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Q63ZE4

- S22AA_HUMAN

UniProt

Q63ZE4 - S22AA_HUMAN

Protein

Solute carrier family 22 member 10

Gene

SLC22A10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. transmembrane transporter activity Source: InterPro

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.1.19.27. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 10
    Alternative name(s):
    Organic anion transporter 5
    Gene namesi
    Name:SLC22A10
    Synonyms:OAT5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Organism-specific databases

    HGNCiHGNC:18057. SLC22A10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38283.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 541541Solute carrier family 22 member 10PRO_0000233716Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ63ZE4.
    PRIDEiQ63ZE4.

    Expressioni

    Tissue specificityi

    Detected in fetal and adult liver, and in adult kidney.2 Publications

    Gene expression databases

    BgeeiQ63ZE4.
    CleanExiHS_SLC22A10.
    GenevestigatoriQ63ZE4.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000327569.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63ZE4.
    SMRiQ63ZE4. Positions 153-525.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini37 – 145109ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini167 – 19327CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini215 – 23016ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini252 – 2598CytoplasmicSequence Analysis
    Topological domaini281 – 34969ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini371 – 3777CytoplasmicSequence Analysis
    Topological domaini399 – 4068ExtracellularSequence Analysis
    Topological domaini428 – 4369CytoplasmicSequence Analysis
    Topological domaini458 – 47215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini494 – 4952CytoplasmicSequence Analysis
    Topological domaini517 – 54125ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei231 – 25121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei350 – 37021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei407 – 42721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei437 – 45721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei473 – 49321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei496 – 51621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    InParanoidiQ63ZE4.
    KOiK08206.
    OMAiSVAVHFI.
    OrthoDBiEOG7J70FK.
    PhylomeDBiQ63ZE4.
    TreeFamiTF315847.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q63ZE4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAFEELLSQV GGLGRFQMLH LVFILPSLML LIPHILLENF AAAIPGHRCW    50
    VHMLDNNTGS GNETGILSED ALLRISIPLD SNLRPEKCRR FVHPQWQLLH 100
    LNGTIHSTSE ADTEPCVDGW VYDQSYFPST IVTKWDLVCD YQSLKSVVQF 150
    LLLTGMLVGG IIGGHVSDRF GRRFILRWCL LQLAITDTCA AFAPTFPVYC 200
    VLRFLAGFSS MIIISNNSLP ITEWIRPNSK ALVVILSSGA LSIGQIILGG 250
    LAYVFRDWQT LHVVASVPFF VFFLLSRWLV ESARWLIITN KLDEGLKALR 300
    KVARTNGIKN AEETLNIEVV RSTMQEELDA AQTKTTVCDL FRNPSMRKRI 350
    CILVFLRFAN TIPFYGTMVN LQHVGSNIFL LQVLYGAVAL IVRCLALLTL 400
    NHMGRRISQI LFMFLVGLSI LANTFVPKEM QTLRVALACL GIGCSAATFS 450
    SVAVHFIELI PTVLRARASG IDLTASRIGA ALAPLLMTLT VFFTTLPWII 500
    YGIFPIIGGL IVFLLPETKN LPLPDTIKDV ENQKKNLKEK A 541
    Length:541
    Mass (Da):60,257
    Last modified:November 30, 2010 - v2
    Checksum:i73016CF8246BE9D9
    GO
    Isoform 2 (identifier: Q63ZE4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-155: Missing.
         383-424: VLYGAVALIV...LVGLSILANT → KCRPCVWLWH...PLFSGQELQE
         425-541: Missing.

    Show »
    Length:269
    Mass (Da):30,397
    Checksum:i12D49827FEB46125
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 155155Missing in isoform 2. 1 PublicationVSP_056645Add
    BLAST
    Alternative sequencei383 – 42442VLYGA…ILANT → KCRPCVWLWHVWESAVLLLL FPVLLFTSLNSSPLFSGQEL QE in isoform 2. 1 PublicationVSP_056646Add
    BLAST
    Alternative sequencei425 – 541117Missing in isoform 2. 1 PublicationVSP_056647Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB075876 mRNA. Translation: BAD38658.1.
    AP001858 Genomic DNA. No translation available.
    AP001880 Genomic DNA. No translation available.
    AP003420 Genomic DNA. No translation available.
    BK001421 mRNA. Translation: DAA01503.1.
    CCDSiCCDS41661.1.
    RefSeqiNP_001034841.3. NM_001039752.3.
    UniGeneiHs.188982.

    Genome annotation databases

    EnsembliENST00000332793; ENSP00000327569; ENSG00000184999.
    GeneIDi387775.
    KEGGihsa:387775.
    UCSCiuc009yor.3. human.

    Polymorphism databases

    DMDMi313104183.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB075876 mRNA. Translation: BAD38658.1 .
    AP001858 Genomic DNA. No translation available.
    AP001880 Genomic DNA. No translation available.
    AP003420 Genomic DNA. No translation available.
    BK001421 mRNA. Translation: DAA01503.1 .
    CCDSi CCDS41661.1.
    RefSeqi NP_001034841.3. NM_001039752.3.
    UniGenei Hs.188982.

    3D structure databases

    ProteinModelPortali Q63ZE4.
    SMRi Q63ZE4. Positions 153-525.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000327569.

    Protein family/group databases

    TCDBi 2.A.1.19.27. the major facilitator superfamily (mfs).

    Polymorphism databases

    DMDMi 313104183.

    Proteomic databases

    PaxDbi Q63ZE4.
    PRIDEi Q63ZE4.

    Protocols and materials databases

    DNASUi 387775.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332793 ; ENSP00000327569 ; ENSG00000184999 .
    GeneIDi 387775.
    KEGGi hsa:387775.
    UCSCi uc009yor.3. human.

    Organism-specific databases

    CTDi 387775.
    GeneCardsi GC11P062905.
    H-InvDB HIX0035825.
    HGNCi HGNC:18057. SLC22A10.
    MIMi 607580. gene.
    neXtProti NX_Q63ZE4.
    PharmGKBi PA38283.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000234569.
    HOVERGENi HBG108433.
    InParanoidi Q63ZE4.
    KOi K08206.
    OMAi SVAVHFI.
    OrthoDBi EOG7J70FK.
    PhylomeDBi Q63ZE4.
    TreeFami TF315847.

    Miscellaneous databases

    GeneWikii SLC22A10.
    GenomeRNAii 387775.
    NextBioi 101618.
    PROi Q63ZE4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q63ZE4.
    CleanExi HS_SLC22A10.
    Genevestigatori Q63ZE4.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
      Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
      Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Isolation of a family of organic anion transporters from human liver and kidney."
      Sun W., Wu R.R., van Poelje P.D., Erion M.D.
      Biochem. Biophys. Res. Commun. 283:417-422(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
    4. "Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters."
      Eraly S.A., Nigam S.K.
      Biochem. Biophys. Res. Commun. 297:1159-1166(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiS22AA_HUMAN
    AccessioniPrimary (citable) accession number: Q63ZE4
    Secondary accession number(s): Q68CJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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