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Q63ZE4 (S22AA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 22 member 10
Alternative name(s):
Organic anion transporter 5
Gene names
Name:SLC22A10
Synonyms:OAT5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length541 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Detected in fetal and adult liver, and in adult kidney. Ref.2 Ref.3

Sequence similarities

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiontransmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 541541Solute carrier family 22 member 10
PRO_0000233716

Regions

Topological domain1 – 1515Cytoplasmic Potential
Transmembrane16 – 3621Helical; Potential
Topological domain37 – 145109Extracellular Potential
Transmembrane146 – 16621Helical; Potential
Topological domain167 – 19327Cytoplasmic Potential
Transmembrane194 – 21421Helical; Potential
Topological domain215 – 23016Extracellular Potential
Transmembrane231 – 25121Helical; Potential
Topological domain252 – 2598Cytoplasmic Potential
Transmembrane260 – 28021Helical; Potential
Topological domain281 – 34969Extracellular Potential
Transmembrane350 – 37021Helical; Potential
Topological domain371 – 3777Cytoplasmic Potential
Transmembrane378 – 39821Helical; Potential
Topological domain399 – 4068Extracellular Potential
Transmembrane407 – 42721Helical; Potential
Topological domain428 – 4369Cytoplasmic Potential
Transmembrane437 – 45721Helical; Potential
Topological domain458 – 47215Extracellular Potential
Transmembrane473 – 49321Helical; Potential
Topological domain494 – 4952Cytoplasmic Potential
Transmembrane496 – 51621Helical; Potential
Topological domain517 – 54125Extracellular Potential

Amino acid modifications

Glycosylation561N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q63ZE4 [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: 73016CF8246BE9D9

FASTA54160,257
        10         20         30         40         50         60 
MAFEELLSQV GGLGRFQMLH LVFILPSLML LIPHILLENF AAAIPGHRCW VHMLDNNTGS 

        70         80         90        100        110        120 
GNETGILSED ALLRISIPLD SNLRPEKCRR FVHPQWQLLH LNGTIHSTSE ADTEPCVDGW 

       130        140        150        160        170        180 
VYDQSYFPST IVTKWDLVCD YQSLKSVVQF LLLTGMLVGG IIGGHVSDRF GRRFILRWCL 

       190        200        210        220        230        240 
LQLAITDTCA AFAPTFPVYC VLRFLAGFSS MIIISNNSLP ITEWIRPNSK ALVVILSSGA 

       250        260        270        280        290        300 
LSIGQIILGG LAYVFRDWQT LHVVASVPFF VFFLLSRWLV ESARWLIITN KLDEGLKALR 

       310        320        330        340        350        360 
KVARTNGIKN AEETLNIEVV RSTMQEELDA AQTKTTVCDL FRNPSMRKRI CILVFLRFAN 

       370        380        390        400        410        420 
TIPFYGTMVN LQHVGSNIFL LQVLYGAVAL IVRCLALLTL NHMGRRISQI LFMFLVGLSI 

       430        440        450        460        470        480 
LANTFVPKEM QTLRVALACL GIGCSAATFS SVAVHFIELI PTVLRARASG IDLTASRIGA 

       490        500        510        520        530        540 
ALAPLLMTLT VFFTTLPWII YGIFPIIGGL IVFLLPETKN LPLPDTIKDV ENQKKNLKEK 


A 

« Hide

References

« Hide 'large scale' references
[1]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Isolation of a family of organic anion transporters from human liver and kidney."
Sun W., Wu R.R., van Poelje P.D., Erion M.D.
Biochem. Biophys. Res. Commun. 283:417-422(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
[3]"Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters."
Eraly S.A., Nigam S.K.
Biochem. Biophys. Res. Commun. 297:1159-1166(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP001880 Genomic DNA. No translation available.
BK001421 mRNA. Translation: DAA01503.1.
RefSeqNP_001034841.3. NM_001039752.3.
UniGeneHs.188982.

3D structure databases

ProteinModelPortalQ63ZE4.
SMRQ63ZE4. Positions 147-525.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000327569.

Protein family/group databases

TCDB2.A.1.19.27. the major facilitator superfamily (mfs).

Polymorphism databases

DMDM313104183.

Proteomic databases

PaxDbQ63ZE4.
PRIDEQ63ZE4.

Protocols and materials databases

DNASU387775.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332793; ENSP00000327569; ENSG00000184999.
GeneID387775.
KEGGhsa:387775.
UCSCuc009yor.3. human.

Organism-specific databases

CTD387775.
GeneCardsGC11P062905.
H-InvDBHIX0035825.
HGNCHGNC:18057. SLC22A10.
MIM607580. gene.
neXtProtNX_Q63ZE4.
PharmGKBPA38283.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000234569.
HOVERGENHBG108433.
InParanoidQ63ZE4.
KOK08206.
OMAHFIELIP.
OrthoDBEOG7J70FK.
PhylomeDBQ63ZE4.
TreeFamTF315847.

Gene expression databases

BgeeQ63ZE4.
CleanExHS_SLC22A10.
GenevestigatorQ63ZE4.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC22A10.
GenomeRNAi387775.
NextBio101618.
PROQ63ZE4.
SOURCESearch...

Entry information

Entry nameS22AA_HUMAN
AccessionPrimary (citable) accession number: Q63ZE4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM