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Q63WC3

- AMPA_BURPS

UniProt

Q63WC3 - AMPA_BURPS

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Protein
Probable cytosol aminopeptidase
Gene
pepA, BPSL0965
Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.

Cofactori

Binds 2 manganese ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi274 – 2741Manganese 2 By similarity
Metal bindingi279 – 2791Manganese 1 By similarity
Metal bindingi279 – 2791Manganese 2 By similarity
Active sitei286 – 2861 Reviewed prediction
Metal bindingi297 – 2971Manganese 2 By similarity
Metal bindingi356 – 3561Manganese 1 By similarity
Metal bindingi358 – 3581Manganese 1 By similarity
Metal bindingi358 – 3581Manganese 2 By similarity
Active sitei360 – 3601 Reviewed prediction

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciBPSE272560:GJNI-984-MONOMER.

    Protein family/group databases

    MEROPSiM17.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytosol aminopeptidase (EC:3.4.11.1)
    Alternative name(s):
    Leucine aminopeptidase (EC:3.4.11.10)
    Short name:
    LAP
    Leucyl aminopeptidase
    Gene namesi
    Name:pepA
    Ordered Locus Names:BPSL0965
    OrganismiBurkholderia pseudomallei (strain K96243)
    Taxonomic identifieri272560 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000000605: Chromosome 1

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Probable cytosol aminopeptidaseUniRule annotation
    PRO_0000165733Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272560.BPSL0965.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63WC3.
    SMRiQ63WC3. Positions 20-502.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M17 family.

    Phylogenomic databases

    eggNOGiCOG0260.
    HOGENOMiHOG000243132.
    KOiK01255.
    OMAiAFISHFS.
    OrthoDBiEOG6FV8B3.

    Family and domain databases

    HAMAPiMF_00181. Cytosol_peptidase_M17.
    InterProiIPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view]
    PfamiPF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view]
    PRINTSiPR00481. LAMNOPPTDASE.
    PROSITEiPS00631. CYTOSOL_AP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63WC3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFSIKGCDW SKGTANGFLT GKSDCIVLGV FEAQTLSGAA LDIDEATKGL    50
    VSRVIKAGDI DGKLGKTLFL HEVSGIGASR VLLVGLGRQD AFSQKAYGDA 100
    AKAAWRALLG TKVVQVTFTL AQLPVPERAS DWGVRAAILA LRNETYKFTQ 150
    MKSKPDAGAP ALKRVVFSVD PADDKAAKVA AKQAVALANG MDLTRDLGNL 200
    PGNVCTPTYL ANTAKKIAKD WGLKVDVLGL KQIQALKMGS FLSVAKGSVE 250
    PPQFIVLQYR GAAAKAAPVV LVGKGITFDS GGISLKPGEG MDEMKYDMCG 300
    AGSVLGTMRA VAEMGLKVNV VAIVPTCENM PAGNANKPGD IVTSMKGLTI 350
    EVLNTDAEGR LILCDALTYA ERFKPAAVID VATLTGACII ALGHHNTGLF 400
    SKDDALAGEL LDASREAGDP AWRLPLDDEY QDQLKSNFAD LANIGGRPAG 450
    SVTAACFLSR FAENYPWAHL DIAGTAWKSG AAKGATGRPV PLLAQFLIDR 500
    AGA 503
    Length:503
    Mass (Da):52,653
    Last modified:October 25, 2004 - v1
    Checksum:iA641EACDE75CEC4F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571965 Genomic DNA. Translation: CAH34961.1.
    RefSeqiYP_107593.1. NC_006350.1.

    Genome annotation databases

    EnsemblBacteriaiCAH34961; CAH34961; BPSL0965.
    GeneIDi3092640.
    KEGGibps:BPSL0965.
    PATRICi19261635. VBIBurPse99623_1046.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571965 Genomic DNA. Translation: CAH34961.1 .
    RefSeqi YP_107593.1. NC_006350.1.

    3D structure databases

    ProteinModelPortali Q63WC3.
    SMRi Q63WC3. Positions 20-502.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 272560.BPSL0965.

    Protein family/group databases

    MEROPSi M17.003.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH34961 ; CAH34961 ; BPSL0965 .
    GeneIDi 3092640.
    KEGGi bps:BPSL0965.
    PATRICi 19261635. VBIBurPse99623_1046.

    Phylogenomic databases

    eggNOGi COG0260.
    HOGENOMi HOG000243132.
    KOi K01255.
    OMAi AFISHFS.
    OrthoDBi EOG6FV8B3.

    Enzyme and pathway databases

    BioCyci BPSE272560:GJNI-984-MONOMER.

    Family and domain databases

    HAMAPi MF_00181. Cytosol_peptidase_M17.
    InterProi IPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view ]
    Pfami PF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00481. LAMNOPPTDASE.
    PROSITEi PS00631. CYTOSOL_AP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K96243.

    Entry informationi

    Entry nameiAMPA_BURPS
    AccessioniPrimary (citable) accession number: Q63WC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: October 25, 2004
    Last modified: June 11, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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