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Q63VB7

- PCKG_BURPS

UniProt

Q63VB7 - PCKG_BURPS

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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881SubstrateUniRule annotation
Binding sitei229 – 2291Substrate; via amide nitrogenUniRule annotation
Metal bindingi236 – 2361ManganeseUniRule annotation
Binding sitei236 – 2361SubstrateUniRule annotation
Metal bindingi256 – 2561Manganese; via tele nitrogenUniRule annotation
Binding sitei278 – 2781SubstrateUniRule annotation
Active sitei280 – 2801UniRule annotation
Metal bindingi305 – 3051ManganeseUniRule annotation
Binding sitei401 – 4011GTPUniRule annotation
Binding sitei432 – 4321GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi279 – 2846GTPUniRule annotation
Nucleotide bindingi529 – 5324GTPUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPSE272560:GJNI-1354-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:BPSL1324
OrganismiBurkholderia pseudomallei (strain K96243)
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000000605: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103593Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272560.BPSL1324.

Structurei

3D structure databases

ProteinModelPortaliQ63VB7.
SMRiQ63VB7. Positions 20-620.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni399 – 4013Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiWDNPAGV.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63VB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRSNVVAAT RTVPIDVPEY VKHRGLIDWV ARIAELTEPD RVVWCDGSQQ
60 70 80 90 100
EYDRLCDAMV EQRTMVRLNP AKRPNSFLAL SDPSDVARVE DRTFICSEHR
110 120 130 140 150
DDAGPTNHWV APAEMRATLN GLFRGAMRGR TLYVVPFSMG PLGSPIAHIG
160 170 180 190 200
VELSDSPYVV VNMRIMTRMG RAVLDALGER GEYVPCVHSV GRPLAAGEQD
210 220 230 240 250
VPWPCNPTKY IVHFPESREI WSFGSGYGGN ALLGKKCFAL RIASTMGRDE
260 270 280 290 300
GWLAEHMLIL GVTSPEGRKY HIAAAFPSAC GKTNFAMLIP PKGFEGWRVT
310 320 330 340 350
TIGDDIAWLK PGRDGRLYAI NPEAGYFGVA PGTGEKTNPN ALATLRENVI
360 370 380 390 400
FTNVALTEDG DVWWEGLTDT PPARLTDWQG NAWTPEIGRE TGRKAAHPNS
410 420 430 440 450
RFTAPASQCP SIDDDWENPG GVPIDAFIFG GRRSTTVPLV TEARDWIEGV
460 470 480 490 500
YMAATMGSET TAAAAGQQGI VRRDPFAMLP FCGYNMSDYF SHWLALGEKL
510 520 530 540 550
AAAGATLPKI YCVNWFRKDA DGRFAWPGFG ENMRVLKWML DRIDGRGEGV
560 570 580 590 600
EHAFGVTPRY EDLHWAGLAF SPAQYAQVTS MNPDEWRAEL ALHAELFDKL
610 620
SARLPDALAE TKARIEKRLG G
Length:621
Mass (Da):68,534
Last modified:October 25, 2004 - v1
Checksum:i685A6B4BF4291419
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571965 Genomic DNA. Translation: CAH35322.1.
RefSeqiYP_107949.1. NC_006350.1.

Genome annotation databases

EnsemblBacteriaiCAH35322; CAH35322; BPSL1324.
GeneIDi3093468.
KEGGibps:BPSL1324.
PATRICi19262519. VBIBurPse99623_1485.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571965 Genomic DNA. Translation: CAH35322.1 .
RefSeqi YP_107949.1. NC_006350.1.

3D structure databases

ProteinModelPortali Q63VB7.
SMRi Q63VB7. Positions 20-620.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272560.BPSL1324.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH35322 ; CAH35322 ; BPSL1324 .
GeneIDi 3093468.
KEGGi bps:BPSL1324.
PATRICi 19262519. VBIBurPse99623_1485.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi WDNPAGV.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci BPSE272560:GJNI-1354-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K96243.

Entry informationi

Entry nameiPCKG_BURPS
AccessioniPrimary (citable) accession number: Q63VB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2004
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3