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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227.

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:BPSL1757
OrganismiBurkholderia pseudomallei (strain K96243)
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000000605 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002577521 – 363Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST363

Interactioni

Protein-protein interaction databases

STRINGi272560.BPSL1757.

Structurei

3D structure databases

ProteinModelPortaliQ63U59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EE8. Bacteria.
COG1903. LUCA.
HOGENOMiHOG000009126.
KOiK02188.
OMAiMMVHSKS.

Family and domain databases

HAMAPiMF_00787. CbiD. 1 hit.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63U59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDETPEQPA PLRFGYTTGS CASATSLAAA RLLLTGVASD TVDIVLPKGQ
60 70 80 90 100
HVAMRLAFCR ATDDGGAEAG TIKDAGDDPD VTHGALVFAR VRLVHEPGVR
110 120 130 140 150
FRAGPGVGTV TRAGLPIAVG EPAINPVPRR MMTEHLAALA AEHGYAGGFD
160 170 180 190 200
VAIGVENGEA LARKTMNPRL GIVGGLSILG TTGIVRPFSC SAYIASIHQG
210 220 230 240 250
IDVARANGVT HIAACTGNAS EDAVRARYGL PDIALIEMGD FAGAVLKYLR
260 270 280 290 300
RASVARLTLC GGFGKLSKLA AGHLDLHSRH SSIDLPLLAE WAGEAGASAV
310 320 330 340 350
LQHEIRAANT SQQALALALA HHVPLGDVVC AHARRVARDI VPGEVDVETL
360
AIDREGRIVG VAP
Length:363
Mass (Da):37,595
Last modified:October 25, 2004 - v1
Checksum:i5D60C1CEE45C3275
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571965 Genomic DNA. Translation: CAH35756.1.
RefSeqiWP_004552847.1. NC_006350.1.
YP_108357.1. NC_006350.1.

Genome annotation databases

EnsemblBacteriaiCAH35756; CAH35756; BPSL1757.
GeneIDi3094469.
KEGGibps:BPSL1757.
PATRICi19263501. VBIBurPse99623_1972.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571965 Genomic DNA. Translation: CAH35756.1.
RefSeqiWP_004552847.1. NC_006350.1.
YP_108357.1. NC_006350.1.

3D structure databases

ProteinModelPortaliQ63U59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272560.BPSL1757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH35756; CAH35756; BPSL1757.
GeneIDi3094469.
KEGGibps:BPSL1757.
PATRICi19263501. VBIBurPse99623_1972.

Phylogenomic databases

eggNOGiENOG4105EE8. Bacteria.
COG1903. LUCA.
HOGENOMiHOG000009126.
KOiK02188.
OMAiMMVHSKS.

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227.

Family and domain databases

HAMAPiMF_00787. CbiD. 1 hit.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCBID_BURPS
AccessioniPrimary (citable) accession number: Q63U59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 25, 2004
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.