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Q63ZR6

- UD3A1_XENLA

UniProt

Q63ZR6 - UD3A1_XENLA

Protein

UDP-glucuronosyltransferase 3A1

Gene

ugt3a1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.By similarity

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 3A1 (EC:2.4.1.17)
    Short name:
    UDPGT 3A1
    Gene namesi
    Name:ugt3a1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-5824808. ugt3a2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 523500UDP-glucuronosyltransferase 3A1PRO_0000299152Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ63ZR6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 483460ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini505 – 52319CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei484 – 50421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG106370.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q63ZR6-1 [UniParc]FASTAAdd to Basket

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    MAVGRKSLIL SLLIQHFVLL HGAKILTVCF LGGSHYLWMD EISRILHNNG    50
    QEVTMFLQIA DGLLPDYQMQ ESPYRLITWS LDKNYLKEFS EFFRDSKYNF 100
    KDCDELSSYL GLMTHFSRQC KMIFNQTSIM NLLKEEKYDL AVIDSFNPCT 150
    FLVSEKLGIP FIATHPFPVK SPWHSGIPNQ LSYMPVYQSQ LTDHMDFFER 200
    VKNVFMYIAS AVLERKIYSL FDDVIEEHFP ACSRPSFEEL YKKTALWMYL 250
    TDFTIEFPHP FFPNVLYIGG VLAKPAKPVS EELEDFIAQS GEHGFIIVTF 300
    GSMVPSNPLT EFVKEMNDGF SKIPQKVIWR YRISEWPKVL QLAPNVKIMN 350
    WISQNDLLGH PKARLLVTHG GVNSIQEAIY HGVPMVAIPL FFDQFDNAVR 400
    IKAKHLGTFI PKDQLKAEKL ANAIRDVIGG ESYKNSAMHL SLIQRSQPFP 450
    KDQQIVRWVE HIVKVGGTDH LIPYSYQQPL YQQYLLDVFL FVCVCVIGAC 500
    YLTVKLLKMF IQKLCSFRKL KQN 523
    Length:523
    Mass (Da):60,436
    Last modified:October 25, 2004 - v1
    Checksum:i73B728B7D1CE5CA0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC082844 mRNA. Translation: AAH82844.1.
    RefSeqiNP_001088053.1. NM_001094584.1.
    UniGeneiXl.25599.

    Genome annotation databases

    GeneIDi494747.
    KEGGixla:494747.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC082844 mRNA. Translation: AAH82844.1 .
    RefSeqi NP_001088053.1. NM_001094584.1.
    UniGenei Xl.25599.

    3D structure databases

    ProteinModelPortali Q63ZR6.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 494747.
    KEGGi xla:494747.

    Organism-specific databases

    CTDi 167127.
    Xenbasei XB-GENE-5824808. ugt3a2.

    Phylogenomic databases

    HOVERGENi HBG106370.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiUD3A1_XENLA
    AccessioniPrimary (citable) accession number: Q63ZR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3