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Q63ZE4

- S22AA_HUMAN

UniProt

Q63ZE4 - S22AA_HUMAN

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Protein
Solute carrier family 22 member 10
Gene
SLC22A10, OAT5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.1.19.27. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 10
Alternative name(s):
Organic anion transporter 5
Gene namesi
Synonyms:OAT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:18057. SLC22A10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei16 – 3621Helical; Reviewed prediction
Add
BLAST
Topological domaini37 – 145109Extracellular Reviewed prediction
Add
BLAST
Transmembranei146 – 16621Helical; Reviewed prediction
Add
BLAST
Topological domaini167 – 19327Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei194 – 21421Helical; Reviewed prediction
Add
BLAST
Topological domaini215 – 23016Extracellular Reviewed prediction
Add
BLAST
Transmembranei231 – 25121Helical; Reviewed prediction
Add
BLAST
Topological domaini252 – 2598Cytoplasmic Reviewed prediction
Transmembranei260 – 28021Helical; Reviewed prediction
Add
BLAST
Topological domaini281 – 34969Extracellular Reviewed prediction
Add
BLAST
Transmembranei350 – 37021Helical; Reviewed prediction
Add
BLAST
Topological domaini371 – 3777Cytoplasmic Reviewed prediction
Transmembranei378 – 39821Helical; Reviewed prediction
Add
BLAST
Topological domaini399 – 4068Extracellular Reviewed prediction
Transmembranei407 – 42721Helical; Reviewed prediction
Add
BLAST
Topological domaini428 – 4369Cytoplasmic Reviewed prediction
Transmembranei437 – 45721Helical; Reviewed prediction
Add
BLAST
Topological domaini458 – 47215Extracellular Reviewed prediction
Add
BLAST
Transmembranei473 – 49321Helical; Reviewed prediction
Add
BLAST
Topological domaini494 – 4952Cytoplasmic Reviewed prediction
Transmembranei496 – 51621Helical; Reviewed prediction
Add
BLAST
Topological domaini517 – 54125Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Solute carrier family 22 member 10
PRO_0000233716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ63ZE4.
PRIDEiQ63ZE4.

Expressioni

Tissue specificityi

Detected in fetal and adult liver, and in adult kidney.2 Publications

Gene expression databases

BgeeiQ63ZE4.
CleanExiHS_SLC22A10.
GenevestigatoriQ63ZE4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327569.

Structurei

3D structure databases

ProteinModelPortaliQ63ZE4.
SMRiQ63ZE4. Positions 153-525.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ63ZE4.
KOiK08206.
OMAiSVAVHFI.
OrthoDBiEOG7J70FK.
PhylomeDBiQ63ZE4.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63ZE4-1 [UniParc]FASTAAdd to Basket

« Hide

MAFEELLSQV GGLGRFQMLH LVFILPSLML LIPHILLENF AAAIPGHRCW    50
VHMLDNNTGS GNETGILSED ALLRISIPLD SNLRPEKCRR FVHPQWQLLH 100
LNGTIHSTSE ADTEPCVDGW VYDQSYFPST IVTKWDLVCD YQSLKSVVQF 150
LLLTGMLVGG IIGGHVSDRF GRRFILRWCL LQLAITDTCA AFAPTFPVYC 200
VLRFLAGFSS MIIISNNSLP ITEWIRPNSK ALVVILSSGA LSIGQIILGG 250
LAYVFRDWQT LHVVASVPFF VFFLLSRWLV ESARWLIITN KLDEGLKALR 300
KVARTNGIKN AEETLNIEVV RSTMQEELDA AQTKTTVCDL FRNPSMRKRI 350
CILVFLRFAN TIPFYGTMVN LQHVGSNIFL LQVLYGAVAL IVRCLALLTL 400
NHMGRRISQI LFMFLVGLSI LANTFVPKEM QTLRVALACL GIGCSAATFS 450
SVAVHFIELI PTVLRARASG IDLTASRIGA ALAPLLMTLT VFFTTLPWII 500
YGIFPIIGGL IVFLLPETKN LPLPDTIKDV ENQKKNLKEK A 541
Length:541
Mass (Da):60,257
Last modified:November 30, 2010 - v2
Checksum:i73016CF8246BE9D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP001880 Genomic DNA. No translation available.
BK001421 mRNA. Translation: DAA01503.1.
CCDSiCCDS41661.1.
RefSeqiNP_001034841.3. NM_001039752.3.
UniGeneiHs.188982.

Genome annotation databases

EnsembliENST00000332793; ENSP00000327569; ENSG00000184999.
GeneIDi387775.
KEGGihsa:387775.
UCSCiuc009yor.3. human.

Polymorphism databases

DMDMi313104183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP001880 Genomic DNA. No translation available.
BK001421 mRNA. Translation: DAA01503.1 .
CCDSi CCDS41661.1.
RefSeqi NP_001034841.3. NM_001039752.3.
UniGenei Hs.188982.

3D structure databases

ProteinModelPortali Q63ZE4.
SMRi Q63ZE4. Positions 153-525.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000327569.

Protein family/group databases

TCDBi 2.A.1.19.27. the major facilitator superfamily (mfs).

Polymorphism databases

DMDMi 313104183.

Proteomic databases

PaxDbi Q63ZE4.
PRIDEi Q63ZE4.

Protocols and materials databases

DNASUi 387775.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332793 ; ENSP00000327569 ; ENSG00000184999 .
GeneIDi 387775.
KEGGi hsa:387775.
UCSCi uc009yor.3. human.

Organism-specific databases

CTDi 387775.
GeneCardsi GC11P062905.
H-InvDB HIX0035825.
HGNCi HGNC:18057. SLC22A10.
MIMi 607580. gene.
neXtProti NX_Q63ZE4.
PharmGKBi PA38283.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000234569.
HOVERGENi HBG108433.
InParanoidi Q63ZE4.
KOi K08206.
OMAi SVAVHFI.
OrthoDBi EOG7J70FK.
PhylomeDBi Q63ZE4.
TreeFami TF315847.

Miscellaneous databases

GeneWikii SLC22A10.
GenomeRNAii 387775.
NextBioi 101618.
PROi Q63ZE4.
SOURCEi Search...

Gene expression databases

Bgeei Q63ZE4.
CleanExi HS_SLC22A10.
Genevestigatori Q63ZE4.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Isolation of a family of organic anion transporters from human liver and kidney."
    Sun W., Wu R.R., van Poelje P.D., Erion M.D.
    Biochem. Biophys. Res. Commun. 283:417-422(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  3. "Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters."
    Eraly S.A., Nigam S.K.
    Biochem. Biophys. Res. Commun. 297:1159-1166(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiS22AA_HUMAN
AccessioniPrimary (citable) accession number: Q63ZE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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