ID   S22AA_HUMAN             Reviewed;         541 AA.
AC   Q63ZE4; Q68CJ0;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   24-JAN-2024, entry version 136.
DE   RecName: Full=Solute carrier family 22 member 10;
DE   AltName: Full=Organic anion transporter 5;
GN   Name=SLC22A10; Synonyms=OAT5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX   PubMed=15221005; DOI=10.1038/sj.onc.1207782;
RA   Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S.,
RA   Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S.,
RA   Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.;
RT   "Expression profiling and differential screening between hepatoblastomas
RT   and the corresponding normal livers: identification of high expression of
RT   the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.";
RL   Oncogene 23:5901-5911(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   IDENTIFICATION, AND TISSUE SPECIFICITY.
RX   PubMed=11327718; DOI=10.1006/bbrc.2001.4774;
RA   Sun W., Wu R.R., van Poelje P.D., Erion M.D.;
RT   "Isolation of a family of organic anion transporters from human liver and
RT   kidney.";
RL   Biochem. Biophys. Res. Commun. 283:417-422(2001).
RN   [4]
RP   IDENTIFICATION, AND TISSUE SPECIFICITY.
RX   PubMed=12372408; DOI=10.1016/s0006-291x(02)02343-4;
RA   Eraly S.A., Nigam S.K.;
RT   "Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine
RT   transporters.";
RL   Biochem. Biophys. Res. Commun. 297:1159-1166(2002).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q63ZE4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q63ZE4-2; Sequence=VSP_056645, VSP_056646, VSP_056647;
CC   -!- TISSUE SPECIFICITY: Detected in fetal and adult liver, and in adult
CC       kidney. {ECO:0000269|PubMed:11327718, ECO:0000269|PubMed:12372408}.
CC   -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC       Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
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DR   EMBL; AB075876; BAD38658.1; -; mRNA.
DR   EMBL; AP001858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP003420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK001421; DAA01503.1; -; mRNA.
DR   CCDS; CCDS41661.1; -. [Q63ZE4-1]
DR   RefSeq; NP_001034841.3; NM_001039752.3. [Q63ZE4-1]
DR   RefSeq; XP_011543318.1; XM_011545016.2.
DR   AlphaFoldDB; Q63ZE4; -.
DR   SMR; Q63ZE4; -.
DR   BioGRID; 132437; 1.
DR   STRING; 9606.ENSP00000327569; -.
DR   DrugBank; DB00286; Conjugated estrogens.
DR   DrugBank; DB01032; Probenecid.
DR   DrugBank; DB00936; Salicylic acid.
DR   TCDB; 2.A.1.19.27; the major facilitator superfamily (mfs).
DR   GlyCosmos; Q63ZE4; 2 sites, No reported glycans.
DR   GlyGen; Q63ZE4; 2 sites.
DR   iPTMnet; Q63ZE4; -.
DR   PhosphoSitePlus; Q63ZE4; -.
DR   BioMuta; SLC22A10; -.
DR   DMDM; 313104183; -.
DR   EPD; Q63ZE4; -.
DR   MassIVE; Q63ZE4; -.
DR   PaxDb; 9606-ENSP00000327569; -.
DR   PeptideAtlas; Q63ZE4; -.
DR   ProteomicsDB; 65900; -. [Q63ZE4-1]
DR   ProteomicsDB; 66001; -.
DR   Antibodypedia; 43868; 46 antibodies from 13 providers.
DR   DNASU; 387775; -.
DR   Ensembl; ENST00000332793.11; ENSP00000327569.6; ENSG00000184999.13. [Q63ZE4-1]
DR   GeneID; 387775; -.
DR   KEGG; hsa:387775; -.
DR   MANE-Select; ENST00000332793.11; ENSP00000327569.6; NM_001039752.4; NP_001034841.3.
DR   UCSC; uc009yor.4; human. [Q63ZE4-1]
DR   AGR; HGNC:18057; -.
DR   CTD; 387775; -.
DR   DisGeNET; 387775; -.
DR   GeneCards; SLC22A10; -.
DR   HGNC; HGNC:18057; SLC22A10.
DR   HPA; ENSG00000184999; Tissue enriched (liver).
DR   MIM; 607580; gene.
DR   neXtProt; NX_Q63ZE4; -.
DR   OpenTargets; ENSG00000184999; -.
DR   PharmGKB; PA38283; -.
DR   VEuPathDB; HostDB:ENSG00000184999; -.
DR   eggNOG; KOG0255; Eukaryota.
DR   GeneTree; ENSGT00940000163667; -.
DR   HOGENOM; CLU_001265_33_3_1; -.
DR   InParanoid; Q63ZE4; -.
DR   OMA; HFIELIP; -.
DR   OrthoDB; 2088942at2759; -.
DR   PhylomeDB; Q63ZE4; -.
DR   TreeFam; TF315847; -.
DR   PathwayCommons; Q63ZE4; -.
DR   SIGNOR; Q63ZE4; -.
DR   BioGRID-ORCS; 387775; 16 hits in 1151 CRISPR screens.
DR   ChiTaRS; SLC22A10; human.
DR   GeneWiki; SLC22A10; -.
DR   GenomeRNAi; 387775; -.
DR   Pharos; Q63ZE4; Tdark.
DR   PRO; PR:Q63ZE4; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q63ZE4; Protein.
DR   Bgee; ENSG00000184999; Expressed in liver and 52 other cell types or tissues.
DR   ExpressionAtlas; Q63ZE4; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015711; P:organic anion transport; IBA:GO_Central.
DR   CDD; cd17374; MFS_OAT; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR24064; SOLUTE CARRIER FAMILY 22 MEMBER; 1.
DR   PANTHER; PTHR24064:SF278; SOLUTE CARRIER FAMILY 22 MEMBER 10; 1.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..541
FT                   /note="Solute carrier family 22 member 10"
FT                   /id="PRO_0000233716"
FT   TOPO_DOM        1..15
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        37..145
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        167..193
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        215..230
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        252..259
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        281..349
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        371..377
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        399..406
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        428..436
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        437..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        458..472
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        473..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        494..495
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        496..516
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        517..541
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        56
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        102
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..155
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15221005"
FT                   /id="VSP_056645"
FT   VAR_SEQ         383..424
FT                   /note="VLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSILANT -> KCRPCV
FT                   WLWHVWESAVLLLLFPVLLFTSLNSSPLFSGQELQE (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15221005"
FT                   /id="VSP_056646"
FT   VAR_SEQ         425..541
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15221005"
FT                   /id="VSP_056647"
SQ   SEQUENCE   541 AA;  60257 MW;  73016CF8246BE9D9 CRC64;
     MAFEELLSQV GGLGRFQMLH LVFILPSLML LIPHILLENF AAAIPGHRCW VHMLDNNTGS
     GNETGILSED ALLRISIPLD SNLRPEKCRR FVHPQWQLLH LNGTIHSTSE ADTEPCVDGW
     VYDQSYFPST IVTKWDLVCD YQSLKSVVQF LLLTGMLVGG IIGGHVSDRF GRRFILRWCL
     LQLAITDTCA AFAPTFPVYC VLRFLAGFSS MIIISNNSLP ITEWIRPNSK ALVVILSSGA
     LSIGQIILGG LAYVFRDWQT LHVVASVPFF VFFLLSRWLV ESARWLIITN KLDEGLKALR
     KVARTNGIKN AEETLNIEVV RSTMQEELDA AQTKTTVCDL FRNPSMRKRI CILVFLRFAN
     TIPFYGTMVN LQHVGSNIFL LQVLYGAVAL IVRCLALLTL NHMGRRISQI LFMFLVGLSI
     LANTFVPKEM QTLRVALACL GIGCSAATFS SVAVHFIELI PTVLRARASG IDLTASRIGA
     ALAPLLMTLT VFFTTLPWII YGIFPIIGGL IVFLLPETKN LPLPDTIKDV ENQKKNLKEK
     A
//