Q63W06 (UBIC_BURPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable chorismate--pyruvate lyase
Short name=CL
Short name=CPL
EC=4.1.3.40

Gene names

Name:	ubiC
Ordered Locus Names:	BPSL1088

Organism

Burkholderia pseudomallei (Pseudomonas pseudomallei)

Taxonomic identifier

28450 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity. HAMAP MF_01632
Catalytic activity	Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632
Subcellular location	Cytoplasm By similarity HAMAP MF_01632.
Sequence similarities	Belongs to the ubiC family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chorismate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	Probable chorismate--pyruvate lyase HAMAP MF_01632		PRO_0000240538
Sites
	Binding site	73	1	Substrate By similarity
	Binding site	111	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q63W06 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: E009ED2A861D9EA1	FASTA	197	21,770
	10 20 30 40 50 60 MRFDAADAHW RETPRPGASS AQKDWLTRGG SLTAHLARLG RVTVRVTRET VAAPWADEHR 70 80 90 100 110 120 ALSCASRAPV WVREVVLAVD GAPFVAAHSI APLAASKGVW QAMRRLRTRP LAELLYSDPE 130 140 150 160 170 180 VTRSALVSRR VLAGHPLFSL ASLALARAYA TEHAFAARRS VFERRGTPLM VTECMLPALW 190 RHLDAHGERR ARGLEQT

References

[1]

"Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei." Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M., Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D., Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A., Brown N.F., Challis G.L. , Cherevach I., Chillingworth T., Cronin A., Crossett B., Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z., Hauser H., Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S., Price C., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M., Simmonds M., Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M., Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004) [PubMed: 15377794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K96243.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571965 Genomic DNA. Translation: CAH35082.1.
RefSeq	YP_107710.1. NC_006350.1.
3D structure databases
ProteinModelPortal	Q63W06.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3091588.
GenomeReviews	Gene locus BPSL1088 in contig BX571965_GR.
KEGG	bps:BPSL1088.
PATRIC	19261907. VBIBurPse99623_1181.
Phylogenomic databases
HOGENOM	HBG644467.
OMA	TREAVDC.
ProtClustDB	CLSK920196.
Enzyme and pathway databases
BioCyc	BPSE272560:BPSL1088-MONOMER.
Family and domain databases
HAMAP	MF_01632. UbiC. [Tree]
InterPro	IPR007440. Chorismate--pyruvate_lyase. [Graphical view]
KO	K03181.
Pfam	PF04345. Chor_lyase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIC_BURPS

Accession

Primary (citable) accession number: Q63W06

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program