Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q63ZE4

- S22AA_HUMAN

UniProt

Q63ZE4 - S22AA_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Solute carrier family 22 member 10

Gene

SLC22A10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.1.19.27. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 10
Alternative name(s):
Organic anion transporter 5
Gene namesi
Name:SLC22A10
Synonyms:OAT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:18057. SLC22A10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Topological domaini37 – 145109ExtracellularSequence AnalysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence AnalysisAdd
BLAST
Topological domaini167 – 19327CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST
Topological domaini215 – 23016ExtracellularSequence AnalysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence AnalysisAdd
BLAST
Topological domaini252 – 2598CytoplasmicSequence Analysis
Transmembranei260 – 28021HelicalSequence AnalysisAdd
BLAST
Topological domaini281 – 34969ExtracellularSequence AnalysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence AnalysisAdd
BLAST
Topological domaini371 – 3777CytoplasmicSequence Analysis
Transmembranei378 – 39821HelicalSequence AnalysisAdd
BLAST
Topological domaini399 – 4068ExtracellularSequence Analysis
Transmembranei407 – 42721HelicalSequence AnalysisAdd
BLAST
Topological domaini428 – 4369CytoplasmicSequence Analysis
Transmembranei437 – 45721HelicalSequence AnalysisAdd
BLAST
Topological domaini458 – 47215ExtracellularSequence AnalysisAdd
BLAST
Transmembranei473 – 49321HelicalSequence AnalysisAdd
BLAST
Topological domaini494 – 4952CytoplasmicSequence Analysis
Transmembranei496 – 51621HelicalSequence AnalysisAdd
BLAST
Topological domaini517 – 54125ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Solute carrier family 22 member 10PRO_0000233716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ63ZE4.
PRIDEiQ63ZE4.

Expressioni

Tissue specificityi

Detected in fetal and adult liver, and in adult kidney.2 Publications

Gene expression databases

BgeeiQ63ZE4.
CleanExiHS_SLC22A10.
ExpressionAtlasiQ63ZE4. baseline.
GenevestigatoriQ63ZE4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327569.

Structurei

3D structure databases

ProteinModelPortaliQ63ZE4.
SMRiQ63ZE4. Positions 153-525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ63ZE4.
KOiK08206.
OMAiSVAVHFI.
OrthoDBiEOG7J70FK.
PhylomeDBiQ63ZE4.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q63ZE4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFEELLSQV GGLGRFQMLH LVFILPSLML LIPHILLENF AAAIPGHRCW
60 70 80 90 100
VHMLDNNTGS GNETGILSED ALLRISIPLD SNLRPEKCRR FVHPQWQLLH
110 120 130 140 150
LNGTIHSTSE ADTEPCVDGW VYDQSYFPST IVTKWDLVCD YQSLKSVVQF
160 170 180 190 200
LLLTGMLVGG IIGGHVSDRF GRRFILRWCL LQLAITDTCA AFAPTFPVYC
210 220 230 240 250
VLRFLAGFSS MIIISNNSLP ITEWIRPNSK ALVVILSSGA LSIGQIILGG
260 270 280 290 300
LAYVFRDWQT LHVVASVPFF VFFLLSRWLV ESARWLIITN KLDEGLKALR
310 320 330 340 350
KVARTNGIKN AEETLNIEVV RSTMQEELDA AQTKTTVCDL FRNPSMRKRI
360 370 380 390 400
CILVFLRFAN TIPFYGTMVN LQHVGSNIFL LQVLYGAVAL IVRCLALLTL
410 420 430 440 450
NHMGRRISQI LFMFLVGLSI LANTFVPKEM QTLRVALACL GIGCSAATFS
460 470 480 490 500
SVAVHFIELI PTVLRARASG IDLTASRIGA ALAPLLMTLT VFFTTLPWII
510 520 530 540
YGIFPIIGGL IVFLLPETKN LPLPDTIKDV ENQKKNLKEK A
Length:541
Mass (Da):60,257
Last modified:November 30, 2010 - v2
Checksum:i73016CF8246BE9D9
GO
Isoform 2 (identifier: Q63ZE4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.
     383-424: VLYGAVALIV...LVGLSILANT → KCRPCVWLWH...PLFSGQELQE
     425-541: Missing.

Show »
Length:269
Mass (Da):30,397
Checksum:i12D49827FEB46125
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 155155Missing in isoform 2. 1 PublicationVSP_056645Add
BLAST
Alternative sequencei383 – 42442VLYGA…ILANT → KCRPCVWLWHVWESAVLLLL FPVLLFTSLNSSPLFSGQEL QE in isoform 2. 1 PublicationVSP_056646Add
BLAST
Alternative sequencei425 – 541117Missing in isoform 2. 1 PublicationVSP_056647Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075876 mRNA. Translation: BAD38658.1.
AP001858 Genomic DNA. No translation available.
AP001880 Genomic DNA. No translation available.
AP003420 Genomic DNA. No translation available.
BK001421 mRNA. Translation: DAA01503.1.
CCDSiCCDS41661.1. [Q63ZE4-1]
RefSeqiNP_001034841.3. NM_001039752.3. [Q63ZE4-1]
UniGeneiHs.188982.

Genome annotation databases

EnsembliENST00000332793; ENSP00000327569; ENSG00000184999. [Q63ZE4-1]
GeneIDi387775.
KEGGihsa:387775.
UCSCiuc009yor.3. human. [Q63ZE4-1]

Polymorphism databases

DMDMi313104183.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075876 mRNA. Translation: BAD38658.1 .
AP001858 Genomic DNA. No translation available.
AP001880 Genomic DNA. No translation available.
AP003420 Genomic DNA. No translation available.
BK001421 mRNA. Translation: DAA01503.1 .
CCDSi CCDS41661.1. [Q63ZE4-1 ]
RefSeqi NP_001034841.3. NM_001039752.3. [Q63ZE4-1 ]
UniGenei Hs.188982.

3D structure databases

ProteinModelPortali Q63ZE4.
SMRi Q63ZE4. Positions 153-525.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000327569.

Chemistry

DrugBanki DB00286. Conjugated Estrogens.
DB01032. Probenecid.
DB00936. Salicylic acid.

Protein family/group databases

TCDBi 2.A.1.19.27. the major facilitator superfamily (mfs).

Polymorphism databases

DMDMi 313104183.

Proteomic databases

PaxDbi Q63ZE4.
PRIDEi Q63ZE4.

Protocols and materials databases

DNASUi 387775.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332793 ; ENSP00000327569 ; ENSG00000184999 . [Q63ZE4-1 ]
GeneIDi 387775.
KEGGi hsa:387775.
UCSCi uc009yor.3. human. [Q63ZE4-1 ]

Organism-specific databases

CTDi 387775.
GeneCardsi GC11P062905.
H-InvDB HIX0035825.
HGNCi HGNC:18057. SLC22A10.
MIMi 607580. gene.
neXtProti NX_Q63ZE4.
PharmGKBi PA38283.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00760000118852.
HOGENOMi HOG000234569.
HOVERGENi HBG108433.
InParanoidi Q63ZE4.
KOi K08206.
OMAi SVAVHFI.
OrthoDBi EOG7J70FK.
PhylomeDBi Q63ZE4.
TreeFami TF315847.

Miscellaneous databases

GeneWikii SLC22A10.
GenomeRNAii 387775.
NextBioi 101618.
PROi Q63ZE4.
SOURCEi Search...

Gene expression databases

Bgeei Q63ZE4.
CleanExi HS_SLC22A10.
ExpressionAtlasi Q63ZE4. baseline.
Genevestigatori Q63ZE4.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
    Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
    Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Isolation of a family of organic anion transporters from human liver and kidney."
    Sun W., Wu R.R., van Poelje P.D., Erion M.D.
    Biochem. Biophys. Res. Commun. 283:417-422(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  4. "Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters."
    Eraly S.A., Nigam S.K.
    Biochem. Biophys. Res. Commun. 297:1159-1166(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiS22AA_HUMAN
AccessioniPrimary (citable) accession number: Q63ZE4
Secondary accession number(s): Q68CJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 30, 2010
Last modified: November 26, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3