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Q63U95

- ASSY_BURPS

UniProt

Q63U95 - ASSY_BURPS

Protein

Argininosuccinate synthase

Gene

argG

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei87 – 871CitrullineUniRule annotation
    Binding sitei117 – 1171ATP; via amide nitrogenUniRule annotation
    Binding sitei119 – 1191AspartateUniRule annotation
    Binding sitei123 – 1231AspartateUniRule annotation
    Binding sitei123 – 1231CitrullineUniRule annotation
    Binding sitei124 – 1241AspartateUniRule annotation
    Binding sitei127 – 1271CitrullineUniRule annotation
    Binding sitei176 – 1761CitrullineUniRule annotation
    Binding sitei261 – 2611CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 179ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBPSE272560:GJNI-1757-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:BPSL1721
    OrganismiBurkholderia pseudomallei (strain K96243)
    Taxonomic identifieri272560 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000000605: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Argininosuccinate synthasePRO_0000148579Add
    BLAST

    Proteomic databases

    PRIDEiQ63U95.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272560.BPSL1721.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63U95.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiGIKSKFD.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63U95-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPKHILLAY SGGLDTSTAL HFLKRHFDCR VTAYCANLGQ KEDWERMKRR    50
    AAIAGADELV IEDLRETFIG DFVFPALKAN ASYERDYLLG TPLARPAIVK 100
    GLIEYARKHD VDCLSHGCTQ KGNDQVRFEM AAKILAPDLP TVAPWRIWSL 150
    QSREDLFAYC QQHGIPVESR PDNLLSHDEN LVHITTEGDY LESVANAFDW 200
    RDANWITPPT QAPDAIETIT LGFRRGVPVS VDGAALGPVE LVERLNEAGA 250
    RNGVGFQDII ENRINGLKVR GVFENPALTI LHAAHRKLEK ITLGRDVERL 300
    RNLVSDDYGD IVYRGLWFSD ERLCLQALID ESQKYVSGDV KVQLYKGSCT 350
    PCAVESEQSL YSRELVTLHA GRAISGEDAT GFLNTLGLRI GIEAARAGNT 400
    GAGA 404
    Length:404
    Mass (Da):44,744
    Last modified:October 25, 2004 - v1
    Checksum:iDDDC9B73AC7EBA68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571965 Genomic DNA. Translation: CAH35720.1.
    RefSeqiYP_108321.1. NC_006350.1.

    Genome annotation databases

    EnsemblBacteriaiCAH35720; CAH35720; BPSL1721.
    GeneIDi3093741.
    KEGGibps:BPSL1721.
    PATRICi19263417. VBIBurPse99623_1930.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571965 Genomic DNA. Translation: CAH35720.1 .
    RefSeqi YP_108321.1. NC_006350.1.

    3D structure databases

    ProteinModelPortali Q63U95.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272560.BPSL1721.

    Proteomic databases

    PRIDEi Q63U95.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH35720 ; CAH35720 ; BPSL1721 .
    GeneIDi 3093741.
    KEGGi bps:BPSL1721.
    PATRICi 19263417. VBIBurPse99623_1930.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi GIKSKFD.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci BPSE272560:GJNI-1757-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K96243.

    Entry informationi

    Entry nameiASSY_BURPS
    AccessioniPrimary (citable) accession number: Q63U95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3