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Q63ZR6 (UD3A1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 3A1

Short name=UDPGT 3A1
EC=2.4.1.17
Gene names
Name:ugt3a1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionglucuronosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 523500UDP-glucuronosyltransferase 3A1
PRO_0000299152

Regions

Topological domain24 – 483460Extracellular Potential
Transmembrane484 – 50421Helical; Potential
Topological domain505 – 52319Cytoplasmic Potential

Amino acid modifications

Glycosylation1251N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q63ZR6 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 73B728B7D1CE5CA0

FASTA52360,436
        10         20         30         40         50         60 
MAVGRKSLIL SLLIQHFVLL HGAKILTVCF LGGSHYLWMD EISRILHNNG QEVTMFLQIA 

        70         80         90        100        110        120 
DGLLPDYQMQ ESPYRLITWS LDKNYLKEFS EFFRDSKYNF KDCDELSSYL GLMTHFSRQC 

       130        140        150        160        170        180 
KMIFNQTSIM NLLKEEKYDL AVIDSFNPCT FLVSEKLGIP FIATHPFPVK SPWHSGIPNQ 

       190        200        210        220        230        240 
LSYMPVYQSQ LTDHMDFFER VKNVFMYIAS AVLERKIYSL FDDVIEEHFP ACSRPSFEEL 

       250        260        270        280        290        300 
YKKTALWMYL TDFTIEFPHP FFPNVLYIGG VLAKPAKPVS EELEDFIAQS GEHGFIIVTF 

       310        320        330        340        350        360 
GSMVPSNPLT EFVKEMNDGF SKIPQKVIWR YRISEWPKVL QLAPNVKIMN WISQNDLLGH 

       370        380        390        400        410        420 
PKARLLVTHG GVNSIQEAIY HGVPMVAIPL FFDQFDNAVR IKAKHLGTFI PKDQLKAEKL 

       430        440        450        460        470        480 
ANAIRDVIGG ESYKNSAMHL SLIQRSQPFP KDQQIVRWVE HIVKVGGTDH LIPYSYQQPL 

       490        500        510        520 
YQQYLLDVFL FVCVCVIGAC YLTVKLLKMF IQKLCSFRKL KQN 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC082844 mRNA. Translation: AAH82844.1.
RefSeqNP_001088053.1. NM_001094584.1.
UniGeneXl.25599.

3D structure databases

ProteinModelPortalQ63ZR6.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID494747.
KEGGxla:494747.

Organism-specific databases

CTD167127.
XenbaseXB-GENE-5824808. ugt3a2.

Phylogenomic databases

HOVERGENHBG106370.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUD3A1_XENLA
AccessionPrimary (citable) accession number: Q63ZR6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 25, 2004
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families