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Q63VB7

- PCKG_BURPS

UniProt

Q63VB7 - PCKG_BURPS

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei88 – 881SubstrateUniRule annotation
    Binding sitei229 – 2291Substrate; via amide nitrogenUniRule annotation
    Metal bindingi236 – 2361ManganeseUniRule annotation
    Binding sitei236 – 2361SubstrateUniRule annotation
    Metal bindingi256 – 2561Manganese; via tele nitrogenUniRule annotation
    Binding sitei278 – 2781SubstrateUniRule annotation
    Active sitei280 – 2801UniRule annotation
    Metal bindingi305 – 3051ManganeseUniRule annotation
    Binding sitei401 – 4011GTPUniRule annotation
    Binding sitei432 – 4321GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi279 – 2846GTPUniRule annotation
    Nucleotide bindingi529 – 5324GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBPSE272560:GJNI-1354-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:BPSL1324
    OrganismiBurkholderia pseudomallei (strain K96243)
    Taxonomic identifieri272560 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000000605: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 621621Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103593Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272560.BPSL1324.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63VB7.
    SMRiQ63VB7. Positions 20-620.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni399 – 4013Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiWDNPAGV.
    OrthoDBiEOG6MPWQS.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    PROSITEiPS00505. PEPCK_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63VB7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRSNVVAAT RTVPIDVPEY VKHRGLIDWV ARIAELTEPD RVVWCDGSQQ    50
    EYDRLCDAMV EQRTMVRLNP AKRPNSFLAL SDPSDVARVE DRTFICSEHR 100
    DDAGPTNHWV APAEMRATLN GLFRGAMRGR TLYVVPFSMG PLGSPIAHIG 150
    VELSDSPYVV VNMRIMTRMG RAVLDALGER GEYVPCVHSV GRPLAAGEQD 200
    VPWPCNPTKY IVHFPESREI WSFGSGYGGN ALLGKKCFAL RIASTMGRDE 250
    GWLAEHMLIL GVTSPEGRKY HIAAAFPSAC GKTNFAMLIP PKGFEGWRVT 300
    TIGDDIAWLK PGRDGRLYAI NPEAGYFGVA PGTGEKTNPN ALATLRENVI 350
    FTNVALTEDG DVWWEGLTDT PPARLTDWQG NAWTPEIGRE TGRKAAHPNS 400
    RFTAPASQCP SIDDDWENPG GVPIDAFIFG GRRSTTVPLV TEARDWIEGV 450
    YMAATMGSET TAAAAGQQGI VRRDPFAMLP FCGYNMSDYF SHWLALGEKL 500
    AAAGATLPKI YCVNWFRKDA DGRFAWPGFG ENMRVLKWML DRIDGRGEGV 550
    EHAFGVTPRY EDLHWAGLAF SPAQYAQVTS MNPDEWRAEL ALHAELFDKL 600
    SARLPDALAE TKARIEKRLG G 621
    Length:621
    Mass (Da):68,534
    Last modified:October 25, 2004 - v1
    Checksum:i685A6B4BF4291419
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571965 Genomic DNA. Translation: CAH35322.1.
    RefSeqiYP_107949.1. NC_006350.1.

    Genome annotation databases

    EnsemblBacteriaiCAH35322; CAH35322; BPSL1324.
    GeneIDi3093468.
    KEGGibps:BPSL1324.
    PATRICi19262519. VBIBurPse99623_1485.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571965 Genomic DNA. Translation: CAH35322.1 .
    RefSeqi YP_107949.1. NC_006350.1.

    3D structure databases

    ProteinModelPortali Q63VB7.
    SMRi Q63VB7. Positions 20-620.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272560.BPSL1324.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH35322 ; CAH35322 ; BPSL1324 .
    GeneIDi 3093468.
    KEGGi bps:BPSL1324.
    PATRICi 19262519. VBIBurPse99623_1485.

    Phylogenomic databases

    eggNOGi COG1274.
    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi WDNPAGV.
    OrthoDBi EOG6MPWQS.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci BPSE272560:GJNI-1354-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    PROSITEi PS00505. PEPCK_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K96243.

    Entry informationi

    Entry nameiPCKG_BURPS
    AccessioniPrimary (citable) accession number: Q63VB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3