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Q63WC3

- AMPA_BURPS

UniProt

Q63WC3 - AMPA_BURPS

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Protein

Probable cytosol aminopeptidase

Gene
pepA, BPSL0965
Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.

Cofactori

Binds 2 manganese ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi274 – 2741Manganese 2 By similarity
Metal bindingi279 – 2791Manganese 1 By similarity
Metal bindingi279 – 2791Manganese 2 By similarity
Active sitei286 – 2861 Reviewed prediction
Metal bindingi297 – 2971Manganese 2 By similarity
Metal bindingi356 – 3561Manganese 1 By similarity
Metal bindingi358 – 3581Manganese 1 By similarity
Metal bindingi358 – 3581Manganese 2 By similarity
Active sitei360 – 3601 Reviewed prediction

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciBPSE272560:GJNI-984-MONOMER.

Protein family/group databases

MEROPSiM17.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidase (EC:3.4.11.1)
Alternative name(s):
Leucine aminopeptidase (EC:3.4.11.10)
Short name:
LAP
Leucyl aminopeptidase
Gene namesi
Name:pepA
Ordered Locus Names:BPSL0965
OrganismiBurkholderia pseudomallei (strain K96243)
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000000605: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Probable cytosol aminopeptidaseUniRule annotationPRO_0000165733Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272560.BPSL0965.

Structurei

3D structure databases

ProteinModelPortaliQ63WC3.
SMRiQ63WC3. Positions 20-502.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.

Phylogenomic databases

eggNOGiCOG0260.
HOGENOMiHOG000243132.
KOiK01255.
OMAiAFISHFS.
OrthoDBiEOG6FV8B3.

Family and domain databases

HAMAPiMF_00181. Cytosol_peptidase_M17.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PfamiPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63WC3-1 [UniParc]FASTAAdd to Basket

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MDFSIKGCDW SKGTANGFLT GKSDCIVLGV FEAQTLSGAA LDIDEATKGL    50
VSRVIKAGDI DGKLGKTLFL HEVSGIGASR VLLVGLGRQD AFSQKAYGDA 100
AKAAWRALLG TKVVQVTFTL AQLPVPERAS DWGVRAAILA LRNETYKFTQ 150
MKSKPDAGAP ALKRVVFSVD PADDKAAKVA AKQAVALANG MDLTRDLGNL 200
PGNVCTPTYL ANTAKKIAKD WGLKVDVLGL KQIQALKMGS FLSVAKGSVE 250
PPQFIVLQYR GAAAKAAPVV LVGKGITFDS GGISLKPGEG MDEMKYDMCG 300
AGSVLGTMRA VAEMGLKVNV VAIVPTCENM PAGNANKPGD IVTSMKGLTI 350
EVLNTDAEGR LILCDALTYA ERFKPAAVID VATLTGACII ALGHHNTGLF 400
SKDDALAGEL LDASREAGDP AWRLPLDDEY QDQLKSNFAD LANIGGRPAG 450
SVTAACFLSR FAENYPWAHL DIAGTAWKSG AAKGATGRPV PLLAQFLIDR 500
AGA 503
Length:503
Mass (Da):52,653
Last modified:October 25, 2004 - v1
Checksum:iA641EACDE75CEC4F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571965 Genomic DNA. Translation: CAH34961.1.
RefSeqiYP_107593.1. NC_006350.1.

Genome annotation databases

EnsemblBacteriaiCAH34961; CAH34961; BPSL0965.
GeneIDi3092640.
KEGGibps:BPSL0965.
PATRICi19261635. VBIBurPse99623_1046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571965 Genomic DNA. Translation: CAH34961.1 .
RefSeqi YP_107593.1. NC_006350.1.

3D structure databases

ProteinModelPortali Q63WC3.
SMRi Q63WC3. Positions 20-502.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272560.BPSL0965.

Protein family/group databases

MEROPSi M17.003.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH34961 ; CAH34961 ; BPSL0965 .
GeneIDi 3092640.
KEGGi bps:BPSL0965.
PATRICi 19261635. VBIBurPse99623_1046.

Phylogenomic databases

eggNOGi COG0260.
HOGENOMi HOG000243132.
KOi K01255.
OMAi AFISHFS.
OrthoDBi EOG6FV8B3.

Enzyme and pathway databases

BioCyci BPSE272560:GJNI-984-MONOMER.

Family and domain databases

HAMAPi MF_00181. Cytosol_peptidase_M17.
InterProi IPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view ]
Pfami PF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view ]
PRINTSi PR00481. LAMNOPPTDASE.
PROSITEi PS00631. CYTOSOL_AP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K96243.

Entry informationi

Entry nameiAMPA_BURPS
AccessioniPrimary (citable) accession number: Q63WC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: October 25, 2004
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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