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Q63V58

- UPPP1_BURPS

UniProt

Q63V58 - UPPP1_BURPS

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Protein

Undecaprenyl-diphosphatase 1

Gene

uppP1

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBPSE272560:GJNI-1416-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 1UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 1UniRule annotation
Undecaprenyl pyrophosphate phosphatase 1UniRule annotation
Gene namesi
Name:uppP1UniRule annotation
Ordered Locus Names:BPSL1383
OrganismiBurkholderia pseudomallei (strain K96243)
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000000605: Chromosome 1

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Undecaprenyl-diphosphatase 1PRO_0000151126Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272560.BPSL1383.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalUniRule annotationAdd
BLAST
Transmembranei44 – 6421HelicalUniRule annotationAdd
BLAST
Transmembranei87 – 10721HelicalUniRule annotationAdd
BLAST
Transmembranei114 – 13421HelicalUniRule annotationAdd
BLAST
Transmembranei150 – 17021HelicalUniRule annotationAdd
BLAST
Transmembranei190 – 21021HelicalUniRule annotationAdd
BLAST
Transmembranei222 – 24221HelicalUniRule annotationAdd
BLAST
Transmembranei251 – 27121HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiSDIMRIA.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63V58-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLWFLVFLS VLQGVTELFP VSSLGHTLLV PALFGMHIDK HAPQLLPFLV
60 70 80 90 100
ALHLGTALAL LWYFRERWIA LIAGFFASLN GRKNDEGHLM WALIIGTIPT
110 120 130 140 150
GLVGLLLEKR IERVFHDLRI VAAALIINGV LLWLGDRIQR ARAHRPPEKL
160 170 180 190 200
TFKQAFFVGL AQVGALIPGF SRSGLTMIAG NAAGLTADKA AEFSFLLGTP
210 220 230 240 250
IIFAAGLLEL PKLFHAPDQL ADALLGGVLT AIAAYLSVRF LMRYFEGRGR
260 270
LASFGLYCVL AGLFCLGWFM FHAQPV
Length:276
Mass (Da):30,247
Last modified:October 25, 2004 - v1
Checksum:i27C258F7FAC6845D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571965 Genomic DNA. Translation: CAH35383.1.
RefSeqiYP_108008.1. NC_006350.1.

Genome annotation databases

EnsemblBacteriaiCAH35383; CAH35383; BPSL1383.
GeneIDi3094294.
KEGGibps:BPSL1383.
PATRICi19262655. VBIBurPse99623_1552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571965 Genomic DNA. Translation: CAH35383.1 .
RefSeqi YP_108008.1. NC_006350.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272560.BPSL1383.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH35383 ; CAH35383 ; BPSL1383 .
GeneIDi 3094294.
KEGGi bps:BPSL1383.
PATRICi 19262655. VBIBurPse99623_1552.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi SDIMRIA.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BPSE272560:GJNI-1416-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K96243.

Entry informationi

Entry nameiUPPP1_BURPS
AccessioniPrimary (citable) accession number: Q63V58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 25, 2004
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3