Reviewed, UniProtKB/Swiss-Prot Q63VT1 (HEM6_BURPS)

Names and origin

Protein names

Recommended name:
    Coproporphyrinogen 3 oxidase, aerobic
    EC=1.3.3.3
Alternative name(s):
    Coproporphyrinogen III oxidase, aerobic
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase

Gene names

Name:	hemF
Ordered Locus Names:	BPSL1163

Organism

Burkholderia pseudomallei (Pseudomonas pseudomallei) [Complete proteome] [HAMAP]

Taxonomic identifier

28450 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen III (O2 route): step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the aerobic coproporphyrinogen III oxidase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Coproporphyrinogen 3 oxidase, aerobic		PRO_0000109890

Sequences

	Sequence		Length	Mass (Da)
	Q63VT1-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 7A5FCC82FA3139A1	FASTA	307	34,569
	10 20 30 40 50 60 MTDSTYDVNR VRAYLQGLQM RIADALGAFD GTPLAADTWR RGPGERLRGG GCTRILEAGG 70 80 90 100 110 120 FFERAGIGFS DVAGDALPPS ASASRPQLAG RGFEALGVSL VLHPRNPYCP TVHMNVRMLI 130 140 150 160 170 180 ATKPGEAPVF WFGGGMDLTP IYGFEEDARH FHRTCRAALE PFGAELYPRF KKWCDDYFFL 190 200 210 220 230 240 KHRNEARGIG GIFFDDFSEL GFERSFEMLQ SVGDAFLPSY LPIVERRRDT PYGERERAFQ 250 260 270 280 290 300 AYRRGRYVEF NLVFDRGTLF GLQSGGRTES ILLSMPPTAG WRYDWHPDPG TPEARLQSEF LVPRDWA

References

[1]

"Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei." Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M., Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D., Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A., Brown N.F., Challis G.L. , Cherevach I., Chillingworth T., Cronin A., Crossett B., Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z., Hauser H., Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S., Price C., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M., Simmonds M., Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M., Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004) [PubMed: 15377794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K96243.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX571965 Genomic DNA. Translation: CAH35158.1.
RefSeq	YP_107785.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3092344.
GenomeReviews	Gene locus BPSL1163 in contig BX571965_GR.
KEGG	bps:BPSL1163.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q63VT1.
Enzyme and pathway databases
BioCyc	BPSE272560:BPSL1163-MON.
Family and domain databases
HAMAP	MF_00333. [Tree]
InterPro	IPR001260. Coprogen_oxidas. [Graphical view]
Gene3D	G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHER	PTHR10755. Coprogen_oxidas. 1 hit.
Pfam	PF01218. Coprogen_oxidas. 1 hit. [Graphical view]
PIRSF	PIRSF000166. Coproporphyri_ox. 1 hit.
PRINTS	PR00073. COPRGNOXDASE.
PROSITE	PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEM6_BURPS

Accession

Primary (citable) accession number: Q63VT1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	October 25, 2004
Last modified:	November 4, 2008
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)