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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Burkholderia pseudomallei (strain K96243)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseImported
Biological processGlyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation
LigandManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:BPSL0896Imported
OrganismiBurkholderia pseudomallei (strain K96243)Imported
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000000605 Componenti: Chromosome 1

PTM / Processingi

Proteomic databases

PRIDEiQ63WJ4.

Interactioni

Protein-protein interaction databases

STRINGi272560.BPSL0896.

Structurei

3D structure databases

ProteinModelPortaliQ63WJ4.
SMRiQ63WJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 414Iso_dhInterPro annotationAdd BLAST385

Phylogenomic databases

eggNOGiENOG4108HMX. Bacteria.
COG0538. LUCA.
HOGENOMiHOG000021113.
KOiK00031.
OMAiFQQIQTR.

Family and domain databases

InterProiView protein in InterPro
IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
PANTHERiPTHR43504. PTHR43504. 1 hit.
PfamiView protein in Pfam
PF00180. Iso_dh. 1 hit.
SMARTiView protein in SMART
SM01329. Iso_dh. 1 hit.
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiView protein in PROSITE
PS00470. IDH_IMDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63WJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYQHIKVPE GGDKITVNKD FSLNVSDQPI IPYIEGDGTG FDITPVMIKV
60 70 80 90 100
VDAAVEKAYG GKKKIHWMEI YAGEKATKVY GPDVWLPEET LQVLKEYVVS
110 120 130 140 150
IKGPLTTPVG GGIRSLNVAL RQELDLYVCL RPIQYFKGVP SPVREPEKTN
160 170 180 190 200
MVIFRENSED IYAGIEWAAE SEQAKKVIKF LQEEMGVKKI RFPQTSGIGI
210 220 230 240 250
KPVSKEGTER LVRKAIQYAI DNDRKSVTLV HKGNIMKFTE GAFRDAGYAL
260 270 280 290 300
AQKEFGAELI DGGPWMKFKN PKTGNEIVVK DSIADAFLQQ ILLRPAEYDV
310 320 330 340 350
IATLNLNGDY ISDALAAQVG GIGIAPGANL SDSVAMFEAT HGTAPKYAGK
360 370 380 390 400
DYVNPGSEIL SAEMMLRHLG WTEAADVIIS AMEKSIKQKR VTYDFARLME
410
GATQVSCSGF GQVLIENME
Length:419
Mass (Da):46,146
Last modified:October 25, 2004 - v1
Checksum:iF85E7112F2CB3C69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571965 Genomic DNA. Translation: CAH34889.1.
RefSeqiWP_004189552.1. NZ_CP009538.1.
YP_107522.1. NC_006350.1.

Genome annotation databases

EnsemblBacteriaiCAH34889; CAH34889; BPSL0896.
GeneIDi3092199.
KEGGibps:BPSL0896.
PATRICifig|272560.51.peg.688.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ63WJ4_BURPS
AccessioniPrimary (citable) accession number: Q63WJ4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 25, 2004
Last sequence update: October 25, 2004
Last modified: June 7, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported