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Q63VN7 (PNP_BURPS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polyribonucleotide nucleotidyltransferase

EC=2.7.7.8
Alternative name(s):
Polynucleotide phosphorylase
Short name=PNPase
Gene names
Name:pnp
Ordered Locus Names:BPSL1207
OrganismBurkholderia pseudomallei (strain K96243) [Reference proteome] [HAMAP]
Taxonomic identifier272560 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length713 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity. HAMAP-Rule MF_01595

Catalytic activity

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate. HAMAP-Rule MF_01595

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01595

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01595.

Sequence similarities

Belongs to the polyribonucleotide nucleotidyltransferase family.

Contains 1 KH domain.

Contains 1 S1 motif domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 713713Polyribonucleotide nucleotidyltransferase HAMAP-Rule MF_01595
PRO_0000329558

Regions

Domain560 – 61960KH
Domain629 – 69769S1 motif

Sites

Metal binding4931Magnesium By similarity
Metal binding4991Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63VN7 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: D29B58F0FB8602B9

FASTA71376,990
        10         20         30         40         50         60 
MSLFNKIVKE FQWGQHKVRL ETGEIARQAS GAVIVDIEDT VVLATVVGAK SAKPGQDFFP 

        70         80         90        100        110        120 
LTVDYIEKTY SAGKIPGGFF RREGRPSEHE TLTSRLIDRP LRPLFPEGFY NEVQVVIHVL 

       130        140        150        160        170        180 
SVNPEIPADI PALIGASAAL AVSGLPFNGP VGAARVAYVN NEYVLNPTRE QIKASRLDLV 

       190        200        210        220        230        240 
VAGTERAVLM VESEADQLPE DVMLGAVVFG HEQMQTAIDA IHELVREGGK PEWDWQPAPK 

       250        260        270        280        290        300 
DEALNARVTE LAQPELLAAY QIRDKQARST KLKEVYAATS AKLEEEAVAA GTVAADKATV 

       310        320        330        340        350        360 
GNILFDLEAK IVRGQILNGE PRIDGRDTRT VRPIEIRTGV LPRTHGSALF TRGETQALVV 

       370        380        390        400        410        420 
ATLGTKGDEQ IIDALEGEYR ERFMLHYNMP PFATGETGRV GSPKRREIGH GRLAKRALVA 

       430        440        450        460        470        480 
CLPSADEFGY SIRVVSEITE SNGSSSMASV CGGCLALMDA GVPMKAHVAG IAMGLILEGN 

       490        500        510        520        530        540 
KFAVLTDILG DEDHLGDMDF KVAGTADGVT ALQMDIKIQG ITKEIMQVAL AQAKEGRMHI 

       550        560        570        580        590        600 
LGKMKDAVAG ANTQLSEFAP RMITIKINPE KIRDVIGKGG SVIRALTEET GTTIDISDDG 

       610        620        630        640        650        660 
VVTIASTNSE GMAEAKKRIE NITAEIEVGH VYEGTVLKLL DFGAIVNLLP GKDGLLHISE 

       670        680        690        700        710 
IVNERVKDIN DYLKEGQQVK VKVIQTDEKG RVRLSAKALL NEAAAQADTP PQQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571965 Genomic DNA. Translation: CAH35202.1.
RefSeqYP_107829.1. NC_006350.1.

3D structure databases

ProteinModelPortalQ63VN7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272560.BPSL1207.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH35202; CAH35202; BPSL1207.
GeneID3092633.
KEGGbps:BPSL1207.
PATRIC19262211. VBIBurPse99623_1337.

Phylogenomic databases

eggNOGCOG1185.
HOGENOMHOG000218326.
KOK00962.
OMAHGNFKSN.
OrthoDBEOG6WT8CC.

Enzyme and pathway databases

BioCycBPSE272560:GJNI-1226-MONOMER.

Family and domain databases

Gene3D1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPMF_01595. PNPase.
InterProIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERPTHR11252. PTHR11252. 1 hit.
PfamPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFPIRSF005499. PNPase. 1 hit.
SMARTSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsTIGR03591. polynuc_phos. 1 hit.
PROSITEPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePNP_BURPS
AccessionPrimary (citable) accession number: Q63VN7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families