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Protein

Solute carrier family 22 member 10

Gene

SLC22A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:G66-32580-MONOMER.

Protein family/group databases

TCDBi2.A.1.19.27. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 10
Alternative name(s):
Organic anion transporter 5
Gene namesi
Name:SLC22A10
Synonyms:OAT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:18057. SLC22A10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 145ExtracellularSequence analysisAdd BLAST109
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 193CytoplasmicSequence analysisAdd BLAST27
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215 – 230ExtracellularSequence analysisAdd BLAST16
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Topological domaini252 – 259CytoplasmicSequence analysis8
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Topological domaini281 – 349ExtracellularSequence analysisAdd BLAST69
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Topological domaini371 – 377CytoplasmicSequence analysis7
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Topological domaini399 – 406ExtracellularSequence analysis8
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 436CytoplasmicSequence analysis9
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Topological domaini458 – 472ExtracellularSequence analysisAdd BLAST15
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 495CytoplasmicSequence analysis2
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21
Topological domaini517 – 541ExtracellularSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184999.
PharmGKBiPA38283.

Chemistry databases

DrugBankiDB00286. Conjugated Estrogens.
DB01032. Probenecid.
DB00936. Salicylic acid.

Polymorphism and mutation databases

BioMutaiSLC22A10.
DMDMi313104183.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002337161 – 541Solute carrier family 22 member 10Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ63ZE4.
PaxDbiQ63ZE4.
PeptideAtlasiQ63ZE4.
PRIDEiQ63ZE4.

PTM databases

iPTMnetiQ63ZE4.
PhosphoSitePlusiQ63ZE4.

Expressioni

Tissue specificityi

Detected in fetal and adult liver, and in adult kidney.2 Publications

Gene expression databases

BgeeiENSG00000184999.
CleanExiHS_SLC22A10.
ExpressionAtlasiQ63ZE4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327569.

Structurei

3D structure databases

ProteinModelPortaliQ63ZE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ63ZE4.
KOiK08206.
OMAiSVAVHFI.
OrthoDBiEOG091G04H6.
PhylomeDBiQ63ZE4.
TreeFamiTF315847.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q63ZE4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFEELLSQV GGLGRFQMLH LVFILPSLML LIPHILLENF AAAIPGHRCW
60 70 80 90 100
VHMLDNNTGS GNETGILSED ALLRISIPLD SNLRPEKCRR FVHPQWQLLH
110 120 130 140 150
LNGTIHSTSE ADTEPCVDGW VYDQSYFPST IVTKWDLVCD YQSLKSVVQF
160 170 180 190 200
LLLTGMLVGG IIGGHVSDRF GRRFILRWCL LQLAITDTCA AFAPTFPVYC
210 220 230 240 250
VLRFLAGFSS MIIISNNSLP ITEWIRPNSK ALVVILSSGA LSIGQIILGG
260 270 280 290 300
LAYVFRDWQT LHVVASVPFF VFFLLSRWLV ESARWLIITN KLDEGLKALR
310 320 330 340 350
KVARTNGIKN AEETLNIEVV RSTMQEELDA AQTKTTVCDL FRNPSMRKRI
360 370 380 390 400
CILVFLRFAN TIPFYGTMVN LQHVGSNIFL LQVLYGAVAL IVRCLALLTL
410 420 430 440 450
NHMGRRISQI LFMFLVGLSI LANTFVPKEM QTLRVALACL GIGCSAATFS
460 470 480 490 500
SVAVHFIELI PTVLRARASG IDLTASRIGA ALAPLLMTLT VFFTTLPWII
510 520 530 540
YGIFPIIGGL IVFLLPETKN LPLPDTIKDV ENQKKNLKEK A
Length:541
Mass (Da):60,257
Last modified:November 30, 2010 - v2
Checksum:i73016CF8246BE9D9
GO
Isoform 2 (identifier: Q63ZE4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.
     383-424: VLYGAVALIV...LVGLSILANT → KCRPCVWLWH...PLFSGQELQE
     425-541: Missing.

Show »
Length:269
Mass (Da):30,397
Checksum:i12D49827FEB46125
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0566451 – 155Missing in isoform 2. 1 PublicationAdd BLAST155
Alternative sequenceiVSP_056646383 – 424VLYGA…ILANT → KCRPCVWLWHVWESAVLLLL FPVLLFTSLNSSPLFSGQEL QE in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_056647425 – 541Missing in isoform 2. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075876 mRNA. Translation: BAD38658.1.
AP001858 Genomic DNA. No translation available.
AP001880 Genomic DNA. No translation available.
AP003420 Genomic DNA. No translation available.
BK001421 mRNA. Translation: DAA01503.1.
CCDSiCCDS41661.1. [Q63ZE4-1]
RefSeqiNP_001034841.3. NM_001039752.3. [Q63ZE4-1]
XP_011543318.1. XM_011545016.2. [Q63ZE4-1]
UniGeneiHs.188982.

Genome annotation databases

EnsembliENST00000332793; ENSP00000327569; ENSG00000184999. [Q63ZE4-1]
GeneIDi387775.
KEGGihsa:387775.
UCSCiuc009yor.4. human. [Q63ZE4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075876 mRNA. Translation: BAD38658.1.
AP001858 Genomic DNA. No translation available.
AP001880 Genomic DNA. No translation available.
AP003420 Genomic DNA. No translation available.
BK001421 mRNA. Translation: DAA01503.1.
CCDSiCCDS41661.1. [Q63ZE4-1]
RefSeqiNP_001034841.3. NM_001039752.3. [Q63ZE4-1]
XP_011543318.1. XM_011545016.2. [Q63ZE4-1]
UniGeneiHs.188982.

3D structure databases

ProteinModelPortaliQ63ZE4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000327569.

Chemistry databases

DrugBankiDB00286. Conjugated Estrogens.
DB01032. Probenecid.
DB00936. Salicylic acid.

Protein family/group databases

TCDBi2.A.1.19.27. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ63ZE4.
PhosphoSitePlusiQ63ZE4.

Polymorphism and mutation databases

BioMutaiSLC22A10.
DMDMi313104183.

Proteomic databases

EPDiQ63ZE4.
PaxDbiQ63ZE4.
PeptideAtlasiQ63ZE4.
PRIDEiQ63ZE4.

Protocols and materials databases

DNASUi387775.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332793; ENSP00000327569; ENSG00000184999. [Q63ZE4-1]
GeneIDi387775.
KEGGihsa:387775.
UCSCiuc009yor.4. human. [Q63ZE4-1]

Organism-specific databases

CTDi387775.
GeneCardsiSLC22A10.
H-InvDBHIX0035825.
HGNCiHGNC:18057. SLC22A10.
MIMi607580. gene.
neXtProtiNX_Q63ZE4.
OpenTargetsiENSG00000184999.
PharmGKBiPA38283.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ63ZE4.
KOiK08206.
OMAiSVAVHFI.
OrthoDBiEOG091G04H6.
PhylomeDBiQ63ZE4.
TreeFamiTF315847.

Enzyme and pathway databases

BioCyciZFISH:G66-32580-MONOMER.

Miscellaneous databases

GeneWikiiSLC22A10.
GenomeRNAii387775.
PROiQ63ZE4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184999.
CleanExiHS_SLC22A10.
ExpressionAtlasiQ63ZE4. baseline and differential.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22AA_HUMAN
AccessioniPrimary (citable) accession number: Q63ZE4
Secondary accession number(s): Q68CJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.