLIL SLLIQHFVLL HGAKILTVCF LGGSHYLWMD EISRILHNNG QEVTMFLQIA 70 80 90 100 110 120 DGLLPDYQMQ ESPYRLITWS LDKNYLKEFS EFFRDSKYNF KDCDELSSYL GLMTHFSRQC 130 140 150 160 170 180 KMIFNQTSIM NLLKEEKYDL AVIDSFNPCT FLVSEKLGIP FIATHPFPVK SPWHSGIPNQ 190 200 210 220 230 240 LSYMPVYQSQ LTDHMDFFER VKNVFMYIAS AVLERKIYSL FDDVIEEHFP ACSRPSFEEL 250 260 270 280 290 300 YKKTALWMYL TDFTIEFPHP FFPNVLYIGG VLAKPAKPVS EELEDFIAQS GEHGFIIVTF 310 320 330 340 350 360 GSMVPSNPLT EFVKEMNDGF SKIPQKVIWR YRISEWPKVL QLAPNVKIMN WISQNDLLGH 370 380 390 400 410 420 PKARLLVTHG GVNSIQEAIY HGVPMVAIPL FFDQFDNAVR IKAKHLGTFI PKDQLKAEKL 430 440 450 460 470 480 ANAIRDVIGG ESYKNSAMHL SLIQRSQPFP KDQQIVRWVE HIVKVGGTDH LIPYSYQQPL 490 500 510 520 YQQYLLDVFL FVCVCVIGAC YLTVKLLKMF IQKLCSFRKL KQN

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC082844 mRNA. Translation: AAH82844.1.
RefSeq	NP_001088053.1.
UniGene	Xl.25599
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Genome annotation databases
GeneID	494747.
KEGG	xla:494747.
Organism-specific databases
Xenbase	XB-FEAT-5824771. ugt3a2.
Phylogenomic databases
HOVERGEN	Q63ZR6.
Enzyme and pathway databases
BRENDA	2.4.1.17. 648.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UD3A1_XENLA

Accession

Primary (citable) accession number: Q63ZR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	October 25, 2004
Last modified:	April 14, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project