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Q63T25

- LPXB_BURPS

UniProt

Q63T25 - LPXB_BURPS

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciBPSE272560:GJNI-2192-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:BPSL2146
    OrganismiBurkholderia pseudomallei (strain K96243)
    Taxonomic identifieri272560 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000000605: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Lipid-A-disaccharide synthasePRO_0000255165Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272560.BPSL2146.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63T25.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiIARMLVN.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q63T25-1 [UniParc]FASTAAdd to Basket

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    MAFQLTPLRV ALVAGEPSGD LLGASLLGGL HARLPASSRY YGIGGPRMSA    50
    VEFDAHWPME KLAVRGYVEA LKHIPEILRI RGELKRQLLA EPPDAFVGID 100
    APDFNFGLEQ ALRGAGIPTI HFVCPSIWAW RGGRIKKIVK AVDHMLCLFP 150
    FEPELLEKAG VAATFVGHPL ADEIPLEPDT HGARIALGLP DGGPVIAVLP 200
    GSRRSEIELI GPTFFDAMEL MQQREPGVRF VVPAATPVLR ALLQPLVDAH 250
    PSLSVTLTEG RAQVAMTAAD AILVKSGTVT LEAALLKKPM VISYKVPWLT 300
    GQIMRRQGYL PYVGLPNILA GRFVVPELLQ HFATPDALAD ATLTQLRDDA 350
    NRRALTDIFT DMHLALRQNT AQRAAEAVAR VIDSRKPR 388
    Length:388
    Mass (Da):42,147
    Last modified:October 25, 2004 - v1
    Checksum:i78753260D4CD3AA2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571965 Genomic DNA. Translation: CAH36148.1.
    RefSeqiWP_011205135.1. NC_006350.1.
    YP_108741.1. NC_006350.1.

    Genome annotation databases

    EnsemblBacteriaiCAH36148; CAH36148; BPSL2146.
    GeneIDi3094043.
    KEGGibps:BPSL2146.
    PATRICi19264449. VBIBurPse99623_2440.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571965 Genomic DNA. Translation: CAH36148.1 .
    RefSeqi WP_011205135.1. NC_006350.1.
    YP_108741.1. NC_006350.1.

    3D structure databases

    ProteinModelPortali Q63T25.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272560.BPSL2146.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH36148 ; CAH36148 ; BPSL2146 .
    GeneIDi 3094043.
    KEGGi bps:BPSL2146.
    PATRICi 19264449. VBIBurPse99623_2440.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi IARMLVN.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci BPSE272560:GJNI-2192-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K96243.

    Entry informationi

    Entry nameiLPXB_BURPS
    AccessioniPrimary (citable) accession number: Q63T25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3