Q63ZM7 (STABP_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
STAM-binding protein-like
EC=3.4.19.-

Gene names

Name:

stambp

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains By similarity. Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes By similarity.
Cofactor	Binds 2 zinc ion per subunit By similarity.
Domain	The JAMM motif is essential for the protease activity By similarity.
Sequence similarities	Belongs to the peptidase M67C family. Contains 1 MPN (JAB/Mov34) domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	STAM-binding protein-like		PRO_0000194873
Regions
	Domain	244 – 353	110	MPN
	Motif	327 – 340	14	JAMM motif
	Compositional bias	87 – 193	107	Glu-rich
Sites
	Metal binding	327	1	Zinc 1; catalytic By similarity
	Metal binding	329	1	Zinc 1; catalytic By similarity
	Metal binding	340	1	Zinc 1; catalytic By similarity
	Metal binding	342	1	Zinc 2 By similarity
	Metal binding	382	1	Zinc 2 By similarity
	Metal binding	388	1	Zinc 2 By similarity
	Metal binding	390	1	Zinc 2 By similarity
	Site	272	1	Indirect zinc-binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q63ZM7 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: D003FF93D50FA876	FASTA	416	47,595
	10 20 30 40 50 60 MPEHSDASLP PEERIRALVL KGTSVEVNDD IPPKRYYRSG VELIRMANVY SGEGSIENAF 70 80 90 100 110 120 ILYNKYITLF IEKLPKHRDY KTANVPEKKE TLKKLKEIAF PKAEELKKEL HKRYKKEYEE 130 140 150 160 170 180 YSEKQRKEEE ERARRLALQQ QLDAEKQRVA LLKQQQEQQE QVQAFEEMMR RKELEAERLR 190 200 210 220 230 240 ILHQFSKDEP EAEPLGSPLI PGMNEPPVTP LLPSYGTVQP HPPAVDRSLK PSSYGSNSSG 250 260 270 280 290 300 VTSDGLRHVK IPRDVCCKFL QLSENNTQRG VETCGILCGK LLQNEFTVTH VIVPKQSGGP 310 320 330 340 350 360 DYCNTESEEE LFLIQDQQGL ITLGWIHTHP TQTAFLSSVD LHTHCSYQMM LPESIAIVCS 370 380 390 400 410 PKFQETGFFK LTDYGMKEIG ECRQKGFHPH CKEPPLFSAG GHVSVTEQDV TMMDLR

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC082885 mRNA. Translation: AAH82885.1.
RefSeq	NP_001088078.1. NM_001094609.1.
UniGene	Xl.48301.
3D structure databases
ProteinModelPortal	Q63ZM7.
ModBase	Search...
Protein family/group databases
MEROPS	M67.006.
Proteomic databases
PRIDE	Q63ZM7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	494775.
KEGG	xla:494775.
Organism-specific databases
CTD	494775.
Xenbase	XB-GENE-5926903. stambp.
Phylogenomic databases
HOVERGEN	HBG058519.
Family and domain databases
InterPro	IPR000555. Mov34_MPN_PAD1. [Graphical view]
KO	K11866.
Pfam	PF01398. Mov34. 1 hit. [Graphical view]
SMART	SM00232. JAB_MPN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

STABP_XENLA

Accession

Primary (citable) accession number: Q63ZM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	October 25, 2004
Last modified:	November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program