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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi238 – 245ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPSE272560:G1G3Q-75-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotation
Gene namesi
Name:dnaAUniRule annotation
Ordered Locus Names:BPSL0075
OrganismiBurkholderia pseudomallei (strain K96243)
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000000605 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001141511 – 533Chromosomal replication initiator protein DnaAAdd BLAST533

Interactioni

Protein-protein interaction databases

STRINGi272560.BPSL0075

Structurei

3D structure databases

ProteinModelPortaliQ63YW5
SMRiQ63YW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI4 Bacteria
COG0593 LUCA
HOGENOMiHOG000235659
KOiK02313
OMAiREFNPLF

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
3.30.300.180, 1 hit
HAMAPiMF_00377 DnaA_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR024633 DnaA_N_dom
IPR038454 DnaA_N_sf
IPR027417 P-loop_NTPase
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PF11638 DnaA_N, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00362 DnaA, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit

Sequencei

Sequence statusi: Complete.

Q63YW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDFWQHCSA LLERELTPQQ YVTWIKPLAP VAFDAAANTL SIAAPNRFKL
60 70 80 90 100
DWVKSQFSGR ISDLARDFWN APIEVQFVLD PKAGQRSPAG ATPLAPRAPL
110 120 130 140 150
PSANPAPVAP GPASAPAVDA HAPAPAGMNA ATAAAVAAAQ AAQAAQANAA
160 170 180 190 200
ALNADEAADL DLPSLTAHEA AAGRRTWRPG AANANSEAAD SMYERSKLNP
210 220 230 240 250
VLTFDNFVTG KANQLARAAA IQVADNPGIS YNPLFLYGGV GLGKTHLIHA
260 270 280 290 300
IGNQLLLDKP GARIRYIHAE QYVSDVVKAY QRKAFDDFKR YYHSLDLLLI
310 320 330 340 350
DDIQFFSGKS RTQEEFFYAF EALVANKAQV IITSDTYPKE ISGIDDRLIS
360 370 380 390 400
RFDSGLTVAI EPPELEMRVA ILMRKAQSEG VSLSEDVAFF VAKHLRSNVR
410 420 430 440 450
ELEGALRKIL AYSKFHGREI TIELTKEALK DLLTVQNRQI SVENIQKTVA
460 470 480 490 500
DFYNIKVADM YSKKRPANIA RPRQIAMYLA KELTQKSLPE IGELFGGRDH
510 520 530
TTVLHAVRKI ADERGKDAQL NHELHVLEQT LKG
Length:533
Mass (Da):58,352
Last modified:October 25, 2004 - v1
Checksum:iAC277CE737A21B6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571965 Genomic DNA Translation: CAH34058.1
RefSeqiWP_004525818.1, NC_006350.1
YP_106700.1, NC_006350.1

Genome annotation databases

EnsemblBacteriaiCAH34058; CAH34058; BPSL0075
GeneIDi3093573
KEGGibps:BPSL0075
PATRICifig|272560.51.peg.1660

Entry informationi

Entry nameiDNAA_BURPS
AccessioniPrimary (citable) accession number: Q63YW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 25, 2004
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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